hexafluoroacetone

H280 (73.8%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]

H301+H311 (15%): Toxic if swallowed or in contact with skin [Danger Acute toxicity, oral; acute toxicity, dermal]

H301 (62%): Toxic if swallowed [Danger Acute toxicity, oral]

H310 (25.1%): Fatal in contact with skin [Danger Acute toxicity, dermal]

H311 (36.9%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H314 (73.8%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H315 (26.2%): Causes skin irritation [Warning Skin corrosion/irritation]

H318 (40.1%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H330 (98.9%): Fatal if inhaled [Danger Acute toxicity, inhalation]

H360 (46%): May damage fertility or the unborn child [Danger Reproductive toxicity]

H360Fd (15%): May damage fertility; Suspected of damaging the unborn child [Danger Reproductive toxicity]

H370 (25.1%): Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372 (25.1%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P203, P260, P262, P264, P264+P265, P270, P271, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P308+P316, P316, P317, P318, P319, P320, P321, P330, P332+P317, P361+P364, P362+P364, P363, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 187 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H280: Contains gas under pressure; may explode if heated [Warning Gases under pressure]

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H330: Fatal if inhaled [Danger Acute toxicity, inhalation]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P203, P260, P264, P264+P265, P270, P271, P280, P284, P302+P352, P304+P340, P305+P351+P338, P308+P316, P316, P318, P319, P320, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement)

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . ON FROSTBITE: rinse with plenty of water, do NOT remove clothes.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Excerpt from NIOSH Pocket Guide for Hexafluoroacetone:

Eye: FROSTBITE - If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.

Skin: FROSTBITE - If frostbite has occurred, seek medical attention immediately; do NOT rub the affected areas or flush them with water. In order to prevent further tissue damage, do NOT attempt to remove frozen clothing from frostbitten areas. If frostbite has NOT occurred, immediately and thoroughly wash contaminated skin with soap and water.

Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible. (NIOSH, 2024)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· In case of contact with liquefied gas, only medical personnel should attempt thawing frosted parts.

· In case of skin contact with hydrogen fluoride, anhydrous (UN1052), if calcium gluconate gel is available, rinse 5 minutes, then apply gel. Otherwise, continue rinsing until medical treatment is available.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Frostbite - If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.

Skin: Frostbite - Compressed gases may create low temperatures when they expand rapidly. Leaks and uses that allow rapid expansion may cause a frostbite hazard. Wear appropriate personal protective clothing to prevent the skin from becoming frozen.

Breathing: Respiratory support

Excerpt from ERG Guide 125 [Gases - Toxic and/or Corrosive]:

SMALL FIRE: Dry chemical or CO2.

LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Do not get water inside containers. Damaged cylinders should be handled only by specialists.

FIRE INVOLVING TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devices; icing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)

In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep cylinder cool by spraying with water.

HIGHLY DANGEROUS; WHEN HEATED, EMITS HIGHLY TOXIC FUMES. /FLUORINE/

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Many gases are heavier than air and will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· If possible, turn leaking containers so that gas escapes rather than liquid.

· Prevent entry into waterways, sewers, basements or confined areas.

· Do not direct water at spill or source of leak.

· Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material.

· Isolate area until gas has dispersed.

Excerpt from ERG Guide 125 [Gases - Toxic and/or Corrosive]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 2420 datasheet.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 1600 meters (1 mile) in all directions; also, consider initial evacuation for 1600 meters (1 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 1600 meters (1 mile) in all directions; also, consider initial evacuation for 1600 meters (1 mile) in all directions.

Small spill:

- ISOLATE in all directions: 100 m (300 ft)

Large spill:

- ISOLATE in all directions: 1000 m (3000 ft)

- PROTECT people from downwind during DAY time: 0.7 km (0.4 mi)

- PROTECT people from downwind during NIGHT time: 2.7 km (1.7 mi)

- PROTECT people from downwind during DAY time: 11.0+ km (7.0+ mi)

- PROTECT people from downwind during NIGHT time: 11.0+ km (7.0+ mi)

Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Remove gas with fine water spray.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Excerpt from ERG Guide 125 [Gases - Toxic and/or Corrosive]:

Do not touch or walk through spilled material. Stop leak if you can do it without risk. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Do not direct water at spill or source of leak. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Isolate area until gas has dispersed. (ERG, 2024)

Fireproof if in building. Cool.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: ppm)

AEGL 2: Irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape (Unit: ppm)

AEGL 3: Life-threatening health effects or death (Unit: ppm)

NR = Not recommended due to insufficient data

AEGLs Status: Final

0.018 [ppm]

0.20 [ppm]

80 [ppm]

0.1 ppm (0.7 mg/m³)

TWA 0.1 ppm (0.7 mg/m³) [skin]

none See Appendix G

9 ppm (NIOSH, 2024)

9.0 [ppm]

See: 2016-172

0.1 [ppm]

8 hr Time Weighted Avg (TWA): 0.1 ppm, skin. /Hexachloronaphthalene/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /Hexachloronaphthalene/

0.1 ppm as TWA; (skin)

0.1 ppm [1986]

Small Fire

· Dry chemical or CO2.

Large Fire

· Water spray, fog or regular foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Do not get water inside containers.

· Damaged cylinders should be handled only by specialists.

Fire Involving Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Do not direct water at source of leak or safety devices; icing may occur.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

ERPG-1: Not appropriate - one hour exposure limit: 1 = mild transient health effects or objectionable odor [AIHA]

ERPG-2: 1 ppm - one hour exposure limit: 2 = impaired ability to take protective action [AIHA]

ERPG-3: 50 ppm - one hour exposure limit: 3 = life threatening health effects [AIHA]

A harmful concentration of this gas in the air will be reached very quickly on loss of containment.

Hexafluoroacetone is a colorless, toxic, and highly reactive gas. At ambient temperatures, it is likely to generate a considerable amount of vapor. It is an irritant to skin, eyes and mucous membranes and is toxic by ingestion, skin absorption, and inhalation. When heated to high temperatures it emits toxic fluoride fumes. Prolonged exposure of the container to fire or intense heat may cause it to violently rupture and rocket. It is used in the production of other chemicals.

Colorless gas with a musty odor. [Note: Shipped as a liquefied compressed gas.]; [NIOSH]

COLOURLESS GAS WITH CHARACTERISTIC ODOUR.

Colorless gas with a musty odor.

Colorless gas with a musty odor. [Note: Shipped as a liquefied compressed gas.]

COLORLESS GAS

Colorless gas [Note: Shipped as a liquefied compressed gas].

MUSTY ODOR BECOMES ACRID IN PRESENCE OF ACIDIC IMPURITIES

Musty odor.

-18 °F at 760 mmHg (NIOSH, 2024)

-27.4 °C @760 [mm Hg]

-188 °F (NIOSH, 2024)

-125.45 °C @ 101.3 kPa

-125.45 °C

Reacts with water (NIOSH, 2024)

Solubility in water: reaction, releasing heat

1.33 G/ML @ 25 °C (LIQUID)

DENSITY: 1.65 @ 25 °C (LIQUID)

1.33 @25 °C

5.76(relative gas density)

5.76 (NIOSH, 2024) - Heavier than air; will sink (Relative to Air)

Relative vapor density (air = 1): 5.7

5.8 atm (NIOSH, 2024)

5.0 mm Hg @ 25 °C, from experimentally derived coefficients

750 [mm Hg] @-27.6 °C

Log Kow = 1.46

DANGEROUS; WHEN HEATED TO DECOMP, OR ON CONTACT WITH ACID OR ACID FUMES, THEY EMIT HIGHLY TOXIC FUMES. /FLUORIDES/

550 °C. This produces toxic and corrosive fumes. Reacts vigorously with water and moisture. This produces a highly acidic hydrate. Attacks glass and most metals.

21.51 kJ/mol @ -27.28 °C

11.81 eV

HYGROSCOPIC; HIGHLY REACTIVE; REACTS VIGOROUSLY WITH WATER & OTHER SUBSTANCES, RELEASING CONSIDERABLE HEAT

FP: -122 °C

Heat of Formation = 1250 kJ/mol

Schoenflies notation

Boiling point

Chemical bond

Composition

Compressibility

Dielectric constant

Electric dipole moment

Reacts with water or water vapor to form a highly acidic product.

Fluorinated Organic Compounds

Water-Reactive

HEXAFLUOROACETONE is incompatible with the following: Water, acids [Note: Hygroscopic (i.e., absorbs moisture from the air); reacts with moisture to form a highly acidic sesquihydrate.] (NIOSH, 2024).

Water and acids. [Note: Hygroscopic (ie, absorbs moisture from the air); reacts with moisture to form a highly acidic sesquihydrate.]

Water, acids [Note: Hygroscopic (i.e., absorbs moisture from the air); reacts with moisture to form a highly acidic sesquihydrate.]

The substance can be absorbed into the body by inhalation and through the skin.

inhalation, skin absorption, skin and/or eye contact

Cough. Sore throat. Burning sensation. Laboured breathing. Shortness of breath. Symptoms may be delayed.

MAY BE ABSORBED! Redness. Pain. ON CONTACT WITH LIQUID: FROSTBITE.

Redness. Pain.

irritation eyes, skin, mucous membrane, respiratory system; pulmonary edema; liquid: frostbite; In Animals: teratogenic, reproductive effects; kidney injury

Eyes, skin, respiratory system, kidneys, reproductive system

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

LC50 (rat) = 275 ppm/3h

HIGH /ACUTE/ IRRITATION TO SKIN, EYES & MUCOUS MEMBRANES BY INHALATION & POSSIBLY DERMAL ROUTES. HIGH: CAPABLE OF CAUSING DEATH OR PERMANENT INJURY DUE TO EXPOSURES OF NORMAL USE; INCAPACITATING & POISONOUS; REQUIRES SPECIAL HANDLING.

INHALATION EXPOSURES OF RATS INDICATED A 4-HR LETHAL CONCN OF 300 PPM; 200 PPM HFA (GAS) FOR 4 HR PRODUCED INJURY TO THE LIVER, KIDNEY, TESTES & THYMUS; & 100 PPM DAMAGED THE TESTES ONLY. DAILY, 6-HR REPEATED EXPOSURES OF RATS AT 60 PPM RESULTED IN DECREASED SPERMATOGENESIS AFTER 10 EXPOSURES & DECREASED BONE-MARROW ERYTHROPOIESIS AFTER TERMINATION OF EXPOSURE. TESTICULAR REGENERATION WAS STILL INCOMPLETE AT 57 DAYS FOLLOWING A SINGLE, 4-HR EXPOSURE AT 60 PPM HFA.

NINETY DAYS EXPOSURE AT 0.1 PPM RESULTED IN NO GROSS BIOCHEMICAL, HEMATOLOGIC OR HISTOPATHOLOGIC CHANGES IN EITHER RATS OR DOGS, ALTHOUGH THE LUNG WEIGHTS OF THE DOGS EXCEEDED THAT OF THE CONTROLS. AT 1 PPM, REVERSIBLE RENAL DYSFUNCTION IN RATS & INCREASED LUNG WEIGHT IN DOGS OVER THAT OF CONTROLS WAS ALL THAT WAS NOTED OF SIGNIFICANCE, NO HISTOPATHOLOGIC CHANGES. AT 12 PPM, SERIOUS TISSUE DAMAGE OCCURRED; THE RATE OF WEIGHT GAIN, ADRENAL & TESTES WEIGHTS OF MALE RATS, WERE LESS THAN THOSE OF CONTROLS. TRENDS TOWARD INCREASED WEIGHTS OF HEART, STOMACH, LIVER & LUNG WERE OBSERVED. IN ADDITION, THERE WAS EVIDENCE OF A TREND TOWARD LYMPHOCYTOSIS & RENAL DYSFUNCTION. HISTOPATHOLOGICALLY, SEVERE, BUT REVERSIBLE, TESTICULAR DAMAGE, & SLIGHT HYPERPLASIA OF THE SPLEEN, THYMUS, LYMPH NODES & BONE MARROW OCCURRED.

... SEVERE INJURY FROM 12 PPM LEVEL /HAS/ RESULTED IN DOGS; THE TESTES WEIGHT DECREASED, & THE WEIGHTS OF PITUITARY & LUNG INCREASED. DOGS ALSO DEVELOPED NEUTROPHILIA, HYPERGLYCEMIA, HYPOALBUMINERIA, & ANEMIA. AS WITH RATS, THE DOGS DEVELOPED SEVERE, BUT REVERSIBLE, TESTICULAR DAMAGE & SLIGHT HYPOPLASIA OF THE SPLEEN, THYMUS & LYMPH NODES. /FROM 90 DAYS INHALATION/

Testicular degeneration and atrophy were seen in rats given dermal doses of 65, 130, or 260 mg/kg 5 days/wk for 2 wk. These changes were still apparent 14 days after the last dose. They were not produced by a dermal dosage of 13 mg/kg for 14 days. The dose of 13 mg/kg/day HFA was considered a no-observed-effect level (NOEL). The structural changes (testicular atrophy) and altered lipid metabolism correlated well. In these studies, changes in steroidogenesis was due to inhibition in Leydig cells and was not due to a direct or immediate effect of HFA nor by hormonal mediation. HFA (as the sesquihydrate) was applied to the skin of pregnant rats at various dosages on days 6 through 16 of gestation. Maternal toxicity was observed at 90 mg/kg/day. The number of resorptions and live fetuses per litter suggested fetal toxicity at 25 mg/kg with fetal size being reduced at the 5 and 25 mg/kg doses (but not at 1 mg/kg). A small increase in soft tissue and external abnormalities was seen, but a definite teratogenic response could not be concluded. /Sesquihydrate/

For more Non-Human Toxicity Excerpts (Complete) data for 1,1,1,3,3,3-HEXAFLUORO-2-PROPANONE (11 total), please visit the HSDB record page.

During 1,1,1,3,3,3-hexafluoro-2-propanone's production and subsequent use as a chemical intermediate, component of fluoropolymers, as a solvent, and polymer adhesive it may be released to the environment through various waste streams. If released to the atmosphere, 1,1,1,3,3,3-hexafluoro-2-propanone will exist solely in the vapor-phase. In the vapor phase, 1,1,1,3,3,3-hexafluoro-2-propanone is not expected to react significantly with hydroxyl radicals. It may directly photolyze in the atmosphere. Based on an estimated Koc of 150, 1,1,1,3,3,3-hexafluoro-2-propanone should be moderately mobile in soil. In moist soils, 1,1,1,3,3,3-hexafluoro-2-propanone is expected to vigorously react with water producing 1,1,1,3,3,3-hexafluoro-2,2-propanediol, a stable solid hydrate, as well as liquid hydrates. If released to dry soils, 1,1,1,3,3,3-hexafluoro-2-propanone may quickly volatilize based on a vapor pressure of 5 mm Hg at 25 °C. 1,1,1,3,3,3-Hexafluoro-2-propanone on soil surfaces may also photolyze; this compound decomposes under UV irradiation to trifluoromethyl radicals and carbon monoxide. In aquatic systems, 1,1,1,3,3,3-hexafluoro-2-propanone is expected to vigorously react with water producing 1,1,1,3,3,3-hexafluoro-2,2-propanediol, a stable solid hydrate, as well as liquid hydrates. 1,1,1,3,3,3-Hexafluoro-2-propanone is not expected to bioconcentrate in aquatic organisms. (SRC)

1,1,1,3,3,3-Hexafluoro-2-propanone is widely used in the synthesis of polymers, medicinals, agriculture chemicals, and as a component of high-performance fluoropolymers and in the manufacture of the solvent 1,1,1,3,3,3-hexafluoro-2-propanol(1). It is also used as a chemical intermediate for hexafluoroisopropanol, polyacrylates used for textile coating, and polyester coatings for textiles; a solvent for acetal resins and polyamides; and a polymer adhesive(2). During 1,1,1,3,3,3-hexafluoro-2-propanone's production and subsequent use in the above products, it may be released to the environment through various waste streams(SRC).

TERRESTRIAL FATE: An estimated Koc of 150(1,SRC), based on an experimental log Kow(2), indicates that 1,1,1,3,3,3-hexafluoro-2-propanone will have moderate mobility in soil(3,SRC). In moist soils, 1,1,1,3,3,3-hexafluoro-2-propanone is expected to vigorously react with water producing 1,1,1,3,3,3-hexafluoro-2,2-propanediol, a stable solid hydrate as well as liquid hydrates(4,5). If released to dry soils, 1,1,1,3,3,3-hexafluoro-2-propanone may quickly volatilize based on a vapor pressure of 5 mm Hg at 25 °C(6,SRC). 1,1,1,3,3,3-Hexafluoro-2-propanone on soil surfaces may photolyse(SRC); this compound decomposes under UV irradiation to trifluoromethyl radicals and carbon monoxide(7).

AQUATIC FATE: 1,1,1,3,3,3-Hexafluoro-2-propanone is expected to vigorously react with water producing 1,1,1,3,3,3-hexafluoro-2,2-propanediol, a stable solid hydrate as well as liquid hydrates(1,2). This is expected to be a major fate process for 1,1,1,3,3,3-hexafluoro-2-propanone in aquatic systems(SRC). An estimated BCF value of 8(4), based on an experimental log Kow(3), indicates that 1,1,1,3,3,3-hexafluoro-2-propanone should not bioconcentrate in aquatic organisms(SRC).

ATMOSPHERIC FATE: Based on a vapor pressure of 5.0 mm Hg at 25 °C(1,SRC), as extrapolated from experimentally derived coefficients, 1,1,1,3,3,3-hexafluoro-2-propanone will exist solely in the vapor phase(2,SRC). 1,1,1,3,3,3-hexafluoro-2-propanone absorbs in the 220 to 400 nm region with a lambda max of 302 nm(2) and may thus directly photolyse(3,SRC). This compound decomposes under UV irradiation to trifluoromethyl radicals and carbon monoxide(3). The rate constant for the vapor-phase reaction of 1,1,1,3,3,3-hexafluoro-2-propanone with photochemically produced hydroxyl radicals has been estimated to be less than 1X10-16 cu cm/molecule-sec at 25 °C(4,SRC) indicating that 1,1,1,3,3,3-hexafluoro-2-propanone is essentially non-reactive and that degradation via hydroxyl radical reaction is not a major fate process for this compound in the atmosphere(SRC).

1,1,1,3,3,3-Hexafluoro-2-propanone reacts readily with nucleophilic reagents(1). 1,1,1,3,3,3-Hexafluoro-2-propanone reacts vigorously with water(2). In water, this compound forms 1,1,1,3,3,3-hexafluoro-2,2-propanediol, a stable solid hydrate. Further addition of water produces liquid hydrates. With ammonia and primary or secondary amines it forms stable 2,2-amino alcohols(1). 1,1,1,3,3,3-Hexafluoro-2-propanone absorbs in the 220 to 400 nm region with a lambda max of 302 nm(3). This compound decomposes under UV irradiation to trifluoromethyl radicals and carbon monoxide(3). Small amounts of CF3CO radical have also been detected in low temperature flash photolysis(3). The rate constant for the vapor phase reaction of 1,1,1,3,3,3-hexafluoro-2-propanone with photochemically produced hydroxyl radicals has been estimated to be less than 1X10-16 cu cm/molecule-sec at 25 °C(4,SRC); this indicates that 1,1,1,3,3,3-hexafluoro-2-propanone is essentially non-reactive and that degradation via hydroxyl radical reaction is not a major fate process for this compound in the atmosphere(SRC).

A BCF of 8 was calculated for 1,1,1,3,3,3-hexafluoro-2-propanone, using an experimental log Kow of 1.46(1) and a recommended regression-derived equation(2,SRC). This BCF value suggests that 1,1,1,3,3,3-hexafluoro-2-propanone will not bioconcentrate in aquatic organisms(2,SRC).

Based on an experimental log Kow of 1.46(1), the Koc of 1,1,1,3,3,3-hexafluoro-2-propanone is estimated as approximately 150 using a regression-derived equation(2,SRC). According to a suggested classification scheme(3), this estimated Koc value suggests that 1,1,1,3,3,3-hexafluoro-2-propanone has moderate mobility in soil(SRC).

The Henry's Law constant for 1,1,1,3,3,3-hexafluoro-2-propanone is estimated as 3.07X10-3 atm-cu m/mole(1,SRC). This indicates that 1,1,1,3,3,3-hexafluoro-2-propanone will volatilize from water surfaces(2,SRC). This compound's rapid rate of hydrolysis(3) indicates that hydrolysis should preclude volatilization in aquatic environments(SRC).

Exposure to 1,1,1,3,3,3- hexafluoro-2-propanone occurs via inhalation and via skin exposure(1).

During 1,1,1,3,3,3-hexafluoro-2-propanone's production and subsequent use as a chemical intermediate, component of fluoropolymers, as a solvent, and polymer adhesive it may be released to the environment through various waste streams. If released to the atmosphere, 1,1,1,3,3,3-hexafluoro-2-propanone will exist solely in the vapor-phase. In the vapor phase, 1,1,1,3,3,3-hexafluoro-2-propanone is not expected to react significantly with hydroxyl radicals. It may directly photolyze in the atmosphere. Based on an estimated Koc of 150, 1,1,1,3,3,3-hexafluoro-2-propanone should be moderately mobile in soil. In moist soils, 1,1,1,3,3,3-hexafluoro-2-propanone is expected to vigorously react with water producing 1,1,1,3,3,3-hexafluoro-2,2-propanediol, a stable solid hydrate, as well as liquid hydrates. If released to dry soils, 1,1,1,3,3,3-hexafluoro-2-propanone may quickly volatilize based on a vapor pressure of 5 mm Hg at 25 °C. 1,1,1,3,3,3-Hexafluoro-2-propanone on soil surfaces may also photolyze; this compound decomposes under UV irradiation to trifluoromethyl radicals and carbon monoxide. In aquatic systems, 1,1,1,3,3,3-hexafluoro-2-propanone is expected to vigorously react with water producing 1,1,1,3,3,3-hexafluoro-2,2-propanediol, a stable solid hydrate, as well as liquid hydrates. 1,1,1,3,3,3-Hexafluoro-2-propanone is not expected to bioconcentrate in aquatic organisms. (SRC)

1,1,1,3,3,3-Hexafluoro-2-propanone is widely used in the synthesis of polymers, medicinals, agriculture chemicals, and as a component of high-performance fluoropolymers and in the manufacture of the solvent 1,1,1,3,3,3-hexafluoro-2-propanol(1). It is also used as a chemical intermediate for hexafluoroisopropanol, polyacrylates used for textile coating, and polyester coatings for textiles; a solvent for acetal resins and polyamides; and a polymer adhesive(2). During 1,1,1,3,3,3-hexafluoro-2-propanone's production and subsequent use in the above products, it may be released to the environment through various waste streams(SRC).

TERRESTRIAL FATE: An estimated Koc of 150(1,SRC), based on an experimental log Kow(2), indicates that 1,1,1,3,3,3-hexafluoro-2-propanone will have moderate mobility in soil(3,SRC). In moist soils, 1,1,1,3,3,3-hexafluoro-2-propanone is expected to vigorously react with water producing 1,1,1,3,3,3-hexafluoro-2,2-propanediol, a stable solid hydrate as well as liquid hydrates(4,5). If released to dry soils, 1,1,1,3,3,3-hexafluoro-2-propanone may quickly volatilize based on a vapor pressure of 5 mm Hg at 25 °C(6,SRC). 1,1,1,3,3,3-Hexafluoro-2-propanone on soil surfaces may photolyse(SRC); this compound decomposes under UV irradiation to trifluoromethyl radicals and carbon monoxide(7).

AQUATIC FATE: 1,1,1,3,3,3-Hexafluoro-2-propanone is expected to vigorously react with water producing 1,1,1,3,3,3-hexafluoro-2,2-propanediol, a stable solid hydrate as well as liquid hydrates(1,2). This is expected to be a major fate process for 1,1,1,3,3,3-hexafluoro-2-propanone in aquatic systems(SRC). An estimated BCF value of 8(4), based on an experimental log Kow(3), indicates that 1,1,1,3,3,3-hexafluoro-2-propanone should not bioconcentrate in aquatic organisms(SRC).

ATMOSPHERIC FATE: Based on a vapor pressure of 5.0 mm Hg at 25 °C(1,SRC), as extrapolated from experimentally derived coefficients, 1,1,1,3,3,3-hexafluoro-2-propanone will exist solely in the vapor phase(2,SRC). 1,1,1,3,3,3-hexafluoro-2-propanone absorbs in the 220 to 400 nm region with a lambda max of 302 nm(2) and may thus directly photolyse(3,SRC). This compound decomposes under UV irradiation to trifluoromethyl radicals and carbon monoxide(3). The rate constant for the vapor-phase reaction of 1,1,1,3,3,3-hexafluoro-2-propanone with photochemically produced hydroxyl radicals has been estimated to be less than 1X10-16 cu cm/molecule-sec at 25 °C(4,SRC) indicating that 1,1,1,3,3,3-hexafluoro-2-propanone is essentially non-reactive and that degradation via hydroxyl radical reaction is not a major fate process for this compound in the atmosphere(SRC).

1,1,1,3,3,3-Hexafluoro-2-propanone reacts readily with nucleophilic reagents(1). 1,1,1,3,3,3-Hexafluoro-2-propanone reacts vigorously with water(2). In water, this compound forms 1,1,1,3,3,3-hexafluoro-2,2-propanediol, a stable solid hydrate. Further addition of water produces liquid hydrates. With ammonia and primary or secondary amines it forms stable 2,2-amino alcohols(1). 1,1,1,3,3,3-Hexafluoro-2-propanone absorbs in the 220 to 400 nm region with a lambda max of 302 nm(3). This compound decomposes under UV irradiation to trifluoromethyl radicals and carbon monoxide(3). Small amounts of CF3CO radical have also been detected in low temperature flash photolysis(3). The rate constant for the vapor phase reaction of 1,1,1,3,3,3-hexafluoro-2-propanone with photochemically produced hydroxyl radicals has been estimated to be less than 1X10-16 cu cm/molecule-sec at 25 °C(4,SRC); this indicates that 1,1,1,3,3,3-hexafluoro-2-propanone is essentially non-reactive and that degradation via hydroxyl radical reaction is not a major fate process for this compound in the atmosphere(SRC).

A BCF of 8 was calculated for 1,1,1,3,3,3-hexafluoro-2-propanone, using an experimental log Kow of 1.46(1) and a recommended regression-derived equation(2,SRC). This BCF value suggests that 1,1,1,3,3,3-hexafluoro-2-propanone will not bioconcentrate in aquatic organisms(2,SRC).

Based on an experimental log Kow of 1.46(1), the Koc of 1,1,1,3,3,3-hexafluoro-2-propanone is estimated as approximately 150 using a regression-derived equation(2,SRC). According to a suggested classification scheme(3), this estimated Koc value suggests that 1,1,1,3,3,3-hexafluoro-2-propanone has moderate mobility in soil(SRC).

The Henry's Law constant for 1,1,1,3,3,3-hexafluoro-2-propanone is estimated as 3.07X10-3 atm-cu m/mole(1,SRC). This indicates that 1,1,1,3,3,3-hexafluoro-2-propanone will volatilize from water surfaces(2,SRC). This compound's rapid rate of hydrolysis(3) indicates that hydrolysis should preclude volatilization in aquatic environments(SRC).

Exposure to 1,1,1,3,3,3- hexafluoro-2-propanone occurs via inhalation and via skin exposure(1).

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

If ... THERE IS NO FIRE, go directly to the Table of Initial Isolation and Protective Action Distances /(see table below)/ ... to obtain initial isolation and protective action distances. IF THERE IS A FIRE, or IF A FIRE IS INVOLVED, go directly to the appropriate guide /(see guide(s) below)/ and use the evacuation information shown under PUBLIC SAFETY.

Table: Table of Isolation and Protective Action Distances for Hexafluoroacetone [Table#4278]

/GUIDE 125: GASES - CORROSIVE/ Health: TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Vapors are extremely irritating and corrosive. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control may cause pollution.

/GUIDE 125: GASES - CORROSIVE/ Fire or Explosion: Some may burn, but none ignite readily. Vapors from liquefied gas are initially heavier than air and spread along ground. Some of these materials may react violently with water. Cylinders exposed to fire may vent and release toxic and/or corrosive gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket.

/GUIDE 125: GASES - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Many gases are heavier than air and will spread along ground and collect in low or confined areas (sewers, basements, tanks). Keep out of low areas. Ventilate closed spaces before entering.

For more DOT Emergency Guidelines (Complete) data for 1,1,1,3,3,3-HEXAFLUORO-2-PROPANONE (9 total), please visit the HSDB record page.

UN 1082; Hexafluoroacetone

IMO 2.3; Hexafluoroacetone

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Poison Gas Corrosive

UN Hazard Class: 2.3; UN Subsidiary Risks: 8