Nitroguanidine

H201 (93.9%): (Deleted) Explosive; mass explosion hazard [Danger Explosives]

P210, P230, P240, P250, P280, P370+P380, P372, P373, P401, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 163 reports by companies from 5 notifications to the ECHA C&L Inventory.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H201: (Deleted) Explosive; mass explosion hazard [Danger Explosives]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P210, P230, P240, P250, P264+P265, P280, P305+P351+P338, P337+P317, P370+P380, P372, P373, P401, and P501 (click each P-code to see the statement)

Excerpt from ERG Guide 113 [Flammable Materials (Wet / Desensitized Explosive)]:

Refer to the "General First Aid" section. (ERG, 2024)

Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

Excerpt from ERG Guide 113 [Flammable Materials (Wet / Desensitized Explosive)]:

CARGO FIRE: DO NOT fight fire when fire reaches cargo! Cargo may EXPLODE! Stop all traffic and clear the area for at least 1600 meters (1 mile) in all directions and let burn. Do not move cargo or vehicle if cargo has been exposed to heat.

TIRE OR VEHICLE FIRE: Use plenty of water - FLOOD it! If water is not available, use CO2, dry chemical or dirt. If possible, and WITHOUT RISK, use unmanned master stream devices or monitor nozzles from maximum distance to prevent fire from spreading to cargo area. Pay special attention to tire fires as re-ignition may occur. Stand by, at a safe distance, with extinguisher ready for possible re-ignition. (ERG, 2024)

Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:

If material on fire or involved in fire: Dangerously explosive. Do not fight fires in a cargo of explosives. Evacuate area and let burn. /Nitroguanidine, dry/

Evacuation: If the material is on fire or involved in fire consider evacuation of one (1) mile radius. /Nitroguanidine, dry/

If material on fire or involved in fire: Dangerously explosive. Flood with water. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. /Nitroguanidine, wetted/

Evacuation: If fire becomes uncontrollable - consider evacuation of one (1) mile radius. /Nitroguanidine, wetted/

Wear positive pressure self-contained breathing apparatus when fighting fires involving this material.

The primary hazard is from effects of a blast as they are not designed to produce significant fragmentation or throw projectiles. /Nitroguanidine, dry/

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

Small Spill

· Flush area with large amounts of water.

Large Spill

· Wet down with water and dike for later disposal.

· KEEP "WETTED" PRODUCT WET BY SLOWLY ADDING FLOODING QUANTITIES OF WATER.

Excerpt from ERG Guide 113 [Flammable Materials (Wet / Desensitized Explosive)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area immediately for at least 100 meters (330 feet) in all directions.

LARGE SPILL: Consider initial evacuation for 500 meters (1/3 mile) in all directions.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area immediately for at least 500 meters (1/3 mile) in all directions.

LARGE SPILL: Consider initial evacuation for 800 meters (1/2 mile) in all directions.

FIRE: If rail car or trailer is involved in a fire, ISOLATE for 1600 meters (1 mile) in all directions; also, initiate evacuation including emergency responders for 1600 meters (1 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area immediately for at least 100 meters (330 feet) in all directions.

· Consider initial evacuation for 500 meters (1/3 mile) in all directions.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Use personal protective equipment. Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations. Keep in suitable, closed containers for disposal.

PROCESS PARAMETERS HAVE BEEN DEVELOPED WHICH PERMIT PURIFICATION OF WASTEWATERS CONTAINING DISSOLVED EXPLOSIVES BY TREATING THE WASTEWATER WITH SURFACTANT OF THE QUATERNARY AMINE TYPE AT PH OF APPROX 11.5. NITROGUANIDINE IS UNAFFECTED BY THE SURFACTANT TREATMENT, BUT CAN BE DESTROYED BY CONTACT WITH ION EXCHANGE RESIN. A METHOD OF ANALYSIS IS DESCRIBED.

STUDIES WERE CONDUCTED TO DETERMINE DECOMP RATE OF NITROGUANIDINE BY USE OF SODIUM SULFIDE & SODIUM HYDROXIDE. SODIUM HYDROXIDE WAS USED TO ADJUST PH ABOVE 11.0 & TO INCR SULFIDE REACTION RATE. THESE STUDIES SHOWED THAT NITROGUANIDINE CANNOT BE EFFECTIVELY DECOMPOSED WITH SODIUM HYDROXIDE ALONE; HOWEVER, IT WAS EFFECTIVE IN COMBINATION WITH SODIUM SULFIDE & THE NITROGUANIDINE DECOMPOSITION RATE WAS A FUNCTION OF THE SULFIDE CONCN ADDED. ALTHOUGH SUCCESSFUL, USE OF RELATIVELY LARGE AMT OF SULFIDE IS UNDESIRABLE.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Observe all federal, state, and local environmental regulations. Contact a licensed professional waste disposal service to dispose of this material.

NITROGUANIDINE REMOVED FROM WASTEWATERS & SOLID WASTE PROPELLANTS & EXPLOSIVES FROM MFR OF MILITARY WEAPONS WAS DISPOSED OF IN SEVERAL DIFFERENT WAYS.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep spilled material wet. Wet spilled material before picking it up. Do not attempt to sweep up dry material. /Nitroguanidine, dry/

Personnel protection: Avoid breathing dusts, and fumes from burning material ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. /Nitroguanidine, dry/

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Keep spilled material wet. Do not attempt to sweep up dry material. /Nitroguanidine, wetted/

Personnel protection: Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. /Nitroguanidine, wetted/

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Excerpt from ERG Guide 113 [Flammable Materials (Wet / Desensitized Explosive)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material.

SMALL SPILL: Flush area with large amounts of water.

LARGE SPILL: Wet down with water and dike for later disposal. KEEP "WETTED" PRODUCT WET BY SLOWLY ADDING FLOODING QUANTITIES OF WATER. (ERG, 2024)

Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. DO NOT OPERATE RADIO TRANSMITTERS WITHIN 100 METERS (330 FEET) OF ELECTRIC DETONATORS. DO NOT CLEAN-UP OR DISPOSE OF, EXCEPT UNDER SUPERVISION OF A SPECIALIST. (ERG, 2024)

Keep container tightly closed in a dry and well-ventilated place. Store in cool place. Keep in a dry place. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

CARGO Fire

· DO NOT fight fire when fire reaches cargo! Cargo may EXPLODE!

· Stop all traffic and clear the area for at least 1600 meters (1 mile) in all directions and let burn.

· Do not move cargo or vehicle if cargo has been exposed to heat.

TIRE or VEHICLE Fire

· Use plenty of water - FLOOD it! If water is not available, use CO2, dry chemical or dirt.

· If possible, and WITHOUT RISK, use unmanned master stream devices or monitor nozzles from maximum distance to prevent fire from spreading to cargo area.

· Pay special attention to tire fires as re-ignition may occur. Stand by, at a safe distance, with extinguisher ready for possible re-ignition.

Excerpt from ERG Guide 113 [Flammable Materials (Wet / Desensitized Explosive)]:

Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)

Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:

Choose body protection according to the amount and concentration of the dangerous substance at the work place. Safety glasses. Handle with gloves. Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Where risk assessment shows air-purifying respirators are appropriate use a dust mask type N95 (US) or type P1 (EN 143) respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Nitroguanidine is shipped as a slurry or wet mass of pale yellow crystals. If it should dry out it can explode due to shock, heat, flame, or friction. The primary hazard is blast where the entire load can explode instantaneously and not from flying projectiles and fragments. Under prolonged exposure to fire or heat they can explode.

Nitroguanidine, [dry] appears as a yellow solid in the form of crystalline needles. Decomposes at 480 °F and emits toxic oxides of nitrogen. May explode under exposure to intense heat or fire. Primary hazard is blast of explosion, not flying projectiles or fragments.

Exists as two isomers, needles and plates; [Hawley] Yellow solid; Shipped as a slurry or wet mass; [CAMEO] White powder; [Aldrich MSDS]

Needles, prisms from water /alpha 1-Nitroguanidine/

Long, thin, flat, flexible lustrous needles (alpha); small, thin elongated plates (beta)

239 °C (decomposes)

Slightly soluble in ethanol; insoluble in ethyl ether; very soluble in alkali

Slightly soluble in methanol (less than 0.5%), alcohol; practically insoluble in ether; soluble in concentrated acids from which it is precipitated by water; soluble in cold solution of alkalies (not of carbonates) with slow decomposition /alpha/

Beta form appears to be more soluble in water than alpha form

In water, 4.40X10+3 mg/L at 25 °C

1.43X10-11 mm Hg at 25 °C

log Kow = -0.89

Henry's Law constant = 4.45X10-16 atm cu m/mol at 25 °C

Alpha is the usual stable form...

Decomposes immediately on melting to form ammonia, water vapor, and solid products. The gases from the decomposition of nitroguanidine are far less erplosive than gases from other similar explosives.

When heated to decomposition it emits highly toxic fumes of /nitroxides/.

It decomposes at 480 °F and emits toxic oxides of nitrogen. /Nitroguanidine, dry/

Decomposition at 225-250 °C (depending on speed of heating) giving off ammonia fumes /alpha/

Heat of formation = -92.4 kJ/mol

When heated to decomposition it emits toxic fumes of NOx.

Nitrogen Compounds -> Other Nitrogen Compounds

Flammable agents - 4th degree

Reactive agents - 3rd degree

Pesticide -> EPA IRIS

No rapid reaction with air. No rapid reaction with water.

Amines, Phosphines, and Pyridines

Azo, Diazo, Azido, Hydrazine, and Azide Compounds

Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic

Water and Aqueous Solutions

Strong Oxidizing Agent

Explosive

Nitroalkanes, such as NITROGUANIDINE, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. Nitroalkanes are milder oxidizing agents, but still react violently with reducing agents at higher temperature and pressures. Nitroalkanes react with inorganic bases to form explosive salts. The presence of metal oxides increases the thermal sensitivity of nitroalkanes. Nitroalkanes with more than one nitro group are generally explosive. Nitroalkanes are insoluble in water. Flammable/combustible material. May be ignited by heat, sparks or flames. DRIED OUT material may explode if exposed to heat, flame, friction or shock; Treat as an explosive. Mercury and silver complex salts of nitroguanidine are very impact sensitive.

Can react vigorously with oxidizing materials and the derivatives can be explosive.

Materials to avoid: strong oxidizing agents, strong bases

Nitroguanidine

Developmental

1 x 10 ^-1 mg/kg-day

CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: Pertinent data regarding carcinogenicity have not been located in the available literature. HUMAN CARCINOGENICITY DATA: None. ANIMAL CARCINOGENICITY DATA: None. /Based on former classification system/

1 x 10^-1 mg/kg-day

PDF Document

Inadequate information to assess carcinogenic potential

IRIS Current

PPRTV Current

LD50 Rat oral 10,200 mg/kg

LD50 Mouse ip 48 mg/kg

LD50 Mouse oral 3850 mg/kg

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Dinitrophenol and Related Compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination. flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . Rapid body cooling may be necessary in case of hyperthermia. Salicylates are contraindicated. /Dinitrophenol and Related Compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of 0.9% saline (NS) or lactated Ringer's (LR) /SRP: "To keep open", minimal flow rate/. For dehydration and hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Dinitrophenol and Related Compounds/

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ The 90-day subchronic oral toxicity of nitroguanidine was evaluated in male and female Sprague-Dawley rats. Nitroguanidine was administered in the diet at dose levels of 0, 100, 316, and 1000 mg/kg/day for 90 days. There were 15 animals/sex/dose. The addition of nitroguanidine to the diet consistently reduced food consumption and caused significant (p<=0.05) increases in water consumption. Significantly (p<=0.05) reduced weight gains were observed in the female high-dose group for 5 of the 13 weeks of the study period. No other clinical signs attributable to the test compound were observed during the study. Blood samples taken at necropsy for hematological and serum chemistry analyses exhibited no significant abnormalities that could be attributed to nitroguanidine dosing. Microscopic examination of tissues from the control and 1000 mg/kg/day dose group animals revealed no lesions attributable to the administration of nitroguanidine. The female 1000 mg/kg/day group had a significantly (p<=0.05) increased brain-to- body weight ratio compared with that of the controls at terminal sacrifice. Based on a significant decrease in the rate of growth of female rats at 1000 mg/kg/day on weeks 5, 6, 8, 9 and 12, the NOAEL is 316 mg/kg/day.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ The 90-day subchronic oral toxicity of nitroguanidine was evaluated in male and female ICR mice. There were 15 animals/sex/ dose. Nitroguanidine was administered in the diet at dose levels of 0, 100, 316, and 1000 mg/kg/day for 90 days. The addition of nitroguanidine to the diet had no effect on food consumption or weight gains, but there was a significant dose- response increase in water consumption. Several serum chemistry parameters did exhibit statistically significant (p<=0.05) alterations from the control values, but these changes were isolated occurrences with no consistent dose- related trends being noted. With the exception of the brain-to-body weight ratio in the high-dose males at interim sacrifice, organ weights and their respective ratios were not significantly affected by dosing. Microscopic examination of tissues from the control and 1000 mg/kg/day dose group animals revealed no lesions attributable to the administration of nitroguanidine. The findings of increased water consumption suggest that nitroguanidine, which is excreted unchanged in the mouse's urine, may be acting as an osmotic diuretic. The finding of increased brain-to-body weight ratios in male mice at 1000 mg/kg/day at interim sacrifice is supportive of a 316 mg/kg/day NOAEL.

/LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ The potential of nitroguanidine to produce developmental toxicity was evaluated in pregnant Sprague-Dawley rat. Nitroguanidine, suspended in 1% carboxymethylcellulose, was administered at doses of 0, 100, 316, and 1000 mg/kg/day by oral gavage on days 6 through 15 of gestation. Fetuses were delivered by cesarean section on day 20, weighed, examined externally, and processed in either Bouin's solution for visceral examination or alizarin red stain for skeletal examination. Following a generalized failure to thrive, two animals in the 1000 mg/kg/day group were significantly smaller than controls with an increased incidence of retarded ossification of the sternebrae, caudal vertebrae, and pubis. There was no evidence of developmental toxicity of nitroguanidine in rats under conditions of this study. Nitroguanidine produced maternal and fetal toxicity at the 1000 mg/kg/day dose level. The NOEL was 316 mg/kg/day.

/LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ The potential of nitroguanidine to produce developmental toxicity was evaluated in pregnant New Zealand White rabbits. Nitroguanidine, suspended in 1% carboxymethylcellulose, was administered at doses of 0, 100, 316, and 1000 mg/kg/day by oral gavage on days 6 through 18 of gestation. Fetuses were delivered by Cesarean section on day 29, weighed and examined externally. The soft tissues were examined while the body was being eviscerated for subsequent processing in alizarin red stain for skeletal examination. Ten dams in the 1000-mg/kg/day group died or were terminated in a moribund condition following a generalized failure to thrive. The dams administered nitroguanidine at 1000 mg/kg/day exhibited weight loss and decreased food consumption. There was an increased incidence of resorptions in all dose groups. Fetuses in the 1000 mg/kg/day group were lighter in weight and had an increased incidence of retarded ossification of the sternebrae, olecranon, patellae, and phalanges. There were no dose-related malformations. On the basis of these findings, we concluded that nitroguanidine had no teratogenic potential. There is weak to equivocal evidence for potential developmental toxicity based on percent resorptions in all dose groups.

For more Non-Human Toxicity Excerpts (Complete) data for 1-Nitroguanidine (11 total), please visit the HSDB record page.

6.30e+03

8.20e+04

2.00e+03

1.00e+03

4.80e-01

1.00e-01

Volatile

1.90e+04

2.50e+05

6.00e+03

1-Nitroguanidine's production and use as an explosive, propellant and chemical intermediate may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 1.43X10-11 mm Hg at 25 °C indicates 1-nitroguanidine will exist solely in the particulate phase in the atmosphere. Particulate-phase 1-nitroguanidine will be removed from the atmosphere by wet or dry deposition. 1-Nitroguanidine absorbs light at wavelengths of approximately 260 nm and greater, and therefore may be susceptible to direct photolysis by sunlight. If released to soil, 1-nitroguanidine is expected to have very high mobility based upon an estimated Koc of 21. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 4.45X10-16 atm-cu m/mole. Utilizing the Japanese MITI test, less than 14% of the theoretical BOD was reached in 4 weeks, indicating that biodegradation is not an important environmental fate process. If released into water, 1-nitroguanidine is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. The aquatic fate of 1-nitroguanidine is dominated by photolysis, with half-lives at 40 deg N latitude ranging from 0.6 days in summer to 2.3 days in winter. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. An estimated BCF of 3.2 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to 1-nitroguanidine may occur through dermal contact with this compound at workplaces where 1-nitroguanidine is produced or used. (SRC)

1-Nitroguanidine's production and use as an explosive, propellant and chemical intermediate(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 12(SRC), determined from a log Kow of -0.89(2) and a regression-derived equation(3), indicates that 1-nitroguanidine is expected to have very high mobility in soil(SRC). Volatilization of 1-nitroguanidine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.45X10-16 atm-cu m/mole derived from its vapor pressure, 1.43X10-11 mm Hg(4), and water solubility, 4.4X10+3 mg/L(5). 1-Nitroguanidine is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Utilizing the Japanese MITI test, less than 14% of the theoretical BOD was reached in 4 weeks(5), indicating that biodegradation is not an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 21(SRC), determined from a log Kow of -0.89(2) and a regression-derived equation(3), indicates that 1-nitroguanidine is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon a Henry's Law constant of 4.45X10-16 atm-cu m/mole(SRC), derived from its vapor pressure, 1.43X10-11 mm Hg(5), and water solubility, 4.40X10+3 mg/L(6). According to a classification scheme(7), an estimated BCF of 3.2(SRC), from its log Kow(2) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). The aquatic fate of 1-nitroguanidine is dominated by photolysis, with half-lives at 40 deg N latitude ranging from 0.6 days in summer to 2.3 days in winter(9). Utilizing the Japanese MITI test, less than 14% of the theoretical BOD was reached in 4 weeks(10), indicating that biodegradation is not an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-nitroguanidine, which has a vapor pressure of 1.43X10-11 mm Hg at 25 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase 1-nitroguanidine will be removed from the atmosphere by wet or dry deposition. 1-Nitroguanidine absorbs light at wavelengths of approximately 260 nm and greater(3) and therefore may be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: 1-Nitroguanidine is not susceptible to aerobic biodegradation in activated sludge, and was stable under sterile reducing conditions(1,2). No decomposition occurred under aerobic conditions in either batch or continuous cultures(2). After acclimation, nitroguanidine co-metabolizes to form nitrosoguanidine(2). 1-Nitroguanidine, present at 100 mg/L, reached less than 14% of its theoretical BOD after 4 weeks in an activated sludge inoculum at 30 mg/L in the Japanese MITI test(3).

ANAEROBIC: 1-Nitroguanidine biodegrades anaerobically after acclimation of an anaerobic sewage sludge. No decomposition occurred in cultures without a nutrient broth(1). In an anaerobic continous culture test, no nitroguanidine was present in the culture vessel after 7 days. After acclimation 1-nitroguanidine is cometabolically reduced to form nitrosoguanidine(1).

1-Nitroguanidine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(1). 1-Nitroguanidine absorbs light at wavelengths of approximately 260 nm and greater(2) and therefore may be susceptible to direct photolysis by sunlight(SRC). 1-Nitroguanidine in aqueous solutions was photolyzed by UV light and sunlight to form guanidine nitrite, cyanoguanidine, ammonia, and nitrate(3); 1-nitroguanidine in natural surface water was photolyzed to form nitrite and hydroxyguanidine(4). In surface water, the photolysis half-lives of nitroguanidine at 40 deg N latitude ranged from 0.6 days in summer to 2.3 days in winter(4).

An estimated BCF of 3.2 was calculated in fish for 1-nitroguanidine(SRC), using a log Kow of -0.89(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of 1-nitroguanidine is estimated as 21(SRC), using a log Kow of -0.89(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 1-nitroguanidine is expected to have very high mobility in soil. A sorption partition coefficient of <0.1 was calculated using sediments characterized by high surface areas(4).

6.30e+03

8.20e+04

2.00e+03

1.00e+03

4.80e-01

1.00e-01

Volatile

1.90e+04

2.50e+05

6.00e+03

1-Nitroguanidine's production and use as an explosive, propellant and chemical intermediate may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 1.43X10-11 mm Hg at 25 °C indicates 1-nitroguanidine will exist solely in the particulate phase in the atmosphere. Particulate-phase 1-nitroguanidine will be removed from the atmosphere by wet or dry deposition. 1-Nitroguanidine absorbs light at wavelengths of approximately 260 nm and greater, and therefore may be susceptible to direct photolysis by sunlight. If released to soil, 1-nitroguanidine is expected to have very high mobility based upon an estimated Koc of 21. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 4.45X10-16 atm-cu m/mole. Utilizing the Japanese MITI test, less than 14% of the theoretical BOD was reached in 4 weeks, indicating that biodegradation is not an important environmental fate process. If released into water, 1-nitroguanidine is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. The aquatic fate of 1-nitroguanidine is dominated by photolysis, with half-lives at 40 deg N latitude ranging from 0.6 days in summer to 2.3 days in winter. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. An estimated BCF of 3.2 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to 1-nitroguanidine may occur through dermal contact with this compound at workplaces where 1-nitroguanidine is produced or used. (SRC)

1-Nitroguanidine's production and use as an explosive, propellant and chemical intermediate(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 12(SRC), determined from a log Kow of -0.89(2) and a regression-derived equation(3), indicates that 1-nitroguanidine is expected to have very high mobility in soil(SRC). Volatilization of 1-nitroguanidine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.45X10-16 atm-cu m/mole derived from its vapor pressure, 1.43X10-11 mm Hg(4), and water solubility, 4.4X10+3 mg/L(5). 1-Nitroguanidine is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Utilizing the Japanese MITI test, less than 14% of the theoretical BOD was reached in 4 weeks(5), indicating that biodegradation is not an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 21(SRC), determined from a log Kow of -0.89(2) and a regression-derived equation(3), indicates that 1-nitroguanidine is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon a Henry's Law constant of 4.45X10-16 atm-cu m/mole(SRC), derived from its vapor pressure, 1.43X10-11 mm Hg(5), and water solubility, 4.40X10+3 mg/L(6). According to a classification scheme(7), an estimated BCF of 3.2(SRC), from its log Kow(2) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). The aquatic fate of 1-nitroguanidine is dominated by photolysis, with half-lives at 40 deg N latitude ranging from 0.6 days in summer to 2.3 days in winter(9). Utilizing the Japanese MITI test, less than 14% of the theoretical BOD was reached in 4 weeks(10), indicating that biodegradation is not an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-nitroguanidine, which has a vapor pressure of 1.43X10-11 mm Hg at 25 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase 1-nitroguanidine will be removed from the atmosphere by wet or dry deposition. 1-Nitroguanidine absorbs light at wavelengths of approximately 260 nm and greater(3) and therefore may be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: 1-Nitroguanidine is not susceptible to aerobic biodegradation in activated sludge, and was stable under sterile reducing conditions(1,2). No decomposition occurred under aerobic conditions in either batch or continuous cultures(2). After acclimation, nitroguanidine co-metabolizes to form nitrosoguanidine(2). 1-Nitroguanidine, present at 100 mg/L, reached less than 14% of its theoretical BOD after 4 weeks in an activated sludge inoculum at 30 mg/L in the Japanese MITI test(3).

ANAEROBIC: 1-Nitroguanidine biodegrades anaerobically after acclimation of an anaerobic sewage sludge. No decomposition occurred in cultures without a nutrient broth(1). In an anaerobic continous culture test, no nitroguanidine was present in the culture vessel after 7 days. After acclimation 1-nitroguanidine is cometabolically reduced to form nitrosoguanidine(1).

1-Nitroguanidine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(1). 1-Nitroguanidine absorbs light at wavelengths of approximately 260 nm and greater(2) and therefore may be susceptible to direct photolysis by sunlight(SRC). 1-Nitroguanidine in aqueous solutions was photolyzed by UV light and sunlight to form guanidine nitrite, cyanoguanidine, ammonia, and nitrate(3); 1-nitroguanidine in natural surface water was photolyzed to form nitrite and hydroxyguanidine(4). In surface water, the photolysis half-lives of nitroguanidine at 40 deg N latitude ranged from 0.6 days in summer to 2.3 days in winter(4).

An estimated BCF of 3.2 was calculated in fish for 1-nitroguanidine(SRC), using a log Kow of -0.89(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of 1-nitroguanidine is estimated as 21(SRC), using a log Kow of -0.89(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 1-nitroguanidine is expected to have very high mobility in soil. A sorption partition coefficient of <0.1 was calculated using sediments characterized by high surface areas(4).

The Henry's Law constant for 1-nitroguanidine is estimated as 4.45X10-16 atm-cu m/mole(SRC) derived from its vapor pressure, 1.43X10-11 mm Hg(1), and water solubility, 4.40X10+3 mg/L(2). This Henry's Law constant indicates that 1-nitroguanidine is expected to be essentially nonvolatile from water surfaces(3). 1-Nitroguanidine is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

Occupational exposure to 1-nitroguanimine may occur through dermal contact with this compound at workplaces where 1-nitroguanidine is produced or used. (SRC)

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Observe all federal, state, and local environmental regulations. Contact a licensed professional waste disposal service to dispose of this material.

NITROGUANIDINE REMOVED FROM WASTEWATERS & SOLID WASTE PROPELLANTS & EXPLOSIVES FROM MFR OF MILITARY WEAPONS WAS DISPOSED OF IN SEVERAL DIFFERENT WAYS.

/GUIDE 113: FLAMMABLE SOLIDS - TOXIC (WET/DESENSITIZED EXPLOSIVE)/ Fire or Explosion: Flammable/combustible material. May be ignited by heat, sparks or flames. DRIED OUT material may explode if exposed to heat, flame, friction or shock; treat as an explosive (GUIDE 112). Keep material wet with water or treat as an explosive (Guide 112). Runoff to sewer may create fire or explosion hazard. /Nitroguanidine (Picrite), wetted with not less than 20% water; Nitroguanidine, wetted with not less than 20% water; Picrite, wetted/

/GUIDE 113: FLAMMABLE SOLIDS - TOXIC (WET/DESENSITIZED EXPLOSIVE)/ Health: Some are toxic and may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may cause pollution. /Nitroguanidine (Picrite), wetted with not less than 20% water; Nitroguanidine, wetted with not less than 20% water; Picrite, wetted/

/GUIDE 113: FLAMMABLE SOLIDS - TOXIC (WET/DESENSITIZED EXPLOSIVE)/ Public Safety: CALL Emergency Response Telephone Number. ... Isolate spill or leak area immediately for at least 100 meters (330 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Ventilate closed spaces before entering. /Nitroguanidine (Picrite), wetted with not less than 20% water; Nitroguanidine, wetted with not less than 20% water; Picrite, wetted/

/GUIDE 113: FLAMMABLE SOLIDS - TOXIC (WET/DESENSITIZED EXPLOSIVE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. /Nitroguanidine (Picrite), wetted with not less than 20% water; Nitroguanidine, wetted with not less than 20% water; Picrite, wetted/

For more DOT Emergency Guidelines (Complete) data for 1-Nitroguanidine (8 total), please visit the HSDB record page.

UN 1336; Nitroguanidine, wetted or picrite, wetted with not less than 20% water, by mass

UN 0282; Nitroguanidine or picrite, dry or wetted with less than 20% water, by mass

IMO 1.1; Nitroguanidine, dry or wetted with less than 20% water, by mass

IMO 4.1; Nitroguanidine, wetted with not less than 20% water, by mass

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Solid

Explosive 1.1D