Sulfotep

H300: Fatal if swallowed [Danger Acute toxicity, oral]

H310: Fatal in contact with skin [Danger Acute toxicity, dermal]

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P262, P264, P270, P273, P280, P301+P316, P302+P352, P316, P321, P330, P361+P364, P391, P405, and P501 (click each P-code to see the statement)

H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]

H310 (100%): Fatal in contact with skin [Danger Acute toxicity, dermal]

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Aggregated GHS information provided per 42 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

H330: Fatal if inhaled [Danger Acute toxicity, inhalation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P203, P260, P261, P262, P264, P264+P265, P270, P271, P280, P284, P301+P316, P302+P352, P304+P340, P305+P351+P338, P308+P316, P316, P318, P319, P320, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention .

Warning: Effects may be delayed up to 12 hours. Caution is advised.

Note: Sulfotep is a cholinesterase inhibitor.

Signs and Symptoms of Sulfotep Exposure: Acute exposure to sulfotep may produce the following signs and symptoms: sweating, pinpoint pupils, blurred vision, headache, dizziness, profound weakness, muscle spasms, seizures, and coma. Mental confusion and psychosis may occur. Excessive salivation, nausea, vomiting, anorexia, diarrhea, and abdominal pain may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Chest pain may be noted. Hypotension (low blood pressure) may be observed, although hypertension (high blood pressure) is not uncommon. Respiratory signs include dyspnea (shortness of breath), pulmonary edema, respiratory depression, and respiratory paralysis.

Emergency Life-Support Procedures: Acute exposure to sulfotep may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:

1. Move victims to fresh air. Emergency personnel should avoid self-exposure to sulfotep.

2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

4. RUSH to a health care facility!

Dermal/Eye Exposure:

1. Remove victims from exposure. Emergency personnel should avoid self-exposure to sulfotep.

3. Remove and isolate contaminated clothing as soon as possible.

4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.

5. Wash exposed skin areas thoroughly with water.

6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

7. RUSH to a health care facility!

Ingestion Exposure:

1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of sulfotep is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step

4. Ipecac should not be administered to children under 6 months of age. Warning: Ingestion of sulfotep may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step

4. The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.

4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.

5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.

6. RUSH to a health care facility! (EPA, 1998)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

(Non-Specific -- Organophosphorus Pesticide, n.o.s.) Wear positive pressure breathing apparatus and special protective clothing.

(Non-Specific -- Organophosphorus Pesticide, n.o.s.) For small fires, use dry chemical, carbon dioxide, water spray, or foam. For large fires, use water spray, fog, or foam. Fight fire from maximum distance. (EPA, 1998)

Use water spray, foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Extinguish fire using agent suitable for type of surrouding fire (material itself does not burn or burns with difficulty). Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Tetraethyl dithiopyrophosphate mixture, dry/

If material is involved in fire: Extinguish fire using agent suitable for type of surrounding fire (material itself does not burn or burns with difficulty). Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use alcohol foam, dry chemical, or carbon dioxide. /Tetraethyl dithiopyrophosphate and compressed gas mixture or liquid/

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. Use water spray to knock down vapors. /Tetraethyl dithiopyrophosphate mixture, liquid/

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· DO NOT GET WATER INSIDE CONTAINERS.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.

Absorb with paper towels. Place in a plastic bag. Burn in an open pan with help of flammable solvent or in a furnace.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number P109, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Potential candidate for rotary kiln incineration with a temperature range of 820 to 1600 °C with residence times for liquids and gases: seconds; solids, hours. Also, a potential candidate for liquid injection incineration with a temperature range of 650 to 1600 °C with residence times of 0.1 to 2 seconds. Also, a potential candidate for fluidized bed incineration with a temperature range of 450 to 980 °C with residence times for liquids and gases, seconds; solids, longer.

This compound should be susceptible to removal from wastewater by air stripping.

Incinerate with added flammable solvent in furnace equipped with afterburner and alkaline scrubber. Recommendable method: Incineration.

Employees should wash immediately when skin is wet or contaminated. Remove non-impervious clothing immediately if wet or contaminated.

Evacuation: If material is leaking (not on fire), consider evacuation from from downwind area based on amount of material spilled, location, and weather conditions. /Tetraethyl dithiopyrophosphate, mixture, liquid or tetraethyl dithiopyrophosphate, liquid/

Evacuation: If material leaking (not on fire) consider evacuation from downwind area based on amount of material spilled, location, and weather conditions. /Tetraethyl dithiopyphosphate and compressed gas mixture/

Avoid breathing vapors. Keep upwind. ... Avoid bodily contact with the material. ... Do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. /Tetraethyl dithiopyrophosphate and compressed gas mixture or tetraethyl dithiopyrophosphate mixture, dry or tetraethyl dithiopyrophosphate mixture, liquid or tetraethyl dithiopyrophosphate, liquid/

For more Preventive Measures (Complete) data for SULFOTEP (13 total), please visit the HSDB record page.

(Non-Specific -- Organophosphate Pesticide) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Remove and isolate contaminated clothing at the site. Do not touch spilled material; stop leak if you can do it without risk. Use water spray to reduce vapors.

Small spills: take up with sand or other noncombustible absorbent material and place into containers for later disposal.

Large spills: dike far ahead of spill for later disposal. (EPA, 1998)

Dry. Well closed. Separated from strong oxidants and food and feedstuffs. Keep in a well-ventilated room. Do NOT store or transport in containers made from metal. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

Biological Exposure Indices (BEI) [ACGIH] - Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

0.13 [mg/m3], inhalable fraction[German Research Foundation (DFG)]

0.30 [mg/m3]

3.5 [mg/m3]

10 [mg/m3]

0.2 mg/m³

TWA 0.2 mg/m3 [skin]

0.2 [mg/m3]

10 mg/m3 (NIOSH, 2024)

10.0 [mg/m3]

10 mg/cu m

10 mg/m³

10 mg/m3

See: 3689245

0.1 [mg/m3], inhalable fraction and vapor

8 hr Time Weighted Avg (TWA): 0.1 mg/cu m, skin, inhalable fraction and vapor.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

A4; Not classifiable as a human carcinogen.

Biological Exposure Index (BEI): Determinant: cholinesterase activity in red blood cells; Sampling Time: discretionary; BEI: 70% of individual's baseline. The determinant is nonspecific, since it is also observed after exposure to other chemicals. /Acetylcholinesterase inhibiting pesticides/

0.1 mg/m

0.1 mg/m³ (inhalable fraction and vapor) [1993]

0.13 mg/m

Small Fire

· Dry chemical, CO2 or water spray.

Large Fire

· Dry chemical, CO2, alcohol-resistant foam or water spray.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Do not get water inside containers.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C.

The substance is irritating to the eyes and skin. The substance may cause effects on the nervous system. This may result in convulsions and respiratory failure. Cholinesterase inhibition. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated.

Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms.

Tetraethyl dithiopyrophosphate is an organic phosphate pesticide which acts as an inhibitor of cholinesterase, and as such it is highly toxic by all routes of exposure. It is a colorless to pale yellow mobile oil with an odor of garlic. It may be found as a liquid or as a dry mixture where the liquid is absorbed onto a dry carrier.

Pale-yellow liquid with a garlic-like odor; [NIOSH]

PALE YELLOW LIQUID WITH CHARACTERISTIC ODOUR.

Pale-yellow liquid with a garlic-like odor.

Pale-yellow liquid with a garlic-like odor. [Note: A pesticide that may be absorbed on a solid carrier or mixed in a more flammable liquid.]

COLORLESS OIL

Pale yellow mobile liquid

Possesses a garlic odor

277 to 282 °F at 2 mmHg (EPA, 1998)

136-139 °C @ 2 mm Hg

at 0.2666kPa: 136-139 °C

277-282 °F at 2 mmHg

310 °C @760 [mm Hg]

Decomposes

Not combustible (EPA, 1998)

less than 0.1 mg/mL at 64 °F (NTP, 1992)

Miscible in n-hexane, dichloromethane, 2-propanol, toluene

Miscible with most organic solvents. Sparingly soluble in ligroin and petroleum ether.

Sol in water, 30 mg/l @ 20 °C

Solubility in water: none

1.196 at 77 °F (EPA, 1998) - Denser than water; will sink

1.196 @ 25 °C/4 °C

Relative density (water = 1): 1.2

1.196 (at 77 °F)

1.19 @ 20°C

(77 °F): 1.20

0.00017 mmHg at 68 °F (EPA, 1998)

0.0002 [mmHg]

1.05X10-4 mm Hg @ 20 °C

Vapor pressure, Pa at 20 °C: 0.0226

0.0002 mmHg

0.000105 [mm Hg] @20 °C

log Kow = 3.99

Hydrolyzes very slowly in aqueous solution.

When heated to decomposition it emits toxic fumes of /phosphorus oxides and sulfur oxides/.

DT50 (estimated) 10.7 days (pH 4), 8.2 days (pH 7), 9.1 days (pH 9) (22 °C)

Corrosive to iron

Index of refraction: 1.4753 for 25 °C and sodium light

172.2 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID7024328]

DARK-COLORED LIQUID; BOILING POINT: 131-135 °C @ 2 MM HG; INDEX OF REFRACTION: 1.4725 @ 25 °C/D /TECHNICAL GRADE/

Insoluble in water.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

Anhydrides

TETRAETHYL DITHIOPYROPHOSPHATE is incompatible with the following: Strong oxidizers, iron [Note: Corrosive to iron.] (NIOSH, 2024). Organothiophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Incompatible with strong oxidizers

Strong oxidizers, iron [Note: Corrosive to iron].

Strong oxidizers, iron [Note: Corrosive to iron.]

Tetraethyldithiopyrophosphate

5 x 10 ^-4 mg/kg-day

Sulfotepp

Pesticide

Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP

A4; Not classifiable as a human carcinogen.

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

Blue lips, fingernails and skin. Dizziness. Drowsiness. Headache. Pupillary constriction, muscle cramp, excessive salivation. Sweating. Laboured breathing. Nausea. Convulsions. Unconsciousness. Weakness. See Ingestion.

MAY BE ABSORBED! Redness. Further see Inhalation.

Redness. Pain. Pupillary constriction.

Abdominal cramps. Confusion. Diarrhoea. Vomiting. Further see Inhalation.

irritation eyes, skin; eye pain, blurred vision, lacrimation (discharge of tears); rhinorrhea (discharge of thin nasal mucus); headache; cyanosis; anorexia, nausea, vomiting, diarrhea; localized sweating, lassitude (weakness, exhaustion), twitching, paralysis, Cheyne-Stokes respiration, convulsions, low blood pressure, cardiac irreg

Eyes, skin, respiratory system, central nervous system, cardiovascular system, blood cholinesterase

Other Poison - Organophosphate

ACGIH Carcinogen - Not Classifiable.

IRIS Current

HEAST Current

LC50 (rat) = 38 mg/m3/4h

LD50 Mouse subcutaneous 8 mg/kg

LD50 Rabbit percutaneous 20 mg/kg

LD50 Rat oral 5-13.8 mg/kg

LD50 Mouse oral 21.5-29.4 mg/kg

For more Non-Human Toxicity Values (Complete) data for SULFOTEP (18 total), please visit the HSDB record page.

Consider the points of attack /central nervous system, respiratory system, cardiovascular system/ in preplacement and periodic physical examinations.

/Protect/ from exposure when cholinesterase in red blood cell or plasma falls to 50% of normal. May return to work when cholinesterase is again above 75% of normal.

/SIGNS AND SYMPTOMS/ In a review of available epidemiological information on sulfotepp EPA described an instance where a greenhouse worker experienced symptoms of organophosphate poisoning (headache, nausea, diarrhea, vomiting, cough, dizziness, sweating, fatigue, abdominal pain, anxiety, muscle aches, chest tightness, drowsiness, restlessness, shortness of breath, and excessive salivation) when applying the compound. Skin lesions have been reported during the spraying of sulfotepp.

/SIGNS AND SYMPTOMS/ SYMPTOMATOLOGY: 1. Nausea is often the first symptom, followed by vomiting, abdominal cramps, diarrhea, and excessive salivation (sialorrhea). Hypothermia has been reported in animals and at least once in man as an early sign. 2. Headache, giddiness, vertigo, and weakness. 3. Rhinorrhea and a sensation of tightness in the chest are common in inhalation exposures. 4. Blurring or dimness of vision, miosis (with fixed pinpoint pupils), tearing, ciliary muscle spasm, loss of accommodation, and ocular pain. None of these eye effects are diagnostically dependable except in primary ocular exposures. Indeed, mydriasis is sometimes seen, probably due to sympatho-adrenal discharge. 5. Bradycardia or tachycardia. Varying degrees of AV heart block are described, as well as atrial arrhythmias. 6. Loss of muscle coordination, slurring of speech, fasciculations and twitching of muscles (particularly of the tongue and eyelids), and generalized profound weakness. 7. Mental confusion, disorientation, and drowsiness. 8. Difficulty in breathing, excessive secretion of saliva and of respiratory tract mucus, oronasal frothing, cyanosis, pulmonary rales and rhonchi, and hypertension (presumably due to asphyxia). 9. Random jerky movements, incontinence, convulsions, and coma. 10. Death primarily due to respiratory arrest arising from failure of the respiratory muscles, intense bronchoconstriction, or all three. /Parathion/

/CASE REPORTS/ Two spraymen working in public health occupations in Alexandria, Egypt, experienced acute toxicity resulting from exposure to diazinon (insecticide). Symptomatology was similar to that previously reported for exposure to parathion or other organophosphorus insecticides (nausea, motor toxicity, and headache). Plasma and red blood cell cholinesterase activity values were determined in blood samples obtained from both individuals at various times after the incident. Cholinesterase activity showed a marked reduction up to 18 days after exposure. Blood cholinesterase activity recovered to 90% of the normal level of activity 28 days after the poisoning incident in 1 individual. This activity recovered to about the same level in the other individual, but after only 20 days from the poisoning date. This acute toxicity resulted from unsuitable storage conditions of the emulsifiable concentrate formulation of diazinon. ... The emulsifiable concentrate (60%) was not in compliance with the WHO's standard specifications regarding the emulsion stability tests because of the presence of crystals... . A sample of this crystalline material was analyzed .../and/ failed to identify intact diazinon in samples of that material. The sample represented complete conversion of diazinon into transformation products. Sulfotepp and monothiono-TEPP (tetraethylpyrophosphate) were two of the identified products in the sample, both of which were more toxic than diazinon.

/EPIDEMIOLOGY STUDIES/ About 77% of farmers in a citrus fruit growing area in the Ehime prefecture (Japan) had experienced contact dermatitis due to pesticides. ... /Sulfotep/, maneb, and manzeb were the pesticides which frequently caused skin lesions. The incidence rate of skin injuries caused by spraying pesticides was 0% in males and 3.8% in females in May, 8.2% in males and 13.0% in females in June, and increased to 26.0% in males and 50% in females in July.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ When dogs were given diets that contained 0, 0.5, 3, 15, or 75 ppm sulfotepp (equivalent to about 0, 0.014, 0.11-0.12, 0.55-0.57, or 2.75- 3.07 mg/kg/day) for 13 weeks, food consumption and body weight gain decreased at 75 ppm. Plasma cholinesterase activity was inhibited at 3 ppm or higher, whereas RBC cholinesterase was inhibited at 15 ppm sulfotepp or higher. Occasional diarrhea and vomiting occurred in dogs at 15 ppm and were common in dogs at 75 ppm.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ When rats were exposed to 0, 0.89, 1.94, and 2.83 mg/cu m sulfotepp aerosol for 6 hours/day, 5 days/wk for 12 weeks, no changes in appearance, behavior, or body weight gain occurred at any dose. RBC acetylcholinesterase was not inhibited at any dose; however, plasma cholinesterase activity was inhibited in rats exposed to 2.83 mg/cu m. Absolute and relative lung weights of females exposed to 2.83 mg/cu m were significantly higher than those of controls due to edema. No effects were observed at sulfotepp concns <2.83 mg/cu m.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ ... 60 PPM ... WAS HIGHEST DIETARY CONCN ... FOR 12 WK THAT PRODUCED NO SYMPTOMS IN RATS; 180 PPM ... PRODUCED BOTH ILLNESS & TISSUE CHANGE.

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Carcinogenesis: No signs of carcinogenicity or other adverse effects occurred at any dose level in mice or rats given diets that contained 0, 2, 10, or 50 ppm (equivalent to 0, 0.29, 1.43, or 7.14 mg/kg/day (mice); 0.13, 0.67 or 3.33 mg/kg/day (rats)) sulfotepp for 2 years. There were no signs of toxicity other than inhibition of plasma and RBC cholinesterase at 50 ppm.

For more Non-Human Toxicity Excerpts (Complete) data for SULFOTEP (7 total), please visit the HSDB record page.

LC50 Pimephales promelas (fathead minnow) 0.178 mg/l/96 hr /Conditions of bioassay not specified/

LC50 Lepomis macrochirus (bluegill sunfish) 0.0016 mg/l/96 hr /Conditions of bioassay not specified/

LC50 Rainbow trout 0.018 mg/l/96 hr /Conditions of bioassay not specified/

/PLANTS/ Phytotoxic to some ornamentals, for example chrysanthemums, orchids, and some rose varieties.

3.20e+01

LC50 Pimephales promelas (fathead minnow) 0.178 mg/l/96 hr /Conditions of bioassay not specified/

LC50 Lepomis macrochirus (bluegill sunfish) 0.0016 mg/l/96 hr /Conditions of bioassay not specified/

LC50 Rainbow trout 0.018 mg/l/96 hr /Conditions of bioassay not specified/

/PLANTS/ Phytotoxic to some ornamentals, for example chrysanthemums, orchids, and some rose varieties.

3.20e+01

4.10e+02

7.10e+00

5.00e+00

5.20e-03

5.00e-04

Volatile

9.50e+01

1.20e+03

2.10e+01

The substance is very toxic to aquatic organisms. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

Sulfotep's production may result in its release to the environment through various waste streams; it's use as an insecticide/miticide will result in its direct release to the environment. If released to air, a vapor pressure of 1.05X10-4 mm Hg at 20 °C indicates sulfotep will exist solely as a vapor in the ambient atmosphere. Vapor-phase sulfotep will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 2 hrs. If released to soil, sulfotep is expected to have slight mobility based upon an estimated Koc of 3,500. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 4.4X10-6 atm-cu m/mole. However, adsorption to soil is expected to attenuate volatilization. No soil biodegradation data were located. If released into water, sulfotep is expected to adsorb to suspended solids and sediment based upon the estimated Koc. No aquatic biodegradation data were located. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 28 and 206 days, respectively. However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. An estimated BCF of 240 suggests the potential for bioconcentration in aquatic organisms is high. Hydrolysis is not expected to be an important environmental fate process since this compound only hydrolyzes in alkaline solutions. Occupational exposure to sulfotep may occur through inhalation and dermal contact with this compound at workplaces where sulfotep is produced or used. Distribution and use of sulfotep and sulfotep products will be unlawful after Sept 30, 2004. (SRC)

Sulfotep's production may result in its release to the environment through various waste streams; it's use as an insecticide/miticide(1) will result in its direct release to the environment(SRC). Because sulfotep is registered for indoor use only, ecological exposures are expected to be minimal(1).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 3,500(SRC), determined from a log Kow of 3.99(2) and a regression-derived equation(4), indicates that sulfotep is expected to have slight mobility in soil(SRC). Volatilization of sulfotep from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.4X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 1.05X10-4 mm Hg(2), and water solubility, 30 mg/l(3). However, adsorption to soil is expected to attenuate volatilization(SRC). Sulfotep is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2). No soil biodegradation data were located(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 3,500(SRC), determined from a log Kow of 3.99(2) and a regression-derived equation(4), indicates that sulfotep is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon an estimated Henry's Law constant of 4.4X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 1.05X10-4 mm Hg(2), and water solubility, 30 mg/l(3). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 28 and 206 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 68 months if adsorption is considered(5). Sulfotep underwent no observable photolysis upon laboratory irradiation in pure water(6). According to a classification scheme(7), an estimated BCF of 240(SRC), from its log Kow(2) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms high(SRC). No aquatic biodegradation data were located(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), sulfotep, which has a vapor pressure of 1.05X10-4 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase sulfotep is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2 hrs(SRC), calculated from its rate constant of 1.8X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Sulfotep underwent no observable photolysis upon laboratory irradiation in pure water(4).

Hydrolytic and oxidative metabolism. The cleavage products are diethyl phosphate, monoethyl phosphate, and phosphoric acid.

The rate constant for the vapor-phase reaction of sulfotep with photochemically-produced hydroxyl radicals has been estimated as 1.8X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 2 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Sulfotep underwent no observable photolysis upon laboratory irradiation in pure water(2). When humic acid was added to the water at 10 and 100 mg/l, the half life for photolysis was reduced to 38.4 and 12.4 hr, respectively(2). The laboratory photolysis at 254 nm of solid sulfotep on filter paper produced no observable degradation(3). Direct photolytic degradation in water, or in the atmosphere, are therefore not expected to be important fate processes(SRC). Sulfotep has been listed as being stable to hydrolysis(4), hydrolyzing only in alkaline solution(5).

An estimated BCF of 240 was calculated for sulfotep(SRC), using a log Kow of 3.99(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC).

The Koc of sulfotep is estimated as 3,500(SRC), using a log Kow of 3.99(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that sulfotep is expected to have slight mobility in soil. Sulfotep, applied to anaerobic soil columns using anaerobic leachate from a municipal landfill in Forlev, Denmark, showed a relative velocity of <10% after 10 months(4).

/SULFOTEP IS/ ... OF LOW PERSISTENCE ON SPRAYED FOLIAGE, PROBABLY BECAUSE OF VOLATILIZATION.

The Henry's Law constant for sulfotep is estimated as 4.4X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 1.05X10-4 mm Hg(1), and water solubility, 30 mg/l(2). This estimated Henry's Law constant indicates that sulfotep is expected to volatilize from water surfaces(3). Based on this estimated Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 28 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 206 days(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 68 months if adsorption is considered(4). Sulfotep's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC); however this process may be attenuated by adsorption to soil. Sulfotep is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

SEDIMENT: Sulfotep was found in four out of twelve sediment samples in Nissum Broad, Denmark, near a pesticide manufacturing plant, at concentrations ranging from <0.3-9.5 kg/kg dry weight(1).

Sulfotep was listed as a pesticide found infrequently in leaf and stem vegetables, 1970-1976(1). The compound was not detected during 1994 regulatory monitoring of 329 pesticides conducted in the US(2). Sulfotep was detected in 1 of 31 Danish pepper samples collected in 1996 for the Danish National Pesticide Monitoring Program(3).

Those involved in the manufacture, formulation, and application of this insecticide.

NIOSH (NOES Survey 1981-1983) has statistically estimated that 8,085 workers (27 of these are female) are potentially exposed to sulfotep in the US(1). The NOES Survey does not include farm workers. Occupational exposure to sulfotep may occur through inhalation and dermal contact with this compound at workplaces where sulfotep is produced or used(SRC). Distribution and use of sulfotep and sulfotep products will be unlawful after Sept 30, 2004(2).

The average daily intake of sulfotep reported in the Belgian Total Diet analysis of plant-based foods conducted during 1991-1993 was 0.00002 mg/kg/day(3); it was detected in one sample of parsley, at 0.05 ppm(3).

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number P109, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Potential candidate for rotary kiln incineration with a temperature range of 820 to 1600 °C with residence times for liquids and gases: seconds; solids, hours. Also, a potential candidate for liquid injection incineration with a temperature range of 650 to 1600 °C with residence times of 0.1 to 2 seconds. Also, a potential candidate for fluidized bed incineration with a temperature range of 450 to 980 °C with residence times for liquids and gases, seconds; solids, longer.

This compound should be susceptible to removal from wastewater by air stripping.

Incinerate with added flammable solvent in furnace equipped with afterburner and alkaline scrubber. Recommendable method: Incineration.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Tetraethyl dithiopyrophosphate; Tetraethyl dithiopyrophosphate, mixture, dry or liquid/

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. /Tetraethyl dithiopyrophosphate; Tetraethyl dithiopyrophosphate, mixture, dry or liquid/

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Tetraethyl dithiopyrophosphate; Tetraethyl dithiopyrophosphate, mixture, dry or liquid/

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Tetraethyl dithiopyrophosphate; Tetraethyl dithiopyrophosphate, mixture, dry or liquid/

For more DOT Emergency Guidelines (Complete) data for SULFOTEP (8 total), please visit the HSDB record page.

UN 1704; Tetraethyl dithiopyrophosphate

IMO 6.1; Tetraethyl dithiopyrophosphate

49 205 44; Tetraethyl dithiopyrophosphate and compressed gas mixture

49 214 81; Tetraethyl dithiopyrophosphate, mixture, dry

49 214 82; Tetraethyl dithiopyrophosphate, mixture, liquid

49 214 80; Tetraethyl dithiopyrophosphate, liquid

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Do not transport with food and feedstuffs. Marine pollutant.

Symbol: T+, N; R: 27/28-50/53; S: (1/2)-23-28-36/37-45-60-61

UN Hazard Class: 6.1; UN Pack Group: II