2,5-Diaminotoluene sulfate

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H312: Harmful in contact with skin [Warning Acute toxicity, dermal]

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P261, P264, P270, P271, P272, P273, P280, P301+P316, P302+P352, P304+P340, P317, P321, P330, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement)

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

H312+H332 (39.3%): Harmful in contact with skin or if inhaled [Warning Acute toxicity, dermal; acute toxicity, inhalation]

H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H319 (52.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H373 (52.9%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H400 (50.7%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (14.7%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

H411 (90.1%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P333+P317, P337+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 272 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H411 (100%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Aggregated GHS information provided per 26 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

P264, P264+P265, P270, P301+P316, P305+P351+P338, P321, P330, P337+P317, P405, and P501 (click each P-code to see the statement)

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P260, P261, P264, P270, P271, P272, P273, P280, P301+P316, P302+P352, P304+P340, P317, P319, P321, P330, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement)

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give a slurry of activated charcoal in water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Fires involving this material should be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Use water spray, foam, dry powder, carbon dioxide.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then dampen the solid spill material with toluene, then transfer the dampened material to a suitable container. Use absorbent paper dampened with toluene to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash all contaminated surfaces with toluene followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is mildly irritating to the eyes and skin.

Repeated or prolonged contact may cause skin sensitization.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

NO open flames.

Use local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety goggles.

Do not eat, drink, or smoke during work. Wash hands before eating.

2,5-toluenediamine sulfate is a light tan to light purple powder. (NTP, 1992)

Off-white solid; [HSDB] Light tan to light purple solid; [CAMEO]

Grey to white solid; [ICSC] Light brown powder; [Sigma-Aldrich MSDS]

GREY-TO-WHITE POWDER.

Grey to white powder

Off-white powder

less than 1 mg/mL at 68 °F (NTP, 1992)

In water, 5.03 g/L at 20 °C

Soluble in water and ethanol

In acetone/water 1:1 <1 g/L; in dimethylsulfoxide: 5 to 15 g/L; in ethanol: 1 to 10 g/L

Solubility in water: good

1.366 g/mL at 20 °C

log Kow = 0.74

When heated to decomp it emits very toxic fumes of /nitrogen oxides and sulfur oxides/.

pH = 2.47, 20 °C; saturated aqueous solution

69.7 mN/m at 20 °C, in water

pKa1 = 6.39; pKa2 = 2.77 (calculated)

When heated to decompostion it emits toxic fumes of SOx and NOx

Nitrogen Compounds -> Amines, Aromatic

Cosmetic ingredients (Toluene-2,5-Diamine Sulfate) -> CIR (Cosmetic Ingredient Review)

Hair dyeing

Insoluble in water.

Salts, Acidic

Acidic organic/inorganic salts, such as 2,5-TOLUENEDIAMINE SULFATE, are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

On the basis of the data presented in this report the CIR Expert Panel concludes that toluene-2,5-diamine and toluene-2,5-diamine sulfate are safe as hair dye ingredients in the present practices of use and concentration as described in this safety assessment, but the availaale data are insufficient to support the safety of toluene-3,4 diamine as a hair dye ingredient

Safe for use in cosmetics, with qualifications

Classification of carcinogenicity: 1) evidence in humans: No data; 2) evidence in animals: insufficient. Overall summary evaluation of carcinogenic risk to humans is Group 3: The agent is not classifiable as to its carcinogenicity to humans. /2,5-Diaminotoluene/

2,5-Toluenediamine sulfate

TR-126: Bioassay of 2,5-Toluenediamine Sulfate for Possible Carcinogenicity (CASRN 6369-59-1) (1978 )

06/25/78

No Evidence

Under the conditions of this bioassay, sufficient evidence was not obtained to demostrate the carcinogenicity of 2,5-toluenediamine sulfate in either Fischer 344 rats or B6C3F1 mice.

The substance can be absorbed into the body through the skin and by ingestion.

Redness.

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

1,4-Benzenediamine-2-methyl sulfate

PDF Document

Suggestive evidence of carcinogenic potential

2-Methylbenzene-1,4-diamine sulfate

SCREEN Current

PPRTV Current

LD50 Rat oral 98 mg/kg /oil-in-water emulsion/

LD50 Rat ip 49 mg/kg /in dimethylsulfoxide/

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/Amines and related compounds/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/Amines and related compounds/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/Amines and related compounds/

/HUMAN EXPOSURE STUDIES/ The degree and pattern of hand eczema in hairdresser trainees and hairdressers was compared in Norway. 75 hairdressers affected by hand eczema and 74 hairdresser trainees with or without hand eczema were examined and patch tested with a hairdressers' series and some additional substances from the standard series. 2.7% of the hairdressers affected by hand eczema were test positive to toluene-2,5-diamine sulfate, compared to 0% of the hairdresser trainees.

/HUMAN EXPOSURE STUDIES/ 103 hairdressers (not dermatitis patients) in the Netherlands (96 females and 8 males) were patch tested with a special series including standard allergens and hairdressers' allergens. 2% were positive to toluene-2,5-diamine sulfate, 6% to p-phenylenediamine and 4% to 2-nitro-4-phenylenediamine.

/HUMAN EXPOSURE STUDIES/ In a multi-center study by the German Contact Dermatitis Group (DKG), 178 dermatitis patients (hairdressers) were patch tested with hairdressers' allergens in 11 centers. 18.0% were test positive to toluene-2,5-diamine, 8.4% to toluene-2,5-diamine sulfate, 18.0% to p-phenylenediamine base, 0.6% to resorcinol, 1.1% to 3-aminophenol, 2.2% to p-aminodiphenylamin hydrochloride, 3.4% to 4-aminophenol and 6.2% to o-nitro-p-phenylendiamine.

/HUMAN EXPOSURE STUDIES/ In a multi-center study by the Italian Contact Dermatitis Research Group (GIRDCA), a total of 302 dermatitis patients (hairdressers) (259 females and 43 males) were patch tested with hairdressers' allergens in 9 Italian centers. 13.2% were positive to toluene-2,5-diamine sulfate, 16.6% to p-phenylenediamine base (in 1989-1990), 7.6% to p-phenylenediamine dihydrochloride (in 1985-1988), 7.9% to o-nitro-p-phenylenediamine, 1.3% to resorcinol and 10.6% to p-aminodiphenylamine.

For more Human Toxicity Excerpts (Complete) data for 2,5-DIAMINOTOLUENE SULFATE (10 total), please visit the HSDB record page.

/LABORATORY ANIMALS: Acute Exposure/ The ocular irritancy potential of toluene-2,5-diamine sulfate was studied using the chorioallantoic membrane of 6 freshly fertilized White Leghorn chicken eggs in a Hen's Egg Test Chorioallantoic Membrane (HET-CAM) test. The test material was undiluted (99.9% pure) and was applied to the chorioallantoic membrane and rinsed off with physiological saline after 30 seconds. Texapon ASV 70 (sodium magnesium laurylmyristyl-6-ethoxysulfate) at a concentration of 5% was used as a reference material, as it is defined as moderately irritating to rabbit eyes in vivo. End points of hemorrhage, coagulation, and blood vessel lysis were semi-quantitatively scored at 30 seconds (for the reference material) or 180 seconds (for the test material) after rinsing. The end points were scored as 0, 0, and 0, respectively, for toluene-2,5-diamine sulfate. In the reference material, the end points were 12, 9, and 0, respectively.

/LABORATORY ANIMALS: Acute Exposure/ A 10% concentration of toluene-2,5-diamine sulfate was administered to CFY strain rats (groups of 5 per sex) by oral intubation at doses of 0, 64, 100, 160, or 250 mg/kg of body weight. Treatment-related effects included lethargy, piloerection, ataxia, and increased salivation. Respiratory rates were increased in the 100-mg/kg dose group and decreased in the dose groups above 100 mg/kg. ...Necropsies were performed on the surviving rats. No abnormalities indicative of residual systemic effects were observed.

/LABORATORY ANIMALS: Acute Exposure/ The aim was to assess the skin sensitizing potency in the guinea pig of ten dye intermediates, including toluene-2,5-diamine sulphate, and to compare the results with results from patch testing hair coloring dermatitis patients in Japan. The study was performed by a non-guideline method. Pre-tests were performed by occluded exposure to determine the irritancy threshold. Topical induction was performed by occluded exposure for 48 hours on the nape, 3 times per week for two weeks. Following a 2 week rest period, challenge was performed by occluded exposure for 48 hours on the flank. Readings were made at 24 and 48 hours after removal of the test material. It was reported that 40% of the animals were positive to toluene-2,5-diamine sulfate at challenge with 1%, and 10% at challenge with 0.10%.

/LABORATORY ANIMALS: Acute Exposure/ The skin sensitizing potential of 2-methyl-1,4-benzenediamine sulfate was investigated by measuring the cell proliferation in the draining lymph nodes after topical application on the ear. 25 uL containing 0 (vehicle only), 0.5, 1.5 and 5.0% of the test substance in DMSO were applied to the surface of the ear to each of five mice per group for three consecutive days. p-Phenylenediamine (PPD) at 1% in DMSO was used as the positive control in parallel under identical test conditions. On day 5, the mice received an intravenous injection of 250 uL phosphate buffered saline containing 20 uCi of (3)H-methyl thymidine. Approximately five hours later, the mice were sacrificed by CO2-inhalation and the draining auricular lymph nodes were removed. After preparing a single cell suspension for each mouse, cells were precipitated by TCA and the radioactivity was determined (incorporation of (3)H-methyl thymidine in the pellets) by means of liquid scintillation counting as disintegration per minute (dpm). The mean dpm per treated group was determined and the stimulation index (test item compared to the concurrent vehicle control) was calculated. Mean stimulation indices (SI) of 4.9, 4.2, and 3.7 were obtained for the test concentrations of 0.5, 1.5 and 5%, respectively. No EC3 value was calculated, since all stimulation indices were above 3. The positive control (PPD 1% in DMSO) caused a stimulation index of 10.

For more Non-Human Toxicity Excerpts (Complete) data for 2,5-DIAMINOTOLUENE SULFATE (36 total), please visit the HSDB record page.

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from, as of November 6, 2012: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=6369-59-1]

A bioassay for possible carcinogenicity of 2,5-toluenediamine sulfate was conducted using Fischer 344 rats and B6C3F1 mice. 2,5-Toluenediamine sulfate was administered in the feed, at either of two concentrations, to groups of 50 males and 50 females of each species. The high and low time-weighted average concentrations of the compound were, respectively, 0.2 and 0.06% for rats and 0.1 and 0.6% for mice. Because compound administration to the high and low dose groups of each species was not begun simultaneously, each dosed group was assigned a control group. All control groups consisted of 50 animals, except for the high dose male and female rat control groups which were composed of 25 animals. The dosing period was for 78 weeks, followed by an additional 28 to 31 weeks of observation in rats and an additional 16 to 19 weeks in mice. Under the conditions of this bioassay, sufficient evidence was not obtained to demonstrate the carcinogenicity of 2,5-toluenediamine sulfate in either Fischer 344 rats or B6C3F1 mice. Levels of Evidence of Carcinogenicity: Male Rats: Negative; Female Rats: Negative; Male Mice: Negative; Female Mice: Negative.

The ability of 2,5-toluenediamine sulfate to induce morphological transformation in Syrian golden hamster embryo cells (Cell Transformation Assay) was evaluated prior to and after Simian adenovirus 7 inoculation. 2,5-Toluenediamine was tested in duplicate, at concentrations of 3.13, 6.25, 12.5, 25 or 50ug/ml prior to virus inoculation, resulting in a range of 100% to 25% relative survival (trial I) and 100% to 47% relative survival (trial II). Assays preformed after virus inoculation at concentrations of 1.00, 1.50, 2.24, 3.34 or 5.00ug/ml, resulting in a range of 100% to 23% relative survival. In a second trial, assays performed after virus inoculation at concentrations of 1.00, 1.78, 3.16, 5.62 or 10.0ug/ml, resulting in a range of 100% to 0% relative survival. At least one of the treatments in all four trials produced greater transformation frequencies (p < 0.01) relative to the negative control. A dose-response relationship was also observed.

The ability 2,5-toluenediamine sulfate to induce 6-thioguanine resistant mutants of Chinese hamster ovary (CHO) cells was evaluated in the presence and absence of Aroclor-induced rat liver S9 metabolic activation. Nonactivated cultures were tested at concentrations up to 50ug/mL, and activated cultures were tested at concentrations up to 750ug/mL. Choice of test concentrations and relative growth after treatment were not reported. 2,5-Toluene diamine sulfate produced mutant frequencies greater than the negative control with and without metabolic activation, but a dose-response was not observed.

The mutagenicity of 2,5-toluenediamine sulfate was evaluated in Salmonella tester strains TA98, TA100, TA1535, TA1537 and TA1538 (Ames Test), both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Based on preliminary toxicity determinations, 2,5-toluenediamine sulfate, was tested at concentrations up to 5000ug/plate using the plate incorporation technique. 2,5-Toluenediamine sulfate produced a positive response in tester strains TA98, TA100, TA1537 and TA1538 with metabolic activation, and a clear dose-response was observed.

The effect of 2,5-toluenediamine sulfate (TDS) on testicular DNA synthesis was evaluated in Charles River mice. Animals were sacrificed and testes removed 3.5 hours following administration of test article at 63 mg/kg by intraperitoneal injection in one test and at 32 mg/kg in a second test. In the first test (63 mg/kg) TDS statistically significantly (t-test, p < 0.01) inhibited testicular DNA synthesis as measured by the amount of tritiated thymidine incorporated into DNA of testes homogenates from treated (1.85 dpm/ug) vs control animals (19.09 dpm/ug). In the second test (32 mg/kg), significant inhibition was not observed (p > 0.10).

/OTHER TERRESTRIAL SPECIES/ ...The toxicity of 10 benzamines was tested by the well diffusion assay technique against 18 common bacterial species including the nitrogen-fixing bacterium Azotobacter vinelandii. ... 2,5-Diaminotoluene was inhibitory to the growth of P. fluorescens and Streptococcus mitis. The growth of A. vinelandii was inhibited by p-phenylenediamine and 2,5-diaminotoluene in the well diffusion assay. ... The nitrogenase activity of A. vinelandii was inhibited by p-phenylenediamine, 2,5-diaminotoluene, p-nitroaniline, 2-nitro-p-phenylenediamine, 3-nitro-o-phenylenediamine, and 4-nitro-o-phenylenediamine. Because many of these organisms are common soil and aquatic bacteria, the accumulation of these benzamine compounds in the environment may have an adverse impact on soil biochemical activities. /2,5-diaminotoluene/

5.40e+00

2.30e+01

7.80e-01

5.00e+00

2.20e-04

1.00e-01

3.00e-04

Volatile

4.00e+01

5.70e+01

7.40e+02

1.80e+01

Environmental effects from the substance have not been investigated adequately.

NIOSH (NOES Survey 1981-1983) has statistically estimated that 39,400 workers (32,217 of these were female) were potentially exposed to 2,5-diaminotoluene sulfate in the US(1). Occupational exposure to 2,5-diaminotoluene sulfate may occur through inhalation and dermal contact with this compound at workplaces where 2,5-diaminotoluene sulfate is produced or used. Use data indicate that the general population may be exposed to 2,5-diaminotoluene sulfate via dermal contact with consumer products containing 2,5-diaminotoluene sulfate(SRC).

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Symbol: T, N; R: 20/21-25-43-51/53; S: (1/2)-24-37-45-61

UN Hazard Class: 6.1; UN Pack Group: II