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Trifluoroacetic anhydride

CAS No. 407-25-0 | PubChem CID 9845
Section 1. Identification
Chemical NameTrifluoroacetic anhydride CAS No.407-25-0
Synonymsbis(trifluoroa-cetic)anhydride; trifluoroaceticanhydride Chinese Name三氟乙酸酐
Molecular FormulaC4F6O3 Molecular Weight210.04
UN No.3265 Data SourcePubChem (NIH/NLM)
GHS Hazard Classification
Signal Word DANGER
Pictograms GHS05 · Corrosive GHS07 · Irritant GHS08 · Health Hazard
Hazard Statements H314H318H332H412
Precautionary Statements P203P260P261P264P264+P265P271P273P280P301+P330+P331P302+P361+P354P304+P340P305+P354+P338P316P317P318P321P363P405P501

Section 2. Hazards Identification

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318 (21.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H332 (93%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H361d (18.4%): Suspected of damaging the unborn child [Warning Reproductive toxicity]

H412 (51.8%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P203, P260, P261, P264, P264+P265, P271, P273, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P321, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 114 reports by companies from 21 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Section 8. Exposure Controls / Personal Protection

0.60 [mg/m3]

6.6 [mg/m3]

40 [mg/m3]

Section 9. Physical and Chemical Properties

Colorless liquid; [MSDSonline]

39.5 °C @760 [mm Hg]

1.49 @25 °C

41.2 [mmHg]

Schoenflies notation

Boiling point

Chemical bond

Dielectric constant

Heat of sublimation

Internuclear distance

Molecular structure

Optical coefficient

Point group

Refractive index

Vapor pressure

Virial coefficient

Other Classes -> Acid Anhydrides, Other

PFAS -> Suspected persistent, mobile, toxic (PMT) PFAS or PFAS-like compounds

PFAS -> PFAS identified in REACH Regulation EC No. 1272/2008

Section 11. Toxicological Information

Dermatotoxin - Skin burns.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

Source: PubChem CID 9845 (NIH/NLM, public domain). Retrieved from PubChem, a public-domain chemistry database maintained by the U.S. National Library of Medicine. Last updated: 2026-08-02 09:17:43.
Disclaimer: This information is compiled for reference only and does not replace the manufacturer's official Safety Data Sheet. Always consult the supplier's SDS before handling any chemical.