Vinyl Fluoride

H220 (100%): Extremely flammable gas [Danger Flammable gases]

H280 (100%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]

H341 (45.6%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H350 (45.6%): May cause cancer [Danger Carcinogenicity]

H373 (45.6%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P203, P210, P222, P260, P280, P318, P319, P377, P381, P403, P405, P410+P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 114 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H220: Extremely flammable gas [Danger Flammable gases]

H231: May react explosively even in the absence of air at elevated pressure and/or temperature [Danger Flammable gases]

H280: Contains gas under pressure; may explode if heated [Warning Gases under pressure]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H350: May cause cancer [Danger Carcinogenicity]

P203, P210, P222, P261, P271, P280, P304+P340, P318, P319, P337, P377, P381, P403, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement)

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P203, P210, P222, P260, P261, P271, P280, P304+P340, P318, P319, P377, P381, P403, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement)

H350i: May cause cancer by inhalation [Danger Carcinogenicity]

P203, P280, P318, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Artificial respiration may be needed.

Rinse and then wash skin with water and soap. ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer immediately for medical attention.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Excerpt from NIOSH Pocket Guide for Vinyl fluoride:

Eye: FROSTBITE - If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.

Skin: FROSTBITE - If frostbite has occurred, seek medical attention immediately; do NOT rub the affected areas or flush them with water. In order to prevent further tissue damage, do NOT attempt to remove frozen clothing from frostbitten areas. If frostbite has NOT occurred, immediately and thoroughly wash contaminated skin with soap and water.

Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible. (NIOSH, 2024)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· In case of contact with liquefied gas, only medical personnel should attempt thawing frosted parts.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Frostbite - If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.

Skin: Frostbite - Compressed gases may create low temperatures when they expand rapidly. Leaks and uses that allow rapid expansion may cause a frostbite hazard. Wear appropriate personal protective clothing to prevent the skin from becoming frozen.

Breathing: Respiratory support

Excerpt from ERG Guide 116 [Gases - Flammable (Unstable); polymerization hazard]:

DO NOT EXTINGUISH A LEAKING GAS FIRE UNLESS LEAK CAN BE STOPPED.

SMALL FIRE: Dry chemical or CO2.

LARGE FIRE: Water spray or fog. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devices; icing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Shut off supply; if not possible and no risk to surroundings, let the fire burn itself out. In other cases extinguish with powder, carbon dioxide. In case of fire: keep cylinder cool by spraying with water.

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. /Vinyl fluoride, stabilized/

Evacuation: If fire becomes uncontrollable or container is exposed to direct flame - consider evacuation of one-half (1/2) mile radius. /Vinyl fluoride, stabilized/

In case of fire: Shut off supply; if not possible and no risk to surroundings, let the fire burn itself out; in other cases extinguish with powder, carbon dioxide. In case of fire: keep cylinder cool by spraying with water. ... NEVER direct water jet on liquid ...

Vapor is heavier than air and may travel considerable distance to a source of ignition and flash back.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Many gases are heavier than air and will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Stop leak if you can do it without risk.

· Do not touch or walk through spilled material.

· Do not direct water at spill or source of leak.

· Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material.

· If possible, turn leaking containers so that gas escapes rather than liquid.

· Prevent entry into waterways, sewers, basements or confined areas.

· Isolate area until gas has dispersed.

Excerpt from ERG Guide 116 [Gases - Flammable (Unstable); polymerization hazard]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 800 meters (1/2 mile).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 1600 meters (1 mile) in all directions; also, consider initial evacuation for 1600 meters (1 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

Large Spill

· Consider initial downwind evacuation for at least 800 meters (1/2 mile).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 1600 meters (1 mile) in all directions; also, consider initial evacuation for 1600 meters (1 mile) in all directions.

Evacuate danger area! Consult an expert! Ventilation. NEVER direct water jet on liquid. Personal protection: self-contained breathing apparatus. Remove fumes with fine water spray. Do NOT wash away into sewer.

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": HEPA (high-efficiency particulate arrestor) filters ... can be disposed of by incineration. For spent charcoal filters, the adsorbed material can be stripped off at high temp & carcinogenic wastes generated by this treatment conducted to & burned in an incinerator. ... LIQUID WASTE: ... Disposal should be carried out by incineration at temp that ... ensure complete combustion. SOLID WASTE: Carcasses of lab animals, cage litter & misc solid wastes ... should be disposed of by incineration at temp high enough to ensure destruction of chem carcinogens or their metabolites. /Chemical Carcinogens/

For more Disposal Methods (Complete) data for VINYL FLUORIDE (6 total), please visit the HSDB record page.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors. /Vinyl fluoride, stabilized/

Personnel protection: Avoid breathing vapors. Keep upwind. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Approach fire with caution. /Vinyl fluoride, stabilized/

Evacuation: If material leaking (not on fire) consider evacuation downwind area based on amount of material spilled, location and weather conditions. /Vinyl fluoride, stabilized/

For more Preventive Measures (Complete) data for VINYL FLUORIDE (14 total), please visit the HSDB record page.

Excerpt from ERG Guide 116 [Gases - Flammable (Unstable); polymerization hazard]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Stop leak if you can do it without risk. Do not touch or walk through spilled material. Do not direct water at spill or source of leak. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Isolate area until gas has dispersed. (ERG, 2024)

Fireproof. Separated from strong oxidants. Cool. Store only if stabilized.

PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

570 [ppm]

6200* [ppm]

37000*** [ppm]

TWA 1 ppm C 5 ppm [use 1910.1017]

See: IDLH INDEX

1.0 [ppm]

8 hr Time Weighted Avg (TWA): 1ppm.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

A2; Suspected human carcinogen.

1 ppm as TWA; A2 (suspected human carcinogen)

1 ppm [1996]

· DO NOT EXTINGUISH A LEAKING GAS FIRE UNLESS LEAK CAN BE STOPPED.

Small Fire

· Dry chemical or CO2.

Large Fire

· Water spray or fog.

· If it can be done safely, move undamaged containers away from the area around the fire.

Fire Involving Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Do not direct water at source of leak or safety devices; icing may occur.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

A harmful concentration of this gas in the air will be reached very quickly on loss of containment.

The liquid may cause frostbite. The substance may cause effects on the central nervous system.

This substance is probably carcinogenic to humans.

Excerpt from NIOSH Pocket Guide for Vinyl fluoride:

Skin: FROSTBITE - Compressed gases may create low temperatures when they expand rapidly. Leaks and uses that allow rapid expansion may cause a frostbite hazard. Wear appropriate personal protective clothing to prevent the skin from becoming frozen.

Eyes: FROSTBITE - Wear appropriate eye protection to prevent eye contact with the liquid that could result in burns or tissue damage from frostbite.

Wash skin: No recommendation is made specifying the need for washing the substance from the skin (either immediately or at the end of the work shift).

Remove: WHEN WET (FLAMMABLE) - Work clothing that becomes wet should be immediately removed due to its flammability hazard (i.e., for liquids with a flash point <100 °F).

Change: No recommendation is made specifying the need for the worker to change clothing after the workshift.

Provide: FROSTBITE WASH - Quick drench facilities and/or eyewash fountains should be provided within the immediate work area for emergency use where there is any possibility of exposure to liquids that are extremely cold or rapidly evaporating. (NIOSH, 2024)

Protective gloves; safety glasses; self-contained breathing apparatus.

Wear appropriate personal protective clothing to prevent the skin from becoming frozen from contact with the liquid or from contact with vessels containing the liquid.

Wear appropriate eye protection to prevent eye contact with the liquid that could result in burns or tissue damage from frostbite.

Quick drench facilities and/or eyewash fountains should be provided within the immediate work area for emergency use where there is any possibility of exposure to liquids that are extremely cold or rapidly evaporating.

Vinyl fluoride, stabilized appears as a colorless gas with a faint ethereal odor. Shipped as a confined liquid under its vapor pressure. Any leak can either be liquid or vapor. Contact with the liquid can cause frostbite. Easily ignited. Vapors are heavier than air. Can asphyxiate by the displacement of air. Under prolonged exposure to fire or intense heat the containers may rupture violently and rocket.

Colorless gas with a faint, ethereal odor; Note: Shipped as a liquefied compressed gas; [NIOSH]

COLOURLESS COMPRESSED LIQUEFIED GAS WITH CHARACTERISTIC ODOUR.

Colorless gas with a faint, ethereal odor.

Colorless gas with a faint, ethereal odor. [Note: Shipped as a liquefied compressed gas.]

Colorless gas [Note: Shipped as a liquefied compressed gas].

Faint, ethereal odor.

-98 °F at 760 mmHg (USCG, 1999)

-72 °C @760 [mm Hg]

-258 °F (USCG, 1999)

-160.5 °C

Flammable gas

NA (Gas)

Insoluble (NIOSH, 2024)

Soluble in ether.

Soluble in ethanol and acetone

Water solubility at 80 °C (g/100 g water): 0.94 (at 3.4 MPa), 1.54 (at 6.9 MPa)

In water, 1.29X10+4 mg/L at 25 °C /Estimated/

Solubility in water: none

Insoluble

0.707 at 32 °F (USCG, 1999) - Less dense than water; will float

0.636 (liquid) at 21 °C

Heat of evaporation: 13494 J/mol at -20 °C; Density = 0.775 g/cu cm at -30 °C; Critical density = 0.320 g/cu cm

0.707 at 32 °F

0.636 @ 21°C (Liquid)

1.60(relative gas density)

1.6 (NIOSH, 2024) - Heavier than air; will sink (Relative to Air)

1.58 (Air= 1)

Relative vapor density (air = 1): 1.6

25.2 atm (NIOSH, 2024)

Vapor pressure = 2.4 mPa @ 21 °C

1.98X10+4 mm Hg at 25 °C /Extrapolated/

25.2 atm

750 [mm Hg] @-72.2 °C

log Kow = 1.19 /Estimated/

Henry's Law constant = 1.2X10-1 atm-cu m/mole at 25 °C /Estimated/

860 °F (USCG, 1999)

860 °F (460 °C)

When heated to decomposition it emits toxic fumes of /hydrogen fluoride/.

3.2347E-04 pascal/seconds (liquid) @ boiling point

Highly flammable, reacts with air to form peroxides

Fluorinated Organic Compounds

Polymerizable Compounds

Highly Flammable

Polymerizable

Peroxidizable Compound

VINYL FLUORIDE is light sensitive, peroxidizable monomer may initiate exothermic polymerization of the bulk material [Handling Chemicals Safely 1980. p. 958]. Sensitive to many oxidants.

During ozonolysis of vinyl fluoride an explosive solid residue is produced, and the volatile ozonide, trapped at -63 °C, may explode spontaneously or during removal by syringe.

None reported [Note: Inhibited with 0.2% terpenes to prevent polymerization.]

Evaluation: There is inadequate evidence in humans for the carcinogenicity of vinyl fluoride. There is sufficient evidence in experimental animals for the carcinogenicity of vinyl fluoride. Overall evaluation: Vinyl fluoride is probably carcinogenic to humans (Group 2A). In making the overall evaluation, the working group took into account the following evidence: Vinyl fluoride is closely related structurally to the known carcinogen, vinyl chloride. The two chemicals cause the same rare tumor (hepatic hemangiosarcoma) in experimental animals, which is also a tumor caused by vinyl chloride in humans.

A2; Suspected human carcinogen.

Vinyl Fluoride: reasonably anticipated to be a human carcinogen.

Vinyl fluoride

Group 2A: Probably carcinogenic to humans

Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)

Volume 63: (1995) Dry Cleaning, Some Chlorinated Solvents and Other Industrial Chemicals

Volume 97: (2008) 1,3-Butadiene, Ethylene Oxide and Vinyl Halides (Vinyl Fluoride, Vinyl Chloride and Vinyl Bromide)

NB (1) Overall evaluation upgraded to Group 2A based on mechanistic and other relevant data; (2) For practical purposes, vinyl fluoride should be considered to act similarly to the human carcinogen vinyl chloride

The substance can be absorbed into the body by inhalation.

inhalation, skin and/or eye contact (liquid)

Headache. Dizziness. Confusion. Incoordination. Nausea. Vomiting. Shortness of breath.

ON CONTACT WITH LIQUID: FROSTBITE.

See Skin.

headache, dizziness, confusion, incoordination, narcosis, nausea, vomiting; liquid: frostbite

central nervous system

Neurotoxin - Acute solvent syndrome

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

IARC Carcinogen - Class 2: International Agency for Research on Cancer classifies chemicals as probable (2a), or possible (2b) human carcinogens.

NTP Carcinogen - Reasonably anticipated to be a human carcinogen.

ACGIH Carcinogen - Suspected Human.

LC (rat) = 800,000 ppm/12.5h

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with sterile dressings after decontamination ... . /Halogenated aliphatic hydrocarbons and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of myocardial irritability and fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Halogenated aliphatic hydrocarbons and related compounds/

PRECAUTIONS FOR "CARCINOGENS": Whenever medical surveillance is indicated, in particular when exposure to a carcinogen has occurred, ad hoc decisions should be taken concerning ... /cytogenetic and/or other/ tests that might become useful or mandatory. /Chemical Carcinogens/

/HUMAN EXPOSURE STUDIES/ /Investigators/ reported polyvinyl fluoride produced no skin reaction when /evaluated/ for irritation and sensitization on 215 human subjects. Contact with liquid vinyl fluoride may cause frost bite, and exposure to the vapor may cause headache or dizziness.

/SIGNS AND SYMPTOMS/ The vapor if inhaled will cause headache or dizziness. Liquid will cause frost bite /on contact/.

/OTHER TOXICITY INFORMATION/ In chronic fluoride poisoning of human beings it has been said that changes in the bones of the skull have sometimes led to optic atrophy through compression of the optic nerves, but no direct toxic effect on these nerves is known. /Fluorides/

/LABORATORY ANIMALS: Acute Exposure/ /Rats exposed to high concentrations showed/ ... slight intoxication at ... 30% by volume in air or more. At 60%, animals lost postural reflex. At 70% they lost righting reflex. ... At 80% for 12.5 hr ... still retained corneal reflex. Recovery was immediate when animals were moved to fresh air. ... Showed slight intoxication & ... dyspnea /at 80%/.

/LABORATORY ANIMALS: Acute Exposure/ Male rats were pretreated by gavage with PCB aroclor 1254 for 3 days. On 4th day rats were exposed by inhalation to fluoride monomer for 4 hr. elevation of alanine-alpha-ketoglutarate transaminase & severe degeneration & necrosis of liver were observed.

/LABORATORY ANIMALS: Acute Exposure/ The acute lethality of vinyl fluoride is so low that concentrations can be increased to the point at which oxygen becomes limiting.

/LABORATORY ANIMALS: Acute Exposure/ Exposure of rats to vinyl fluoride at 10,000 ppm (18,800 mg/cu m) after pretreatment with Aroclor 1254 resulted in liver damage.

For more Non-Human Toxicity Excerpts (Complete) data for VINYL FLUORIDE (11 total), please visit the HSDB record page.

The ability of fluoroethene to cause mutations at the gene locus coding for hypoxanthine-guanine phosphoribosyl transferase in Chinese hamster ovary cells (CHO/HPRT Assay) was evaluated in the presence and absence of metabolic activation from Aroclor induced rat liver S-9 fraction. Preliminary toxicity tests of nonactivated cultures treated with nominal concentrations of 0, 20, 40, 60, 80, and 100% fluoroethene gas produced a cloning efficiency in the range of 32.5-109% relative to the nitrogen gas control. Assays at the same nominal concentrations with metabolic activation produced cloning efficiency ranging from 76.2-179.8% relative to the nitrogen gas control. None of the nonactivated test cultures exhibited a significant increase in the mutant frequency compared to the negative control. Activated cultures exhibited a significant increase in the mutant frequency at all concentrations of fluoroethene tested.

Environmental effects from the substance have not been investigated adequately.

Vinyl fluoride's production and use as a prepolymer/copolymer may result in its release to the environment through various waste streams. If released to air, an extrapolated vapor pressure of 1.98X10+4 mm Hg at 25 °C indicates vinyl fluoride will exist solely as a gas in the ambient atmosphere. Gas-phase vinyl fluoride will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 3 days. Reaction with atmospheric ozone will contribute to its atmospheric degradation; estimated half-life is 16 days. If released to soil, vinyl fluoride is expected to have very high mobility based upon an estimated Koc of 24. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 0.12 atm-cu m/mole. Insufficient data are available to predict the relative importance or rate of biodegradation in the environment. If released into water, vinyl fluoride is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 2 hrs and 3 days, respectively. An estimated BCF of 2 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to vinyl fluoride may occur through inhalation and dermal contact with this compound at workplaces where vinyl fluoride is produced or used. (SRC)

It is not known whether vinyl fluoride occurs as a natural product(1).

Vinyl fluoride's production and use as a monomer in the synthesis of poly(vinyl fluoride)(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 24(SRC), determined from a structure estimation method(2), indicates that vinyl fluoride is expected to have very high mobility(SRC). Volatilization of vinyl fluoride from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.12 atm-cu m/mole(SRC), using a fragment constant estimation method(3). The potential for volatilization of vinyl fluoride from dry soil surfaces may exist(SRC) based upon an extrapolated vapor pressure of 1.98X10+4 mm Hg(4). Insufficient data are available to predict the relative importance or rate of biodegradation in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 24(SRC), determined from a structure estimation method(2), indicates that vinyl fluoride is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 0.12 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2 hrs and 3 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 2(SRC), from an estimated log Kow of 1.2(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Insufficient data are available to predict the relative importance or rate of biodegradation in water(SRC).

Environmental effects from the substance have not been investigated adequately.

Vinyl fluoride's production and use as a prepolymer/copolymer may result in its release to the environment through various waste streams. If released to air, an extrapolated vapor pressure of 1.98X10+4 mm Hg at 25 °C indicates vinyl fluoride will exist solely as a gas in the ambient atmosphere. Gas-phase vinyl fluoride will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 3 days. Reaction with atmospheric ozone will contribute to its atmospheric degradation; estimated half-life is 16 days. If released to soil, vinyl fluoride is expected to have very high mobility based upon an estimated Koc of 24. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 0.12 atm-cu m/mole. Insufficient data are available to predict the relative importance or rate of biodegradation in the environment. If released into water, vinyl fluoride is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 2 hrs and 3 days, respectively. An estimated BCF of 2 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to vinyl fluoride may occur through inhalation and dermal contact with this compound at workplaces where vinyl fluoride is produced or used. (SRC)

It is not known whether vinyl fluoride occurs as a natural product(1).

Vinyl fluoride's production and use as a monomer in the synthesis of poly(vinyl fluoride)(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 24(SRC), determined from a structure estimation method(2), indicates that vinyl fluoride is expected to have very high mobility(SRC). Volatilization of vinyl fluoride from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.12 atm-cu m/mole(SRC), using a fragment constant estimation method(3). The potential for volatilization of vinyl fluoride from dry soil surfaces may exist(SRC) based upon an extrapolated vapor pressure of 1.98X10+4 mm Hg(4). Insufficient data are available to predict the relative importance or rate of biodegradation in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 24(SRC), determined from a structure estimation method(2), indicates that vinyl fluoride is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 0.12 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2 hrs and 3 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 2(SRC), from an estimated log Kow of 1.2(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Insufficient data are available to predict the relative importance or rate of biodegradation in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), vinyl fluoride, which has an extrapolated vapor pressure of 1.98X10+4 mm Hg at 25 °C(2), is expected to exist solely as a gas in the ambient atmosphere. Gas-phase vinyl fluoride is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 3 days(SRC), calculated from its rate constant of 5.56X10-12 cu cm/molecule-sec at 25 deg(3). Vinyl fluoride also reacts with ozone(4), which will contribute to its atmospheric degradation with an estimated half-life of about 16 days(SRC).

The rate constant for the vapor-phase reaction of vinyl fluoride with photochemically-produced hydroxyl radicals has been measured as 5.6X10-12 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 3 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Vinyl fluoride is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2) nor to directly photolyze due to the lack of absorption in the environmental UV spectrum. The rate constant for the vapor-phase reaction of vinyl fluoride with ozone has been measured as 7.0X10-19 cu cm/molecule-sec at 21 °C(SRC) and 1.4X10-19 cu cm/molecule-sec at -13 °C(3). This corresponds to an atmospheric half-life of about 16 days(SRC) at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(4).

An estimated BCF of 2 was calculated for vinyl fluoride(SRC), using an estimated log Kow of 1.19(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC), provided the compound is not altered physically or chemically once released into the environment.

Using a structure estimation method based on molecular connectivity indices(1), the Koc for vinyl fluoride can be estimated to be 24(SRC). According to a classification scheme(2), this estimated Koc value suggests that vinyl fluoride is expected to have very high mobility in soil.

The Henry's Law constant for vinyl fluoride is estimated as 0.12 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that vinyl fluoride is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 2 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 3 days(SRC). Vinyl fluoride's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of vinyl fluoride from dry soil surfaces may exist(SRC) based upon an extrapolated vapor pressure of 1.98X10+4 mm Hg(3).

Occupational exposure to vinyl fluoride may occur through inhalation and dermal contact with this compound at workplaces where vinyl fluoride is produced or used(SRC). Surveys made at a vinyl fluoride manufacturing plant and a vinyl fluoride polymerization plant showed that exposure levels for production and control operations were generally <4mg/cu m, while exposures associated with polymer operations ranged from 2-9 mg/cu m, with a time-weighted average of 3.6 mg/cu m(1,2).

Vinyl fluoride was detected (concn not reported) in expired air collected from a control population of humans in a study of expired air constituents from diabetics(1).

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": HEPA (high-efficiency particulate arrestor) filters ... can be disposed of by incineration. For spent charcoal filters, the adsorbed material can be stripped off at high temp & carcinogenic wastes generated by this treatment conducted to & burned in an incinerator. ... LIQUID WASTE: ... Disposal should be carried out by incineration at temp that ... ensure complete combustion. SOLID WASTE: Carcasses of lab animals, cage litter & misc solid wastes ... should be disposed of by incineration at temp high enough to ensure destruction of chem carcinogens or their metabolites. /Chemical Carcinogens/

For more Disposal Methods (Complete) data for VINYL FLUORIDE (6 total), please visit the HSDB record page.

/GUIDE 116P: GASES - FLAMMABLE (UNSTABLE)/ Fire or Explosion: EXTREMELY FLAMMABLE. Will be easily ignited by heat, sparks or flames. Will form explosive mixtures with air. ... Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Vapors from liquefied gas are initially heavier than air and spread along ground. Vapors may travel to source of ignition and flash back. Cylinders exposed to fire may vent and release flammable gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket. /Vinyl fluoride, inhibited; Vinyl fluoride, stabilized/

/GUIDE 116P: GASES - FLAMMABLE (UNSTABLE)/ Health: Vapors may cause dizziness or asphyxiation without warning. Some may be toxic if inhaled at high concentrations. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire may produce irritating and/or toxic gases. /Vinyl fluoride, inhibited; Vinyl fluoride, stabilized/

/GUIDE 116P: GASES - FLAMMABLE (UNSTABLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Many gases are heavier than air and will spread along ground and collect in low or confined areas (sewers, basements, tanks). Keep out of low areas. /Vinyl fluoride, inhibited; Vinyl fluoride, stabilized/

/GUIDE 116P: GASES - FLAMMABLE (UNSTABLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. /Vinyl fluoride, inhibited; Vinyl fluoride, stabilized/

For more DOT Emergency Guidelines (Complete) data for VINYL FLUORIDE (8 total), please visit the HSDB record page.

1860 116P

1860 116P(inhibited)

UN 1860; Vinyl fluoride, stabilized

IMO 2.1; Vinyl fluoride, stabilized

49 057 93; Vinyl fluoride

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

PRECAUTIONS FOR "CARCINOGENS": Procurement ... of unduly large amt ... should be avoided. To avoid spilling, carcinogens should be transported in securely sealed glass bottles or ampoules, which should themselves be placed inside strong screw-cap or snap-top container that will not open when dropped & will resist attack from the carcinogen. Both bottle & the outside container should be appropriately labelled. ... National post offices, railway companies, road haulage companies & airlines have regulations governing transport of hazardous materials. These authorities should be consulted before ... material is shipped. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": When no regulations exist, the following procedure must be adopted. The carcinogen should be enclosed in a securely sealed, watertight container (primary container), which should be enclosed in a second, unbreakable, leakproof container that will withstand chem attack from the carcinogen (secondary container). The space between primary & secondary container should be filled with absorbent material, which would withstand chem attack from the carcinogen & is sufficient to absorb the entire contents of the primary container in the event of breakage or leakage. Each secondary container should then be enclosed in a strong outer box. The space between the secondary container & the outer box should be filled with an appropriate quantity of shock-absorbent material. Sender should use fastest & most secure form of transport & notify recipient of its departure. If parcel is not received when expected, carrier should be informed so that immediate effort can be made to find it. Traffic schedules should be consulted to avoid ... arrival on weekend or holiday ... /Chemical Carcinogens/

Flammable Gas

UN Hazard Class: 2.1