2,5-dichlorophenol

This chemical does not meet GHS hazard criteria for 1.1% (2 of 186) of reports.

H302 (98.9%): Harmful if swallowed [Warning Acute toxicity, oral]

H314 (36%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H315 (62.9%): Causes skin irritation [Warning Skin corrosion/irritation]

H318 (15.1%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H319 (62.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H411 (61.3%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P260, P264, P264+P265, P270, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P321, P330, P332+P317, P337+P317, P362+P364, P363, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 186 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 2 of 186 reports by companies.

There are 7 notifications provided by 184 of 186 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]

H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P260, P261, P264, P270, P271, P273, P304+P340, P308+P316, P319, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.

Rinse mouth. Rest. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Phenols are very toxic poisons AND corrosive and irritating, so that inducing vomiting may make medical problems worse. IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Use water spray, foam, powder, carbon dioxide.

Extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn or burns with difficulty. /Trichlorophenol/

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Land Spill: Dig a pit, pond, lagoon, or holding area /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner/ to contain liquid or solid material. Cover solids with plastic sheet to prevent dissolving in rain or fire fighting water.

Water Spill: Use natural deep water pockets, excavated lagoons, or sand bag barriers to trap material at bottom. If dissolved, apply activated carbon at ten times the spilled amount in region of 10 ppm or greater concentration. Remove trapped material with suction hoses. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.

Activated carbon is a good method for removing chlorophenols from water. Competitive adsorption occurs between chlorophenols & humic substances present in nearly all municipal water supplies. This competition decr the capacity of carbon for chlorophenols. /Chlorophenols/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Chemical Treatability of 2,5-Dichlorophenol; Concentration Process: Biological Treatment; Chemical Classification: Phenols; Scale of Study: Laboratory Scale; Type of Wastewater Used: Pure compound (one solute in a solvent); Results of Study: 100% reduction in 38 hours; (Biodegradation by mutant pseudomonas species.)

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

Keep material out of water sources and sewers; Build dikes to contain flow as necessary; Keep upwind; Avoid breathing vapors or dusts; Wash away any material which may have contacted the body with copious amounts of water or soap and water. /Trichlorophenol/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Immediately wash contaminated areas of skin with concentrated soap solution. Contaminated gloves, clothing, shoes should be removed without delay and disposed by incineration.

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should store this chemical under ambient temperatures, and keep it away from oxidizing materials. (NTP, 1992)

Store only in original container. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing. Separated from oxidants and food and feedstuffs. Ventilation along the floor.

A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered.

The substance is severely irritating to the eyes, skin and respiratory tract. Exposure could cause chloracne.

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Wear boots, protective gloves, and goggles. /Trichlorophenol/

/Wear/ approved dust respirator for toxic dusts; Protective clothing to prevent contact with skin. /Trichlorophenol/

NO open flames.

STRICT HYGIENE! PREVENT DISPERSION OF DUST!

Use local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

Do not eat, drink, or smoke during work.

Prisms (from benzene, petroleum ether) or white crystals. Odor threshold 30 micrograms/liter at 68-72 °F; 33 micrograms/liter at 86 °F. Taste threshold 0.5 micrograms/liter. (NTP, 1992)

Colorless solid; [ICSC] Crystalline solid; [MSDSonline]

COLOURLESS CRYSTALS WITH CHARACTERISTIC ODOUR.

Prisms from benzene and petroleum ether

Taste Threshold in water - 0.5 ug/l.

412 °F at 760 mmHg (NTP, 1992)

at 99.2kPa: 211 °C

133 to 136 °F (NTP, 1992)

less than 1 mg/mL at 68 °F (NTP, 1992)

Very soluble in ethanol, ethyl ether; soluble in benzene, petroleum ether

In water, 2,000 mg/L at 25 °C

2 mg/mL at 25 °C

Solubility in water, g/100ml: 0.2 (poor)

Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.00

Relative vapor density (air = 1): 5.6

0.06 [mmHg]

0.0562 mm Hg at 25 °C

Vapor pressure, Pa at 25 °C: 7

log Kow = 3.06

When heated to decomposition it emits toxic vapors of /hydrogen chloride/.

In water 33 ug/L at 30 °C.

In water 30 ug/L at 20-22 °C.

pKa = 7.51

123.3 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID7025003]

13C nuclear magnetic resonance spectrum

Chemical shift

Fusion temperature

Melting temperature

Nuclear quadrupole resonance spectroscopy

Phase transition

Quadrupole coupling

Spin-spin coupling constant

Transition enthalpy

Other Classes -> Chlorophenols

Insoluble in water.

Phenols and Cresols

Acids, Weak

Aryl Halides

2,5-DICHLOROPHENOL is incompatible with acid chlorides, acid anhydrides and oxidizing agents. (NTP, 1992)

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Sore throat. Cough. Burning sensation.

Redness. Pain.

Sore throat. Burning sensation.

Neurotoxin - Other CNS neurotoxin

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.

Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

Dermatotoxin - Skin burns.

IARC Carcinogen - Class 3: Chemicals are not classifiable by the International Agency for Research on Cancer.

LC50 (rat) > 185,000 mg/m3/4h

LD50 Rat oral 580 mg/kg

LD50 Mouse (male CD-1 ICR) oral 1600 mg/kg.

LD50 Mouse (female CD-1 ICR) oral 946 mg/kg.

LD50 Rat (Wistar female, weight 80-97 g) oral 2475 mg/kg bw (95% confidence interval: 2101-2916 mg/kg bw)

For more Non-Human Toxicity Values (Complete) data for 2,5-DICHLOROPHENOL (6 total), please visit the HSDB record page.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Phenols and related compounds/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Administer activated charcoal ... . Do not use emetics. Cover skin burns with dry, sterile dressings after decontamination ... . Maintain body temperature. /Phenols and related compounds/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. DIRECT PHYSICIAN ORDER ONLY ... Treat seizures with diazepam or lorazepam. ... Use proparacaine hydrochloride to assist eye irrigation ... . /Phenols and related compounds/

/SIGNS AND SYMPTOMS/ SYMPTOMATOLOGY: Burning pain in mouth and throat. White necrotic lesions in mouth, esophagus and stomach. Abdominal pain, vomiting ... and bloody diarrhea. Pallor, sweating, weakness, headache, dizziness, tinnitus. Shock: Weak irregular pulse, hypotension, shallow respirations, cyanosis, pallor, and a profound fall in body temperature. Possibly fleeting excitement and confusion, followed by unconsciousness. ... Stentorous breathing, mucous rales, rhonchi, frothing at nose and mouth and other signs of pulmonary edema are sometimes seen. Characteristic odor of phenol on the breath. Scanty, dark-colored ... urine ... moderately severe renal insufficiency may appear. Methemoglobinemia, Heinz body hemolytic anemia and hyperbilirubinemia have been reported. ... Death from respiratory, circulatory or cardiac failure. If spilled on skin, pain is followed promptly by numbness. The skin becomes blanched, and a dry opaque eschar forms over the burn. When the eschar sloughs off, a brown stain remains. /Phenol/

/EPIDEMIOLOGY STUDIES/ Many phthalates and phenols are hormonally active and are suspected to alter the course of development. ... Prenatal exposures to phthalate and phenol metabolites and their associations with body size measures of the infants at birth /were investigated/. /Investigators/ measured 5 phenol and 10 phthalate urinary metabolites in a multiethnic cohort of 404 women in New York City during their third trimester of pregnancy and recorded size of infants at birth. Median urinary concentrations were > 10 ug/L for 2 of 5 phenols and 6 of 10 phthalate monoester metabolites. Concentrations of low-molecular-weight phthalate monoesters (low-MWP) were approximately 5-fold greater than those of high-molecular-weight metabolites. Low-MWP metabolites had a positive association with gestational age [0.97 day gestational age per ln-biomarker; 95% confidence interval (CI), 0.07-1.9 days, multivariate adjusted] and with head circumference. Higher prenatal exposures to 2,5-dichlorophenol (2,5-DCP) predicted lower birth weight in boys (-210 g average birth weight difference between the third tertile and first tertile of 2,5-DCP; 95% CI, 71-348 g). Higher maternal benzophenone-3 (BP3) concentrations were associated with a similar decrease in birth weight among girls but with greater birth weight in boys. ...

/EPIDEMIOLOGY STUDIES/ Several epidemiological studies have been published concerning human cancer outcomes following occupational exposure to chlorophenols, phenoxy herbicides (made from or contaminated with chlorophenols) and chlorinated dibenzo-p-dioxins and dibenzofurans (microcontaminants found in some chlorophenols and phenoxy herbicides). Most of these studies (case-control and cohort studies) have been described and reviewed in several publications by IARC (1979, 1986, 1987). Equivocal relationships between chlorophenols and cases of soft tissue sarcoma, malignant lymphoma (Hodgkins disease and non-Hodgkins lymphoma), nasal and nasopharyngeal cancer and lung cancer have been reported. IARC concluded that there is a limited evidence of carcinogenicity from occupational exposure to chlorophenols ... /Chlorophenols/

/ALTERNATIVE and IN VITRO TESTS/ Nineteen isomeric chlorophenols were tested for their toxicity to HeLa cells. Cytotoxicity (median inhibitory concn IC50) varied between 0.37 and 900 mg/L and generally increased in proportion to the number of chlorine substituents and the partition coeffient. Ortho-chlorination decreased toxicity, whereas meta-chlorination had the opposite effect. A good correlation was found between HeLa cell toxicity and data on the bacterial toxicity of the substances.

/OTHER TOXICITY INFORMATION/ The toxicity of chlorophenols tends to increase as chlorination is increased. /Chlorophenols/

/LABORATORY ANIMALS: Acute Exposure/ In rats oral, subcutaneous, and intraperitoneal lethal doses of the chlorophenols produce similar signs of poisoning. Oral administration, however, results in fatal poisoning in smaller dosage and in a shorter period of time than sc administration. /Chlorophenols/

/LABORATORY ANIMALS: Acute Exposure/ Spartan /rats/... 10 (5 male, 5 female; weight at study initiation 216-243 g) /were exposed by/ inhalation (whole body) .../for/ 4 hours /at/... concentrations: 50000 mg/cu m; 185000 mg/cu m. ...Mortality: - Number of deaths at each dose: 50000 mg/cu m: none; 185000 mg/cu m: 2 (females) - Time of death: during exposure (both). Clinical signs: 50000 mg/cu m, (all rats): increased/decreased motor activity, eye squint, erythema, lacrimation, salivation, clear nasal discharge, ocular and nasal porphyrin discharge, slight dyspnea. The symptoms disappeared in all rats 24 hours after exposure. 185000 mg/cu m, (all rats): The same symptoms as at 50000 mg/cu m, with addition of marked dyspnea, corneal opacity, ataxia, sedation and body jerking. The symptoms disappeared 72 hours after exposure (one rat exhibiting nasal porphyrin discharge at day 10). Necropsy findings: congested lungs and liver, slight corneal opacity (in the animals that died).

/LABORATORY ANIMALS: Acute Exposure/ CD-1-mice were fasted for 18 hours prior to dosing. Five doses were employed with 10 mice of each sex in each dose group. Mice were observed for 14 days. All mice that died were autopsied. The primary signs of toxicity were increased respiration, tremors, and slight convulsions followed by central nervous system (CNS) depression for all compounds except pentachlorophenol which elicited signs of CNS depression only. Mean times of death for most groups were less than 24 hours. Acute oral LD50s for males and females, respectively, were: ... 2,5-dichlorophenol, 1,600 and 946 mg/kg ...

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Sprague-Dawley rats ...age 8 weeks, weight at study initiation: males 206-230 g, females 192-224 g /were exposed/ 6 hours/day, 5 days/week /for/ 4 weeks /by/ inhalation (whole body) /at/ doses of 0.1, 0.3 and 1.0 mg/L /(10 animals/sex/treatment)/. ...Clinical signs: Nasal irritation with or without discharge in all treatment groups and controls. Ocular irritation and discharge in all treatment groups. Salivation in 8 males and 4 females at 0.3 mg/L and in 7 males and 7 females at 1.0 mg/L. Dyspnea in one male and 7 females at 0.3 mg/L. Incidental findings: respiratory distress, skin irritation, cloudy spots on eyes, decreased activity and soaked abdomen. Body weight gain: decreased at 0.3 mg/L during week 2-4 and at 1.0 during week 1-4. Hematology: Hb increased at the high dose group, No. of leucocytes increased in females at 0.3 and 1.0 mg/L. Clinical chemistry: ASAT increased in high dose males and females. Urinalysis: no treatment related effects. Organ weights: Decreased absolute liver and brain weight in males at 0.3 and 1.0 mg/L. Increased relative lung weight in females at 1.0 mg/L. Decreased absolute heart weight in males at 0.3 mg/L. Increased relative kidney weight in all treated males. Gross pathology: Brown cyanotic/discolored areas, foci and atelectasis in the lungs were seen in 1-2 animals/sex/treatment and in controls. At 1.0 mg/L the incidence was slightly increased in females. Other incidental effects included hemorrhagic/hyperemic lymphnodes, effects on stomach mucosa, pale/discolored liver areas/foci and hemorrhagic foci and discoloration of the kidneys. Histopathology: Inflammatory cell and lymphocyte infiltrate, macrophage aggregation and septal fibrosis in the lungs of all treated animals. Inflammation of the nasal cavity (mucosa) in animals at 1.0 mg/L. Lymphocytic infiltrate, inflammation, foci and necrosis of the liver in treated and control animals. The incidence in control animals was slightly lower (9/20) compared to treatd animals (14-16/20). Statistical results: The effects on body weight, organ weight and blood parameters were statistically significant. None of the effects showed a clear concentration-response relationship. Conclusion: LOAEL 0.1 mg/L based on liver effects. Other effects seen were related to a weight decrease (organ weights) or could be attributed to irritant properties of the test substance (effects in the respiratory tract).

For more Non-Human Toxicity Excerpts (Complete) data for 2,5-DICHLOROPHENOL (12 total), please visit the HSDB record page.

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=583-78-8]

EC50; Species: Oryzias latipes (Medaka); Conditions: freshwater, static; Concentration: 2600 ug/L for 15 days (95% confidence interval: 1900-3800 ug/L); Effect: hatch mortality

LC50; Species: Oryzias latipes (Medaka); Conditions: freshwater, static; Concentration: 3300 ug/L for 15 days (95% confidence interval: 2500-4500 ug/L)

LC50; Species: Carassius auratus (Goldfish, weight 1.0 g); Conditions: freshwater, static, 27-28 °C, pH 7.0; Concentration: 36.8 umol/L for 2.5 hr /100% purity/

LC50; Species: Carassius auratus (Goldfish, weight 1.0 g); Conditions: freshwater, static, 27-28 °C, pH 7.0; Concentration: 30.7 umol/L for 5 hr /100% purity/

LC50; Species: Platichthys flesus (European flounder, weight 56 g); Conditions: saltwater, static, 6 °C, pH 8, salinity 5 ppt; Concentration: 3290 ug/L for 96 hr /98-99% purity/

The substance is toxic to aquatic organisms. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

2,5-Dichlorophenol's formation as a result of water and wastewater treatment, wood pulp processing, incineration processes and the degradation/metabolism of 1,4-dichlorbenzene and 2,4,5-T pesticide may result in its release to the environment through various waste streams. It may naturally occur in soil via direct synthesis by soil fungi or fungi-derived enzymes utilizing humic phenols. Chlorophenols may be released into the environment through burning of biomass during forest fires. If released to air, a vapor pressure of 0.056 mm Hg at 25 °C indicates 2,5-dichlorophenol will exist solely as a vapor in the atmosphere. Vapor-phase 2,5-dichlorophenol will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be about 55 hours. 2,5-Dichlorophenol contains chromophores that absorb at wavelengths >290 nm and therefore may be susceptible to direct photolysis by sunlight. If released to soil, 2,5-dichlorophenol is expected to have low mobility based upon a Koc of 600. The pKa of 2,5-dichlorophenol is 7.51, indicating that this compound will partially exist in the anion form and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 6.03X10-6 atm-cu m/mole. 2,5-Dichlorophenol is not expected to volatilize from dry soil surfaces based upon its vapor pressure of 0.056 mm Hg. A 5% of theoretical BOD using activated sludge in the Japanese MITI test suggests that biodegradation is not an important environmental fate process. If released into water, 2,5-dichlorophenol is expected to adsorb to suspended solids and sediment based upon the Koc of 600. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 8 and 61 days, respectively. A BCF range of 4-35 suggests bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to 2,5-dichlorophenol may occur through dermal contact with this compound at workplaces where 2,5-dichlorophenol is produced or used. Monitoring data indicate that the general population may be exposed to 2,5-dichlorophenol via ingestion of drinking water, via dermal contact with this compound, and via exposure to 1,4-dichlorobenzene, which is metabolized to 2,5-dichlorophenol. 2,5-Dichlorophenol has been detected in groundwater, surface waters, sewage effluents and industrial effluents. 2,5-Dichlorophenol has been detected in human urine and amniotic fluid. (SRC)

Dichlorophenols can be synthesized directly by soil fungi utilizing chloride ions and humic phenols found in soil(1); chloroperoxidase enzymes released into soil by fungi can also bring about the chlorination of humic phenols with chloride ions(1). Chlorophenols may be released into the environment through burning of fresh lignocellulosic biomass during forest fires(2).

Dichlorophenol isomer formation as a result of the chlorination processes involving water and wastewater treatment(1,2), wood pulp processing(3) and municipal incineration(4,5) may result in the release of 2,5-dichlorophenol to the environment through various waste streams(SRC). 2,5-Dichlorophenol is a possible degradation/metabolism product of 1,4-dichlorobenzene, the pesticide 2,4,5-T, and the pesticide lindane (no longer registered in the US)(6) which may have resulted in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 600(SRC), determined from a log Kow of 3.06(2) and a regression-derived equation(3), indicates that 2,5-dichlorophenol is expected to have low mobility in soil(SRC). The pKa of 2,5-dichlorphenol is 7.51(4), indicating that this compound will partially exist in the anion form and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization of 2,5-dichlorophenol from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 6.03X10-6 atm-cu m/mole, derived from its vapor pressure, 0.056 mm Hg(6), and water solubility, 2,000 mg/L(7). 2,5-Dichlorophenol is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(6). A 5% of theoretical BOD using activated sludge in the Japanese MITI test(8) suggests that biodegradation is not an important environmental fate process in soil(SRC).

EC50; Species: Oryzias latipes (Medaka); Conditions: freshwater, static; Concentration: 2600 ug/L for 15 days (95% confidence interval: 1900-3800 ug/L); Effect: hatch mortality

LC50; Species: Oryzias latipes (Medaka); Conditions: freshwater, static; Concentration: 3300 ug/L for 15 days (95% confidence interval: 2500-4500 ug/L)

LC50; Species: Carassius auratus (Goldfish, weight 1.0 g); Conditions: freshwater, static, 27-28 °C, pH 7.0; Concentration: 36.8 umol/L for 2.5 hr /100% purity/

LC50; Species: Carassius auratus (Goldfish, weight 1.0 g); Conditions: freshwater, static, 27-28 °C, pH 7.0; Concentration: 30.7 umol/L for 5 hr /100% purity/

LC50; Species: Platichthys flesus (European flounder, weight 56 g); Conditions: saltwater, static, 6 °C, pH 8, salinity 5 ppt; Concentration: 3290 ug/L for 96 hr /98-99% purity/

The substance is toxic to aquatic organisms. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

2,5-Dichlorophenol's formation as a result of water and wastewater treatment, wood pulp processing, incineration processes and the degradation/metabolism of 1,4-dichlorbenzene and 2,4,5-T pesticide may result in its release to the environment through various waste streams. It may naturally occur in soil via direct synthesis by soil fungi or fungi-derived enzymes utilizing humic phenols. Chlorophenols may be released into the environment through burning of biomass during forest fires. If released to air, a vapor pressure of 0.056 mm Hg at 25 °C indicates 2,5-dichlorophenol will exist solely as a vapor in the atmosphere. Vapor-phase 2,5-dichlorophenol will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be about 55 hours. 2,5-Dichlorophenol contains chromophores that absorb at wavelengths >290 nm and therefore may be susceptible to direct photolysis by sunlight. If released to soil, 2,5-dichlorophenol is expected to have low mobility based upon a Koc of 600. The pKa of 2,5-dichlorophenol is 7.51, indicating that this compound will partially exist in the anion form and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 6.03X10-6 atm-cu m/mole. 2,5-Dichlorophenol is not expected to volatilize from dry soil surfaces based upon its vapor pressure of 0.056 mm Hg. A 5% of theoretical BOD using activated sludge in the Japanese MITI test suggests that biodegradation is not an important environmental fate process. If released into water, 2,5-dichlorophenol is expected to adsorb to suspended solids and sediment based upon the Koc of 600. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 8 and 61 days, respectively. A BCF range of 4-35 suggests bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to 2,5-dichlorophenol may occur through dermal contact with this compound at workplaces where 2,5-dichlorophenol is produced or used. Monitoring data indicate that the general population may be exposed to 2,5-dichlorophenol via ingestion of drinking water, via dermal contact with this compound, and via exposure to 1,4-dichlorobenzene, which is metabolized to 2,5-dichlorophenol. 2,5-Dichlorophenol has been detected in groundwater, surface waters, sewage effluents and industrial effluents. 2,5-Dichlorophenol has been detected in human urine and amniotic fluid. (SRC)

Dichlorophenols can be synthesized directly by soil fungi utilizing chloride ions and humic phenols found in soil(1); chloroperoxidase enzymes released into soil by fungi can also bring about the chlorination of humic phenols with chloride ions(1). Chlorophenols may be released into the environment through burning of fresh lignocellulosic biomass during forest fires(2).

Dichlorophenol isomer formation as a result of the chlorination processes involving water and wastewater treatment(1,2), wood pulp processing(3) and municipal incineration(4,5) may result in the release of 2,5-dichlorophenol to the environment through various waste streams(SRC). 2,5-Dichlorophenol is a possible degradation/metabolism product of 1,4-dichlorobenzene, the pesticide 2,4,5-T, and the pesticide lindane (no longer registered in the US)(6) which may have resulted in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 600(SRC), determined from a log Kow of 3.06(2) and a regression-derived equation(3), indicates that 2,5-dichlorophenol is expected to have low mobility in soil(SRC). The pKa of 2,5-dichlorphenol is 7.51(4), indicating that this compound will partially exist in the anion form and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization of 2,5-dichlorophenol from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 6.03X10-6 atm-cu m/mole, derived from its vapor pressure, 0.056 mm Hg(6), and water solubility, 2,000 mg/L(7). 2,5-Dichlorophenol is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(6). A 5% of theoretical BOD using activated sludge in the Japanese MITI test(8) suggests that biodegradation is not an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 600(SRC), determined from a log Kow of 3.06(2) and a regression-derived equation(3), indicates that 2,5-dichlorophenol is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 6.03X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 0.056 mm Hg(4), and water solubility, 2,000 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 8 and 61 days, respectively(SRC). According to a classification scheme(6), a measured BCF of 4.0 to 35(7), and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low. A 5% of theoretical BOD using activated sludge in the Japanese MITI test(7) suggests that biodegradation is not an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2,5-dichlorophenol, which has a vapor pressure of 0.056 mm Hg at 25 °C(2) is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2,5-dichlorophenol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 55 hours(SRC), calculated from its estimated rate constant of 6.99X10-12 cu cm/molecule-sec at 25 °C(3). 2,5-Dichlorophenol contains chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC).

The biological degradation of chlorophenols in activated sludge /was studied/. 2,5-Dichlorophenol was more resistent to degradation than 2,4-dichlorophenol. While 2,4-dichlorophenol was 100% degraded, including ring degradation, in five days, 2,5-dichlorophenol was only 52% ring-degraded in four days.

The microbial decomposition of 2,5-dichlorophenol in a Dunkirk soil suspension /was studied/. Disappearance was not complete at the end of 72 days.

AEROBIC: 2,5-Dichlorophenol, present at 100 mg/L, reached 5% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI I test(1), and therefore this compound is not expected to biodegrade rapidly. 2,5-Dichlorophenol, present at 30 ppm in Wiggins, Mississippi acidic sandy loam with a pH of 4.8, reached ca. 90% transformation to unspecified intermediates in 54 days, with a half-life of 18 days(1); 2,5-dichlorophenol, present at 300 ppm in Austin, Texas basic sandy silt loam with a pH of 7.8, reached 90% transformation to unspecified intermediates in 51 days, with a half-life of 17 days(2).

AEROBIC: Approximately 78-81% of added 2,5-dichlorophenol remained after 12 weeks of incubation in four freshwater pond sediments(1); the chlorine at the 2-position was the most susceptible to the reductive dechlorination which occurred(1). After a lag period of approximately 4-6 weeks, 100% of the 2,5-dichlorophenol initially added to a freshwater pond sediment (which had been contaminated with asphalt) was observed to degrade within 2 weeks(1). The time required for 100% UV disappearance of 2,5-dichlorophenol being incubated in an aerobic silt loam soil suspension was in excess of 72 days(2). A ring degradation rate of 52% was observed over a 4 day incubation period in a mineral salts solution using an acclimated activated sludge(3). A microbial mixture consisting of a blend of five pseudomonads, one klebsiella, four rhodococci and two fungal strains degraded 100% of an initial concn of 2,5-dichlorophenol over a 6-day incubation period(4).

For more Environmental Biodegradation (Complete) data for 2,5-DICHLOROPHENOL (7 total), please visit the HSDB record page.

The rate constant for the vapor-phase reaction of 2,5-dichlorophenol with photochemically-produced hydroxyl radicals has been estimated as 6.99X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 55 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 2,5-Dichlorophenol undergoes direct photolysis in water upon UV irradiation at wavelengths greater than 280 nm, producing polyphenolic compounds and dechlorinated cyclopentenoic acids(2). 2,5-Dichlorophenol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). 2,5-Dichlorophenol contains chromophores that absorb at wavelengths >290 nm(3) and therefore may be susceptible to direct photolysis by sunlight(SRC).

A BCF of 4.0 to 35 was measured in fish for 2,5-dichlorophenol using carp (Cyprinus carpio) which were exposed over a six week period to a water concentration of 30 ppb, according to the standard test of the Japanese Ministry of Industry and Trade (MITI)(1). According to a classification scheme(2), this BCF suggest the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of 2,5-dichlorophenol is estimated as 600(SRC), using a log Kow of 3.06(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 2,5-dichlorophenol is expected to have low mobility in soil. The pKa of 2,5-dichlorophenol is 7.51(4), indicating that this compound will partially exist in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

The Henry's Law constant for 2,5-dichlorophenol is estimated as 6.03X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 0.056 mm Hg(1), and water solubility, 2,000 mg/L(2). This Henry's Law constant indicates that 2,5-dichlorophenol is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as about 8 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 61 days(SRC). 2,5-dichlorophenol's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). 2,5-Dichlorophenol is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

GROUNDWATER: 2,5-Dichlorophenol (combined with 2,4-dichlorophenol) was detected in 38 of 38 groundwater samples collected in the vicinity of a sewage treatment plant in Karkola, Finland between September 1989 to November 1990 at an average concentration of 630 ug/L(1).

DRINKING WATER: 2,5-dichlorophenol was detected not quantified in samples collected from the Cincinnati, Ohio waterworks in January 1980(1).

SURFACE WATER: 2,5-Dichlorophenol was detected in 5 of 13 samples collected from the Ijssel River, the Netherlands in 1979 at a maximum concentration of 0.15 ppb(1). 2,5-Dichlorophenol was detected in 39 of 109 samples collected from the Rhine River, Lobith, the Netherlands in 1976 and 1977 at a maximum concentration of 0.29 ppb(2). 2,5-Dichlorophenol was detected in 6 of 6 samples collected from the Isipingo River, South Africa between April 1991 and May 1991 at concentrations ranging from 0.10 to 7.42 ug/L, with an average concentration of 3.1 ug/L(3).

Biologically treated effluent samples from nine Canadian bleached softwood Kraft mills were analyzed for chlorinated phenolic content. Chlorinated phenolics, incl 2,5-dichlorophenol, present in effluent discharged from bleached Kraft mills are not expected to contribute an off odor to recipient waters.

2,5-Dichlorophenol was detected in the effluent downstream from 5% of industrial plants surveyed in England and Wales in 1995 at an average concentration of 3.76 ppb(1). 2,5-Dichlorophenol was detected in the effluent from 5.7% of sewage treatment plants surveyed in England and Wales in 1995 at an average concentration of 0.10 ppb(1). 2,5-Dichlorophenol (combined with 2,4-dichlorophenol) was detected in 12 of 12 samples collected at a sewage treatment plant in Karkola, Finland between September 1989 and November 1990 at an average concentration of 12 ppb(2). 2,5-Dichlorophenol has been detected qualitatively in the effluent from pulp mills in Canada(3).

SEDIMENT: 2,5-Dichlorophenol was detected in 17 of 17 sediment samples collected from Lake Ketelmeer, the Netherlands in 1979 and 1980 with maximum and median concentrations of 11 and 6.3 ug/kg dry sediment weight(1). 2,5-dichlorophenol was detected in 4 of 4 sediment samples collected from the Moselle and Fensch rivers, France in September 1995 at concentrations less than 5 ug/kg dry sediment weight(2). 2,5-Dichlorophenol was detected in 12 of 12 sewage sludge samples collected in the northwest of the U.K. (year unspecified) at concentrations ranging from 0.36 to 8.24 mg/kg dry sludge weight with an average concentration of 2.12 mg/kg(3).

The combined concentrationn of 2,4- and 2,5-dichlorophenol detected in marine worms (Lanice conchilega) collected from the Weser River, Germany estuary bottom in 1977 was 11.8 ng/g wet weight(1).

Workers employed in wood treatment plants, tanneries, textile plants, and pulp and paper mills, as well as pesticide spray operators are potentially at risk from exposure to chlorophenols and to impurities in chlorophenol products. /Chlorophenols/

Dichlorophenols can occur in tap water as a result of standard chlorination treatment(1). Therefore, the general population may be exposed to 2,5-dichlorophenol through oral consumption of or dermal contact with chlorinated tap water(SRC). /Dichlorophenols/

2,5-Dichlorophenol was detected in 980 of 1000 samples of urine collected from adult individuals in the US in 1994 at concentrations ranging from 2.2 to 8700 ppb, with an average concentration of 200 ppb(1); the origin of 2,5-dichlorophenol was believed to be via metabolism of 1,4-dichlorobenzene, which is found in home toilet deoderizers and moth repellents. 2,5-Dichlorophenol was detected in 11 of 20 samples of amniotic fluid collected from adult women in the San Joaquin Valley, California in 2002 at concentrations ranging from 0.37 to 0.43 ug/L, with an average concentration of 0.39 ug/L(2).

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Chemical Treatability of 2,5-Dichlorophenol; Concentration Process: Biological Treatment; Chemical Classification: Phenols; Scale of Study: Laboratory Scale; Type of Wastewater Used: Pure compound (one solute in a solvent); Results of Study: 100% reduction in 38 hours; (Biodegradation by mutant pseudomonas species.)

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Chlorophenols, liquid; Chlorophenols, solid/

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. /Chlorophenols, liquid; Chlorophenols, solid/

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Chlorophenols, liquid; Chlorophenols, solid/

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Chlorophenols, liquid; Chlorophenols, solid/

For more DOT Emergency Guidelines (Complete) data for 2,5-DICHLOROPHENOL (8 total), please visit the HSDB record page.

UN 2020; Chlorophenols, solid

IMO 6.1; Chlorophenol, liquid or solid

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Do not transport with food and feedstuffs. Marine pollutant.

UN Hazard Class: 6.1; UN Pack Group: III