tert-Butyl acetate

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for < 0.1% (1 of 1382) of reports.

H225 (> 99.9%): Highly Flammable liquid and vapor [Danger Flammable liquids]

H332 (34.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H335 (10.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H336 (10.1%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P317, P319, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1382 reports by companies from 17 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 1 of 1382 reports by companies.

There are 16 notifications provided by 1381 of 1382 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P319, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth.

Excerpt from NIOSH Pocket Guide for tert-Butyl acetate:

Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: WATER FLUSH PROMPTLY - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.

Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.

Swallow: MEDICAL ATTENTION IMMEDIATELY - If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2024)

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Fire Extinguishing Agents Not to Be Used: Water may be ineffective.

Fire Extinguishing Agents: Alcohol foam, CO2, dry chemical (USCG, 1999)

Use carbon dioxide, dry powder, foam. In case of fire: keep drums, etc., cool by spraying with water.

To fight fire, use alcohol foam, CO2, dry chemical.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. For small quantities, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be collected and atomized in a suitable combustion chamber.

/Absorbtion/ in vermiculite, dry sand, earth, or a similar material.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

/Proposed methods of disposal should be used on statutory requirements of the state where disposal is to occur. The usual methods would be expected to include:/ 1) Absorbing in vermiculite, dry sand, earth, or a similar material and disposing in a secured sanitary landfill. 2) Atomizing in a suitable combustion chamber.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Employees should wash promptly when skin is wet or contaminated. Remove clothing immediately if wet or contaminated to avoid flammability hazard.

... A complete respiratory protection program should be instituted which includes regular training, maintenance, inspection, cleaning, and evaluation. ... Clothing wet with liquid tert-butyl acetate should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of tert-butyl acetate from the clothing. If the clothing is to be laundered or otherwise cleaned to remove the tert-butyl acetate, the person performing the operation should be informed of tert-butyl acetate's hazardous properties.

The worker should immediately wash the skin when it becomes contaminated.

For more Preventive Measures (Complete) data for TERT-BUTYL ACETATE (6 total), please visit the HSDB record page.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Fireproof. Separated from strong oxidants, strong bases and strong acids.

20.0 [ppm]

40 [ppm]

1700 [ppm]

10000 [ppm]

200 ppm (950 mg/m³)

TWA 200 ppm (950 mg/m3)

200.0 [ppm]

1500 ppm ; Based on 10% of the lower explosive limit. (NIOSH, 2024)

1500.0 [ppm]

Excerpts from Documentation for IDLHs: Exposures of 200 to 300 ppm cause slight irritation of the eyes and nose, and short exposures to 3,300 ppm cause extreme irritation of the eyes and nose [ILO 1983].

1500 ppm [Based on 10% of the lower explosive limit for safety considerations even though the relevant toxicological data indicated that irreversible health effects or impairment of escape existed only at higher concentrations.]

1500 ppm

1500 ppm [10%LEL]

See: 540885

50.0 [ppm]

150.0 [ppm]

8 Hr Time Weighted Avg (TWA): 200 ppm.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

50 ppm as TWA; 150 ppm as STEL.

Finland (1975): 150 ppm; Switzerland (1976): 150 ppm

A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20 °C.

The vapour is irritating to the respiratory tract. The substance is mildly irritating to the eyes and skin. Exposure far above the OEL could cause lowering of consciousness.

The substance defats the skin, which may cause dryness or cracking.

Excerpt from NIOSH Pocket Guide for tert-Butyl acetate:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.

Remove: WHEN WET (FLAMMABLE) - Work clothing that becomes wet should be immediately removed due to its flammability hazard (i.e., for liquids with a flash point <100 °F).

Change: No recommendation is made specifying the need for the worker to change clothing after the workshift. (NIOSH, 2024)

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

Impervious clothing, gloves, and face shields and other protective clothing necessary to prevent repeated or prolonged skin contact with liquid tert-butyl acetate.

Wear appropriate personal protective clothing to prevent skin contact.

Wear appropriate eye protection to prevent eye contact.

For more Personal Protective Equipment (PPE) (Complete) data for TERT-BUTYL ACETATE (8 total), please visit the HSDB record page.

NIOSH/OSHA

Up to 1500 ppm:

(APF = 25) Any supplied-air respirator operated in a continuous-flow mode

(APF = 25) Any powered, air-purifying respirator with organic vapor cartridge(s)

(APF = 50) Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s)

(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister

Tert-butyl acetate is a colorless liquid with a mild odor. Floats on water. Produces irritating vapor. (USCG, 1999)

Liquid; CBI

Colorless liquid with a fruity odor; [NIOSH]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Colorless liquid with a fruity odor.

Colorless liquid

Fruity odor

208 °F at 760 mmHg (USCG, 1999)

97.8 °C @760 [mm Hg]

72 °F (NIOSH, 2024)

72 °F (closed cup)

16.6 - 22.2 °C (CLOSED CUP)

15.5 °C c.c.

Insoluble (NIOSH, 2024)

Soluble in ethanol, ethyl ether, chloroform, acetic acid

Miscible with common industrial organic solvents

Practically insoluble in water

Solubility in water: poor

Insoluble

0.8665 at 68 °F 0.8593 at 25 °C (USCG, 1999) - Less dense than water; will float

0.8665 g/cu cm at 20 °C

Relative density (water = 1): 0.86

0.8593 @25 °C

4.0 at BP (Air = 1)

Relative vapor density (air = 1): 4

47.0 [mmHg]

47 mm Hg at 25 °C /ext/

Vapor pressure, kPa at 25 °C: 6.3

47 [mm Hg] @25 °C

log Kow = 1.76

Heat /contributes to instability/.

799 °F (425 °C) /Butyl acetate/

When heated to decomposition it emits acrid smoke and irritating fumes.

33.07 kJ/mol at bp; 39.03 kJ/mol at 25 °C

Odor Threshold Low: 4.0 [ppm]

Odor Threshold High: 47.0 [ppm]

Odor threshold from "Quick Guide: The Electronic NIOSH Pocket Guide to Chemical Hazards"

Index of refraction: 1.3855 at 20 °C

CONVERSION FACTORS: 4.74 MG/CU M IS EQUIVALENT TO 1 PPM

Softens or dissolves plastics

Highly flammable. Insoluble in water.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

Highly Flammable

TERT-BUTYL ACETATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. This compound is incompatible with the following: Nitrates; strong oxidizers, alkalis & acids (NIOSH, 2024).

Contact with nitrates, strong oxidizers, strong alkalies, and strong acids may cause fires and explosions.

Nitrates; strong oxidizers, alkalis and acids.

Nitrates; strong oxidizers, alkalis & acids

Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org

The substance can be absorbed into the body by inhalation of its vapour.

inhalation, ingestion, skin and/or eye contact

Cough. Sore throat.

Dry skin.

Redness. Pain.

Itch, inflammation eyes; irritation upper resp tract; headache; narcosis; dermatitis

respiratory system, eyes, skin, central nervous system

Neurotoxin - Acute solvent syndrome

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Esters and related compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Provide a low-stimulus environment. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Treat frostbite by rapid rewarming ... . /Esters and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Esters and related compounds/

Consider initial effects on skin and resp tract in any preplacement or periodical exam, as well as liver, and kidney function.

/HUMAN EXPOSURE STUDIES/ A study of sensory irritation (nasal pungency) associated with a series of homologous ketones and secondary and tertiary alcohols and esters was conducted. The study group consisted of three men and one woman, 41 to 65 years old, who lacked a sense of smell (anosmics) and three men and one woman 41 to 68 years old, with normal olfaction (normosmics). The subjects were exposed to 2-propanone (67641), 2-pentanone (107879), 2-heptanone (110430), 2-nonanone (821556), 2-propanol (67630), 2-methyl-2-propanol (75650), 2-butanol (78922), 4-heptanol (589559), tert-butyl-acetate (540885), and sec-butyl-acetate (105464) vapors at concentrations of 1x10-2 to 1x10+6 ppm by sniffing bottles containing the solvents. They also sniffed bottles containing a blank (nonodoriferous solvent). The subjects were asked to estimate the concentration of each solvent at which they could first detect the odor and perceive nasal pungency. Attempts were made to correlate the thresholds with the concentration of the saturated vapor at ambient temperature (23 °C). Both the normosmics and anosmics could detect the solvent vapors; however, the normosmics detected the vapors at much lower concentrations. The nasal pungency and odor thresholds of the ketones decreased with increasing carbon chain length, but tended to plateau at 2-heptanone. The odor and pungency thresholds of the alcohols tended to increase when the hydroxy group was changed from a primary to a secondary carbon atom. The odor and pungency thresholds of the esters were similar. When plotted against the logarithm of the saturation vapor concentration, the logarithm of the pungency thresholds of the compounds conformed to a linear function that was approximately parallel to the saturation vapor concentration. No association between odor threshold and saturation vapor concentration was seen. The authors conclude that anosmics as well as normosmics can detect odors of volatile organic compounds, although at different concentrations. The pungency threshold data suggest that physical rather than chemical factors are involved in the interaction of volatile organic compounds with the nasal mucosa.

/SIGNS AND SYMPTOMS/ ... Exposures to concn of 200-300 ppm cause slight irritation of the eyes and nose and short exposure to a concn of 3300 ppm cause extreme irritation of the eyes and nose.

/SIGNS AND SYMPTOMS/ Overexposure to tert-butyl acetate may cause irritation of the eyes, nose, and throat. Severe overexposure may cause weakness, drowsiness, and unconsciousness. Prolonged overexposure may produce irritation of the skin.

/SIGNS AND SYMPTOMS/ Acute human data /includes/ a report concerning exposure to polyester lacquer, with signs and symptoms manifested as nervous, respiratory, and cardiovascular system disorders.

For more Human Toxicity Excerpts (Complete) data for TERT-BUTYL ACETATE (8 total), please visit the HSDB record page.

/LABORATORY ANIMALS: Acute Exposure/ Exposure to a concentration of 10000 ppm for 5 hr caused irritation and death in guinea-pigs.

/LABORATORY ANIMALS: Acute Exposure/ Application of the liquid to rabbit eyes caused superficial reversible injury, graded 5 on a scale of 1 to 10. /Butyl acetate/

/LABORATORY ANIMALS: Acute Exposure/ A study was conducted on the metabolism of inhaled tert-butyl-acetate. Sprague-Dawley-rats were exposed via a tracheal catheter to tert-butyl-acetate in air and arterial blood samples were analyzed at various times during the exposure. Continuous increases in the blood levels of both tert-butyl-acetate and tert-butyl alcohol were seen during 5 hour and 255 minute exposures to 440 ppm and 900 ppm, respectively, tert-butyl-acetate. During the longer exposure blood concentrations of tert-butyl-alcohol, although initially lower, exceeded those of tert-butyl-acetate after 255 minutes of exposure while during the 900 ppm exposure the concentration of tert-butyl-alcohol was below that of tert-butyl-acetate. Approximately half of the tert-butyl-acetate concentration decreased over the next 45 minutes following cessation of the 255 minute inhalation without a corresponding change in the tert-butyl-alcohol level. The authors conclude that the health risk from occupational inhalation of tert-butyl-acetate appears to exceed that of n-butyl-acetate.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ ... Groups of five male and five female ad libitum-fed Sprague-Dawley rats were exposed to tert-butyl acetate vapour at approximately 0, 580, 2100, or 7900 mg/cu m, 6 hr/day, 5 days/week, for 2 weeks. No treatment-related clinical signs of toxicity or effects on mean body weight, food consumption, or water consumption were observed in any group. Liver weights were increased in male rats exposed at 7900 mg/cu m. Centrilobular hepatocyte hypertrophy was seen in all males at 7900 mg/cu m and in one of five males at 2100 mg/cu m. An increased degree of cortical tubules with hyaline droplets was reported in all male groups treated with tert-butyl acetate. ...

For more Non-Human Toxicity Excerpts (Complete) data for TERT-BUTYL ACETATE (10 total), please visit the HSDB record page.

EC50; Species: Chlorococcales (Green Algae Order); Conditions: freshwater, static; Concentration: 1300000 ug/L for 24 hr; Effect: physiology, assimilation efficiency /formulation/

LC50; Species: Daphnia magna (Water Flea) age < or =24 hr; Conditions: freshwater, static, 20-22 °C; Concentration: 4730000 ug/L for 24 hr /formulation/

LC50; Species: Pimephales promelas (Fathead minnow) age 30 days, length 20.8 mm, weight 0.136 g; Conditions: freshwater, flow through, 25 °C, pH 7.5, hardness 44.8 mg/L CaCO3, alkalinity 43.3 mg/L CaCO3, dissolved oxygen 6.7 mg/L; Concentration: 327000 ug/L for 96 hr (95% confidence interval: 296000-362000 ug/L) /99+% purity/

8.10e+00

3.60e+01

2.20e+00

9.40e+00

3.30e+00

1.00e+02

7.60e-04

5.00e-03

Volatile

8.10e+02

3.60e+03

2.20e+02

9.40e+02

EC50; Species: Chlorococcales (Green Algae Order); Conditions: freshwater, static; Concentration: 1300000 ug/L for 24 hr; Effect: physiology, assimilation efficiency /formulation/

LC50; Species: Daphnia magna (Water Flea) age < or =24 hr; Conditions: freshwater, static, 20-22 °C; Concentration: 4730000 ug/L for 24 hr /formulation/

LC50; Species: Pimephales promelas (Fathead minnow) age 30 days, length 20.8 mm, weight 0.136 g; Conditions: freshwater, flow through, 25 °C, pH 7.5, hardness 44.8 mg/L CaCO3, alkalinity 43.3 mg/L CaCO3, dissolved oxygen 6.7 mg/L; Concentration: 327000 ug/L for 96 hr (95% confidence interval: 296000-362000 ug/L) /99+% purity/

8.10e+00

3.60e+01

2.20e+00

9.40e+00

3.30e+00

1.00e+02

7.60e-04

5.00e-03

Volatile

8.10e+02

3.60e+03

2.20e+02

9.40e+02

3.30e+02

tert-Butyl acetate's production and use as a solvent and gasoline additive may result in its release to the environment through various waste streams. tert-Butyl acetate occurs naturally in bananas and related fruits and may be released into the environment as a plant volatile. If released to air, a vapor pressure of 47 mm Hg at 25 °C indicates tert-butyl acetate will exist solely as a vapor in the atmosphere. Vapor-phase tert-butyl acetate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 36 days. tert-butyl acetate does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, tert-butyl acetate is expected to have very high mobility based upon an estimated Koc of 12. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 4.1X10-4 atm-cu m/mole. tert-Butyl acetate may volatilize from dry soil surfaces based upon its vapor pressure. No biodegradation studies have been located for tert-butyl acetate, however, studies on structurally similar compounds have shown that, in general, the ester functional group of alkyl acetates are biodegradable. If released into water, tert-butyl acetate is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 5.5 hours and 5 days, respectively. An estimated BCF of 7 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is expected to occur slowly based upon experimentally determined hydrolysis half-lives of 135, 14.6 and 1.5 years at pH 7, 8 and 9, respectively. Occupational exposure may be through inhalation and dermal contact with this compound at workplaces where tert-butyl acetate is produced or used. The general population may be exposed to tert-butyl acetate through the ingestion of food sources such as bananas and other related fruits where it occurs as a natural constituent. (SRC)

tert-Butyl acetate occurs in bananas and related fruits(1) and may be released into the environment as a plant volatile(SRC).

tert-Butyl acetate's production and use as a solvent and gasoline additive(1,2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 12(SRC), determined from a structure estimation method(2), indicates that tert-butyl acetate is expected to have very high mobility in soil(SRC). Volatilization of tert-butyl acetate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.1X10-4 atm-cu m/mole(SRC), using a fragment constant estimation method(3). tert-Butyl acetate is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 47 mm Hg at 25 °C(4). No biodegradation studies have been located for tert-butyl acetate, however, studies on structurally similar compounds(5-7) have shown that, in general, the ester functional group of alkyl acetates are biodegradable(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 12(SRC), determined from a structure estimation method(2), indicates that tert-butyl acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 4.1X10-4 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 5.5 hours and 5 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 7(SRC), from its log Kow of 1.76(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). No biodegradation studies have been located for tert-butyl acetate, however, studies on structurally similar compounds(8-10) have shown that, in general, the ester functional group of alkyl acetates are biodegradable(SRC). Hydrolysis is expected to occur slowly based upon experimentally determined hydrolysis half-lives of 135, 14.6 and 1.5 years at pH 7, 8 and 9, respectively(11).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tert-butyl acetate, which has a vapor pressure of 47 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tert-butyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 36 days(SRC), calculated from its rate constant of 4.5X10-13 cu cm/molecule-sec at 25 °C(3). tert-Butyl acetate does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

No biodegradation studies have been located for tert-butyl acetate, however, studies on structurally similar compounds(1-3) have shown that, in general, the ester functional group of alkyl acetates are biodegradable(SRC).

The rate constant for the vapor-phase reaction of tert-butyl acetate with photochemically-produced hydroxyl radicals has been reported as 4.5X10-13 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 36 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Based on experimentally determined acid-catalyzed hydrolysis rate constant of 1.26X10+4 L/mol-sec and base-catalyzed hydrolysis rate constant of 1.5X10-3 L/mol-sec at 20 °C(2), the hydrolysis half-lives of tert-butyl acetate at pH 7, 8, and 9 are 135, 14.6 and 1.5 years, respectively(SRC). tert-Butyl acetate does not contain chromophores that absorb at wavelengths >290 nm(3) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 7 was calculated in fish for tert-butyl acetate(SRC), using a log Kow of 1.76(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of tert-butyl acetate can be estimated to be 12(SRC). According to a classification scheme(2), this estimated Koc value suggests that tert-butyl acetate is expected to have very high mobility in soil.

The Henry's Law constant for tert-butyl acetate is estimated as 4.1X10-4 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that tert-butyl acetate is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 5.5 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 5 days(SRC). tert-Butyl acetate's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). tert-Butyl acetate is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 47 mm Hg(3).

INDOOR: Air samples were collected in 336 different industrial plants in Northern Belgium(1-2); 262 facilities contained one or more glycol esters; of these 262 facilities iso- or tert-butyl acetate was identified in 5% of operations using printing pastes and inks, 17% of those using paints and varnishes, 45% of car repair shops, and 30% of other industries(1,2).

tert-Butyl acetate occurs naturally in bananas and other related fruits(1).

According to the 2006 TSCA Inventory Update Report, the number of workers reasonably likely to be exposed in the industrial manufacturing, processing, and use for tert-butyl acetate is 100 to 999 persons; the data may be greatly underestimated(1).

Occupational exposure may be through inhalation and dermal contact with this compound at workplaces where tert-butyl acetate is produced or used. The general population may be exposed to tert-butyl acetate through the ingestion of food sources such as bananas and other related fruits where it occurs as a natural constituent. (SRC)

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

/Proposed methods of disposal should be used on statutory requirements of the state where disposal is to occur. The usual methods would be expected to include:/ 1) Absorbing in vermiculite, dry sand, earth, or a similar material and disposing in a secured sanitary landfill. 2) Atomizing in a suitable combustion chamber.

/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /Butyl acetates/

/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. /Butyl acetates/

/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering. /Butyl acetates/

/GUIDE 129: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. /Butyl acetates/

For more DOT Emergency Guidelines (Complete) data for TERT-BUTYL ACETATE (8 total), please visit the HSDB record page.

UN 1123; Butyl acetates

IMO 3.2; Butyl acetates

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Liquid

Symbol: F; R: 11-66; S: (2)-16-23-25-29-33; Note: C

UN Hazard Class: 3; UN Pack Group: II