Nitroglycerin

H200: (Deleted) Unstable Explosive [Danger Explosives]

H300: Fatal if swallowed [Danger Acute toxicity, oral]

H310: Fatal in contact with skin [Danger Acute toxicity, dermal]

H330: Fatal if inhaled [Danger Acute toxicity, inhalation]

H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P201, P202, P260, P262, P264, P270, P271, P273, P280, P281, P284, P301+P316, P302+P352, P304+P340, P316, P319, P320, P321, P330, P361+P364, P372, P373, P380, P391, P401, P403+P233, P405, and P501 (click each P-code to see the statement)

H201: (Deleted) Explosive; mass explosion hazard [Danger Explosives]

P210, P230, P240, P250, P260, P262, P264, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P316, P319, P320, P321, P330, P361+P364, P370+P380, P372, P373, P391, P401, P403+P233, P405, and P501 (click each P-code to see the statement)

H200 (53.8%): (Deleted) Unstable Explosive [Danger Explosives]

H300+H310+H330 (43%): Fatal if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]

H300 (98.9%): Fatal if swallowed [Danger Acute toxicity, oral]

H310 (98.9%): Fatal in contact with skin [Danger Acute toxicity, dermal]

H330 (98.9%): Fatal if inhaled [Danger Acute toxicity, inhalation]

H373 (96.8%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H411 (96.8%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Aggregated GHS information provided per 93 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H362: May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P201, P202, P203, P260, P261, P263, P264, P270, P272, P273, P280, P281, P301+P317, P302+P352, P308+P316, P318, P319, P321, P330, P333+P317, P362+P364, P372, P373, P380, P391, P401, P405, and P501 (click each P-code to see the statement)

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P201, P202, P203, P260, P261, P264, P264+P265, P270, P272, P280, P281, P301+P316, P302+P352, P305+P351+P338, P308+P316, P318, P319, P321, P330, P333+P317, P337+P317, P362+P364, P372, P373, P380, P401, P405, and P501 (click each P-code to see the statement)

H351: Suspected of causing cancer [Warning Carcinogenicity]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P203, P210, P230, P240, P250, P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P316, P302+P352, P304+P340, P316, P318, P319, P320, P321, P330, P333+P317, P362+P364, P370+P380, P372, P373, P391, P401, P403+P233, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention.

Excerpt from ERG Guide 113 [Flammable Materials (Wet / Desensitized Explosive)]:

Refer to the "General First Aid" section. (ERG, 2024)

Excerpt from NIOSH Pocket Guide for Nitroglycerine:

Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: SOAP WASH IMMEDIATELY - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.

Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.

Swallow: MEDICAL ATTENTION IMMEDIATELY - If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2024)

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:

Refer to the "General First Aid" section. Specific First Aid: Wash skin with soap and water. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. (ERG, 2024)

Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Wash skin with soap and water.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Soap wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.

Breathing: Respiratory support

Excerpt from ERG Guide 113 [Flammable Materials (Wet / Desensitized Explosive)]:

CARGO FIRE: DO NOT fight fire when fire reaches cargo! Cargo may EXPLODE! Stop all traffic and clear the area for at least 1600 meters (1 mile) in all directions and let burn. Do not move cargo or vehicle if cargo has been exposed to heat.

TIRE OR VEHICLE FIRE: Use plenty of water - FLOOD it! If water is not available, use CO2, dry chemical or dirt. If possible, and WITHOUT RISK, use unmanned master stream devices or monitor nozzles from maximum distance to prevent fire from spreading to cargo area. Pay special attention to tire fires as re-ignition may occur. Stand by, at a safe distance, with extinguisher ready for possible re-ignition. (ERG, 2024)

Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient. CAUTION: For fire involving UN1170, UN1987 or UN3475, alcohol-resistant foam should be used. CAUTION: Ethanol (UN1170) can burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.).

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.

LARGE FIRE: Water spray, fog or alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position.

If material on fire or involved in fire: Dangerously explosive. Do not fight fires in a cargo of explosives. Evacuate area and let burn. If the material is on fire or involved in fire consider evacuation of one mile radius.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 113 [Flammable Materials (Wet / Desensitized Explosive)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area immediately for at least 100 meters (330 feet) in all directions.

LARGE SPILL: Consider initial evacuation for 500 meters (1/3 mile) in all directions.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area immediately for at least 500 meters (1/3 mile) in all directions.

LARGE SPILL: Consider initial evacuation for 800 meters (1/2 mile) in all directions.

FIRE: If rail car or trailer is involved in a fire, ISOLATE for 1600 meters (1 mile) in all directions; also, initiate evacuation including emergency responders for 1600 meters (1 mile) in all directions. (ERG, 2024)

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· Consider initial downwind evacuation for at least 300 meters (1000 feet).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Remove all ignition sources. Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Nitro-compounds and nitrate ester are cathodically reduced from industrial wastewaters.

Solvent used to remove nitroglycerin from nitration plant effluent was dinitrotoluene.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

A good candidate for liquid injection incineration at a temperature range of 650 to 1,600 °C and a residence time of 0.1 to 2 seconds. A good candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A good candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away.

Personnel protection: Avoid breathing vapors or dusts. ...

The worker should immediately wash the skin when it becomes contaminated.

For more Preventive Measures (Complete) data for NITROGLYCERIN (7 total), please visit the HSDB record page.

Excerpt from ERG Guide 113 [Flammable Materials (Wet / Desensitized Explosive)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material.

SMALL SPILL: Flush area with large amounts of water.

LARGE SPILL: Wet down with water and dike for later disposal. KEEP "WETTED" PRODUCT WET BY SLOWLY ADDING FLOODING QUANTITIES OF WATER. (ERG, 2024)

Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. DO NOT OPERATE RADIO TRANSMITTERS WITHIN 100 METERS (330 FEET) OF ELECTRIC DETONATORS. DO NOT CLEAN-UP OR DISPOSE OF, EXCEPT UNDER SUPERVISION OF A SPECIALIST. (ERG, 2024)

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Store only if stabilized. Store in an area without drain or sewer access. Fireproof. Well closed. Separated from food and feedstuffs.

Nitroglycerin injections are practically colorless and stable in their intact containers. The solutions are not explosive. Storage should be at room temperature; the containers should be protected from freezing. Exposure to light, even high intensity light, does not adversely affect nitroglycerin stability. /nitroglycerin injections/

Store at room temp not above 25 °C (77 °F). Do not refrigerate. /Nitroglycerin trans dermal systems/

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

0.01 [ppm] (Value applies for the sum of the concentrations of Ethylene glycol dinitrate, Nitroglycerin and Propylene glycol dinitrate in the air.)[German Research Foundation (DFG)]

0.10 [mg/m3]

2.0 [mg/m3]

75 [mg/m3]

0.1 mg/m³

ST 0.1 mg/m3 [skin]

0.2 ppm (2 mg/m³)

C 0.2 ppm (2 mg/m3) [skin] See Appendix G

75 mg/m3 [From NPG: Nitroglycerine] (NIOSH, 2024)

75 mg/m3 (NIOSH, 2024)

8.0 [ppm]

Excerpts from Documentation for IDLHs: Human data: Headaches have developed in workers exposed to 0.4 to 0.67 mg/m3 for 25 minutes; all had decreases in blood pressure [Trainor and Jones 1966]. Ethylene glycol dinitrate and nitroglycerine are vasodilators and initial exposures result in headache, dizziness, nausea, or decreases in blood pressure; however, workers become tolerant of the vasodilatory activity after 2 to 4 days of exposure [NIOSH 1978]. It has been estimated that the lethal oral dose in humans is 200 mg although others have survived doses of 1,200 mg with no apparent ill effects [Rabinowitch 1944]. [Note: An oral dose of 200 mg is equivalent to a worker being exposed to about 150 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]

75 mg/cu m

75 mg/m³

75 mg/m3

See: 55630

0.05 [ppm]

8 hr Time Weighted Avg (TWA): 0.05 ppm, skin.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

0.05 ppm as TWA; (skin).

0.05 ppm [1980]

0.095 mg/m

0.094 mg/m

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

CAUTION: For fire involving UN1170, UN1987 or UN3475, alcohol-resistant foam should be used.

CAUTION: Ethanol (UN1170) can burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.)

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

Large Fire

· Water spray, fog or alcohol-resistant foam.

· Avoid aiming straight or solid streams directly onto the product.

· If it can be done safely, move undamaged containers away from the area around the fire.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

Glyceryl trinitrate solution appears as a colorless solution of glyceryl trinitrate (nitroglycerin) in water. If allowed to dry out, the remaining nitroglycerin is explosive.

Nitroglycerin, desensitized, [liquid] appears as a pale yellow, viscous liquid that is slightly soluble in water and more dense than water. Sensitive to shock and heat. May explode under prolonged exposure to fire or heat. Primary hazard is the blast of an instantaneous explosion and not flying fragment or projectiles. Used medicinally.

Nitroglycerin, solution in alcohol, with more than 1% but not more than 5% nitroglycerin appears as a dilute solution in ethanol. If the ethanol evaporates the nitroglycerine will become shock sensitive. May then detonate if shocked or heated.

Nitroglycerin, solution in alcohol, with not more than 1% nitroglycerin appears as a flammable, colorless solution of nitroglycerin in alcohol. If allowed to dry out, the remaining nitroglycerin is explosive.

Spirits of nitroglycerin, [1 to 10%] appears as a mixture of nitroglycerin and ethanol. If ethanol evaporates the nitroglycerin becomes shock sensitive and may detonate by friction or impact.

Liquid; Dry Powder

Colorless to pale-yellow, viscous liquid or solid (below 56 degrees F). [Note: An explosive ingredient in dynamite (20-40%) with ethylene glycol dinitrate (80-60%).]; [NIOSH]

COLOURLESS-TO-YELLOW VISCOUS LIQUID OR PALE YELLOW CRYSTALS.

A colorless solution of glyceryl trinitrate (nitroglycerin) in water.

Colorless to pale-yellow, viscous liquid or solid (below 56 °F). [Note: An explosive ingredient in dynamite (20-40%) with ethylene glycol dinitrate (80-60%).]

VISCOUS LIQUID

Pale-yellow, oily liquid

Colorless to pale-yellow, viscous liquid or solid (below 56 degrees F) Note: An explosive ingredient in dynamite (20-40%) with ethylene glycol dinitrate (80-60%).

Sweet, burning taste

Begins to decompose at 122-140 °F (NIOSH, 2024)

Explodes at 218 °C

BOILING POINT: 125 °C @ 2 MM HG

at 2kPa: 160 °C

Begins to decompose at 122-140 °F

56 °F (NIOSH, 2024)

Crystalizes in 2 forms: labile form, 2.8 °C; stable form, 13.5 °C

Explodes (NIOSH, 2024)

518 °F (NFPA, 2010)

explodes

Explodes

0.1 % (NIOSH, 2024)

poor solubility in water

Sparingly sol in petroleum ether, liq petrolatum, glycerol.

One gram dissolves in 4 grams ethanol, 18 g methanol, 120 g carbon disulfide.

Miscible with glacial acetic acid, nitrobenzene, pyridine, ethylene bromide, dichloroethylene, ethyl acetate.

1 g in 800 ml water.

For more Solubility (Complete) data for NITROGLYCERIN (6 total), please visit the HSDB record page.

2.04e-01 g/L

Solubility in water: poor

1.6 (NIOSH, 2024) - Denser than water; will sink

1.5918 @ 25 °C/4 °C; 1.6009 @ 15 °C/4 °C

Heat of formation 1.63 kJ/g; heat of detonation 6.29 kJ/g; gas volume at STP 715 cm/g; activation energy 169 kJ/mol; collision constant, 17.1 log 10/s; applicable temp range 75-105 °C; detonation velocity 7.60 km/s and at density 1.59 g/cu m; vacuum stability at 100 °C ml gas per g per 40 hr at STP: explodes; weight loss at 100 °C 3-5%; explosion temp at 5 s, 220 °C (decomposes); effect of prolonged storage dec 3-4 days at 75 °C; relative impact test value 15% trinitrotoluene (TNT); friction pendulum: explode.

Relative density (water = 1): 1.6

1.5931 @ 20°C

7.8 (Air= 1)

No rapid reaction with air. No rapid reaction with water.

Highly flammable. Slightly soluble in water.

Highly flammable.

Highly flammable. Ethanol is soluble in water.

Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic

Alcohols and Polyols

Explosive

Strong Oxidizing Agent

Highly Flammable

GLYCERYL TRINITRATE SOLUTION is incompatible with the following: Heat, ozone, shock, acids. Note: An OSHA Class A Explosive (1910.109). (NIOSH, 2024). It may react vigorously with reducing agents, including hydrides, sulfides and nitrides. Incompatible with ozone, acids.

Nitroglycerin is incompatible with heat, ozone, shock, and acids, and is an OSHA Class A Explosive (1910.109) (NIOSH, 2024).

NITROGLYCERIN, DESENSITIZED, [LIQUID] is less subject to explosion when heated or shocked than ordinary nitroglycerin because of the addition of desensitizing materials, but is still dangerous. May begin a vigorous reaction that culminates in a detonation if mixed with reducing agents, including hydrides, sulfides and nitrides. Reacts with inorganic bases to form explosive salts. Sensitized toward decomposition by the presence of metal oxides.

NITROGLYCERIN, SOLUTION IN ALCOHOL, WITH MORE THAN 1% BUT NOT MORE THAN 5% NITROGLYCERIN may react vigorously with reducing agents, including hydrides, sulfides and nitrides. Incompatible with ozone, acids.

Nitroalkanes, such as NITROGLYCERIN, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. Nitroalkanes are milder oxidizing agents, but still react violently with reducing agents at higher temperature and pressures. Nitroalkanes react with inorganic bases to form explosive salts. The presence of metal oxides increases the thermal sensitivity of nitroalkanes. Nitroalkanes with more than one nitro group are generally explosive. Nitroalkanes are insoluble in water. Flammable/combustible material. May be ignited by heat, sparks or flames.

Nitroglycerin is incompatible with the following: Heat, ozone, shock, acids. Note: An OSHA Class A Explosive (1910.109). (NIOSH, 2024).

SPIRITS OF NITROGLYCERIN is a mixture of nitroglycerin and ethanol.

Nitroalkanes, such as nitroglycerin, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. Nitroalkanes are milder oxidizing agents, but still react violently with reducing agents at higher temperature and pressures. Nitroalkanes react with inorganic bases to form explosive salts. The presence of metal oxides increases the thermal sensitivity of nitroalkanes. Nitroalkanes with more than one nitro group are generally explosive. Nitroalkanes are insoluble in water. Flammable/combustible material. May be ignited by heat, sparks or flames.

Heat, ozone, shock acids.

Ozone and nitroglycerin explode on mixing.

Heat, ozone, shock, acids [Note: An OSHA Class A Explosive (1910.109).]

IDENTIFICATION: Glyceryl trinitrate is used as an anti-anginal vasodilating agent. It slightly volatile odorless oily liquid with sweet, aromatic and pungent taste. Soluble in water, ethanol, methanol and miscible with ether, acetone and chloroform. Indications: Prophylaxis and treatment of angina and left ventricular failure. Control of hypertension during cardiac surgery. Congestive cardiac failure unresponsive to usual therapy. HUMAN EXPOSURE: Main risks and target organs: Toxic effects of glyceryl trinitrate are caused by vasodilatation and methemoglobinemia. Venous and arterial vasodilatation causes lowering of blood pressure leading to shock. Heart, blood vessels and red blood cells are the target organs in glyceryl trinitrate poisoning. Summary of clinical effects: Features of poisoning may appear within a few minutes to one hour or more after exposure. There is tachycardia and hypotension followed by bradycardia and collapse. Flushing of the face, headache, dizziness, restlessness, syncope, convulsions and coma may be present. Some of the other features are vomiting, diarrhoea, cyanosis and methaemoglobinaemia and respiratory failure. Effects of glyceryl trinitrate are enhanced by alcohol. Contraindications to the use of glyceryl trinitrate is in patients with hypo, head injury, severe anemia, cerebral hemorrhage and in patients predisposed to closed-angle glaucoma. Intravenous administration contraindicated in constrictive pericarditis and uncorrected hypovolaemia. Routes of entry: Oral: Toxic effects can occur by ingestion. Inhalation: Inhalation of dust may cause toxic effects. Dermal: Toxic effects may occur when absorbed through skin. Prolonged skin contact can cause skin eruptions. Parenteral: Toxic effects can occur by the administration of excessive intravenous doses. Absorption by route of exposure: Oral: Glyceryl trinitrate is readily absorbed from the oral mucosa but rapidly metabolized so that it has only a fleeting duration of action. It is also readily absorbed from the gastrointestinal tract, but owing to extensive first-pass metabolism in the liver its bioavailability is reduced. A study involving 5 healthy persons indicated a bioavailability of less than 1% following administration by mouth of glyceryl trinitrate capsule and oral solution. However the weakly pharmacologically active dinitrate metabolites reached relatively high concentrations after oral glyceryl trinitrate administration and it was suggested that these metabolites may be responsible for the activity of oral glyceryl trinitrate. Dermal: Glyceryl trinitrate is also absorbed through the skin from an ointment base. Distribution by route of exposure: The time to peak concentration depends on the route of administration; it occurs after 2 minutes, 40 minutes and one hour after sublingual, oral and dermal administration respectively. Bioavailability is 38% after sublingual and 1% for oral administration. Biological half-life by route of exposure: This drug has a very short plasma half life. Elimination half-life of nitroglycerin is 1.7 to 2.9 minutes. When glyceryl trinitrate was given sublingually peak plasma concentrations appeared within 4 minutes and at least half of the intact glyceryl trinitrate was cleared from the blood in 1 to 3 minutes. Peak plasma concentration following dermal application of 45 mg nitroglycerin ointment occurred in about 1 hour. Metabolism: Glyceryl trinitrate is metabolized by hydrolysis to dinitrates and the mononitrate. The half-life for dinitrate metabolites is about 40 minutes approximately 20 times that of glyceryl trinitrate. Elimination by route of exposure: In 10 healthy volunteers given glyceryl trinitrate 560 ug sublingually, about 22% of the administered dose was excreted in the urine after 24 hours mainly as the mononitrate. Mode of action Toxicodynamics: Glyceryl trinitrate has dilator properties on vascular smooth muscle in virtually all vascular beds. The beneficial effects in therapeutic doses and the effects seen with overdose are attributable to the physiologic consequences of systemic venous and arteriolar vasodilatation. The cardiac preload, systemic blood pressure and systemic vascular resistance all show a progressive decrease. A state of hypotension and circulatory collapse and shock may result. methemoglobinemia may occur in patients following an overdose or after therapy. Pharmacodynamics: Glyceryl trinitrate relaxes smooth muscle including vascular smooth muscle, and reduces systolic blood pressure. It is thought that the anti-anginal effect mainly depends on reducing myocardial oxygen demand by means of peripheral vasodilatation which causes decreased venous return permitting a reduction in left ventricular volume and energy expenditure. The effect of glyceryl trinitrate in relaxing coronary vessels is not considered to increase appreciably coronary blood flow. Interactions: Alcohol enhances the effects of glyceryl trinitrate. Undue dizziness and faint feeling may occur when sublingual nitrates are taken with beta-adrenoceptor blocking drugs. Complete AV block has been reported after use of sublingual nitrates in patients receiving lignocaine by infusion. Even cardiac asystole may occur. Disopyramide (by producing dryness in mouth) may prevent dissolution of sublingual isosorbide dinitrate tablets. This may also occur with tricyclic antidepressants. Delayed dissolution of glyceryl trinitrate tablets in patients with dry mouths has been reported in a patient taking imipramine and in another patient treated with atropine. A patient developed resistance to the effects of heparin on two occasions directly after intravenous administration of glyceryl trinitrate. The interactions could not be attributed to propylene glycol in the solvent since resistance also occurred during administration of a formulation of glyceryl trinitrate without propylene glycol. Explosion flush has been observed in patients with transdermal patch when electric defibrillation was performed. Main adverse effects: The toxicity of the nitrates is unaffected by the chemical form or by the route of administration and all the nitrates have a common profile of adverse effects. Hypotension, reflex tachycardia and palpitations may occur. Postural hypotension and syncope is seen, especially in elderly patients. Rarely severe bradycardia has been reported. Throbbing headache is quite common. This symptoms is likely to recede as tolerance develops. Peripheral edema is also frequently seen. Transient hypoxemia with precipitation of angina is seen occasionally. Transient cerebral ischemic episodes unrelated to changes in blood pressure are rarely seen. In patients with cerebrovascular disease, it is recommended to initiate treatment with small doses. Although tolerance has long been associated with nitrates, its clinical implications are not clear. Tolerance is best defined as a decreasing pharmacological effect over time, often with a need for an increasing dose to achieve a given action. Tolerance may be partial or incomplete and may occur to one aspect of nitrate therapy and not to others. Disappearance of the throbbing headache is useful. However, due to an attenuation of the antihypertensive effect, these agents are not useful in the long term management of hypertension. The part played by the arterial and venous side of the circulation pertaining to the development of tolerance is not clear. By having a long (approximately 8 hours) nitrate free interval, the development of tolerance may be avoided or reduced. Decreasing the number of daily doses of glyceryl trinitrate also helps to achieve this effect. Sustained release preparations are more likely to produce tolerance than the short acting preparations.

Overdose toxicity from nitroglycerin is mainly a consequence of increased vasodilatory response. Hypotension, venous pooling, increased vasodilation, and reduced cardiac output can be expected in these patients. Compensatory effects, such as tachycardia and palpitations, can also be expected. Vasodilation and venous pooling can increase the amount of blood in the cranial space, resulting in increased intracranial pressures; this can cause persistent, throbbing headaches, along with confusion, fever, vertigo, nausea, vomiting, and visual disturbances. As intracranial pressure increases, symptoms will progress to dyspnea secondary to a reduced respiratory effort, heart block, bradycardia, paralysis, seizures, coma, and, eventually, death.

No currently known antagonist is available to counteract the effect of nitroglycerin. Since the effects are related to venodilation and relative arterial hypovolemia, efforts to increase central fluid volume have proven effective. Intravenous administration of normal saline, in addition to the passive elevation of the patient's legs, may provide adequate support, but there are no controlled trials to prove its effectiveness. Epinephrine or other arterial vasoconstricting agents are not recommended as they will not likely improve the patient's condition and may cause more difficulties in the future. Methemoglobinemia has some rare reports as a consequence of nitrate overdose. Clinician suspicion should be raised in patients with hypoxemia symptoms despite a lack of respiratory symptoms, normal arterial PO2, and adequate cardiac output. Blood from patients with methemoglobinemia has a "chocolate brown" appearance in color, with no change in color upon exposure to air. The treatment for methemoglobinemia is an intravenous administration of methylene blue, dosed at 1 to 2 mg/kg of the patient's body weight.

Drug Induced Liver Injury Rank (DILIrank 2.0)

Nitroglycerin

vNo-DILI-concern

No match

DOI:10.1016/j.drudis.2016.02.015

Drug-Induced Liver Injury Severity and Toxicity (DILIst)

nitroglycerin

DILI Negative

DOI:10.1016/j.drudis.2019.09.022

◉ Summary of Use during Lactation

Topical use of nitroglycerin for anal fissures by nursing mothers appears to have no adverse effects on their breastfed infants. Topical use on the nipples has been used for alleviation of Raynaud phenomenon of the nipples, but only after cessation of breastfeeding. Nitroglycerin should not be used topically on the nipples during breastfeeding. Sublingual and intravenous nitroglycerin have not been studied during breastfeeding. Observe infants for flushing and discomfort after breastfeeding.

◉ Effects in Breastfed Infants

Forty nursing mothers used nitroglycerin ointment (dosage not specified) topically for the treatment of postpartum anal fissures for durations ranging from 1 use to 12 months of intermittent use. All but 9 of the women reported side effects from therapy, primarily headache, but also dizziness or lightheadedness. None of the mothers reported any side effects in their breastfed infants.

◉ Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

Headache. Nausea. Flushing of the face. Dizziness.

MAY BE ABSORBED! Further see Inhalation.

Redness. Pain.

Flushing of the face. Headache. Dizziness. Nausea. Vomiting. Shock or collapse.

throbbing headache; dizziness; nausea, vomiting, abdominal pain; hypotension; flush; palpitations; methemoglobinemia; delirium, central nervous system depression; angina; skin irritation

cardiovascular system, blood, skin, central nervous system

Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

Nitroglycerin has many adverse effects of significance, most resulting from the vasodilatory effects of the medication. These include:

* Dizziness

* Weakness

* Palpitations

* Vertigo

* Headaches

* Nausea

* Vomiting

* Diaphoresis

* Syncope

Many of these adverse effects are secondary to the hypotensive effects of nitroglycerin. Patients may report symptoms of orthostatic hypotension, which manifest as dizziness, weakness, palpitations, and vertigo. Profound hypotension may occur in patients with preload-dependent conditions. Some patients can be more sensitive to the hypotension caused by nitrates, potentially resulting in nausea, vomiting, diaphoresis, pallor, and collapse even at therapeutic doses. There have also been reports of flushing, exfoliative dermatitis, and drug rash in some patients taking nitroglycerin. Headaches can be severe, throbbing, and persistent and may occur immediately after use.

Syncope is the most dangerous adverse effect and can result in falls and their resultant injuries. The risk of syncope significantly increases with the concurrent use of a phosphodiesterase-5 (PDE-5) inhibitor. A further discussion is included below under contraindications. In patients with right coronary artery occlusion and chest pain, right ventricular infarction should be ruled out before giving nitroglycerin as nitroglycerin causes venodilation and reduces preload. The right ventricle is volume dependent chamber, and reduction in preload can cause profound hypotension, leading to cardiogenic shock.

LC50 Bluegill 1.28 mg/l/96 hr @ pH 6.0. /Static bioassay/

6.30e+00

8.20e+01

2.00e+00

1.00e+03

8.50e-04

1.70e-02

1.00e-04

Volatile

1.90e+01

2.50e+02

5.90e+00

The substance is toxic to aquatic organisms.

Nitroglycerin's production and use as a propellant and explosive, and as a pharmaceutical product to treat heart related illness, may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 2.0X10-4 mm Hg at 20 °C indicates nitroglycerin will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase nitroglycerin will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 15 days. Nitroglycerin absorbs light weakly in the environmental UV spectrum, but it is unknown weather it undergoes significant direct photolysis in the atmosphere. Particulate-phase nitroglycerin will be removed from the atmosphere by wet and dry deposition. If released to soil, nitroglycerin is expected to have moderate mobility based upon an estimated Koc of 180. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 4.3X10-8 atm-cu m/mole. If released into water, nitroglycerin is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Nitroglycerin was completely biodegraded in 13 days using river water and river water/sediment microcosms obtained from a river near a munitions facility. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. Although hydrolysis is not an important environmental fate process at neutral pH, hydrolysis may be important under alkaline conditions based on half-lives of 37 and 96 days at pH 9 and 25 and 18 °C, respectively. Nitroglycerin may undergo photolysis in sunlit surface waters. The photolysis half-life for nitroglycerin in distilled water, filtered river water and filtered pond water exposed to sunlight were 116, 57 and 73 days, respectively. An estimated BCF of 4 suggests the potential for bioconcentration in aquatic organisms is low. Occupational exposure to nitroglycerin may occur through dermal contact with this compound at workplaces where nitroglycerin is produced or used. The general population is not expected to be exposed to nitroglycerin except for persons that may need to use this compound to treat and prevent chest pain (from angina pectoris), or other heart related conditions. (SRC)

Nitroglycerin's production and use in the manufacture of propellants and explosives(1,2), and as a pharmaceutical product to treat heart conditions(1,2), may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 180(SRC), determined from a log Kow of 1.62(2) and a regression-derived equation(3), indicates that nitroglycerin is expected to have moderate mobility in soil(SRC). Volatilization of nitroglycerin from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.3X10-8 atm-cu m/mole(SRC), derived from its vapor pressure, 2.0X10-4 mm Hg(4), and water solubility, 1,380 mg/l(5). Nitroglycerin is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Hydrolysis under alkaline conditions may be important based upon half-lives of 37 and 96 days at pH 9 and 25 and 18 °C, respectively(6). Biodegradation of nitroglycerin occurs rapidly using batch reactors and digestors(7,8), but its rate of biodegradation in soil is unknown(SRC). Nitroglycerin (10 ppm initial concn) was completely biodegraded in 13 days using river water and river water/sediment microcosms obtained from a river near a munitions facility(9), which may suggest biodegradation can occur in soils(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 180(SRC), determined from a log Kow of 1.62(2) and a regression-derived equation(3), indicates that nitroglycerin is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 4.3X10-8 atm-cu m/mole(SRC), derived from its vapor pressure, 2.0X10-4 mm Hg(4), and water solubility, 1,380 mg/l(5). According to a classification scheme(6), an estimated BCF of 4(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Hydrolysis is expected to be an important environmental fate process under alkaline conditions based on half-lives of 37 and 96 days at pH 9 and 25 and 18 °C, respectively(8). Nitroglycerin was completely biodegraded in 13 days using river water and river water/sediment microcosms obtained from a river near a munitions facility in Virginia(9). Nitroglycerin may undergo photolysis in water slowly in sunlit surface water(9). The half-life for nitroglycerin (5.8 ppm) in distilled water, filtered river water and filtered pond water exposed to sunlight were 116, 57 and 73 days, respectively(9).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), nitroglycerin, which has a vapor pressure of 2.0X10-4 mm Hg at 20 °C(2), is expected to exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase nitroglycerin is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 15 days(SRC), calculated from its rate constant of 1.1X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase nitroglycerin may be removed from the air by wet and dry deposition(SRC). Nitroglycerin absorbs light above 290 nm weakly and may be susceptible to direct photolysis(4), but the kinetics of this reaction in the atmosphere are not known(SRC).

Nitroglycerin and other aliphatic nitric acid esters undergo aerobic biodegradation readily via successive removal of nitrate groups to isomeric derivatives(1). Contrary to some earlier reports that it was recalcitrant to biodegradation, nitroglycerin proved to be readily biodegradable in batch and continuous tests(2). Results of the shake flask test that was run at 30 °C with an activated sludge inoculum showed a 53.6% loss of nitroglycerin in 5 days(2). In a continuous bench-scale activated sludge apparatus, a mean reduction of 92.2% was obtained(2). The apparatus was run at room temperature and the residence time was 84 hr. 1,3-Dinitroglycerol and 1,2-dinitroglycerol were identified at intermediate stages of the process, but they were also essentially absent from the effluent(2). The third experiment employing a chemostat, a continuous culture, aerobic system with no solids recycling, was designed to simulate a plant where propellant wastes would be treated. After a 8-15 hr detention period, no nitrate esters were detectable in the effluent(2). It was found that nitroglycerin is not suitable as a source of carbon and nitrogen so nutrients are essential(2). It was speculated that the earlier experiments which showed nitroglycerin to be recalcitrant were conducted using concns of nitroglycerin that were toxic to the microorganisms(2).

Complete mineralization of nitroglycerin (350 umol/l initial concn) was achieved within 4 days utilizing mixed cultures and an anaerobic digester, using digester sludge from a municipal wastewater treatment plant amended with 2,000 mg/l of glucose(1). Without glucose amendments, the complete mineralization of nitroglycerin took about 25 days in the digester(1). Nitroglycerin, present at 16 mg/l, was rapidly degraded in a sequencing batch reactor using mixed liquor from an industrial wastewater facility and a domestic wastewater treatment plant, with 1,2-dinitroglycerol and 1,3-dinitroglycerol as the initial products(2).

Nitroglycerin (10 ppm initial concn) was completely biodegraded in 13 days using river water and river water/sediment microcosms obtained from a river near a munitions facility in Virginia(1). Pure cultures isolated from river water and sediment near a munitions factory in Virginia degraded nitroglycerin(1). The first-order rate constant was 0.60 hours-1, which corresponds to a half-life of about 1 hour(1).

The rate constant for the vapor-phase reaction of nitroglycerin with photochemically-produced hydroxyl radicals has been estimated as 1.1X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 15 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 0.0215 and 0.00836 1/mol-sec was measured for nitroglycerin at 25 and 18 °C, respectively(2); this corresponds to half-lives of 37 and 96 days at pH 9(2). The hydrolysis half-life at neutral pH has been reported as 10 years(3). Nitroglycerin absorbs light weakly above 290 nm and undergoes photolysis slowly(4). The half-life for nitroglycerin (5.8 ppm) in distilled water, filtered river water and filtered pond water exposed to sunlight were 116, 57 and 73 days, respectively(4).

An estimated BCF of 4 was calculated for nitroglycerin(SRC), using a log Kow of 1.62(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of nitroglycerin is estimated as 180(SRC), using a log Kow of 1.62(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that nitroglycerin is expected to have moderate mobility in soil(SRC).

The Henry's Law constant for nitroglycerin is estimated as 4.3X10-8 atm-cu m/mole(SRC) derived from its vapor pressure, 2.0X10-4 mm Hg(1), and water solubility, 1,380 mg/l(2). This Henry's Law constant indicates that nitroglycerin is expected to be essentially nonvolatile from water surfaces(3). Nitroglycerin is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

SURFACE WATER: Based on pollutant loadings from the Badger Army Ammunition Plant and low stream flows, the maximum nitroglycerin levels that could be encountered in the Wisconsin River at Muscoda, WI and the Mississippi River below its confluence with the Wisconsin river would be 7 ppb and 1.7 ppb, respectively(1). Similarly, the highest concentration levels that would result from releases at the Radford Army Ammunition Plant in the New River (Glen Lyn and Gauley Bridge areas), and the Ohio River below its confluence with the Kanawana River is 8-12 ppb and 0.8 ppb, respectively(1). No actual monitoring data are available.

Wastewater from the Radford Army Munitions plant contained 1,566 mg/l of nitroglycerin(1). Nitroglycerin has been identified, not quantified, in the waste streams of munitions factories and pharmaceutical plants(2).

NITROGLYCERIN WORKERS SHOW MARKED TOLERANCE TO REPEATED EXPOSURE. THIS TOLERANCE DISAPPEARS RAPIDLY, & SHORT ABSENCE FROM EXPOSURE MAY LEAD TO SEVERE POISONING FROM AMT THAT WERE PREVIOUSLY SAFE.

NIOSH (NOES Survey 1981-1983) has statistically estimated that 38,473 workers (29,146 of these are female) are potentially exposed to nitroglycerin in the US(1). Occupational exposure to nitroglycerin may occur through dermal contact with this compound at workplaces where nitroglycerin is produced or used(SRC). The general population is not expected to be exposed to nitroglycerin except for persons that may need to use this compound to treat and prevent chest pain from angina pectoris, or other heart related conditions(SRC).

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

A good candidate for liquid injection incineration at a temperature range of 650 to 1,600 °C and a residence time of 0.1 to 2 seconds. A good candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A good candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.

/GUIDE 127: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /Nitroglycerin, solution in alcohol, with more than 1% but not more than 5% Nitroglycerin; Nitroglycerin, solution in alcohol, with not more than 1% Nitroglycerin/

/GUIDE 127: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE)/ Health: Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution. /Nitroglycerin, solution in alcohol, with more than 1% but not more than 5% Nitroglycerin; Nitroglycerin, solution in alcohol, with not more than 1% Nitroglycerin/

/GUIDE 127: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering. /Nitroglycerin, solution in alcohol, with more than 1% but not more than 5% Nitroglycerin; Nitroglycerin, solution in alcohol, with not more than 1% Nitroglycerin/

/GUIDE 127: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. /Nitroglycerin, solution in alcohol, with more than 1% but not more than 5% Nitroglycerin; Nitroglycerin, solution in alcohol, with not more than 1% Nitroglycerin/

For more DOT Emergency Guidelines (Complete) data for NITROGLYCERIN (8 total), please visit the HSDB record page.

1204 127(< or = 1% solution in alcohol)

3064 127(1-5% solution in alcohol)

UN 0143; Nitroglycerin desensitized with not less than 40% non-volatile water or soluble phlegmatizer, by mass

UN 1204; Nitroglycerin solution in alcohol with not more than 1% nitroglycerin

IMO 3.2; Nitroglycerin solution in alcohol with not more than 1% nitroglycerin; Nitroglycerin, solution in alcohol, with more than 1% but not more than 5% nitroglycerin

UN 0144; Nitroglycerin, solution in alcohol, with more than 1% but not more than 10% nitroglycerin

For more Shipping Name/ Number DOT/UN/NA/IMO (Complete) data for NITROGLYCERIN (6 total), please visit the HSDB record page.

49 015 16; Nitroglycerin, liquid, desensitized (high explosive liquid)

49 015 03; Blasting gelatin (high explosive)

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Liquid

Explosive 1.1D Poison

Explosive 1.1D

Do not transport with food and feedstuffs.

Symbol: E, T+, N; R: 3-26/27/28-33-51/53; S: (1/2)-33-35-36/37-45-61

UN Hazard Class: 1.1D (Desensitized); UN Subsidiary Risks: 6.1 (Desensitized)