Carbon Tetrachloride

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H331: Toxic if inhaled [Danger Acute toxicity, inhalation]

H351: Suspected of causing cancer [Warning Carcinogenicity]

H372 **: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

H420: Harms public health and the environment by destroying ozone in the upper atmosphere [Warning Hazardous to the ozone layer]

P203, P260, P261, P262, P264, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P316, P318, P319, P321, P330, P361+P364, P403+P233, P405, P501, and P502 (click each P-code to see the statement)

H301+H311+H331 (34.4%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

H311 (100%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H317 (51.4%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H331 (100%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]

H372 (98.3%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H412 (95.3%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

H420 (82.7%): Harms public health and the environment by destroying ozone in the upper atmosphere [Warning Hazardous to the ozone layer]

P203, P260, P261, P262, P264, P270, P271, P272, P273, P280, P301+P316, P302+P352, P304+P340, P316, P318, P319, P321, P330, P333+P317, P361+P364, P362+P364, P403+P233, P405, P501, and P502 (click each P-code to see the statement)

Aggregated GHS information provided per 601 reports by companies from 28 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H350: May cause cancer [Danger Carcinogenicity]

H360: May damage fertility or the unborn child [Danger Reproductive toxicity]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P203, P260, P261, P264, P270, P271, P272, P273, P280, P302+P352, P304+P340, P308+P316, P317, P318, P319, P321, P333+P317, P362+P364, P391, P405, P501, and P502 (click each P-code to see the statement)

P203, P280, P318, P405, and P501 (click each P-code to see the statement)

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P203, P260, P261, P264, P264+P265, P270, P271, P280, P302+P352, P304+P340, P305+P351+P338, P308+P316, P317, P318, P319, P321, P332+P317, P337+P317, P362+P364, P405, and P501 (click each P-code to see the statement)

H303: May be harmful if swallowed [Warning Acute toxicity, oral]

P203, P260, P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P308+P316, P318, P319, P321, P332+P317, P337+P317, P362+P364, P405, and P501 (click each P-code to see the statement)

H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]

Remove immediately from exposure. Fresh air, rest. Artificial respiration may be needed. Refer immediately for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer immediately for medical attention.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Soap wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

SMALL FIRE: Dry chemical, CO2 or water spray.

LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Avoid aiming straight or solid streams directly onto the product.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep drums, etc., cool by spraying with water.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Use water spray to keep fire-exposed containers cool. Extinguish fire using agent suitable for surrounding fire.

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire (Material itself does not burn or burns with difficulty.)

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· Cover with plastic sheet to prevent spreading.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· DO NOT GET WATER INSIDE CONTAINERS.

· For solids, prevent dust cloud and avoid inhalation of dust.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

1. Ventilate area of spill or leak. 2. Collect for reclamation or absorb in vermiculite, dry sand, earth, or a similar material.

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

Environmental considerations - Air spill: Apply water spray or mist to knock down vapors. Combustion products included corrosive or toxic vapors.

For more Cleanup Methods (Complete) data for Carbon tetrachloride (7 total), please visit the HSDB record page.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U211 and D019, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber; Contaminated packaging: Dispose of as unused product.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Carbon tetrachloride is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration. Preferably after mixing with another combustible fuel; care must be exercised to assure complete combustion to prevent the formation of phosgene; an acid scrubber is necessary to remove the halo acids produced.

For more Disposal Methods (Complete) data for Carbon tetrachloride (12 total), please visit the HSDB record page.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist.

Appropriate engineering controls: Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

For more Preventive Measures (Complete) data for Carbon tetrachloride (27 total), please visit the HSDB record page.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. For solids, prevent dust cloud and avoid inhalation of dust. (ERG, 2024)

Well closed. Cool. Separated from food and feedstuffs and metals. See Chemical Dangers. Ventilation along the floor. Store in an area without drain or sewer access.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Store in a cool, dry, well-ventilated location. Separate from alkali metals.

Store in a secure poison location. Prior to working with carbon tetrachloride you should be trained on its proper handling and storage. Store in tightly closed containers in a cool, well-ventilated area. Carbon tetrachloride must be stored to avoid contact with chemically active metals, such as sodium, potassium, and magnesium, since violent reactions occur. ... A regulated, marked area should be established where this chemical is handled, used, or stored in compliance with OSHA Standard 1910.1045.

PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

0.5 [ppm]

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: ppm)

AEGL 2: Irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape (Unit: ppm)

AEGL 3: Life-threatening health effects or death (Unit: ppm)

AEGLs Status: Final

1.2 [ppm]

13 [ppm]

340 [ppm]

2 ppm (12.6 mg/m³) [60 minutes]

Ca ST 2 ppm (12.6 mg/m3) [60-minute] See Appendix A

10.0 [ppm], Ceiling(OSHA) = 25 ppm (200 ppm for 5-min peak in any 4 hrs.)

25 ppm [5 min in any 4 hrs]; 200 ppm (Peak)

TWA 10 ppm C 25 ppm 200 ppm (5-minute maximum peak in any 4 hours) See Appendix G

200 ppm ; A potential occupational carcinogen. (NIOSH, 2024)

200.0 [ppm]

Excerpts from Documentation for IDLHs: Other human data: A severe case of poisoning was observed after a 3­hour exposure to concentrations ranging from 75 to 600 ppm and averaging about 210 ppm [Barnes and Jones 1967]. It has been reported that exposures to 1,000 to 2,000 ppm for 0.5 to 1 hour have caused human fatalities from acute kidney damage [AIHA 1961]. It has also been reported that a 30­minute exposure to about 300 ppm causes symptoms of intoxication [Kirk-Othmer 1964].

NIOSH considers Carbon tetrachloride to be a potential occupational carcinogen.

Ca [200 ppm]

See: 56235

5.0 [ppm]

10.0 [ppm]

8 hr Time Weighted Avg (TWA): 5 ppm, skin; 15 min Short Term Exposure Limit (STEL): 10 ppm, skin.

A2; Suspected human carcinogen.

5 ppm as TWA; 10 ppm as STEL; (skin); A2 (suspected human carcinogen).

6.4 mg/m

3.2 mg/m

Intermediate Inhalation: 0.03 ppm (L134)

Chronic Inhalation: 0.03 ppm (L134)

Acute Oral: 0.02 mg/kg/day (L134)

Intermediate Oral: 0.007 mg/kg/day (L134)

Small Fire

· Dry chemical, CO2 or water spray.

Large Fire

· Water spray, fog or regular foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

· Avoid aiming straight or solid streams directly onto the product.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Do not get water inside containers.

Carbon tetrachloride appears as a clear colorless liquid with a characteristic odor. Denser than water (13.2 lb / gal) and insoluble in water. Noncombustible. May cause illness by inhalation, skin absorption and/or ingestion. Used as a solvent, in the manufacture of other chemicals, as an agricultural fumigant, and for many other uses.

Colorless liquid with a characteristic ether-like odor; [NIOSH]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Clear liquid with a characteristic odor.

Colorless liquid with a characteristic ether-like odor.

Colorless, clear, heavy liquid

Colorless liquid

Characteristic, ether-like odor

Sweetish, distinctive odor

Characteristic non-irritant odor

170.1 °F at 760 mmHg (NTP, 1992)

76.80 °C. @ 760.00 mm Hg

170.1 °F

76.8 °C @760 [mm Hg]

-9 °F (NTP, 1992)

-22.2 °C

-22.62 °C

less than 1 mg/mL at 70 °F (NTP, 1992)

In water, 793 mg/L at 25 °C

In water, 1160 mg/L at 25 °C, 800 mg/L at 20 °C

Miscible with alcohol, benzene, chloroform, ether, carbon disulfide, petroleum ether, oils

Soluble in ethanol, acetone; miscible with ethyl ether, benzene, chloroform

Soluble in naphtha

0.793 mg/mL at 25 °C

Solubility in water, mg/l at 20 °C: 800 (very slightly soluble)

1.59 at 68 °F (USCG, 1999) - Denser than water; will sink

1.5940 g/cu cm at 20 °C

Saturated liquid density: 99.080 lb/cu ft; liquid heat capacity: 0.219 Btu/lb °F; liquid viscosity: 0.922 centipoise; ideal gas heat capacity: 0.130 Btu/lb °F (all at 75 °F)

Liquid thermal conductivity: 0.690 Btu-inch/hr-sq ft °F; saturated vapor pressure: 1.874 lb/sq in; saturated vapor density: 0.05069 lb/cu ft (all at 70 °F)

Relative density (water = 1): 1.59 (20 °C)

1.5940 @ 20°C

5.3 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

5.3 (Air = 1)

Relative vapor density (air = 1): 5.3

91 mmHg at 68 °F ; 113 mmHg at 77 °F (NTP, 1992)

115.0 [mmHg]

115 mm Hg at 25 °C

Vapor pressure, kPa at 20 °C: 12.2

75 [mm Hg] @15.8 °C

log Kow = 2.83

Insoluble in water.

Halogenated Organic Compounds

CSL00060

ALUMINUM + CARBON TETRACHLORIDE + MAGNESIUM + CHLOROFORM

Potentially explosive in the presence of Mg or Al powder

Explosive

User-Reported

CSL00123

SODIUM + CARBON TETRACHLORIDE

After standing for a short time, the reaction products are shock-sensitive and highly explosive.

ACS Safety Letters

CARBON TETRACHLORIDE is a commonly used liquid in fire extinguishers to combat small fires. It has no flash point, it is not flammable. However, when heated to decomposition, it will emit fumes of extremely toxic phosgene and of hydrogen chloride. Forms explosive mixtures with chlorine trifluoride, calcium hypochlorite, decaborane, dinitrogen tetraoxide, fluorine. Forms impact-sensitive explosive mixtures with particles of many metals: lithium, sodium, potassium, beryllium, zinc, aluminum, barium. Vigorous exothermic reaction with allyl alcohol, boron trifluoride, diborane, disilane, aluminum chloride, dibenzoyl peroxide, potassium tert-butoxide, liquid oxygen, zirconium. [Bretherick, 5th ed., 1995, p. 666]. Potentially dangerous reaction with dimethylformamide or dimethylacetamide in presence of iron [Cardillo, P. et al., Ann. Chim. (Rome), 1984, 74, p. 129].

Incompatible materials: Strong oxidizing agents.

A reaction between allyl alcohol and carbon tetrachloride produces trichlorobutylene epoxide (oxide) and dichlorobutylene epoxide (oxide), a mixture which during distillation proved to be unstable and detonated in the still.

A bomb containing powdered aluminum and carbon tetrachloride exploded violently when heated to 153 °C. A mixture of powdered aluminum and carbon tetrachloride in a ball mill exploded.

A violent reaction occurred when small chunks of barium were cleaned by submerging in chemically pure carbon tetrachloride.

For more Hazardous Reactivities and Incompatibilities (Complete) data for Carbon tetrachloride (32 total), please visit the HSDB record page.

Chemically-active metals such as sodium, potassium & magnesium; fluorine; aluminum [Note: Forms highly toxic phosgene gas when exposed to flames or welding arcs.]

CDC-ATSDR Toxicological Profile

IDENTIFICATION AND USE: Carbon tetrachloride is a colorless, heavy liquid. It is used in refrigerants, metal degreasing, in chlorinating organic compounds, in the production of semiconductors, and as a solvent (fats, oils, rubber, etc). It was formerly used as anthelmintic. HUMAN STUDIES: Potential symptoms of overexposure are CNS depression, drowsiness, dizziness, incoordination, nausea, and vomiting as well as liver and kidney injury. Direct contact may cause skin and eye irritation, and dermatitis through defatting action. Liver damage appears after 24 hrs or more. Kidney damage is evident often only 2 to 3 weeks following the poisoning. Three case reports describe the occurrence of liver tumors associated with cirrhosis in people who had been exposed to carbon tetrachloride. Covalent binding to macromolecules and lipid peroxidation occur via metabolic intermediates of carbon tetrachloride. Carbon tetrachloride did not demonstrate the DNA damaging activity in a short-term in vitro system which utilized human lymphocytes. ANIMAL STUDIES: The liver and kidney are target organs for carbon tetrachloride toxicity. The severity of the effects on the liver depends on a number of factors such as species susceptibility, route and mode of exposure, diet or co-exposure to other compounds, in particular ethanol. Furthermore, pretreatment with various compounds, such as phenobarbital and vitamin A, enhances hepatotoxicity, while other compounds, such as vitamin E, reduce the hepatotoxic action of carbon tetrachloride. Moderate irritation after dermal application was seen and there was a mild reaction after application into the rabbit eye. Increased fetal mortality was observed in pregnant mice given single doses of 150 mg carbon tetrachloride per animal during the last part of pregnancy. Cause of death was failure of peripheral circulation, mainly due to fetal liver damage. Moreover, circulatory disturbances and necroses were found in the placentas, which probably also contributed to the death of the fetuses. Carbon tetrachloride was not teratogenic to rats exposed orally, subcutaneously, or via inhalation. Carbon tetrachloride produced testicular toxicity in the rat at dose levels where hepatic damage is evident. After 25 wk of inhalation exposure to 200 and 400 ppm, male rats show germ cell degeneration in the testes along with liver toxicity and a high mortality rate. Testicular damage was also observed in rats when carbon tetrachloride was administered ip at a dose level of 1.5 mg/kg. A single injection caused testicular atrophy, a decrease in testes and seminal vesicle weights, and histological evidence of abnormal spermatogenesis. Carbon tetrachloride may have estrogenic properties that can alter male fertility. Its estrogenicity is evidenced by (a) inhibition of hepatic microsomal hydroxylation of estrogens in immature female rats, (b) potentiation of the uterotrophic responses of estrogens, and (c) increased estrogen uterine uptake. Carbon tetrachloride was not mutagenic in bacteria. It was mutagenic in yeast at almost lethal doses. It did not induce chromosomal damage in cultured rat liver epithelial cells and did not induce unscheduled DNA synthesis in the hepatocytes of rats exposed in vivo. Carbon tetrachloride induced hepatomas and hepatocellular carcinomas in mice and rats. The doses inducing hepatic tumors were higher than those inducing cell toxicity. ECOTOXICITY STUDIES: Carbon tetrachloride is considerably more toxic to the embryo-larval stages of several species of fish and amphibians than it is to the adults.

Unmetabolized carbon tetrachloride, depresses the central nervous system. All other toxic effects of carbon tetrachloride are related to its biotransformation via cytochrome P-450 enzymes, specifically CYP2E1. Metabolism of carbon tetrachloride by CYP2E1 may result in the destruction of the enzyme during the metabolic process, either by direct attack of radicals on the cytochrome(s) or highly localized lipid peroxidation resulting in detachment of P-450 proteins from the microsomal membranes. Reactive metabolites of carbon tetrachloride causes hepatic damage via haloalkylation of cellular macromolecules and lipid peroxidation. Carbon tetrachloride also perturbs the intracellular calcium homeostasis. Increased cytosolic levels of calcium may result from an influx of extracellular calcium caused by plasma membrane damage and decreased intracellular calcium sequestering. Higher levels of calcium activate enzymes such as proteases, which hydrolyze proteins in neighboring cells, leading to a progression of the lesion. Carbon tetrachloride's carcinogenicity is likely the result of certain reactive metabolites that bind to nuclear proteins, lipids, and DNA. (T10, L129)

Carbon tetrachloride

Endocrine

4 x 10 ^-3 mg/kg-day

1 x 10 ^-1 mg/m^3

Tetrachloromethane

Volatile Organic Compound (VOC) (Pesticide/Volatile Organic Compound (VOC))

Synonym: Carbon tetrachloride

Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP

Drug-Induced Liver Injury Severity and Toxicity (DILIst)

carbon tetrachloride

DILI Positive

DOI:10.1016/j.drudis.2019.09.022

Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), carbon tetrachloride is "likely to be carcinogenic to humans" based on: (1) inadequate evidence of carcinogenicity in humans and (2) sufficient evidence in animals by oral and inhalation exposure, i.e., hepatic tumors in multiple species (rat, mouse, and hamster) and pheochromocytomas (adrenal gland tumors) in mice.

Evaluation: There is inadequate evidence in humans for the carcinogenicity of carbon tetrachloride. There is sufficient evidence in experimental animals for the carcinogenicity of carbon tetrachloride. Overall evaluation: Carbon tetrachloride is possibly carcinogenic to humans (Group 2B).

A2; Suspected human carcinogen

Carbon tetrachloride is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Group 2B: Possibly carcinogenic to humans

Volume 20: (1979) Some Halogenated Hydrocarbons

Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)

Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Part 1, Part 2, Part 3)

2B, possibly carcinogenic to humans. (L135)

High exposure to carbon tetrachloride can cause liver, kidney, and central nervous system damage. Single cell necrosis, which is evident after 5h to 6h after dosing, progresses to maximal centrilobular necrosis within 24h to 48h. Cellular regeneration is maximal 36h to 48h after dosing. The rate and extent of tissue repair are important determinants of the ultimate outcome of liver injury. In severe cases, coma and even death may occur. (T10, L129)

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

Oral (L129) ; inhalation (L129) ; dermal (L129)

Headache. Nausea. Vomiting. Dizziness. Drowsiness.

MAY BE ABSORBED! Redness. Further see Inhalation.

Redness. Pain.

Burning sensation in the stomach. Abdominal pain. Diarrhoea. Further see Inhalation.

irritation eyes, skin; central nervous system depression; nausea, vomiting; liver, kidney injury; drowsiness, dizziness, incoordination; [potential occupational carcinogen]

Carbon tetrachloride exposure causes headaches, dizziness, sleepiness, nausea, and vomiting. (L129)

Cancer, Hepatic (Liver), Neurological (Nervous System), Renal (Urinary System or Kidneys)

central nervous system, eyes, lungs, liver, kidneys, skin

[in animals: liver cancer]

Neurotoxin - Acute solvent syndrome

Occupational hepatotoxin - Primary hepatotoxins: the toxic effect to the liver is the principal adverse effect of the chemical.

Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.

LC50; Species: Lepomis macrochirus (Bluegill); Conditions: static (unmeasured); Concentration: 125,000 ug/L for 96 hr

LC50; Species: /Lepomis macrochirus/ (Bluegill); Concentration: 27 mg/L for 96 hr (95% confidence limit: 23-33 mg/L) and 38 mg/L for 24 hr at 21-23 °C /Conditions of bioassay not specified in source examined/

LC50; Species: Menidia beryllina (tidewater silverside); Conditions: /static, unmeasured bioassay/; Concentration: 150,000 ug/L for 96 hr

EC50; Species: Pseudokirchneriella subcapitata (Green Algae) 15000 cells/mL; Conditions: freshwater, static, 24 °C; Concentration: 23590 ug/L for 48 hr; Effect: decreased population growth rate

For more Ecotoxicity Values (Complete) data for Carbon tetrachloride (19 total), please visit the HSDB record page.

/AQUATIC SPECIES/ Carbon tetrachloride is considerably more toxic to the embryo-larval stages of several species of fish and amphibians than it is to the adults. The common bullfrog (Rana catesbeiana) was the most susceptible species. At 60 ug/L the incidence of teratic larvae was 1%, rising to 17% at 7.8 mg/L. A more striking effect was found in the hatchability of the embryos, which declined from 92% at 60 ug/L to 23% at 7.8 mg/L.

/AQUATIC SPECIES/ The responses of 27 organic compounds, mainly chloromethanes, -ethanes, -ethenes, and -phenols, were investigated by exposing rainbow trout fingerlings to low microgram-per-liter concentrations in a darkened flow-through system for up to 1 hr. Responses by the fish were followed continuously by observing ventilation rates (frequency and amplitude), swimming patterns, and general activity using the low-voltage electric fields generated by the fishes' activity. The lowest level of response was found for trichloroethylene at 5 ug/L. Dichloromethane, 1,1- and 1,2-dichloroethane, 1,1,1- and 1,1,2-trichloroethane, cis-1,2-dichloroethylene, 1,3-dichloropropene, and allyl acetate were responded to at concentrations of 10 ug/L, carbon tetrachloride at 15 ug/L, and 4-chlorophenol and 2,4-dichlorophenol at levels of 30 ug/L. Unsubstituted phenol was not responded to at levels of up to 50 ug/L.

6.50e-01

2.90e+00

4.70e-01

2.00e+00

4.60e-01

5.00e+00

1.80e-04

1.90e-03

7.00e-02

4.00e-03

1.00e-01

Volatile

4.58e+02

6.50e+01

2.90e+02

4.70e+01

2.00e+02

4.60e+01

It is strongly advised not to let the chemical enter into the environment. The substance is harmful to aquatic organisms. The substance may cause long-term effects in the aquatic environment. Avoid release to the environment because of its impact on the ozone layer.

Carbon tetrachloride's production and use as a solvent for asphalt, benzyl resin, bitumens, chlorinated rubber, ethylcellulose, gums, rosin, chemical intermediate and pharmaceutical solvent may result in its release to the environment through various waste streams. Its former use as a dry cleaning agent, fire extinguisher and grain fumigant as well as former administration as a human and veterinary anthelmintic resulted in its release to the environment through various waste streams and in its direct release to the environment. Carbon tetrachloride was detected in volcanic fumaroles and lava gas. If released to air, a vapor pressure of 115 mm Hg at 25 °C indicates carbon tetrachloride will exist solely as a vapor in the ambient atmosphere. Vapor-phase carbon tetrachloride will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is reported as >300 years. Carbon tetrachloride does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. Carbon tetrachloride is very stable in the troposphere with residence times of 30-50 years. Its main loss mechanism is diffusion to the stratosphere where it photolyzes. If released to soil, carbon tetrachloride is expected to have high mobility based upon a Koc of 71. Volatilization from moist soil surfaces is expected to be an important fate process based upon a Henry's Law constant of 2.76X10-2 atm-cu m/mole. Carbon tetrachloride may volatilize from dry soil surfaces based upon its vapor pressure. Utilizing the Japanese MITI test, 0% of the Theoretical BOD was reached in 2 weeks indicating that aerobic biodegradation is not an important environmental fate process in soil and . However, under methanogenic conditions, incubation of carbon tetrachloride in leachate samples from full scale landfills resulted in >90 to 100% degradation within 50 days, indicating that anaerobic biodegradation may be an important environmental fate process in soil and water. A field experiment conducted in a sand aquifer resulted in carbon tetrachloride degradation, with a half-life of 3-7 days via sulfate reduction. If released into water, carbon tetrachloride is not expected to adsorb to suspended solids and sediment in water based upon the Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 4 hrs and 5 days, respectively. A BCF range of 3.2-7.4 suggests bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process as a hydrolysis half-life in water of 7000 years has been calculated. Occupational exposure to carbon tetrachloride may occur through inhalation and dermal contact with this compound at workplaces where carbon tetrachloride is produced or used. The general population may be exposed to carbon tetrachloride via inhalation of ambient air, smoking cigarettes, ingestion of contaminated foods and drinking water, and dermal contact with a limited number of products containing carbon tetrachloride. Carbon tetrachloride is widely detected in groundwater. (SRC)

Carbon tetrachloride was detected in volcanic fumaroles and lava gas(1).

Carbon tetrachloride's production and use as a powerful solvent for asphalt, benzyl resin, bitumens, chlorinated rubber, ethylcellulose, gums, rosin(1), chemical intermediate and pharmaceutical solvent(2) may result in its release to the environment through various waste streams(SRC). Its former use as a dry cleaning agent, fire extinguisher and grain fumigant as well as former administration as a human and veterinary anthelmintic(2) resulted in its release to the environment through various waste streams and in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), a Koc value of 71(2) indicates that carbon tetrachloride is expected to have high mobility in soil(SRC). Volatilization of carbon tetrachloride from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 2.76X10-2 atm-cu m/mole(3). The potential for volatilization of carbon tetrachloride from dry soil surfaces may exist based upon a vapor pressure of 115 mm Hg(4). Utilizing the Japanese MITI test, 0% of the Theoretical BOD was reached in 2 weeks(5) indicating that aerobic biodegradation is not an important environmental fate process in soil(SRC). However, under methanogenic conditions, incubation of carbon tetrachloride in leachate samples from eight full scale landfills resulted in >90 to 100% degradation within 50 days(6) indicating that anaerobic biodegradation may be an important environmental fate process in soil(SRC). However, under methanogenic conditions, incubation of carbon tetrachloride in leachate samples from eight full scale landfills resulted in >90 to 100% degradation within 50 days. A field experiment conducted in a sand aquifer resulted in carbon tetrachloride degradation, with a half-life of 3-7 days via sulfate reduction(7).

AQUATIC FATE: Based on a classification scheme(1), a Koc value of 71(2) indicates that carbon tetrachloride is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 2.76X10-2 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4 hrs and 5 days, respectively(SRC). According to a classification scheme(5), a BCF of 3.2-7.4(6), suggests the potential for bioconcentration in aquatic organisms is low. Utilizing the Japanese MITI test, 0% of the Theoretical BOD was reached in 2 weeks(6) indicating that aerobic biodegradation is not an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), carbon tetrachloride, which has a vapor pressure of 115 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase carbon tetrachloride is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); a reaction rate constant of 1.20X10-16 cu cm/molecule-sec at 25 °C(3) and half-life of >330 years(4) have been reported. Carbon tetrachloride does not contain chromophores that absorb at wavelengths >290 nm(5) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Carbon tetrachloride is very stable in the troposphere with residence times of 30-50 years. Its main loss mechanism is diffusion to the stratosphere where it photolyzes. It is estimated that <1% of the carbon tetrachloride released to the air is partitioned into the oceans(6).

AEROBIC: Carbon tetrachloride, present at 100 mg/L, reached 0% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). In a standard dilution test, 0% Theoretical BOD for carbon tetrachloride was measured(2). An enrichment static screening flask test method measured >87% degradation of carbon tetrachloride in 7 days in the original test, and 100% degradation in the second, third, and fourth trials(3).

AEROBIC: Atmospheric carbon tetrachloride biodegradation in bulk aerobic soils from tropical, subtropical and boreal environments, respectively, using a 24-hr flux chamber(1).[Table#113]

ANAEROBIC: A field experiment conducted in a sand aquifer at the C.F.B. Borden test site in Ontario, Canada resulted in carbon tetrachloride degradation with a half-life of 3-7 days via sulfate reduction with two thirds of carbon tetrachloride transforming to chloroform and one third to carbon disulfide(1). Carbon tetrachloride degradation was found in a field injection experiment conducted in the anaerobic part of a pollution plume downgradient of the Grindsted landfill in Denmark(2). Nearly complete degradation of carbon tetrachloride was observed at low concentrations (<200 ug/L) after 3 weeks of incubation under methanogenic conditions using batch cultures and continuous flow columns and activated sludge(3). Carbon tetrachloride in methanogenic leachate samples from eight full scale landfills in Denmark was found to degrade 100% in 10 days in 7 landfills and >90% within 50 days in the eigth landfill to produce trichloromethane which was also immediately degraded(4). Using water unsaturated Danish agricultural topsoil, incubated to simulate anoxic conditions, a biodegradation half-life of 4.0 days and an abiotic half-life of 41.0 days were calculated, corresponding to biotic and abiotic rate constants of 0.23 and 0.04/day, respectively; detection limit = 0.05 nmol. The background soil concentration was 60 pg/sample vial(5).

The rate constant for the vapor-phase reaction of carbon tetrachloride with photochemically-produced hydroxyl radicals is 5.0X10-16 cu cm/molecule-sec at 25 °C(1). A half-life of >330 years has been reported(2). The hydrolysis half-life in water is 7000 years at 25 °C(3). Carbon tetrachloride does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). However, irradiation at higher energies (195-254 nm), such as found in the stratosphere results in degradation(5,6). Carbon tetrachloride is stable in the troposphere with residence time of 30-50 years(6). It is not likely to react with any active species in the atmosphere(7). The UV photolysis/ozone half-life in the stratosphere is between 60 and 100 years(8).

BCF values of 3.2 and 7.4 were calculated in fish for carbon tetrachloride using rice fish (Oryzias latipes) which were exposed over an 6-week period(1). Measured BCF values of 17.37(2), 52.48(3), and 30.2(4) were reported for rainbow trout (Salmo gairdneri)(2,3) and bluegill sunfish (Lepomis macrochirus)(4). According to a classification scheme(5), these BCF values suggest the potential for bioconcentration in aquatic organisms is low.

The Koc for carbon tetrachloride was measured to be 71(1). According to a classification scheme(2), this Koc value suggests that carbon tetrachloride is expected to have high mobility in soil. The estimated retardation factor range in breakthrough sampling in groundwater has been reported as 1.44-1.8(3,4).

The Henry's Law constant for carbon tetrachloride is 2.76X10-2 atm-cu m/mole(1). This Henry's Law constant indicates that carbon tetrachloride is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 4 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 5 days(SRC). Measured half-lives of evaporation from water ranges from minutes to hours(3-7). Carbon tetrachloride's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Carbon tetrachloride is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 115 mm Hg(8).

GROUNDWATER: Carbon tetrachloride was detected 484 times in groundwater in 32 of the 479 U.S. Waste Disposal Sites tested(1). 0.2-20 ppb carbon tetrachloride was found in the groundwater for 66 US cities(2), and groundwater in the Netherlands measured at 5 ppb(3). The compound was present at a median concentration of 0.13 ug/L (0.47 ug/L max) in 16 of 3,306 groundwater samples collected from 1993-2001 for the Danish National Groundwater Monitoring Program; maximum residue limit = 1 ug/L(4).

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U211 and D019, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber; Contaminated packaging: Dispose of as unused product.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Carbon tetrachloride is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration. Preferably after mixing with another combustible fuel; care must be exercised to assure complete combustion to prevent the formation of phosgene; an acid scrubber is necessary to remove the halo acids produced.

For more Disposal Methods (Complete) data for Carbon tetrachloride (12 total), please visit the HSDB record page.

/GUIDE 151 SUBSTANCES - TOXIC (Non-combustible)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.

/GUIDE 151 SUBSTANCES - TOXIC (Non-combustible)/ Health: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

/GUIDE 151 SUBSTANCES - TOXIC (Non-combustible)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind, uphill and/or upstream.

/GUIDE 151 SUBSTANCES - TOXIC (Non-combustible)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for Carbon tetrachloride (8 total), please visit the HSDB record page.

UN 1846; Carbon tetrachloride

IMO 6.1; Carbon tetrachloride

49 403 20; Carbon tetrachloride

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. Carbon tetrachloride is included on the dangerous goods list.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. Carbon tetrachloride is included on the dangerous goods list.

PRECAUTIONS FOR "CARCINOGENS": Procurement ... of unduly large amt ... should be avoided. To avoid spilling, carcinogens should be transported in securely sealed glass bottles or ampoules, which should themselves be placed inside strong screw-cap or snap-top container that will not open when dropped & will resist attack from the carcinogen. Both bottle & the outside container should be appropriately labelled. ... National post offices, railway companies, road haulage companies & airlines have regulations governing transport of hazardous materials. These authorities should be consulted before ... material is shipped. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": When no regulations exist, the following procedure must be adopted. The carcinogen should be enclosed in a securely sealed, watertight container (primary container), which should be enclosed in a second, unbreakable, leakproof container that will withstand chem attack from the carcinogen (secondary container). The space between primary & secondary container should be filled with absorbent material, which would withstand chem attack from the carcinogen & is sufficient to absorb the entire contents of the primary container in the event of breakage or leakage. Each secondary container should then be enclosed in a strong outer box. The space between the secondary container & the outer box should be filled with an appropriate quantity of shock-absorbent material. Sender should use fastest & most secure form of transport & notify recipient of its departure. If parcel is not received when expected, carrier should be informed so that immediate effort can be made to find it. Traffic schedules should be consulted to avoid ... arrival on weekend or holiday ... /Chemical Carcinogens/

Unbreakable packaging. Put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs. Marine pollutant.

UN Hazard Class: 6.1; UN Pack Group: II