Guanidine Nitrate

H272 (29.8%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H314 (58.4%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H315 (29.2%): Causes skin irritation [Warning Skin corrosion/irritation]

H318 (70.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H319 (29.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H332 (69.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H335 (26.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P220, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P370+P378, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 178 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P210, P220, P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, P370+P378, and P501 (click each P-code to see the statement)

Fresh air, rest.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

Excerpt from ERG Guide 143 [Oxidizers (Unstable)]:

Refer to the "General First Aid" section. Specific First Aid: Contaminated clothing may be a fire risk when dry. (ERG, 2024)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Contaminated clothing may be a fire risk when dry.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

Excerpt from ERG Guide 143 [Oxidizers (Unstable)]:

SMALL FIRE: Use water. Do not use dry chemicals or foams. CO2 or Halon® may provide limited control.

LARGE FIRE: Flood fire area with water from a distance. Do not move cargo or vehicle if cargo has been exposed to heat. If it can be done safely, move undamaged containers away from the area around the fire. Do not get water inside containers: a violent reaction may occur.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Cool containers with flooding quantities of water until well after fire is out. Dike runoff from fire control for later disposal. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use water in large amounts. In case of fire: keep drums, etc., cool by spraying with water.

If material on fire or involved in fire: Flood with water. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.

Evacuation: If fire becomes uncontrollable - consider evacuation of one-half (1/2) mile radius.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· Keep combustibles (wood, paper, oil, etc.) away from spilled material.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Use water spray to reduce vapors or divert vapor cloud drift.

· Prevent entry into waterways, sewers, basements or confined areas.

Small Spill

· Flush area with large amounts of water.

Large Spill

· DO NOT CLEAN-UP OR DISPOSE OF, EXCEPT UNDER SUPERVISION OF A SPECIALIST.

Excerpt from ERG Guide 143 [Oxidizers (Unstable)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Evacuate danger area! Consult an expert! Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Do NOT absorb in saw-dust or other combustible absorbents. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.

Evacuate danger area and consult an expert in case of large spill. Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Do NOT absorb in saw-dust or other combustible absorbents. Sweep spilled substance into covered containers; if appropriate, moisten first to prevent dusting.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers.

Personnel protection: ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. Approach fire with caution.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Excerpt from ERG Guide 143 [Oxidizers (Unstable)]:

Keep combustibles (wood, paper, oil, etc.) away from spilled material. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Use water spray to reduce vapors or divert vapor cloud drift. Prevent entry into waterways, sewers, basements or confined areas.

SMALL SPILL: Flush area with large amounts of water.

LARGE SPILL: DO NOT CLEAN-UP OR DISPOSE OF, EXCEPT UNDER SUPERVISION OF A SPECIALIST. (ERG, 2024)

Fireproof. Store in an area without drain or sewer access. Separated from combustible substances and reducing agents.

Fireproof. Store in an area without drain or sewer access. Separated from combustible and reducing substances.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

Small Fire

· Use water. Do not use dry chemicals or foams. CO2 or Halon® may provide limited control.

Large Fire

· Flood fire area with water from a distance.

· Do not move cargo or vehicle if cargo has been exposed to heat.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Do not get water inside containers: a violent reaction may occur.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Cool containers with flooding quantities of water until well after fire is out.

· Dike runoff from fire control for later disposal.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

A nuisance-causing concentration of airborne particles can be reached quickly when dispersed, especially if powdered.

The substance is severely irritating to the eyes and skin.

Excerpt from ERG Guide 143 [Oxidizers (Unstable)]:

Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)

Personnel protection: Wear appropriate chemical protective gloves, boots and goggles. ... Wear positive pressure self-contained breathing apparatus when fighting fires involving this material.

NO open flames, NO sparks and NO smoking. NO contact with flammables. Do NOT expose to friction or shock.

PREVENT DISPERSION OF DUST!

Use local exhaust or breathing protection.

Protective gloves.

Wear safety goggles.

Do not eat, drink, or smoke during work.

Guanidine nitrate appears as a white crystalline solid. Soluble in water. Takes some effort to ignite but once ignited it burns with increasing vigor as the fire progresses. If contaminated with combustible materials it accelerates their burning. Prolonged exposure to fire or heat may result in an explosion. Produces toxic oxides of nitrogen during combustion.

Dry Powder; Large Crystals; Liquid

White solid; [Hawley] White crystalline powder; [MSDSonline]

WHITE SOLID IN VARIOUS FORMS.

Crystalline powder

Decomposes at boiling point

Sol in 10 parts water; sol in alcohol

SLIGHTLY SOL IN ACETONE

Solubility in water, g/100ml at 20 °C: 16

1.436 g/cm³

When heated to decomposition it emits very toxic fumes of Nitric acid and /Nitrogen oxide/.

Aq solution is neutral

Strong oxidant

Nitrogen Compounds -> Nitrates and Nitrites

Reactive agents - 3rd degree

Soluble in water.

Amines, Phosphines, and Pyridines

Nitrate and Nitrite Compounds, Inorganic

Explosive

Strong Oxidizing Agent

GUANIDINE NITRATE can explode. Demolished an autoclave built to withstand 50 atmospheres when it exploded as it was being synthesized from ammonium thiocyanate and lead nitrate [C. Angew Chem. 49:23(1936)]. Acts an an oxidizing agent with organic matter.

Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613)

Ingested nitrate or nitrite under conditions that result in endogenous nitrosation is probably carcinogenic to humans (Group 2A). (L135)

Nitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137)

The substance can be absorbed into the body by ingestion.

Oral (L1137) ; inhalation (L1137)

Sore throat. Cough.

Redness. Pain.

Nitrate and nitrite poisoning causes methemoglobinemia. Symptoms include cyanosis, cardiac dysrhythmias and circulatory failure, and progressive central nervous system (CNS) effects. CNS effects can range from mild dizziness and lethargy to coma and convulsions. (L1137)

Guanidine Nitrate

PDF Document

Inadequate information to assess carcinogenic potential

SCREEN Current

PPRTV Current

LD50: 989.6 mg/kg (Oral, Rat) (A676)

LD50 Rat oral 1260 mg/kg

LD50 Rat (male) oral 989.6 mg/kg

LD50 Rat (female) oral 729.8 mg/kg

LD50 Mouse (male) oral 1105 mg/kg

LD50 Mouse (female) oral 1028 mg/kg

Methemoglobinemia can be treated with supplemental oxygen and methylene blue 1% solution administered intravenously slowly over five minutes followed by IV flush with normal saline. Methylene blue restores the iron in hemoglobin to its normal (reduced) oxygen-carrying state. (L1613)

Growth retardation of rats exposed to the smoke of high-sugar cigarettes was decreased by the addition of guanidine nitrate to the cigarettes.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

/ALTERNATIVE and IN VITRO TESTS/ Guanidinium nitrate in vitro caused a significant concentration-related hemolysis of erythrocyte suspensions in humans.

/LABORATORY ANIMALS: Acute Exposure/ In rabbits administered 2,000 mg/kg bw by 24 hr semi-occlusive /dermal/ application, no substance-related deaths or clinical signs of toxicity were observed.

/LABORATORY ANIMALS: Acute Exposure/ The test material was described as slightly irritating to rabbit skin using the Draize method as prescribed in EPA Guideline (1982). Quantity applied: 2,000 mg/kg bw semiocclusively for 24 hr; after 0.5 hr erythema in 9/10 animals and edema in 2/10 animals. After 72 hr erythema in 2/10 animals without observation of edema.

/LABORATORY ANIMALS: Acute Exposure/ Described as highly irritating in the rabbit using the Draize method as described in EPA Guideline (1982). Application quantity: 500 mg; semiocclusive patch for 24 hr; after 14 days, 7/8 animals showed erythema; for edema after 24 hr 4/8 animals with an index of 1, 3/8 animals with an index of 2 and 1/8 with an index of 4; after 14 days no further edema was observed.

/LABORATORY ANIMALS: Acute Exposure/ Test material described as slightly irritating when applied to the skin /rabbit/ using OECD Guideline 404: Acute Dermal Irritation/Corrosion. Application amount: 500 mg; semiocclusive for 4 hours; slight erythema and edema in 1/3 animals after 1 hr.

For more Non-Human Toxicity Excerpts (Complete) data for GUANIDINE, MONONITRATE (8 total), please visit the HSDB record page.

LC50 Leuciscus idus (carp) 2420 mg/L/48 hr /Conditions of bioassay not specified in source examined/

LC50 Pimephales promelas (fathead minnow) 690 mg/L/96 hr; Conditions: flow-through, 20 to 22 °C

LC50 Ictalurus punctatus (channel catfish) 1850 mg/L/96 hr; Conditions: flow-through, 20 to 22 °C

EC50 Daphnia magna (water flea) 70.2 mg/L/48 hr; Conditions: 20 °C; Effect: immobilization test

For more Ecotoxicity Values (Complete) data for GUANIDINE, MONONITRATE (9 total), please visit the HSDB record page.

1.90e+03

2.50e+04

6.00e+02

7.00e+02

1.50e-01

LC50 Leuciscus idus (carp) 2420 mg/L/48 hr /Conditions of bioassay not specified in source examined/

LC50 Pimephales promelas (fathead minnow) 690 mg/L/96 hr; Conditions: flow-through, 20 to 22 °C

LC50 Ictalurus punctatus (channel catfish) 1850 mg/L/96 hr; Conditions: flow-through, 20 to 22 °C

EC50 Daphnia magna (water flea) 70.2 mg/L/48 hr; Conditions: 20 °C; Effect: immobilization test

For more Ecotoxicity Values (Complete) data for GUANIDINE, MONONITRATE (9 total), please visit the HSDB record page.

1.90e+03

2.50e+04

6.00e+02

7.00e+02

1.50e-01

3.00e-02

Volatile

5.70e+03

7.40e+04

1.80e+03

The substance is harmful to aquatic organisms.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

/GUIDE 143: OXIDIZERS (UNSTABLE)/ Fire or Explosion: May explode from friction, heat or contamination. These substances will accelerate burning when involved in a fire. May ignite combustibles (wood, paper, oil, clothing, etc.). Some will react explosively with hydrocarbons (fuels). Containers may explode when heated. Runoff may create fire or explosion hazard.

/GUIDE 143: OXIDIZERS (UNSTABLE)/ Health: TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns, or death. Fire may produce irritating and/or toxic gases. Toxic fumes or dust may accumulate in confined areas (basement, tanks, hopper/tank cars, etc.). Runoff from fire control or dilution water may cause pollution.

/GUIDE 143: OXIDIZERS (UNSTABLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 143: OXIDIZERS (UNSTABLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for GUANIDINE, MONONITRATE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Oxidizer

UN Hazard Class: 5.1; UN Pack Group: III