Cyclohexyl acetate

This chemical does not meet GHS hazard criteria for 2.1% (39 of 1843) of reports.

H226 (97.8%): Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1843 reports by companies from 5 notifications to the ECHA C&L Inventory.

Reported as not meeting GHS hazard criteria per 39 of 1843 reports by companies.

There are 4 notifications provided by 1804 of 1843 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H226: Flammable liquid and vapor [Warning Flammable liquids]

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Rest. Refer for medical attention .

INHALATION: Call for medical aid. Remove the victim to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

EYES: Flush immediately with copious amounts of water for at least 15 minutes.

SKIN: Wash immediately with soap and water with copious amounts of water. (USCG, 1999)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Wash skin with soap and water.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]:

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

SMALL FIRE: Dry chemical, CO2, water spray or regular foam. If regular foam is ineffective or unavailable, use alcohol-resistant foam.

LARGE FIRE: Water spray, fog or regular foam. If regular foam is ineffective or unavailable, use alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use dry powder, alcohol-resistant foam, carbon dioxide, water spray. In case of fire: keep drums, etc., cool by spraying with water.

/USE/ FOAM, CARBON DIOXIDE, DRY CHEM...

Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Keep run-off water out of sewers and water sources. Wear positive pressure self-contained breathing apparatus when fighting fires involving this material.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· Consider initial downwind evacuation for at least 300 meters (1000 feet).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

If material not on fire and not involved in fire: keep sparks, flames, and other sources of ignition away; keep material out of water sources and sewers; build dikes to contain flow as necessary; attempt to stop leak if without undue personnel hazard; use water spray to knock-down vapors.

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Fireproof. Separated from strong oxidants.

IN GENERAL, MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS...SHOULD BE STORED IN COOL, WELL-VENTILATED PLACE, OUT OF DIRECT RAYS OF SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD & SHOULD BE PERIODICALLY INSPECTED & MONITORED.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

Small Fire

· Dry chemical, CO2, water spray or regular foam. If regular foam is ineffective or unavailable, use alcohol-resistant foam.

Large Fire

· Water spray, fog or regular foam. If regular foam is ineffective or unavailable, use alcohol-resistant foam.

· Avoid aiming straight or solid streams directly onto the product.

· If it can be done safely, move undamaged containers away from the area around the fire.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C.

The substance is mildly irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. Ingestion of large amounts could cause lowering of consciousness.

The substance defats the skin, which may cause dryness or cracking.

Self-contained breathing apparatus, rubber boots and heavy rubber gloves. (USCG, 1999)

Wear positive-pressure SCBA and protective equipment ... . If special chemical protective clothing is required, consult the chemical manufacturer or specific protective clothing compatibility charts. Delay entry until trained personnel and proper protective equipment are available. Remove patient from contaminated area. Quickly remove and isolate patient's clothing, jewelry, and shoes. Gently blot excess liquids with absorbent material. Rinse patient with warm water, 30 °C/86 °F, if possible. Wash patient with Tincture of Green Soap or a mild liquid soap and large quantities of water.

Wear positive pressure self-contained breathing apparatus.

NO open flames, NO sparks and NO smoking. Above 58 °C use a closed system, ventilation and explosion-proof electrical equipment.

PREVENT GENERATION OF MISTS!

Use ventilation, local exhaust or breathing protection.

Protective gloves.

Wear safety spectacles.

Do not eat, drink, or smoke during work.

Cyclohexyl acetate appears as a colorless liquid. Flash point 136 °F. Slightly less dense than water and insoluble in water. Vapors are much heavier than air and may be narcotic in high concentrations. May emit acrid smoke and irritating fumes when heated to high temperatures. Used as a solvent and in making rubber.

Colorless liquid with a fruity, apple-like odor; [CHEMINFO]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Oily liquid; odour reminiscent of amyl acetate

COLORLESS OILY LIQUID

ODOR REMINISCENT OF AMYL ACETATE

350 °F at 760 mmHg (USCG, 1999)

175.00 to 177.00 °C. @ 760.00 mm Hg

175-177 °C

Freezing point = -65 °C

136 °F (USCG, 1999)

136 °F; 58 °C (Closed cup)

58 °C c.c.

Very soluble in ethyl ether and ethanol.

Solubility in water, g/100ml at 20 °C: 0.2 (slightly soluble)

Insoluble in water; miscible in ether

Miscible at room temperature (in ethanol)

0.966 (USCG, 1999) - Less dense than water; will float

0.968 g/cu cm at 20 °C

Density (at 20 °C): 0.97 g/cm³

Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.02

0.971-0.978

4.9 (AIR= 1)

Relative vapor density (air = 1): 4.9

11.0 [mmHg]

11 mm Hg @ 25 °C

Vapor pressure, kPa at 25 °C: 1.46

2.64 (calculated)

635 °F (335 °C)

WHEN HEATED TO DECOMPOSITION IT EMITS ACRID SMOKE AND IRRITATING FUMES

2.34 mm²/s at 20 °C

ACID VALUE: 0.2 MAX

Index of Refraction = 1.442 at 20 °C/D

1.436-1.443

77 (ETHER= 1)

CONVERSION FACTORS: 1 PPM= 5.8 MG/CU M; 1 MG/L= 156 PPM

CAN REACT WITH OXIDIZING MATERIALS

VAPOR PRESSURE = 7 MM HG @ 30 °C

Boiling point

Dielectric constant

Flammable. Insoluble in water.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

CYCLOHEXANOL ACETATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Exposure mainly occurs via inhalation.

Cough. Sore throat.

Dry skin. Redness.

Redness. Pain.

Drowsiness. Unconsciousness. Further see Inhalation.

Neurotoxin - Acute solvent syndrome

LD50 Rat oral 6.73 g/kg

LD50 Rabbit dermal 10.1 g/kg

For basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Esters and related compounds/

For advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W TKO /SRP: To keep open, "minimal flow rate"/. Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Consider drug therapy for pulmonary edema ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Esters and related cmpds/

EXPOSURE TO 516 PPM...CAUSED SOME IRRITATION OF PHARYNX, LARYNX & CONJUNCTIVA & AS THE ONLY AFTER-EFFECT, A SWEETISH TASTE.

Inhalation exposure of two men to 3 mg/l cyclohexyl acetate for 45 min produced eye and throat irritation, which disappeared soon after exposure ended.

Rabbits exposed to a concn of 700 ppm (4.0 mg/l) cyclohexyl acetate in for 4.8 hr resulted in irritation to nose and eyes, recovery. Exposures to 1700 ppm (10 mg/l) cyclohexyl acetate in for 4.8 hrs resulted in lethal. Cats exposed to 1700 ppm (10 mg/l) cyclohexyl acetate in for 10 hr resulted in deep /SRP: CNS depression and death/. /From table/

...1020-1630 PPM FOR 5 CONSECUTIVE DAYS CAUSED MODERATE IRRITATION OF MUCOUS MEMBRANES, FATIGUE & DROWSINESS BUT WITH COMPLETE RECOVERY /IN CATS & DOGS/.

...ANIMALS ACUTELY INTOXICATED...SHOWED SEVERE IRRITATION OF RESP TRACT & CONGESTION OF LIVER & KIDNEYS...

SYMPTOMS OF INTOXICATION /WERE/ IRRITATION OF EYES & NOSE, RESTLESSNESS, TREMORS, CONVULSIONS, INCOORDINATION FOLLOWED BY /SRP: CNS DEPRESSION/, IF DEEP USUALLY FATAL. IN MICE, SC INJECTION WAS FOLLOWED BY DYSPNEA & PARALYSIS...CHANGES IN THE ORGANISM /WERE/ TRACHEITIS, BRONCHITIS, EDEMA OF LUNGS, HYPEREMIA OF LIVER & KIDNEYS.

For more Non-Human Toxicity Excerpts (Complete) data for CYCLOHEXYL ACETATE (6 total), please visit the HSDB record page.

Environmental effects from the substance have not been investigated adequately.

Cyclohexyl acetate's production and use as a solvent may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 11 mm Hg at 25 °C indicates cyclohexyl acetate will exist solely as a vapor in the ambient atmosphere. Vapor-phase cyclohexyl acetate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 1.4 days. If released to soil, cyclohexyl acetate is expected to have low mobility based upon an estimated Koc of 650. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 1.2X10-4 atm-cu m/mole. Cyclohexyl acetate has the potential to volatilize from dry soil surfaces based upon its vapor pressure. However, adsorption to organic matter is expected to attenuate volatilization from soil surfaces. If released into water, cyclohexyl acetate is expected to adsorb to suspended solids and sediment in water based upon the estimated Koc. Volatilization from water surfaces may be an important fate process based on the estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 12 hours and 7.4 days, respectively. However, adsorption to suspended solids and sediment in the water column is expected to attenuate this process. An estimated BCF of 22 suggests the potential for bioconcentration in aquatic organisms is low. Estimated hydrolysis half-lives of 7.3 years and 270 days at pH values of 7 and 8, respectively, suggest hydrolysis is not expected to be an important process. In general, acetates are expected to be readily biodegradable. Occupational exposure to cyclohexyl acetate may occur through inhalation and dermal contact with this compound at workplaces where cyclohexyl acetate is produced or used. The general population may be exposed to cyclohexyl acetate via ingestion of contaminated drinking water. (SRC)

NOT REPORTED FOUND IN NATURE. /FROM TABLE/

Cyclohexyl acetate's production and use as a solvent(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 650(SRC), determined from an estimated log Kow(2,SRC) and a regression-derived equation(3), indicates that cyclohexyl acetate is expected to have low mobility in soil(SRC). Volatilization of cyclohexyl acetate from moist soil surfaces is expected to be important(SRC) given an estimated Henry's Law constant of 1.2X10-4 atm-cu m/mole(SRC), using a fragment constant estimation method(4). The potential for volatilization of cyclohexyl acetate from dry soil surfaces may exist(SRC) based on a vapor pressure of 11 mm Hg(5). Volatilization from soil surfaces is expected to be attenuated by adsorption to organic matter(SRC). In general, acetates are expected to be readily biodegradable(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 650(SRC), determined from an estimated log Kow of 2.64(2,SRC) and a regression-derived equation(3), indicates that cyclohexyl acetate is expected to adsorb to suspended solids and sediment in water(SRC). Cyclohexyl acetate is expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 1.2X10-4 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Estimated volatilization half-lives for a model river and model lake are 12 hours and 7.4 days, respectively(3,SRC). Adsorption to suspended solids and sediment in the water column is expected to attenuate this process(SRC). The volatilization half-life from a model pond 2 m deep is estimated to be about 5.7 days ignoring adsorption(5); when considering maximum adsorption, the volatilization half-life increases to 17 days(5). According to a classification scheme(6), an estimated BCF of 22(3,SRC), from an estimated log Kow(2,SRC), suggests the potential for bioconcentration in aquatic organisms is low(SRC). In general, acetates are expected to be readily biodegradable(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), cyclohexyl acetate, which has a vapor pressure of 11 mm Hg at 25 °C(2,SRC), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase cyclohexyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.4 days(3,SRC).

The rate constant for the vapor-phase reaction of cyclohexyl acetate with photochemically-produced hydroxyl radicals has been estimated as 1.2X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 1.4 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). A base-catalyzed second-order hydrolysis rate constant of 3.0X10-2 L/mol-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 7.3 years and 270 days at pH values of 7 and 8, respectively(2,SRC).

An estimated BCF of 22 was calculated for cyclohexyl acetate(SRC), using an estimated log Kow of 2.64(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of cyclohexyl acetate is estimated as 650(SRC), using an estimated log Kow of 2.64(1,SRC) and a regression-derived equation(2,SRC). According to a classification scheme(3), this estimated Koc value suggests that cyclohexyl acetate is expected to have low mobility in soil(SRC).

The Henry's Law constant for cyclohexyl acetate is estimated as 1.2X10-4 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that cyclohexyl acetate is expected to volatilize from water surfaces(2,SRC). Based on this Henry's Law constant, the estimated volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 12 hours(2,SRC). The estimated volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 7.4 days(2,SRC). The volatilization half-life from a model pond 2 m deep is estimated to be about 5.7 days ignoring adsorption(3); when considering maximum adsorption, the volatilization half-life increases to 17 days(3). Cyclohexyl acetate's Henry's Law constant(1,SRC) indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of cyclohexyl acetate from dry soil surfaces may exist(SRC) based on a vapor pressure of 11 mm Hg(3).

DRINKING WATER: Cyclohexyl acetate was qualitatively detected in drinking water in Miami, FL, New Orleans, LA, and Philadelphia, PA in 1976(1).

Occupational exposure to cyclohexyl acetate may occur through inhalation and dermal contact with this compound at workplaces where cyclohexyl acetate is produced or used. The general population may be exposed to cyclohexyl acetate via ingestion of contaminated drinking water. (SRC)

Environmental effects from the substance have not been investigated adequately.

Cyclohexyl acetate's production and use as a solvent may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 11 mm Hg at 25 °C indicates cyclohexyl acetate will exist solely as a vapor in the ambient atmosphere. Vapor-phase cyclohexyl acetate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 1.4 days. If released to soil, cyclohexyl acetate is expected to have low mobility based upon an estimated Koc of 650. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 1.2X10-4 atm-cu m/mole. Cyclohexyl acetate has the potential to volatilize from dry soil surfaces based upon its vapor pressure. However, adsorption to organic matter is expected to attenuate volatilization from soil surfaces. If released into water, cyclohexyl acetate is expected to adsorb to suspended solids and sediment in water based upon the estimated Koc. Volatilization from water surfaces may be an important fate process based on the estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 12 hours and 7.4 days, respectively. However, adsorption to suspended solids and sediment in the water column is expected to attenuate this process. An estimated BCF of 22 suggests the potential for bioconcentration in aquatic organisms is low. Estimated hydrolysis half-lives of 7.3 years and 270 days at pH values of 7 and 8, respectively, suggest hydrolysis is not expected to be an important process. In general, acetates are expected to be readily biodegradable. Occupational exposure to cyclohexyl acetate may occur through inhalation and dermal contact with this compound at workplaces where cyclohexyl acetate is produced or used. The general population may be exposed to cyclohexyl acetate via ingestion of contaminated drinking water. (SRC)

NOT REPORTED FOUND IN NATURE. /FROM TABLE/

Cyclohexyl acetate's production and use as a solvent(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 650(SRC), determined from an estimated log Kow(2,SRC) and a regression-derived equation(3), indicates that cyclohexyl acetate is expected to have low mobility in soil(SRC). Volatilization of cyclohexyl acetate from moist soil surfaces is expected to be important(SRC) given an estimated Henry's Law constant of 1.2X10-4 atm-cu m/mole(SRC), using a fragment constant estimation method(4). The potential for volatilization of cyclohexyl acetate from dry soil surfaces may exist(SRC) based on a vapor pressure of 11 mm Hg(5). Volatilization from soil surfaces is expected to be attenuated by adsorption to organic matter(SRC). In general, acetates are expected to be readily biodegradable(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 650(SRC), determined from an estimated log Kow of 2.64(2,SRC) and a regression-derived equation(3), indicates that cyclohexyl acetate is expected to adsorb to suspended solids and sediment in water(SRC). Cyclohexyl acetate is expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 1.2X10-4 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Estimated volatilization half-lives for a model river and model lake are 12 hours and 7.4 days, respectively(3,SRC). Adsorption to suspended solids and sediment in the water column is expected to attenuate this process(SRC). The volatilization half-life from a model pond 2 m deep is estimated to be about 5.7 days ignoring adsorption(5); when considering maximum adsorption, the volatilization half-life increases to 17 days(5). According to a classification scheme(6), an estimated BCF of 22(3,SRC), from an estimated log Kow(2,SRC), suggests the potential for bioconcentration in aquatic organisms is low(SRC). In general, acetates are expected to be readily biodegradable(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), cyclohexyl acetate, which has a vapor pressure of 11 mm Hg at 25 °C(2,SRC), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase cyclohexyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.4 days(3,SRC).

The rate constant for the vapor-phase reaction of cyclohexyl acetate with photochemically-produced hydroxyl radicals has been estimated as 1.2X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 1.4 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). A base-catalyzed second-order hydrolysis rate constant of 3.0X10-2 L/mol-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 7.3 years and 270 days at pH values of 7 and 8, respectively(2,SRC).

An estimated BCF of 22 was calculated for cyclohexyl acetate(SRC), using an estimated log Kow of 2.64(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of cyclohexyl acetate is estimated as 650(SRC), using an estimated log Kow of 2.64(1,SRC) and a regression-derived equation(2,SRC). According to a classification scheme(3), this estimated Koc value suggests that cyclohexyl acetate is expected to have low mobility in soil(SRC).

The Henry's Law constant for cyclohexyl acetate is estimated as 1.2X10-4 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that cyclohexyl acetate is expected to volatilize from water surfaces(2,SRC). Based on this Henry's Law constant, the estimated volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 12 hours(2,SRC). The estimated volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 7.4 days(2,SRC). The volatilization half-life from a model pond 2 m deep is estimated to be about 5.7 days ignoring adsorption(3); when considering maximum adsorption, the volatilization half-life increases to 17 days(3). Cyclohexyl acetate's Henry's Law constant(1,SRC) indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of cyclohexyl acetate from dry soil surfaces may exist(SRC) based on a vapor pressure of 11 mm Hg(3).

DRINKING WATER: Cyclohexyl acetate was qualitatively detected in drinking water in Miami, FL, New Orleans, LA, and Philadelphia, PA in 1976(1).

Occupational exposure to cyclohexyl acetate may occur through inhalation and dermal contact with this compound at workplaces where cyclohexyl acetate is produced or used. The general population may be exposed to cyclohexyl acetate via ingestion of contaminated drinking water. (SRC)

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.

For more DOT Emergency Guidelines (Complete) data for CYCLOHEXYL ACETATE (8 total), please visit the HSDB record page.

UN 2243; Cyclohexyl acetate

IMO 3.3; Cyclohexyl acetate

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Liquid

UN Hazard Class: 3; UN Pack Group: III