Diphosgene

H300 (87%): Fatal if swallowed [Danger Acute toxicity, oral]

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]

P260, P264, P270, P271, P280, P284, P301+P316, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P320, P321, P330, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 46 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth.

In case of fire in the surroundings, use appropriate extinguishing media.

Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

TO DECONTAMINATE IN ENCLOSED SPACES, USE AMMONIA OR STEAM.

ALL MATERIALS SHOULD BE HANDLED SO AS TO PREVENT ALL CONTACT. ... EYEWASH FOUNTAINS SHOULD BE PROVIDED. ALSO, SPECIAL ATTENTION SHOULD BE GIVEN TO EYE & RESPIRATORY TRACT MEDICAL EXAMINATIONS. /CHLOROFORMATES/

Dry. Well closed. Keep in a well-ventilated room.

... THESE CMPD DECOMPOSE EASILY, STORAGE CONTAINERS SHOULD BE VENTED. /CHLOROFORMATES/

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

The compound is currently at the Holding Status AEGLs which have been reviewed by the NAC/AEGL Committee and are on hold due to insufficient data to develop AEGL values.

AEGLs Status: Holding

A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.

The substance is irritating to the respiratory tract, skin and eyes. Lachrymation. Inhalation may cause lung oedema.

AIR-SUPPLIED RESPIRATORS ... SHOULD BE PROVIDED.

STRICT HYGIENE!

Use breathing protection. Use closed system or ventilation.

Protective gloves.

Wear safety goggles.

Do not eat, drink, or smoke during work.

Colorless liquid with a fruity odor or odorless; [CAMEO]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

COLORLESS LIQUID

ODOR SIMILAR TO PHOSGENE (NEWMOWN HAY)

128 °C @ 760 MM HG

Suffocating liquid; Boiling point = 49 °C at 50 mm Hg; Stable at room temp, decomposes to phosgene at approximately 300 °C

at 101.3 kPa: 128 °C

INSOL IN WATER; SOL IN ETHANOL, VERY SOL IN ETHER

SOL IN BENZENE, ALCOHOL, AND ETHER

Solubility in water: reaction

1.6525 @ 14 °C

1.6 g/cm³

Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.08

Relative vapor density (air = 1): 6.83

10 MM HG @ 20 °C

Vapor pressure, kPa at 20 °C: 1.3

Highly dangerous; when heated to decomp ... will react to produce toxic and corrosive fumes. /phosgene/

INDEX OF REFRACTION: 1.4566 @ 22 °C/D

DECOMP BY HEAT, POROUS SUBSTANCES, ACTIVATED CARBONS (WITH EVOLUTION OF PHOSGENE), ALSO BY ALKALIES, HOT WATER; NON-COMBUSTIBLE

CONVERSION FACTOR: 1 PPM= 8.08 MG/CU M

Hydrolyze in water /Chloroformates/

Nuclear quadrupole resonance spectroscopy

Optical coefficient

Quadrupole coupling

Refractive index

Toxic Gases & Vapors -> Acid Halides

WILL REACT WITH WATER OR STEAM TO PRODUCE TOXIC & CORROSIVE FUMES.

The substance can be absorbed into the body in hazardous amounts by inhalation.

Burning sensation. Chest tightness. Sore throat. Cough. Laboured breathing. Shortness of breath. Symptoms may be delayed.

Redness.

Watering of the eyes. Redness.

Sore throat.

Dermatotoxin - Skin burns.

Lacrimator (Lachrymator) - A substance that irritates the eyes and induces the flow of tears.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

LCLo (rabbits) = 900 mg/m3/15 min

EYE IRRITATION, IRRITATION OF UPPER RESPIRATORY TRACT, & SURFACE BURNS HAVE BEEN PRINCIPAL FINDINGS IN EXPOSED HUMANS. PULMONARY EDEMA WOULD UNDOUBTEDLY OCCUR WITH HIGHER LEVELS OF EXPOSURE. EYE IRRITATION MAY PERSIST SOME TIME AFTER EXPOSURE CEASES. SKIN SENSITIZATION MAY OCCUR. /CHLOROFORMATES/

INSIDIOUS POISON AS IT IS NOT IRRITATING IMMEDIATELY, EVEN WHEN FATAL CONCN ARE INHALED. MAY CAUSE SEVERE PULMONARY EDEMA (MAY BE QUICKLY FATAL) OR PNEUMONIA. INHALATION OF HIGH CONCN CAUSES CHOKING, CONSTRICTED FEELING IN CHEST, COUGHING, PAINFUL BREATHING, BLOODY SPUTUM. VAPORS STRONGLY IRRITATING TO THE EYES. /PHOSGENE/

HIGHLY TOXIC BY INHALATION & INGESTION. STRONG IRRITANT TO TISSUE.

NO EVIDENCE EXISTS FOR A SYSTEMIC ACTION OF INHALED PHOSGENE, BUT VASOCONSTRICTION OF PULMONARY VASCULATURE HAS BEEN DESCRIBED IN RABBITS. SEQUELAE INCLUDE PULMONARY SCARRING, LOBULAR EMPHYSEMA, SMALL IRREGULAR AREAS OF ATELECTASIS & BRONCHITIS. /PHOSGENE/

SOME POSSIBLE MECHANISMS OF REDUCED ACTIVITY OF LUNG SURFACTANT IN ACUTE PULMONARY EDEMA WERE STUDIED IN ALBINO RATS & RABBITS. MOST OF THE EDEMOGENIC SUBSTANCES DID NOT CHANGE SURFACTANT ACTIVITY WHILE DIPHOSGENE REDUCED IT.

The purpose of this study was to examine the changes of pulmonary hemodynamics, cardiac impedance parameters and the number of pulmonary microembolus, and leukocyte after diphosgene inhalation in rabbits. Fifty-three rabbits were randomized into two sets, one set was used to monitor the pulmonary hemodynamics, the other set was used to determine the cardiac impedance parameters, microemboli and leukocytes were obtained directly from the pulmonary microcirculation by use of the retrograde perfusion method. As compared with control group, lt was found that pulmonary artery pressure rose and pulmonary vascular resistance increased (p < 0.05), but did not correlate with lung water parameters (p > 0.05). At 1, 6 hr after diphosgene inhalation cardiac Impedance parameters did not change (p > 0.05~, as compared with before inhalation. Microemboli (21.8 increased (p< 0.05), as compared with the control group (106/L, 430e pulmonary hemodynamics, but could not effectively reduce the degree of pulmonary edema.

NO EFFECTS ON GENERAL HEALTH NOR IN LABORATORY FINDINGS (BLOOD STUDIES & LIVER FUNCTION TESTS) OF PERSONS MANUFACTURING CHLOROFORMATES WERE NOTED. /CHLOROFORMATES/

NO EFFECTS ON GENERAL HEALTH NOR IN LABORATORY FINDINGS (BLOOD STUDIES & LIVER FUNCTION TESTS) OF PERSONS MANUFACTURING CHLOROFORMATES WERE NOTED. /CHLOROFORMATES/

If ... THERE IS NO FIRE, go directly to the Table of Initial Isolation and Protective Action Distances /(see table below)/ ... to obtain initial isolation and protective action distances. IF THERE IS A FIRE, or IF A FIRE IS INVOLVED, go directly to the appropriate guide /(see guide(s) below)/ and use the evacuation information shown under PUBLIC SAFETY.

Table: Table of Initial Isolation and Protective Action Distances for CG (when used as a weapon) ID: 1076 [Table#1128]

Table: Table of Initial Isolation and Protective Action Distances for Diphosgene ID: 1076 [Table#1129]

Table: Table of Initial Isolation and Protective Action Distances for DP (when used as a weapon) ID: 1076 [Table#1130]

Table: Table of Initial Isolation and Protective Action Distances for Phosgene ID: 1076 [Table#1131]

For more DOT Emergency Guidelines (Complete) data for DIPHOSGENE (12 total), please visit the HSDB record page.