carbonyl sulfide

H220 (100%): Extremely flammable gas [Danger Flammable gases]

H280 (100%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]

H315 (20.9%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (20.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H331 (100%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H335 (20.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P203, P210, P222, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P332+P317, P337+P317, P362+P364, P377, P381, P403, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 196 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H220: Extremely flammable gas [Danger Flammable gases]

H280: Contains gas under pressure; may explode if heated [Warning Gases under pressure]

H331: Toxic if inhaled [Danger Acute toxicity, inhalation]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P203, P210, P222, P260, P261, P264, P270, P271, P280, P304+P340, P308+P316, P316, P319, P321, P377, P381, P403, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement)

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H330: Fatal if inhaled [Danger Acute toxicity, inhalation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P203, P210, P222, P260, P261, P264, P264+P265, P271, P280, P284, P302+P352, P304+P340, P305+P351+P338, P316, P319, P320, P321, P332+P317, P337+P317, P362+P364, P377, P381, P403, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement)

Excerpt from ERG Guide 119 [Gases - Toxic - Flammable]:

Refer to the "General First Aid" section. Specific First Aid: In case of contact with liquefied gas, only medical personnel should attempt thawing frosted parts. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. (ERG, 2024)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· In case of contact with liquefied gas, only medical personnel should attempt thawing frosted parts.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

Excerpt from ERG Guide 119 [Gases - Toxic - Flammable]:

DO NOT EXTINGUISH A LEAKING GAS FIRE UNLESS LEAK CAN BE STOPPED.

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.

LARGE FIRE: Water spray, fog or alcohol-resistant foam. FOR CHLOROSILANES, DO NOT USE WATER; use alcohol-resistant foam. If it can be done safely, move undamaged containers away from the area around the fire. Damaged cylinders should be handled only by specialists.

FIRE INVOLVING TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devices; icing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Use water spray to cool unopened containers.

Do not extinguish a leaking gas fire unless leak can be stopped. Small fire: Dry chemical, CO2, water spray or alcohol-resistant foam. Large fireE: Water spray, fog or alcohol-resistant foam. For chlorosilanes, do not use waterR; use AFFF alcohol-resistant medium-expansion foam. Move containers from fire area if you can do it without risk. Damaged cylinders should be handled only by specialists. Fire involving tanks: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devices; icing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. Always stay away from tanks engulfed in fire.

For more Fire Fighting Procedures (Complete) data for Carbonyl sulfide (6 total), please visit the HSDB record page.

Under prolonged exposure to fire or intense heat the container may rupture violently or rocket.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Many gases are heavier than air and will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Do not direct water at spill or source of leak.

· Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material.

· FOR CHLOROSILANES, use alcohol-resistant foam to reduce vapors.

· If possible, turn leaking containers so that gas escapes rather than liquid.

· Prevent entry into waterways, sewers, basements or confined areas.

· Isolate area until gas has dispersed.

Excerpt from ERG Guide 119 [Gases - Toxic - Flammable]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 2204 datasheet.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 1600 meters (1 mile) in all directions; also, consider initial evacuation for 1600 meters (1 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 1600 meters (1 mile) in all directions; also, consider initial evacuation for 1600 meters (1 mile) in all directions.

Small spill:

- ISOLATE in all directions: 30 m (100 ft)

Large spill:

- ISOLATE in all directions: 300 m (1000 ft)

- PROTECT people from downwind during DAY time: 0.1 km (0.1 mi)

- PROTECT people from downwind during NIGHT time: 0.3 km (0.2 mi)

- PROTECT people from downwind during DAY time: 1.5 km (1.0 mi)

- PROTECT people from downwind during NIGHT time: 3.6 km (2.3 mi)

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Clean up promptly by sweeping or vacuum.

Eliminate all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Fully encapsulating, vapor-protective clothing should be worn for spills and leaks with no fire. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Do not direct water at spill or source of leak. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. For chlorosilanes, use AFFF alcohol-resistant medium-expansion foam to reduce vapors. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Isolate area until gas has dispersed.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D003, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Use explosion-proof equipment. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.

Appropriate engineering controls: Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Excerpt from ERG Guide 119 [Gases - Toxic - Flammable]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Do not direct water at spill or source of leak. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. FOR CHLOROSILANES, use alcohol-resistant foam to reduce vapors. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Isolate area until gas has dispersed. (ERG, 2024)

Keep container tightly closed in a dry and well-ventilated place. Contents under pressure. Storage class (TRGS 510): Gases

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: ppm)

AEGL 2: Irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape (Unit: ppm)

AEGL 3: Life-threatening health effects or death (Unit: ppm)

NR = Not recommended due to insufficient data.

AEGLs Status: Interim

15 [ppm]

55 [ppm]

150 [ppm]

5.0 [ppm]

8 hr Time Weighted Avg (TWA): 5 ppm.

5 ppm [2011]

· DO NOT EXTINGUISH A LEAKING GAS FIRE UNLESS LEAK CAN BE STOPPED.

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

Large Fire

· Water spray, fog or alcohol-resistant foam.

· FOR CHLOROSILANES, DO NOT USE WATER; use alcohol-resistant foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Damaged cylinders should be handled only by specialists.

Fire Involving Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Do not direct water at source of leak or safety devices; icing may occur.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

Excerpt from ERG Guide 119 [Gases - Toxic - Flammable]:

Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)

Eye/face protection: Face shield and safety glasses. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166 (EU).

Skin protection: Handle with gloves.

Body Protection: Complete suit protecting against chemicals. Flame retardant antistatic protective clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations only; it is not effective in spill situations where direct contact with the substance is possible.

Carbonyl sulfide is a colorless, poisonous, flammable gas with a distinct sulfide odor. The gas is toxic and narcotic in low concentrations and presents a moderate fire hazard. Under prolonged exposure to fire or intense heat the container may rupture violently or rocket. It is used in the synthesis of organic thio compounds.

Gas Vapor

Colorless gas with a rotten egg odor; [CHEMINFO MSDS]

Colorless, poisonous and glammable gas with a distinct sulfide odor.

Colorless gas

Odorless when very pure

Typical sulfide odor except when pure

-50 °C @760 [mm Hg]

-138.8 °C

-58.4 °F

In water, 1,220 mg/L at 25 °C

Solubility at 1 atm (mL/mL): water 0.80 (12.5 °C)

Soluble in water

Soluble in ethanol

For more Solubility (Complete) data for Carbonyl sulfide (6 total), please visit the HSDB record page.

2.456 g/L

Liquid density (174 K): 1.274 g/cu cm. Vapor density (25 °C, 1 atm): 2.849 g/L

2.456 @25 °C

2.1 (Air = 1) (gas)

9410.0 [mmHg]

750 [mm Hg] @-50.4 °C

Stable under recommended storage conditions.

Hazardous decomposition products formed under fire conditions: Carbon oxides, sulfur oxides.

When heated to decomposition it emits toxic fumes of /carbon monoxide/.

Attacks metals in the presence of moisture and is involved in atmospheric sulfur corrosion

27.51 kJ/mole at 25 °C

Burns with bluish flame

log Kow approximately 0.8

Heat of formation: -142.0 kJ/mole; Gibbs free energy, -169.2 kJ/mole; heat capacity 41.5 J/mole K

Heat of fusion: 4.39 kJ/mol at -112.1 °C

Hydroxyl radical reaction rate constant = 2/0X10-15 cu cm/molec sec at 25 °C

Dunham energy parameter

Gibbs energy

Schoenflies notation

Absorbance

Acentric factor

Atomic environment

Boiling point

Bond type

Centrifugal distortion

Highly flammable.

Sulfides, Inorganic

Highly Flammable

CARBONYL SULFIDE is expected to react with vigor with strong oxidants.

Incompatible materials: Strong oxidizing agents

Can react vigorously with oxidizing materials.

IDENTIFICATION AND USE: Carbonyl sulfide is a colorless gas. It is used as grain fumigant, and for small-scale synthesis and experiments. HUMAN STUDIES: There are no data available. ANIMAL STUDIES: Carbonyl sulfide is an odorless gas that produces highly reproducible lesions in the central nervous system. Carbonyl sulfide produced cortical and brainstem lesions and altered auditory neurophysiological responses to click stimuli in rats. In rats exposed to 500 or 600 ppm for up to 4 days, malacia and microgliosis were detected in numerous neuroanatomical regions of the brain by conventional optical microscopy and magnetic resonance microscopy. After a 2-week exposure to 400 ppm slight gait abnormality was detected in 50% of the rats and hypotonia was present in all rats. Continuous exposure of rabbits to approximately 50 ppm carbonyl sulfide for 7 weeks slightly elevated the mean serum cholesterol concentration. Serum triglyceride concentration was largely unaffected. Carbon sulfide is neither genotoxic nor a developmental toxicant but does reversibly impair male fertility. A decrease in pregnancy rate was observed in unexposed female rats mated with male rats exposed to 182 ppm carbonyl sulfide 6 hours/day, 5 days/week for 10 weeks and 6 hours/day, 7 days/week for a 3-week mating period. When the males were allowed to recover for 10 weeks prior to mating to unexposed females, no alterations in fertility were observed. ECOTOXICITY STUDIES: In insects, carbonic anhydrase has a key role in toxicity of carbonyl sulfide.

Carbonyl sulfide

Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

Other Poison - Chemical Asphyxiant

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

Carbonyl Sulfide

1 x 10^-1 mg/m^3

1 mg/m^3

PDF Document

Inadequate information to assess carcinogenic potential

PPRTV Current

LC50 (rat) = 1,070 ppm/4H

LD50 Rat ip 23 mg/kg

LC50 Mouse inhalation 2940 mg/cu m/35 min

LC50 Rat inhalation 2650 mg/cu m/4 hr

Carbonyl sulfide (COS) is acutely toxic to rats, with an LD50 of 22.5 mg/kg, ip. COS is partly metabolized in vivo to hydrogen sulfide. Pretreatment of rats with acetazolamide, reduced the blood levels of hydrogen sulfide and decreased the toxicity of COS. Sodium nitrite pretreatment also protected animals against COS toxicity. Acetazolamide had no effect on hydrogen sulfide toxicity per se.

Pre-exposure to acetazolamide (a carbonic anhydrase inhibitor) resulted in a decrease in mortality in rats exposed via intraperitoneal injection to a lethal dose of carbonyl sulfide ... There is also in vitro evidence that carbonyl sulfide is metabolized by the mixed-function oxidase enzyme system to carbon dioxide ... However, the metabolism was not inhibited by the cytochrome P-450 monooxygenase inhibitors (SKF 525-A, 4-methylpyrazole, metyrapone) or substrate (carbon disulfide).

... In microsomes, (CS2) metabolism was increased by phenobarbital pretreatment of the rats and decreased with pretreatment of the rats with cobaltous chloride. In both microsomes and hepatocytes, CS2 metabolism was inhibited by SKF-525A. Carbon dioxide (CO2) was the major volatile metabolite of CS2 in hepatocytes, and carbonyl sulfide (COS) was the major volatile metabolite in microsomal incubations. Addition of cytosol to microsomal incubations shifted the predominant volatile metabolite from COS to CO2 but did not change total volatile metabolite formation. Acetazolamide, a carbonic anhydrase inhibitor, significantly decreased COS metabolism but not CS2 metabolism in isolated hepatocytes or microsomes fortified with dialyzed cytosol. When [(18)O]H2O was included in incubations of microsomes and CS2, a substantial portion of the resulting COS was [(18)O] enriched.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Hydrogen Sulfide and Related Compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Treat with rapid rewarming techniques if frostbite occurs. /Hydrogen Sulfide and Related Compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . In severe cases use amyl nitrite and sodium nitrite (from the cyanide antidote kit) as described for cyanide poisoning; omit the sodium thiosulfate injection. Early administration will be the most effective. ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Hydrogen Sulfide and Related Compounds/

/LABORATORY ANIMALS: Acute Exposure/ Concentrations of 0.1 vol % and higher produce death in 2 hr or less. At high concentrations rapid exitus occurs in acute respiratory failure.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Non cholesterol-fed rabbits were exposed to carbon monoxide at concentrations in air of either 200, 2000, or 4000 ppm (= 0.02, 0.2, or 0.4% vol/vol). Further, exposure was performed to 0.5 ppm hydrogen cyanide alone or in combination with 200 ppm carbon monoxide or with 200 ppm carbon monoxide and 5 ppm nitric oxide and eventually to 50 ppm carbonyl sulfide. Duration of the continuous exposures were between 1/2 week and 12 weeks. Using the same criteria for intimal damage as in earlier morphological studies, no histotoxic effect on intimal/subintimal morphology of coronary arteries or the aorta could be demonstrated, when light-microscopic evaluation was performed blindly.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Rabbits were continuously exposed to 200 ppm carbon monoxide. Using the same criteria as applied by earlier investigators for morphological myocardial damage, no histotoxic effect on myocardial morphology could be demonstrated when electron-microscopic investigations were performed blindly. Similarly, exposure to 0.5 ppm hydrogen cyanide, 0.5 ppm hydrogen cyanide + 200 ppm carbon monoxide, 0.5 ppm hydrogen cyanide + 200 ppm carbon monoxide + 5 ppm nitric oxide and to 50 ppm carbonyl sulfide for 1-7 weeks had no significant effect on myocardial ultrastructure.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Continuous exposure of rabbits to approximately 50 ppm carbonyl sulfide for 7 weeks slightly elevated the mean serum cholesterol concentration. Serum triglyceride concentration was largely unaffected. There was a small increase in the concentration of free cholesterol in aorta. No significant difference in arterial uptake of labeled cholesterol between exposed animals and controls could be demonstrated. By light microscopic investigation, no histopathological changes in lungs or coronary arteries were found.

For more Non-Human Toxicity Excerpts (Complete) data for Carbonyl sulfide (10 total), please visit the HSDB record page.

The following link will take the user to the National Toxicology Program (NTP) Test Status of Agents Search page, which tabulates the results and current status of tests such as "Short-Term Toxicity Studies", "Long-term Carcinogenicity Studies", "Developmental Studies", "Genetic Toxicology Studies", etc., performed with this chemical. Testing status for carbonyl sulfide is available.[Available from, as of March 27, 2018: https://ntpsearch.niehs.nih.gov/?e=True&ContentType=Testing+Status]

Viscose rayon workers are ... exposed to carbonyl sulfide and are reportedly at an increased death risk due to coronary heart disease.

/OTHER TERRESTRIAL SPECIES/ Carbonyl sulfide (COS) is a ... fumigant used in phytosanitary treatments. It was developed as a potential alternative to methyl bromide, which is being phased out because of its ozone-depletion properties. To understand the molecular and cellular mechanisms occurring in fungal pathogens in response to COS fumigation, we cloned 510 cDNA fragments of Alternaria alternata (Fr.) Keissler genes that are differentially expressed; these genes were cloned using suppression subtractive hybridization. Changes in the levels of transcripts of 79 fragments were confirmed by microarray analysis and qRT-PCR. Further homology search revealed that they are highly homologous to 41 genes of other fungi, which were related to general metabolism, growth and division, defense, cellular transport, and signal transduction. These results provide an overview of differential expression profiles of A. alternata genes following COS treatment and some new clues about the mechanism of COS fungitoxicity.

/OTHER TERRESTRIAL SPECIES/ Carbonyl sulfide (COS) is a ... fumigant which has been a potential alternative to methyl bromide and phosphine in many applications. In this study, we investigated the fungitoxicity of COS towards the pathogen of pear black spot disease Alternaria alternata (Fr.) Keissler (A. alternata). Moreover, proteomic analysis and RT-PCR was performed and our results showed that during the fumigation, the regulation of 21 proteins in protein expression and mRNA accumulation levels is involved, which respond to growth inhibition caused by COS. These results provide new clues for the mechanism of the fungitoxicity of COS.

/OTHER TERRESTRIAL SPECIES/ The analogues carbon dioxide (CO(2)), carbonyl sulfide (COS) and carbon disulfide (CS(2)) have been useful as substrate probes for enzyme activities. Here we explored the affinity of the enzyme carbonic anhydrase for its natural substrate CO(2), as well as COS and CS(2) (1) by in vitro kinetic metabolism studies using pure enzyme and (2) through mortality bioassay of insects exposed to toxic levels of each of the gases during carbonic anhydrase inhibition. Hydrolysis of COS to form hydrogen sulfide was catalyzed rapidly showing parameters K(m) 1.86 mM and K(cat) 41 s(-1) at 25 degrees C; however, the specificity constant (K(cat)/K(m)) was 4000-fold lower than the reported value for carbonic anhydrase-catalyzed hydration of CO(2). Carbonic anhydrase-mediated CS(2) metabolism was a further 65,000-fold lower than COS. Both results demonstrate the deactivating effect toward the enzyme of sulfur substitution for oxygen in the molecule. We also investigated the role of carbonic anhydrases in CO(2), COS and CS(2) toxicity using a specific inhibitor, acetazolamide, administered to Tribolium castaneum (Herbst) larvae via the diet. CO(2) toxicity was greatly enhanced by up to seven-fold in acetazolamide-treated larvae indicating that carbonic anhydrases are a key protective enzyme in elevated CO(2) concentrations. Conversely, mortality was reduced by up to 12-fold in acetazolamide-treated larvae exposed to COS due to reduced formation of toxic hydrogen sulfide. CS(2) toxicity was unaffected by acetazolamide. These results show that carbonic anhydrase has a key role in toxicity of the substrates CO(2) and COS but not CS(2), despite minor differences in chemical formulae.

6.70e+01

2.80e+02

1.00e+02

4.40e+02

2.10e+02

5.00e+00

5.10e-01

1.00e-01

Volatile

/OTHER TERRESTRIAL SPECIES/ Carbonyl sulfide (COS) is a ... fumigant used in phytosanitary treatments. It was developed as a potential alternative to methyl bromide, which is being phased out because of its ozone-depletion properties. To understand the molecular and cellular mechanisms occurring in fungal pathogens in response to COS fumigation, we cloned 510 cDNA fragments of Alternaria alternata (Fr.) Keissler genes that are differentially expressed; these genes were cloned using suppression subtractive hybridization. Changes in the levels of transcripts of 79 fragments were confirmed by microarray analysis and qRT-PCR. Further homology search revealed that they are highly homologous to 41 genes of other fungi, which were related to general metabolism, growth and division, defense, cellular transport, and signal transduction. These results provide an overview of differential expression profiles of A. alternata genes following COS treatment and some new clues about the mechanism of COS fungitoxicity.

/OTHER TERRESTRIAL SPECIES/ Carbonyl sulfide (COS) is a ... fumigant which has been a potential alternative to methyl bromide and phosphine in many applications. In this study, we investigated the fungitoxicity of COS towards the pathogen of pear black spot disease Alternaria alternata (Fr.) Keissler (A. alternata). Moreover, proteomic analysis and RT-PCR was performed and our results showed that during the fumigation, the regulation of 21 proteins in protein expression and mRNA accumulation levels is involved, which respond to growth inhibition caused by COS. These results provide new clues for the mechanism of the fungitoxicity of COS.

/OTHER TERRESTRIAL SPECIES/ The analogues carbon dioxide (CO(2)), carbonyl sulfide (COS) and carbon disulfide (CS(2)) have been useful as substrate probes for enzyme activities. Here we explored the affinity of the enzyme carbonic anhydrase for its natural substrate CO(2), as well as COS and CS(2) (1) by in vitro kinetic metabolism studies using pure enzyme and (2) through mortality bioassay of insects exposed to toxic levels of each of the gases during carbonic anhydrase inhibition. Hydrolysis of COS to form hydrogen sulfide was catalyzed rapidly showing parameters K(m) 1.86 mM and K(cat) 41 s(-1) at 25 degrees C; however, the specificity constant (K(cat)/K(m)) was 4000-fold lower than the reported value for carbonic anhydrase-catalyzed hydration of CO(2). Carbonic anhydrase-mediated CS(2) metabolism was a further 65,000-fold lower than COS. Both results demonstrate the deactivating effect toward the enzyme of sulfur substitution for oxygen in the molecule. We also investigated the role of carbonic anhydrases in CO(2), COS and CS(2) toxicity using a specific inhibitor, acetazolamide, administered to Tribolium castaneum (Herbst) larvae via the diet. CO(2) toxicity was greatly enhanced by up to seven-fold in acetazolamide-treated larvae indicating that carbonic anhydrases are a key protective enzyme in elevated CO(2) concentrations. Conversely, mortality was reduced by up to 12-fold in acetazolamide-treated larvae exposed to COS due to reduced formation of toxic hydrogen sulfide. CS(2) toxicity was unaffected by acetazolamide. These results show that carbonic anhydrase has a key role in toxicity of the substrates CO(2) and COS but not CS(2), despite minor differences in chemical formulae.

6.70e+01

2.80e+02

1.00e+02

4.40e+02

2.10e+02

5.00e+00

5.10e-01

1.00e-01

Volatile

5.89e+03

2.00e+02

8.50e+02

3.10e+02

1.30e+03

6.30e+02

Carbonyl sulfide's production and use as an intermediate in the production of certain thiocarbamate herbicides and for the preparation of aliphatic polyureas may result in its release to the environment through various waste streams. Its former use in the US as a grain fumigant resulted in its direct release to the environment. Carbonyl sulfide may be released to the atmosphere from deciduous trees, volcanoes, coniferous trees, salt marshes and soils. It may also be released to the environment as a fugitive emission from commercial processes and combustion emissions. If released to air, a vapor pressure of 9.41X10+3 mm Hg at 25 °C indicates carbonyl sulfide will exist solely as a gas in the atmosphere. Gas-phase carbonyl sulfide will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 22 hours. Carbonyl sulfide did not absorb UV light at environmental wavelengths >290nm and, therefore, photolysis in the troposphere is negligible. If released to soil, carbonyl sulfide is expected to have very high mobility based upon an estimated Koc of 1. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 0.61 atm-cu m/mole. Carbonyl sulfide may volatilize from dry soil surfaces based upon its vapor pressure. Biodegradation data in soil or water were not available. If released into water, carbonyl sulfide is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 2 hours and 3 days, respectively. An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions (pH 5 to 9). Occupational exposure to carbonyl sulfide may occur through inhalation and dermal contact with this compound at workplaces where carbonyl sulfide is produced or used. Carbonyl sulfide is ubiquitous in the atmosphere. Monitoring data indicate that the general population will be exposed to carbonyl sulfide via inhalation of ambient air and smoking cigarettes. (SRC)

Estimated emissions of carbonyl sulfide from natural sources total 2.7-3.5 teragrams sulfur per year (Tg S/yr). From oceanic emissions (0.4 Tg S/yr), salt marshes (0.12 Tg S/yr), inland swamps (1.85 Tg S/yr), soil and plants (0.2-1.0 Tg S/yr), burning of biomass (0.11 Tg S/yr) and volcanoes and fumaroles (0.01 Tg S/yr)(1). Total biogenic and anthropogenic output to the atmosphere can be estimated at 3 millions tons(1). Emissions of carbonyl sulfide have been associated with deciduous trees, coniferous trees, salt marshes and soils(2). The mean carbonyl sulfide emissions from a hardwood forest were 8.66 ug S/day and 19.86 ug S/day from a pine forest; the emission rate increased dramatically after the addition of fertilizer(3). The average emission of carbonyl sulfide from 5 different soil types was found to range from 0.0014 to 6.36 g S/cu m-yr(4).

Emission rates of the reduced sulfur gases carbonyl sulfide, dimethyl sulfide, and carbon disulfide from 12 representative soils in Germany have been examined by means of a dynamic gas emission chamber. The compounds were sampled by cryogenic technique and measured by subsequent gas chromatography/flame photometric detector analysis. Besides soil type, soil temperature is a major factor controlling carbonyl sulfide source strength. The emission of carbonyl sulfide does not show any clear dependence upon soil moisture, its fraction is about 35 to 40% of the total emission at all sampling sites. Dimethyl sulfide and carbonyl sulfide were the predominant gases emitted from organic soils. Carbonyl sulfide maximum emission rates reached 50 ng sulfur/sq m/min. Measurements of the diurnal variations of emission rates show daily patterns of dimethyl sulfide and carbonyl sulfide emission rates which coincide with the soil temperature curve. Sulfur fluxes of carbonyl sulfide from soil treated with liquid manure were enhanced by a factor of 5 to 6 compared to unfertilized soil of the same type(1).

Carbonyl sulfide's production and use as an intermediate in the production of certain thiocarbamate herbicides and for the preparation of aliphatic polyureas(1) may result in its release to the environment through various waste streams(SRC). Carbonyl sulfide's former use in the US as a grain fumigant(2) resulted in its direct release to the environment(SRC).

Carbonyl sulfide may be released to the environment from automobiles, coal-fired power plants, biomass combustion, fish processing, combustion of refuse, and plastics, petroleum manufacture and manufacture of synthetic fibers, starch and rubber(1). Anthropogenic emissions of carbonyl sulfide have been estimated to be <1/3 of natural emissions(1). Carbonyl sulfide may also be formed in the atmosphere by the gas-phase reaction of carbon disulfide and photochemically produced hydroxyl radicals(2). Carbonyl sulfide was identified in the emissions of volatile sulfur-containing compounds from flue gas desulfurization sludge field storage sites. Total sulfur emissions were from <0.01 to nearly 0.3 kg of sulfur/day for an equivalent 100-acre (40.5-ha) sludge impoundment surface(3).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that carbonyl sulfide is expected to have very high mobility in soil(SRC). Volatilization of carbonyl sulfide from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.61 atm-cu m/mole(SRC), based upon its vapor pressure, 9.41X10+3 mm Hg(3), and water solubility, 1.22X10+3 mg/L(4). Carbonyl sulfide is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Biodegradation data in soil were not available(SRC, 2017).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that carbonyl sulfide is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 0.61 atm-cu m/mole(SRC), derived from its vapor pressure, 9.41X10+3 mm Hg(4), and water solubility, 1.22X10+3 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2 hrs and 3 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 3(SRC), from an estimated log Kow of -1.33(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation data in water were not available(SRC, 2017).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), carbonyl sulfide, which has a vapor pressure of 9.41X10+3 mm Hg at 25 °C(2), is expected to exist solely as a gas in the ambient atmosphere. Gas-phase carbonyl sulfide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 22 years(SRC), calculated from its rate constant of 2.0X10-15 cu cm/molecule-sec at 25 °C(3). Carbonyl sulfide did not absorb UV light at environmental wavelengths >290nm and, therefore, photolysis in the troposphere is negligible(4).

The rate constant for the gas-phase reaction of carbonyl sulfide with photochemically produced hydroxyl radicals was measured as 2.0X10-15 cu cm/molec-sec(1). This corresponds to an atmospheric half-life of about 22 years at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(SRC). Carbonyl sulfide is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). The compound reacts slowly with water to form carbon dioxide and hydrogen sulfide(3). Carbonyl sulfide did not absorb UV light at environmental wavelengths >290 nm and, therefore, photolysis in the troposphere is negligible(4).

An estimated BCF of 3 was calculated in fish for carbonyl sulfide(SRC), using an estimated log Kow of -1.33(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of carbonyl sulfide can be estimated to be 1(SRC). According to a classification scheme(2), this estimated Koc value suggests that carbonyl sulfide is expected to have very high mobility in soil(SRC).

The Henry's Law constant for carbonyl sulfide is estimated as 0.61 atm-cu m/mole(SRC) derived from its extrapolated vapor pressure, 9.41X10+3 mm Hg(1), and water solubility, 1.22X10+3 mg/L(2). This Henry's Law constant indicates that carbonyl sulfide is expected to volatilize rapidly from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 2 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 3 days(SRC). Carbonyl sulfide's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of carbonyl sulfide from dry soil surfaces will exist(SRC) based upon its vapor pressure(1).

Annual Industrial emissions of carbonyl sulfide in the Netherlands, 1980, amounted to 46 ton/yr, all from stationary sources(1). The average concentration of carbonyl sulfide in the waste gas from two different shale oil retorting facilities were 394 ppm and 13 ppm(2). It was identified, not quantified, in one out of sixty-three effluent samples obtained from a wide range of chemical manufacturing plants in the USA(3). The tropospheric burden of carbonyl sulfide is estimated as 28 teragrams sulfur per year (Tg S/yr)(4). Estimated emissions of carbonyl sulfide from anthropogenic sources are 0.20 Tg/yr (range 0.4-0.15 (Tg/yr) from biomass burning and 0.06 Tg/yr (0.01-0.3 Tg/yr) from automobiles, chemical industries and sulfur recovery processes(5). Carbonyl sulfide concentration in biogas ranged from <1 to in Nov and Dec 2000 to 3, 9 and 2 g/cu cm in Feb, May 2001 and May 2002, respectively, from a biogas production plant in Linkoping, Sweden. Emissions prior to upgrade range from <1 to 1190 g/cu m(6). The compound as included in a sulfur compounds class was reported in gaseous emissions inside an unspecified mechanical biological treatment plant for municipal solid waste located in China. It was not detected in outdoor samples. The plant has a 1200 t/day capacity(7).

Major Hot Spots facilities which emitted COS in California in 2012. California Hot Spots is a 1987 Act which requires stationary sources of pollutants to report the types and quantities of certain substances)(1).[Table#5703]

SOIL: Soil is a major contributor to the biosphere-atmosphere exchange of carbonyl sulfide (COS) and carbon monoxide (CO). COS is a tracer with which to quantify terrestrial photosynthesis based on the coupled leaf uptake of COS and CO2, but such use requires separating soil COS flux, which is unrelated to photosynthesis, from ecosystem COS uptake. For CO, soil is a significant natural sink that influences the tropospheric CO budget. In the boreal forest, magnitudes and variabilities of soil COS and CO fluxes remain poorly understood. We measured hourly soil fluxes of COS, CO, and CO2 over the 2015 late growing season (July to November) in a Scots pine forest in Hyytiala, Finland. The soil acted as a net sink of COS and CO, with average uptake rates around 3 pmol-sq m/sec for COS and 1 nmol-sq m/sec for CO. Soil respiration showed seasonal dynamics controlled by soil temperature, peaking at around 4 umol-sq m/sec in late August and September and dropping to 1- 2 umol-sq m/sec in October. In contrast, seasonal variations of COS and CO fluxes were weak and mainly driven by soil moisture changes through diffusion limitation. COS and CO fluxes did not appear to respond to temperature variation, although they both correlated well with soil respiration in specific temperature bins. However, COS:CO2 and CO:CO2 flux ratios increased with temperature, suggesting possible shifts in active COS- and CO-consuming microbial groups. Our results show that soil COS and CO fluxes do not have strong variations over the late growing season in this boreal forest and can be represented with the fluxes during the photosynthetically most active period. Well-characterized and relatively invariant soil COS fluxes strengthen the case for using COS as a photosynthetic tracer in boreal forests(1).

Carbonyl sulfide is the most abundant sulfur-bearing compound in the earth's atmosphere, occurring at levels ranging from about 430 to 570 parts per trillion(1).

The mixing ratios of carbonyl sulfide in the lower stratosphere over northern California and Alaska were 36-51 parts per trillion by volume at altitudes of 15.2 to 20.3 km.

URBAN/SUBURBAN: The concentration of carbonyl sulfide was 0.27-0.80 ug/cu m at several locations in the U.S., 0.25-1.50 ug/cu m in the UK, 1.17 ug/cu m in Philadelphia, PA, 1.21 ug/cu m in Wallops Island, VA, and 1.37 ug/cu m in Lawton, OK, dates not provided(1). The concentration of carbonyl sulfide in Harwell, England, ranged from 0.40 to 0.56 ppb(2).

RURAL/REMOTE: Reported concentrations of carbonyl sulfide in the air range from 60-180 ng/L over salt marshes and 14-19 ng/L over the ocean(1). The average atmospheric concentration of carbonyl sulfide is relatively constant at 500 parts per trillion(2). The concentration of carbonyl sulfide measured during airplane flights over the remote Azores Islands and Bavaria, Germany, ranged from 450-455 parts per trillion(3). The concentration of carbonyl sulfide ranged from 627 to 690 parts per trillion at an altitude between 180 and 1950 m, and decreased to 476 parts per trillion at an altitude of 2900 m at a coastal area of France(4).

For more Atmospheric Concentrations (Complete) data for Carbonyl sulfide (7 total), please visit the HSDB record page.

Carbonyl sulfide was qualitatively detected in 1 of 8 samples of mother's milk obtained from residents of urban centers in PA, NJ, and LA(1).

Carbonyl sulfide is a component of tobacco smoke(1).

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D003, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.

If ... THERE IS NO FIRE, go directly to the Table of Initial Isolation and Protective Action Distances /(see table below)/ ... to obtain initial isolation and protective action distances. IF THERE IS A FIRE, or IF A FIRE IS INVOLVED, go directly to the appropriate guide /(see guide(s) below)/ and use the evacuation information shown under PUBLIC SAFETY.

Table: Table of Initial Isolation and Protective Action Distances for Carbonyl sulfide; Carbonyl sulphide ID: 2204 [Table#5702]

/GUIDE 119 GASES - TOXIC - FLAMMABLE/ Fire or Explosion: Flammable; may be ignited by heat, sparks or flames. May form explosive mixtures with air. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Vapors from liquefied gas are initially heavier than air and spread along ground. Vapors may travel to source of ignition and flash back. Some of these materials may react violently with water. Cylinders exposed to fire may vent and release toxic and flammable gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket. Runoff may create fire or explosion hazard.

/GUIDE 119 GASES - TOXIC - FLAMMABLE/ Health: TOXIC; may be fatal if inhaled or absorbed through skin. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control may cause pollution.

/GUIDE 119 GASES - TOXIC - FLAMMABLE/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. Keep unauthorized personnel away. Stay upwind, uphill and/or upstream. Many gases are heavier than air and will spread along ground and collect in low or confined areas (sewers, basements, tanks). Ventilate closed spaces before entering.

For more DOT Emergency Guidelines (Complete) data for Carbonyl sulfide (9 total), please visit the HSDB record page.

UN 2204; Carbonyl sulfide

IMO 2.3; Carbonyl sulfide

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. Carbonyl sulfide is included on the dangerous goods list.

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. Carbonyl sulfide is included on the dangerous goods list.

Poison Gas Flammable Gas