Methyl Chloride

H220: Extremely flammable gas [Danger Flammable gases]

H351: Suspected of causing cancer [Warning Carcinogenicity]

H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P203, P210, P222, P260, P280, P318, P319, P377, P381, P403, P405, and P501 (click each P-code to see the statement)

H220 (100%): Extremely flammable gas [Danger Flammable gases]

H280 (85.6%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]

H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]

H361 (12.5%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H361f (11.2%): Suspected of damaging fertility [Warning Reproductive toxicity]

H373 (> 99.9%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P203, P210, P222, P260, P280, P318, P319, P377, P381, P403, P405, P410+P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1298 reports by companies from 36 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H360: May damage fertility or the unborn child [Danger Reproductive toxicity]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P203, P210, P222, P260, P261, P264, P270, P271, P280, P304+P340, P308+P316, P317, P318, P319, P321, P377, P381, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

Not Classified

H280: Contains gas under pressure; may explode if heated [Warning Gases under pressure]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

P203, P210, P222, P260, P261, P264, P270, P271, P280, P301+P317, P304+P340, P308+P316, P317, P318, P319, P321, P330, P377, P381, P403, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement)

H340: May cause genetic defects [Danger Germ cell mutagenicity]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

P203, P210, P222, P260, P261, P264, P270, P271, P280, P304+P340, P308+P316, P317, P318, P319, P321, P377, P381, P403, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement)

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P203, P210, P222, P260, P261, P271, P280, P304+P340, P317, P318, P319, P377, P381, P403, P405, and P501 (click each P-code to see the statement)

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: CAUTION: Exposure of skin to compressed gases may result in freezing of the skin. Treatment for frostbite may be necessary. Remove the victim from the source of contamination. IMMEDIATELY wash affected areas gently with COLD water (and soap, if necessary) while removing and isolating all contaminated clothing. Dry carefully with clean, soft towels. If symptoms such as inflammation or irritation develop, IMMEDIATELY call a physician or go to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: This compound is a gas, therefore inhalation is the first route of exposure. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Clothing frozen to the skin should be thawed before being removed.

· In case of contact with liquefied gas, only medical personnel should attempt thawing frosted parts.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Frostbite - If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.

Skin: Frostbite - Compressed gases may create low temperatures when they expand rapidly. Leaks and uses that allow rapid expansion may cause a frostbite hazard. Wear appropriate personal protective clothing to prevent the skin from becoming frozen.

Breathing: Respiratory support

Excerpt from ERG Guide 115 [Gases - Flammable (Including Refrigerated Liquids)]:

DO NOT EXTINGUISH A LEAKING GAS FIRE UNLESS LEAK CAN BE STOPPED. CAUTION: Hydrogen (UN1049), Deuterium (UN1957), Hydrogen, refrigerated liquid (UN1966) and Hydrogen and Methane mixture, compressed (UN2034) will burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.).

SMALL FIRE: Dry chemical or CO2.

LARGE FIRE: Water spray or fog. If it can be done safely, move undamaged containers away from the area around the fire. CAUTION: For LNG - Liquefied natural gas (UN1972) pool fires, DO NOT USE water. Use dry chemical or high-expansion foam.

FIRE INVOLVING TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devices; icing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Shut off supply; if not possible and no risk to surroundings, let the fire burn itself out. In other cases extinguish with water spray. In case of fire: keep cylinder cool by spraying with water. Combat fire from a sheltered position.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Use water spray to cool unopened containers.

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.

For more Fire Fighting Procedures (Complete) data for METHYL CHLORIDE (7 total), please visit the HSDB record page.

Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Many gases are heavier than air and will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· If possible, turn leaking containers so that gas escapes rather than liquid.

· Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material.

· Do not direct water at spill or source of leak.

CAUTION: For LNG - Liquefied natural gas (UN1972), DO NOT apply water, regular or alcohol-resistant foam directly on spill. Use a high-expansion foam if available to reduce vapors.

· Prevent spreading of vapors through sewers, ventilation systems and confined areas.

· Isolate area until gas has dispersed.

CAUTION: When in contact with refrigerated/cryogenic liquids, many materials become brittle and are likely to break without warning.

Excerpt from ERG Guide 115 [Gases - Flammable (Including Refrigerated Liquids)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 800 meters (1/2 mile).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 1600 meters (1 mile) in all directions; also, consider initial evacuation for 1600 meters (1 mile) in all directions. In fires involving Liquefied Petroleum Gases (LPG) (UN1075), Butane (UN1011), Butylene (UN1012), Isobutylene (UN1055), Propylene (UN1077), Isobutane (UN1969), and Propane (UN1978), also refer to the "BLEVE - Safety Precautions" section. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

Large Spill

· Consider initial downwind evacuation for at least 800 meters (1/2 mile).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 1600 meters (1 mile) in all directions; also, consider initial evacuation for 1600 meters (1 mile) in all directions.

· In fires involving Liquefied Petroleum Gases (LPG) (UN1075), Butane (UN1011), Butylene (UN1012), Isobutylene (UN1055), Propylene (UN1077), Isobutane (UN1969), and Propane (UN1978), also refer to the "BLEVE - Safety Precautions" section.

Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. NEVER direct water jet on liquid.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains; Methods and materials for containment and cleaning up: Clean up promptly by sweeping or vacuum.

Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Establish forced ventilation to keep levels below explosive limit. Stop the flow of gas if it can be done safely. If source of leak is a cylinder and the leak cannot be stopped in place, remove leaking cylinder to a safe place in the open air, and repair leak or allow cylinder to empty. Keep this chemical out of confined space, such as a sewer, because of the possibility of explosion, unless the sewer is designed to prevent the buildup of explosive concentrations. It may be necessary to contain and dispose of this chemical as a hazardous waste.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U045, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Methyl chloride is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration.

A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.

For more Disposal Methods (Complete) data for METHYL CHLORIDE (6 total), please visit the HSDB record page.

Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Use explosion-proof equipment. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.

Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Respirators may be used when engineering and work practice controls are not technically feasible, when such controls are in the process of being installed, or when they fail and need to be supplemented. Respirators may also be used for operations which require entry into tanks or closed vessels, and in emergency situations. ...

For more Preventive Measures (Complete) data for METHYL CHLORIDE (11 total), please visit the HSDB record page.

Excerpt from ERG Guide 115 [Gases - Flammable (Including Refrigerated Liquids)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. If possible, turn leaking containers so that gas escapes rather than liquid. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Do not direct water at spill or source of leak. CAUTION: For LNG - Liquefied natural gas (UN1972), DO NOT apply water, regular or alcohol-resistant foam directly on spill. Use a high-expansion foam if available to reduce vapors. Prevent spreading of vapors through sewers, ventilation systems and confined areas. Isolate area until gas has dispersed. CAUTION: When in contact with refrigerated/cryogenic liquids, many materials become brittle and are likely to break without warning. (ERG, 2024)

Fireproof. Ventilation along the floor.

Keep container tightly closed in a dry and well-ventilated place. Contents under pressure. Moisture sensitive. Storage class (TRGS 510): Gases

Store in well-ventilated place controlled below 40 °C. No exposure to direct sunlight. ... Electrical equipment of spark-resistant construction is preferred.

Store separately from all other flammable materials. ... Before entering confined space where this chemical may be present, check to make sure that an explosive concentration does not exist. Methyl chloride must be stored to avoid contact with oxidizers (such as perchlorates, peroxides, chlorates, nitrates, and permanganates) or chemically active metals (such as sodium, potassium, powdered aluminum, zinc, and magnesium), since violent reactions occur. Store in tightly closed containers in a cool, well-ventilated area away from heat and direct sunlight. Sources of ignition, such as smoking and open flames, are prohibited where methyl chloride is used, handled, or stored in a manner that could create a potential fire ot explosion hazard. Wherever methyl chloride is used, handled, manufactured, or stored, use explosion-proof electrical equipment for fittings. Procedures for the handling, use, and storage of cylinders should be in compliance with OSHA 1910.101 and 1910.169, as with the recommendations of the Compressed Gas Association. A regulated, marked area should be established where this chemical is handled, used, or stored in compliance with OSHA Standard 1910.1045.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

· Always wear thermal protective clothing when handling refrigerated/cryogenic liquids.

10.0 [ppm]

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: ppm)

AEGL 2: Irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape (Unit: ppm)

AEGL 3: Life-threatening health effects or death (Unit: ppm)

NR = Not recommended due to insufficient data

AEGLs Status: Final

150 [ppm]

910 [ppm]

3000 [ppm]

Ca See Appendix A

100.0 [ppm], Ceiling(OSHA) = 200 ppm(300 ppm for 5-min peak in any 3 hrs)

100 ppm (210 mg/m³)

200 ppm; 300 ppm (Peak - 5 min in any 3 hrs)

TWA 100 ppm C 200 ppm 300 ppm (5-minute maximum peak in any 3 hours) See Appendix G

2000 ppm ; A potential occupational carcinogen. (NIOSH, 2024)

2000.0 [ppm]

NIOSH considers methyl chloride to be a potential occupational carcinogen.

2000 ppm

Ca [2000 ppm]

See: 74873

50.0 [ppm]

100.0 [ppm]

8 hr Time Weighted Avg (TWA): 50 ppm; 15 min Short Term Exposure Limit (STEL): 100 ppm, skin

A4: Not classifiable as a human carcinogen.

50 ppm as TWA; 100 ppm as STEL; (skin); A4 (not classifiable as a human carcinogen).

50 ppm [1992]

100 ppm [1992]

· DO NOT EXTINGUISH A LEAKING GAS FIRE UNLESS LEAK CAN BE STOPPED.

CAUTION: Hydrogen (UN1049), Deuterium (UN1957), Hydrogen, refrigerated liquid (UN1966) and Hydrogen and Methane mixture, compressed (UN2034) will burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.)

Small Fire

· Dry chemical or CO2.

Large Fire

· Water spray or fog.

· If it can be done safely, move undamaged containers away from the area around the fire.

CAUTION: For LNG - Liquefied natural gas (UN1972) pool fires, DO NOT USE water. Use dry chemical or high-expansion foam.

Fire Involving Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

Methyl chloride appears as a colorless gas with a faint sweet odor. Shipped as a liquid under its vapor pressure. A leak may either be liquid or vapor. Contact with the liquid may cause frostbite by evaporative cooling. Easily ignited. Vapors heavier than air. Can asphyxiate by the displacement of air. Under prolonged exposure to fire or intense heat the containers may rupture violently and rocket. Used to make other chemicals and as a herbicide.

Gas Vapor; CBI; Liquid

Colorless gas with a faint, sweet odor which is not noticeable at dangerous concentrations; Note: Shipped as a liquefied compressed gas; [NIOSH]

COLOURLESS LIQUEFIED GAS.

Colorless gas with a faint, sweet odor which is not noticeable at dangerous concentrations.

Colorless gas with a faint, sweet odor which is not noticeable at dangerous concentrations. [Note: Shipped as a liquefied compressed gas.]

Colorless compressed gas or liquid

Faint sweet ethereal odor

Mild odor

Sweet taste

-11.6 °F at 760 mmHg (NTP, 1992)

-23.7 °C

-24.09 °C @760 [mm Hg]

-143 °F (NTP, 1992)

-97.6 °C

-97.7 °C

-49.9 °F (NTP, 1992)

-45.6 °C

-50 °F (closed cup)

Flammable gas

-49.0 °F

NA (Gas)

Slightly soluble (NTP, 1992)

In water, 5040 mg/L at 25 °C

Solubility at 20 °C (mL/100 mL): benzene 4723, carbon tetrachloride 3756, glacial acetic acid 3679, ethanol 3740; miscible with chloroform, ether

Soluble in ethanol; miscible with ethyl ether, acetone, benzene and chloroform

Solubility in water, g/100ml at 25 °C: 0.5

0.997 at -11.2 °F (USCG, 1999) - Less dense than water; will float

0.911 g/cu cm at 25 °C (pressure > 1 atm)

Bulk density: 7.68 lb/gal at 20 °C

Saturated liquid density: 62.170 lb/cu ft at -20 °F; liquid heat capacity: 0.362 Btu/lb-F at -20 °F; liquid viscosity: 0.320 centipoise at -20 °F; saturated vapor pressure: 67.520 lb/sq in at 65 °F; saturated vapor density: 0.60530 lb/cu ft at 65 °F; ideal gas heat capacity: 0.192 Btu/lb-F at 75 °F

Relative density (water = 1): 0.91

0.997 at -11.2 °F

0.911 @25 °C

1.78(relative gas density)

1.8 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

1.8 (Air = 1)

Relative vapor density (air = 1): 2.47

760 mmHg at -11 °F ; 3672 mmHg at 68 °F (NTP, 1992)

4300 mm Hg at 25 °C

Highly flammable.

Halogenated Organic Compounds

Highly Flammable

METHYL CHLORIDE can react vigorously with oxidizing agents. May react explosively with sodium, potassium, sodium-potassium alloy, magnesium, zinc. Reacts with aluminum powder in the presence of catalytic amounts of aluminum chloride to form pyrophoric trimethylaluminum. When heated to decomposition, it emits highly toxic fumes of chlorine [Bretherick, 5th ed., 1995, p. 176].

Incompatible materials: Strong oxidizing agents, Iron

Contact with chemically active metals such as potassium, powdered aluminum, magnesium and zinc will cause fires and explosions.

Explodes on contact with interhalogens (e.g., bromine, trifluoride, bromine pentafluoride), magnesium and alloys, potassium and alloys, sodium and alloys, zinc. Potentially explosive reaction with aluminum when heated to 152 deg in a sealed container. Mixtures with aluminum chloride + ethylene react exothermically and then explode when pressurized to above 30 bar.

Violent reaction with chemically active metals, such as potassium, powdered aluminum, zinc, and magnesium. Reaction with aluminum trichloride, ethylene. Reacts with water (hydrolizes) to form hydrochloric acid. Attacks many metals in the presence of moisture.

For more Hazardous Reactivities and Incompatibilities (Complete) data for METHYL CHLORIDE (9 total), please visit the HSDB record page.

Chemically-active metals such as potassium, powdered aluminum, zinc & magnesium; water [Note: Reacts with water (hydrolyzes) to form hydrochloric acid.]

CDC-ATSDR Toxicological Profile

IDENTIFICATION AND USE: Methyl chloride is a colorless compressed gas or liquid. Most methyl chloride is used as an intermediate feedstock in silicone fluids, elastomers, and resins. Methyl chloride has been used in timber products processing, as a blowing agent for some polystyrene foams, and as a refrigerant. It was formerly used as an aerosol propellant. As a pesticide, methyl chloride is not registered for current use in the U.S.; but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. HUMAN EXPOSURE AND TOXICITY: The many symptoms of acute exposure include headache, nausea, irritation of the skin and eyes, central nervous system depression, pulmonary edema, hemolysis, chronic intoxication, paresthesia, narcosis, increased risk of spontaneous abortion, intravascular hemolysis, unconsciousness, rapid followed by slow respiration, painful joints, swelling of the extremities, diabetes, aspiration pneumonia, gross hematuria, reduction of blood pH, gastrointestinal injury, upper respiratory tract irritation, depression, fatigue, vertigo, liver damage, blood dyscrasias, acceleration of the pulse, congestion in the head, neurasthenic disorders, digestive disturbances, acoustical and optical delusions, arrhythmias produced by catecholamines, faintness, loss of appetite, hyporeflexia, gross hemoglobinuria, metabolic acidosis, GI hemorrhage, diverticula, kidney damage, lung damage, corneal injury, abdominal pain, increase in salivary gland tumors, cyanosis, convulsions, coma, and death. Deaths have occurred following single severe or repeated prolonged moderate overexposure. Methyl chloride is poisonous intravenously; moderately toxic by ingestion, subcutaneous, and intraperitoneal routes; mildly toxic by inhalation. Most cases of intoxication by methyl chloride have involved concentrations above 500 ppm. After methyl chloride leakage from a refrigerator occurred on board an Icelandic fishing vessel in 1963, many of the crew members were hospitalized due to various neurological symptoms and signs. Follow-up showed increased mortality due to cardiovascular diseases after 47 years. The suicide cases had developed severe depression after the methyl chloride intoxication. Methyl chloride at an atmospheric concentration of 1% (10,000 ppm or 20,700 mg/cu m) was mutagenic to TK6 human lymphoid cells in vitro and caused an increased incidence of sister chromatid exchange and breakage of DNA strands. ANIMAL STUDIES: Exposure of a rabbit's eye to pure methyl chloride gas at room temperature for ninety seconds caused only slight conjunctival hyperemia. CNS depression occurs at 40,000 ppm in rabbits and at 108,600 ppm in cats. Rats and mice were exposed by inhalation to methyl chloride for 6 hr/day for up to 12 days. All male mice exposed to 2000 ppm were dead or moribund by day 2, and all mice in the remaining 2000 ppm groups were moribund by day 5. The principal clinical signs, which were confined to the 5000 and 3500 ppm groups, included severe diarrhea and incoordination of the forelimbs. In rats, lesions observed in tissues examined included vacuolar degeneration of the zona fasciculata of the adrenal glands and degenerative changes in the seminiferous tubules and epididymis. Three of four dogs and both of two monkeys died after 4 weeks and 16 weeks, respectively, after exposure to 500 ppm for 6 hr/day, 6 days/wk. Mice and rats of both sexes were exposed at methyl chloride concentrations of 0, 50, 225 or 1000 ppm for 6 hr/day, 5 days/week for 2 years. A statistically significant increase in both malignant and nonmalignant renal tumors occurred in only the male mice exposed at 1000 ppm. In another two-year inhalation study, male and female rats were exposed to 0, 51, 224 or 997 ppm methyl chloride for 6 hr per day, five days per week. No increase in tumor incidence was reported. Birth defects with retarded development have been observed in rodents. Pregnant mice were exposed via inhalation on days 6-18 of gestation. Exposure at 500 or 750 ppm caused a statistically significant increase in the numbers of cardiac malformations. Exposures at concentrations of 250 or 100 ppm were considered nonteratogenic. Offspring of rats exposed similarly to methyl chloride showed no terata. Methyl chloride is mutagenic to bacteria and induces chromosomal aberrations in plants. It induces DNA damage in mammalian cells in vitro but not in vivo. In cultured mammalian cells, it induces mutations and sister chromatid exchanges and enhances viral cell transformation. Reaction of methyl chloride with glutathione appears to constitute a mechanism of toxication, contrary to the role usually proposed for glutathione in detoxifying xenobiotics.

Methyl chloride

9 x 10 ^-2 mg/m^3

Chloromethane

Volatile Organic Compound (VOC)

Listed as methyl chloride

Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP

The Human Health Assessment Group in EPA's Office of Health and Environmental Assessment has evaluated methyl chloride for carcinogenicity. According to their analysis, the weight-of-evidence for methyl chloride is group C, which is based on limited evidence in animals. No data are available for humans. As a group C chemical, methyl chloride is considered possibly carcinogenic to humans.

Evaluation: There is inadequate evidence for the carcinogenicity of methyl chloride in humans. There is inadequate evidence for the carcinogenicity of methyl chloride in experimental animals. Overall evaluation: Methyl chloride is not classifiable as to its carcinogenicity to humans (Group 3).

A4: Not classifiable as a human carcinogen.

Group 3: Not classifiable as to its carcinogenicity to humans

Volume 41: (1986) Some Halogenated Hydrocarbons and Pesticide Exposures

Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)

Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Part 1, Part 2, Part 3)

The substance can be absorbed into the body by inhalation and through the skin.

inhalation, skin and/or eye contact (liquid)

Staggering gait. Dizziness. Headache. Nausea. Vomiting. Convulsions. Unconsciousness.

MAY BE ABSORBED! ON CONTACT WITH LIQUID: FROSTBITE.

See Skin.

dizziness, nausea, vomiting; visual disturbance, stagger, slurred speech, convulsions, coma; liver, kidney damage; liquid: frostbite; reproductive, teratogenic effects; [potential occupational carcinogen]

Hepatic (Liver), Neurological (Nervous System), Renal (Urinary System or Kidneys), Reproductive (Producing Children)

central nervous system, liver, kidneys, reproductive system

[in animals: lung, kidney & forestomach tumors]

Neurotoxin - Acute solvent syndrome

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

ACGIH Carcinogen - Not Classifiable.

An ADI of 0.54 mg/kg/day (37.8 mg/day) for a 70-kg human ... was derived by U.S. EPA (1982). The Reference Dose (RfD) of 0.0036 mg/kg/day ... supercedes the previously calculated ADI.

3 mg/m^3

PDF Document

Inadequate information to assess carcinogenic potential

HEAST Archive

ATSDR Final

IRIS Current

PPRTV Current

LC50 (rat) = 5,300 mg/m3/4H

LC50 Mouse inhalation 6300 mg/cu m/7 hr

LC50 Mouse (male) inhalation 4600 mg/cu m/6 hr

Toxicity Threshold (Cell Multiplication Inhibition Test) Entosiphon sulcatum (protozoa) 8000 mg/L

Toxicity Threshold (Cell Multiplication Inhibition Test) Scenedesmus quadricauda (green algae) 1450 mg/L

Toxicity Threshold (Cell Multiplication Inhibition Test) Microcystis aeruginosa (algae) 550 mg/L

LC50; Species: Lepomis macrochirus (/Bluegill)/; Conditions: static bioassay in fresh water at 23 °C, mild aeration applied after 24 hr; Concentration: 550 ppm for 96 hr

For more Ecotoxicity Values (Complete) data for METHYL CHLORIDE (6 total), please visit the HSDB record page.

1.10e+02

4.60e+02

9.40e+01

3.90e+02

1.90e+02

8.0E+01(G)

4.90e-02

9.00e-02

Volatile

1.32e+03

3.30e+02

1.40e+03

2.80e+02

1.20e+03

5.60e+02

8.0E+01 (G)

Methyl chloride's production and use as chemical intermediate may result in its release to the environment through various waste streams. It is estimated that up to 99% of methyl chloride released to the environment is from natural sources, such as the oceans or from combustion of grass, wood, charcoal, and coal. If released to air, a vapor pressure of 4,300 mm Hg at 25 °C indicates methyl chloride will exist solely as a vapor in the atmosphere. Gas-phase methyl chloride will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 445 days. Methyl chloride does not absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, methyl chloride is expected to have very high mobility based upon an estimated Koc of 13. Volatilization from moist soil surfaces is expected to be an important fate process based upon a Henry's Law constant of 8.82X10-3 atm-cu m/mole. Methyl chloride is expected to volatilize from dry soil surfaces based upon its vapor pressure. Utilizing the Japanese MITI test, 1% of the Theoretical BOD was reached in 4 weeks, indicating that biodegradation is not an important environmental fate process in soil or water. However, a 77% biodegradation in 28 days using OECD Guideline 301D suggests methyl chloride can biodegrade readily under certain conditions. Overall, methyl chloride is not considered readily biodegradable, but it can be degraded by adapted bacteria and under anaerobic conditions. If released into water, methyl chloride is not expected to adsorb to suspended solids and sediment in water based upon the estimated Koc. Methyl chloride has been shown to biodegrade in environmental waters. Volatilization from water surfaces is expected to be an important fate process based upon this compound's Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 2.1 hours and 2.8 days, respectively. An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. The hydrolysis half-life is 0.93 yr at pH 7 and 25 °C. Occupational exposure to methyl chloride may occur through inhalation and dermal contact with this compound at workplaces where methyl chloride is produced or used. Monitoring data indicate that the general population may be exposed to methyl chloride via inhalation of ambient air and tobacco smoke, ingestion of contaminated drinking water, and dermal contact with seawater containing methyl chloride. (SRC)

Methyl chloride is a natural and ubiquitous constituent of the oceans and atmosphere(1). Major sources of release of methyl chloride to the air include tropical plants, wood-rotting fungi, and soil from wood-rotting fungi(1). It is estimated that up to 99% of methyl chloride released to the environment is from natural sources, such as chemical reactions that occur in the oceans or chemical reactions that occur from combustion of grass, wood, charcoal, and coal(1,2). Millions of kilograms of methyl chloride are produced naturally every day, primarily in the oceans(3). Methyl chloride is produced in seawater by the reaction of methyl iodide, which is produced photosynthetically by several marine organisms, with chloride ions(4). For the eastern Pacific, the mean ocean air flux of 13X10-7 g/sq cm-yr when extrapolated to global waters provide an adequate source to explain the atmospheric reservoir of methyl chloride(5). Methyl chloride is released to the atmosphere from forest fires, brush fires, back yard burning and volcanoes(6-8). Agricultural slash burning is believed to be a source of high levels of methyl chloride in the Amazon and China, the latter specifically from rice agriculture(9). The estimated 0.6 g of methyl chloride per kg vegetation burned is believed to have an impact on the global burden of methyl chloride(6). Plant volatiles from cedar and cypress include methyl chloride(10). Methyl chloride has been identified as a chemical component of tobacco plants(11). Various species of Antarctic macroalgae have been found to produce and release methyl chloride at levels of 1.98 pmol/g (wet wt) per day(2).

Methyl chloride's production and use as an chemical intermediate(1) may result in its release to the environment through various waste streams(SRC). It is released in tobacco smoke and turbine exhaust(2) and can be released from very old refrigeration equipment that used methyl chloride as a refrigerant(3). Coal combustion is thought to contribute to high levels of methyl chloride in parts of China(4). Methyl chloride may be formed in the chlorination of drinking water and sewage effluent(5).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 13(SRC), determined from a structure estimation method(2), indicates that methyl chloride is expected to have very high mobility in soil(SRC). Volatilization of methyl chloride from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 8.82X10-3 atm-cu m/mole(3). Methyl chloride is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 4300 mm Hg at 25 °C(4). Utilizing the Japanese MITI test, 1% of the Theoretical BOD was reached in 4 weeks(5) indicating that biodegradation is not an important environmental fate process in soil(SRC). However, a 77% biodegradation in 28 days using OECD Guideline 301D(6) suggests methyl chloride can biodegrade readily under certain conditions. Methyl chloride has been shown to biodegrade in soil microcosms(8) and in environmental waters(6,7). Overall, methyl chloride is not considered readily biodegradable, but it can be degraded by adapted bacteria and under anaerobic conditions(7).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 13(SRC), determined from an estimation method(2), indicates that methyl chloride is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 8.82X10-3 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2.1 hours and 2.8 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of 0.91(6) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low. Utilizing the Japanese MITI test, 1% of the Theoretical BOD was reached in 4 weeks(5) indicating that biodegradation is not an important environmental fate process in water(SRC). However, a 77% biodegradation in 28 days using OECD Guideline 301D(8) suggests methyl chloride can biodegrade readily under certain conditions. Methyl chloride has been shown to biodegrade in environmental waters(8,9). Overall, methyl chloride is not considered readily biodegradable, but it can be degraded by adapted bacteria and under anaerobic conditions(9). The half-life for the hydrolysis of methyl chloride is 0.93 yr at pH 7 and 25 °C(10); the rate is independent of pH below pH 10(10).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methyl chloride, which has a vapor pressure of 4300 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Gas-phase methyl chloride is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 445 days(SRC), calculated from its rate constant of 3.6X10-14 cu cm/molecule-sec at 25 °C(3). Methyl chloride does not absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight in the troposphere(SRC). The dominant loss mechanism for methyl chloride in the troposphere may be upward diffusion although washout by rain may have some importance(5). From the tropopause to about 30 km, both upward diffusion and reaction with hydroxyl radicals may have approximately equal importance, and above 30 km in the stratosphere diffusion, reaction with hydroxyl radicals, and direct photolysis may have approximately equal weight(5). The surface half-life resulting from upward diffusion is about 80 days(5).

AEROBIC: Methyl chloride, present at 3.79-19.2 mg/L, reached 1% of its theoretical BOD in 4 weeks using an activated sludge inoculum concentration of 1 drop/L in the Japanese MITI test(1). Using OECD Guideline 301D (Ready Biodegradability: Closed Bottle Test) with an activated sludge inoculum, methyl chloride (at 3 mg/L) reached 77% degradation after 28 days of incubation(2). Direct measurements of methyl chloride degradation in coastal seawater from Nova Scotia indicated that loss of methyl chloride was due to microbial activity(3). Strains of bacteria isolated from terrestrial, freshwater, estuarine and marine environments have been shown to be capable of biodegrading methyl chloride(2,4). Methyl chloride was biodegraded in a soil microcosm(5).

ANAEROBIC: Chlorinated methanes released 50-70% of bound Cl when incubated anaerobically for 4-5 days with arable soil or sewage sludge(1). A half-life of <11 days in groundwater was reported using a simulated spill site laboratory test(2). Municipal landfill leachate was collected from a site in Guelph, Ontario, Canada and stored at ambient temperature(3); over a period of four months, methyl chloride decreased from an initial concentration of 60 ug/L to 9 ug/L(3). In lysimeter studies using this same leachate, 3 ug/L methyl chloride was added and none was detected in a 14-day breakthrough effluent(3).

The rate constant for the vapor-phase reaction of methyl chloride with photochemically-produced hydroxyl radicals is 3.6X10-14 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 445 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(2). Aliphatic halides hydrolyze in water by neutral and base catalyzed reactions to give the corresponding alcohol(3). The half-life for the hydrolysis of methyl chloride, extrapolated from data obtained at higher temperatures, is 0.93 yr at pH 7 and 25 °C(3); the rate is independent of pH below pH 10(3). Calculated values of the half-life of methyl chloride in water have been reported to be 88, 14, and 2.5 yr at 0, 10, and 20 °C, respectively(4). Methyl chloride was reported to hydrolyze (9X10-5/hr) in less than 6 months at 25 °C(5). In the stratosphere, photodissociation will occur at a rate approximately equal to its reaction with hydroxyl radicals(6).

An estimated BCF of 3 was calculated for methyl chloride in fish(SRC), using a log Kow of 0.91(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for methyl chloride can be estimated to be 13(SRC). According to a classification scheme(2), this estimated Koc value suggests that methyl chloride is expected to have very high mobility in soil.

The Henry's Law constant for methyl chloride is 8.82X10-3 atm-cu m/mole(1). This Henry's Law constant indicates that methyl chloride is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 2.1 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 2.8 days(SRC). Methyl chloride's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Methyl chloride is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 4,300 mm Hg at 25 °C(3).

The volatilization half-life for 1 ppm methyl chloride from a stirred beaker 6.5 cm deep is 27.6 min(1) which converts to a half-life at a 1 m depth of 7.1 hr(SRC). According to a mathematical model, the cumulative volatilization loss of methyl chloride during the first year after placement 1 m beneath the ground, assuming no water evaporation, is 66.9% and 22.3% for sandy and clay soil, respectively(2). When the buried methyl chloride is subject to 0.1 cm/day of steady upward water flow (water evaporation) the cumulative loss at the end of a year is 77.0% for sandy soil and 42.7% for clay soil(SRC).

GROUNDWATER: Methyl chloride was detected, not quantified, in 11 of 20 groundwaters underlying municipal solid waste landfills in MN(1). Methyl chloride was detected in groundwater from 2 of 9 sites in Managua, Nicaragua (1990, 1992 dates) at levels of 513 and 72.1 ug/L (detection limit of 3.6 ug/L)(2). Samples of an alluvial aquifer collected beneath Denver CO in 1993 had positive methyl chloride detections in about 7% of all samples with a maximum level of 0.6 ug/L(3). Methyl chloride was detected in 4% of 214 groundwater samples collected in industrial areas of Taiwan between 1994-1994(4). A US Geological Survey analysis for VOCs in drinking water from domestic wells sampled during 1985-2002 detected methyl chloride in 117 of 1207 total well samples(5). As part of the National Water-Quality Assessment Program of the USGS, groundwater samples collected from 2948 wells between 1985 and 1995 were analyzed for VOCs(6); methyl chloride was detected in 1.1% of urban wells at levels of 0.2-0.8 ug/L(6); methyl chloride was detected in 0.4% of rural wells at levels of 0.2-20 ug/L(6). Monitoring wells sampled between 1996-1998 in southern New Jersey (95 total wells) had about 14% positive methyl chloride detections (0.254 ug/L method reporting level)(7).

DRINKING WATER: Treated water from 30 Canadian potable water treatment facilities was analyzed and 2 samples were positive for methyl chloride with a mean concentration of 5 ppb(1). A drinking water well in Maine reported in a Council on Environmental Quality survey of contaminated drinking water from groundwater sources reported a maximum methyl chloride level of 44 ppb(2); highest reported concentration of methyl chloride in surface water derived drinking water was 12 ppb(2). Methyl chloride was identified, but not quantified in drinking water in New Orleans, Cincinnati, Miami, Philadelphia, and Ottumwa, IA of 10 cities surveyed(3). Methyl chloride was not detected (detection limit = 0.1 ppb) in treated water at 10 water treatment plants (42 samples) using Great Lakes water(4).

DRINKING WATER: The USEPA Unregulated Contaminant Monitoring Rule (UCMR3) program monitors for 30 contaminants (including methyl chloride) in PWSs (public water systems)(1). All PWSs serving more than 10,000 people and 800 representative PWSs serving 10,000 or fewer people were monitored beginning in January 2013. The April 2016 Data Summary reports that 4,850 systems contained methyl chloride, one of which was at or above the minimum reporting level of 0.2 ug/L(2).

SURFACE WATER: 895 stations in the USEPA STORET data base had 1.4% positive methyl chloride detections with a median concentration of <10 ppb(1). Raw water from 30 Canadian potable water treatment facilities had 1 sample positive, mean concentration <5 ppb(2). Methyl Chloride was detected in the Niagara River and the open water of Lake Ontario(3). It was not detected (detection limit= 0.1 ppb) in raw water at 10 water treatment plants (42 samples) using Great Lakes water(4).

SEAWATER: Seawater has been found to contain 5.9-21X10-9 mL methyl chloride gas/mL seawater(1). Methyl chloride was detected in the Pacific Ocean at 26.8 parts per trillion at surface, 3.3 parts per trillion at 300 m depth(2). Methyl chloride was detected at Point Reyes, CA (nearshore) at 1200 parts per trillion(3). Methyl chloride was detected in the Eastern Pacific surface water (latitude 29 deg N to -29 deg S) at 6.3-42 parts per trillion, 11.5 parts per trillion mean(4).

1298 stations in the USEPA STORET data base had 3.5% positive detections for methyl chloride with a median concentration of <10 ppb(1). Methyl chloride was detected in 1 of 5 leachates from municipal waste landfills in Wisconsin at 170 ppb and detected, not quantified in 4 of 6 leachates from municipal landfills in Minnesota(2). Methyl chloride has been detected in treated wastewater from the following industries (industry (mean concentration)): pharmaceutical manufacturing (2000 ppb), organic chemical manufacturing/plastics (0.1 ppb), timber products processing (140 ppb) and raw wastewater from metal finishing (610 ppb)(3). Ratios of methyl chloride (ppmv) to carbon dioxide (1X10-6 ppmv) in wood smoke ranged from 0.66 to 2.63(4). In a comprehensive survey of wastewater from 4000 industrial and publicly owned treatment works (POTWs) sponsored by the Effluent Guidelines Div of the US EPA, methyl chloride was identified in discharges of the following industrial categories (frequency of occurrence, median concentration in ppb): nonferrous metals (1; 21.6), paint and ink (2; 4128.7), printing and publishing (1; 6.0), organics and plastics (1; 156.7), pharmaceuticals (1; 2558.3), organic chemicals (3; 49.0)(5); the highest effluent concentration was 4194 ppb in the paint and ink industry(5). Methyl chloride has been detected in anhydrous volcanic gases from various locations at levels ranging from 0.61 to 84 ppbv(6). Field studies conducted between June 1998 and June 1999 at two southern California coastal salt marshes reported a daily flux release of methyl chloride of up to 570 umol/sq m-day(7).

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U045, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Methyl chloride is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration.

A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.

For more Disposal Methods (Complete) data for METHYL CHLORIDE (6 total), please visit the HSDB record page.

/GUIDE 115 GASES - FLAMMABLE (Including Refrigerated Liquids)/ Fire or Explosion: EXTREMELY FLAMMABLE. Will be easily ignited by heat, sparks or flames. Will form explosive mixtures with air. Vapors from liquefied gas are initially heavier than air and spread along ground. CAUTION: Hydrogen (UN1049), Deuterium (UN1957), Hydrogen, refrigerated liquid (UN1966) and Methane (UN1971) are lighter than air and will rise. Hydrogen and Deuterium fires are difficult to detect since they burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.) Vapors may travel to source of ignition and flash back. Cylinders exposed to fire may vent and release flammable gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket.

/GUIDE 115 GASES - FLAMMABLE (Including Refrigerated Liquids)/ Health: Vapors may cause dizziness or asphyxiation without warning. Some may be irritating if inhaled at high concentrations. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire may produce irritating and/or toxic gases.

/GUIDE 115 GASES - FLAMMABLE (Including Refrigerated Liquids)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Many gases are heavier than air and will spread along ground and collect in low or confined areas (sewers, basements, tanks). Keep out of low areas.

/GUIDE 115 GASES - FLAMMABLE (Including Refrigerated Liquids)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. Always wear thermal protective clothing when handling refrigerated/cryogenic liquids.

For more DOT Emergency Guidelines (Complete) data for METHYL CHLORIDE (8 total), please visit the HSDB record page.

UN 1063; Methyl chloride

IMO 2.1; Methyl chloride

49 057 61; Methyl chloride

49 201 05; Methyl chloride and chloropicrin mixtures

49 057 64; Methyl chloride and methylene chloride

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. Methyl chloride is included on the dangerous goods list.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. Methyl chloride is included on the dangerous goods list.

Flammable Gas

Symbol: F+, Xn; R: 12-40-48/20; S: (2)-9-16-33

UN Hazard Class: 2.1