Barium acetate

This chemical does not meet GHS hazard criteria for 0.3% (1 of 287) of reports.

H302 (99.7%): Harmful if swallowed [Warning Acute toxicity, oral]

H332 (99.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]

P261, P264, P270, P271, P301+P317, P304+P340, P317, P330, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 287 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 1 of 287 reports by companies.

There are 6 notifications provided by 286 of 287 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P260, P261, P264, P270, P271, P301+P317, P304+P340, P308+P316, P319, P321, P330, P403+P233, P405, and P501 (click each P-code to see the statement)

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

P260, P264, P270, P301+P317, P308+P316, P321, P330, P405, and P501 (click each P-code to see the statement)

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer for medical attention .

In case of fire in the surroundings, use appropriate extinguishing media.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Separated from strong oxidants, acids and food and feedstuffs.

0.5 [mg/m3], as Ba, inhalable fraction(soluble compds)[German Research Foundation (DFG)]

7.4 [mg/m3]

30 [mg/m3]

180 [mg/m3]

0.5 [mg/m3], as Ba

50.0 [mg/m3], as Ba

0.5 mg/m

(as Ba): 0.5 mg/m

(as Ba, inhalable fraction): 0.5 mg/m

Intermediate Oral: 0.2 mg/kg/day (L134)

Chronic Oral: 0.2 mg/kg/day (L134)

A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered.

The substance may cause effects on the gastrointestinal tract and, by lowering serum potassium level, on muscles, heart and nervous system. This may result in muscle paralysis, cardiac dysrhythmia and respiratory failure. Ingestion could cause death.

PREVENT DISPERSION OF DUST! STRICT HYGIENE!

Use local exhaust or breathing protection.

Protective gloves.

Wear safety spectacles.

Do not eat, drink, or smoke during work.

Dry Powder

White solid; [Hawley] White crystals, soluble in water; [MSDSonline]

WHITE CRYSTALS OR POWDER.

Solubility in water, g/100ml at 20 °C: 59

2.47 g/cm³

2.468 @25 °C

Metals -> Organic Acids, Metal Salts

FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis. Some of these barium's effects may also be due to barium induced neuromuscular blockade and membrane depolarization. (L214)

No indication of carcinogenicity to humans (not listed by IARC).

The health effects of the different barium compounds depend on how well the compound dissolves in water or the stomach contents. At low doses, barium acts as a muscle stimulant, while higher doses affect the nervous system, causing cardiac irregularities, tremors, weakness, anxiety, dyspnea, paralysisand possibly death. Barium may also cause gastrointestinal disturbances, damage the kidneys and cause decreases in body weight. (L214)

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Oral (L214) ; inhalation (L214)

Abdominal pain. Diarrhoea. Nausea. Vomiting. Weakness. Shortness of breath.

Ingesting excess barium may cause vomiting, abdominal cramps, diarrhea, difficulties in breathing, increased or decreased blood pressure, numbness around the face, and muscle weakness. High levels may result in changes in heart rhythm or paralysis and possibly death. (L214)

ACGIH Carcinogen - Not Classifiable.

LD50: 921 mg/kg (Oral, Rat) (L271)

Intravenous infusion of potassium often relieves many of the symptoms of barium toxicity. (L214)

The substance is harmful to aquatic organisms.

The substance is harmful to aquatic organisms.

Symbol: Xn; R: 20/22; S: (2)-28; Note: A

UN Hazard Class: 6.1; UN Pack Group: III