English Safety Data Sheet Database 中文版 MSDS

Heptafluorobutyric acid

CAS No. 375-22-4 | PubChem CID 9777
Section 1. Identification
Chemical NameHeptafluorobutyric acid CAS No.375-22-4
Synonymsperfluorobutyricacid; heptafluorobutyricacid Chinese Name七氟丁酸
Molecular FormulaC4HF7O2 Molecular Weight214.0384
UN No. Data SourcePubChem (NIH/NLM)
GHS Hazard Classification
Signal Word DANGER
Pictograms GHS05 · Corrosive GHS08 · Health Hazard
Hazard Statements H314H318H361
Precautionary Statements P260P264P264+P265P280P301+P330+P331P302+P361+P354P304+P340P305+P354+P338P316P317P321P363P405P501P203P318

Section 2. Hazards Identification

This chemical does not meet GHS hazard criteria for 0.6% (1 of 171) of reports.

H314 (99.4%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318 (70.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 171 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 1 of 171 reports by companies.

There are 10 notifications provided by 170 of 171 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

P203, P280, P318, P405, and P501 (click each P-code to see the statement)

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

P264+P265, P280, P305+P354+P338, and P317 (click each P-code to see the statement)

Section 8. Exposure Controls / Personal Protection

0.37 [mg/m3]

4.0 [mg/m3]

24 [mg/m3]

Section 9. Physical and Chemical Properties

Colorless liquid with an unpleasant odor; [MSDSonline]

120.8 °C @760 [mm Hg]

1.645 @25 °C

110.8 Ų [M-H-CO2]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: PFAS]

109.53 Ų [M-H-CO2]-

19F nuclear magnetic resonance spectrum

Boiling point

Chemical shift

Diamagnetic susceptibility

Heat of sublimation

Magnetic susceptibility

Optical coefficient

Refractive index

Sound absorption

Sound propagation

Sound velocity

Spin-spin coupling constant

Vapor pressure

Viscosity

Other Classes -> Perfluoroalkyl Acids

Ionic Liquids

Ionic Liquids -> Fluorinated Ionic Liquids

Pesticide -> EPA IRIS

PFAS -> Perfluorocarboxylic acids

PFAS -> Perfluoroalkyl acids (PFAAs)

PFAS -> Other/unspecified

PFAS -> PFAS with analytical method available

PFAS -> Identified in migrating and extractable food contact chemical data

PFAS -> non-polymer

PFAS -> OECD Category

PFAS (C4HF7O2)

PFAS -> PFcarboxylic acids (PFCA)

Section 11. Toxicological Information

Perfluorobutanoic Acid (PFBA)

Developmental

Endocrine

1 x 10 ^-3 mg/kg-day

Perfluorobutanoic acid (PFBA)

Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP

Dermatotoxin - Skin burns.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

IRIS Current

7.80e+01

1.20e+03

1.80e+01

6.50e-03

1.00e-03

Volatile

2.57e+03

2.30e+02

3.50e+03

5.50e+01

Section 12. Ecological Information

7.80e+01

1.20e+03

1.80e+01

6.50e-03

1.00e-03

Volatile

2.57e+03

2.30e+02

3.50e+03

5.50e+01

Source: PubChem CID 9777 (NIH/NLM, public domain). Retrieved from PubChem, a public-domain chemistry database maintained by the U.S. National Library of Medicine. Last updated: 2026-08-02 09:53:00.
Disclaimer: This information is compiled for reference only and does not replace the manufacturer's official Safety Data Sheet. Always consult the supplier's SDS before handling any chemical.