2-bromopropane

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

H360F ***: May damage fertility [Danger Reproductive toxicity]

H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P203, P210, P233, P240, P241, P242, P243, P260, P280, P303+P361+P353, P318, P319, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for 1.2% (1 of 85) of reports.

H225 (98.8%): Highly Flammable liquid and vapor [Danger Flammable liquids]

H360 (95.3%): May damage fertility or the unborn child [Danger Reproductive toxicity]

H373 (97.6%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Aggregated GHS information provided per 85 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 1 of 85 reports by companies.

There are 14 notifications provided by 84 of 85 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H350: May cause cancer [Danger Carcinogenicity]

H360: May damage fertility or the unborn child [Danger Reproductive toxicity]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]

P203, P210, P233, P240, P241, P242, P243, P260, P264, P270, P273, P280, P303+P361+P353, P308+P316, P318, P319, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

P203, P210, P233, P240, P241, P242, P243, P260, P264, P264+P265, P270, P280, P303+P361+P353, P305+P351+P338, P318, P319, P337+P317, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

H316: Causes mild skin irritation [Warning Skin corrosion/irritation]

P203, P210, P233, P240, P241, P242, P243, P260, P264, P270, P280, P303+P361+P353, P318, P319, P332+P317, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

H360F: May damage fertility [Danger Reproductive toxicity]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Use alcohol foam, dry chemical or carbon dioxide. Keep run-off water out of sewers and water sources. /Bromopropanes/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Use alcohol foam, dry chemical or carbon dioxide. Keep run-off water out of sewers and water sources. /Bromopropanes/

Personnel protection: Avoid breathing vapors. Keep upwind. Do not handle broken packages unless wearing appropriate personal protective equipment. If contact with the material anticipated, wear appropriate chemical protective clothing. /Bromopropanes/

...Materials which are toxic as stored or which can decompose into toxic components...should be stored in a cool, well ventilated place, out of the direct rays of the sun, away from areas of high fire hazard, and should be periodically inspected. Incompatible materials should be isolated...

3.0 [ppm]

230 [ppm]

1400 [ppm]

Personnel Protection: ... Wear appropriate chemical protective gloves, boots and goggles. /Bromopropanes/

Clear liquid; [Hawley]

Colorless to slightly yellow flammable liquid.

Colorless liquid

59-60 °C

59.35 °C @760 [mm Hg]

-89.0 °C

Heat of fusion at melting point = 6.527X10+6 J/kmol

Miscible with alcohol, benzene, chloroform, ether

SLIGHTLY SOL IN ACETONE

In water, 3,180 mg/L at 20 °C

1.31 at 20 °C/4 °C

1.31 @ 20°C

4.27 (Air=1)

216.0 [mmHg]

216 mm Hg at 25 °C (extrapolated)

31.5 kPa

216 [mm Hg] @25 °C

log Kow = 2.14

When heated to decomposition it emits toxic fumes of /hydrogen bromide/.

1.0012X10-3 Pa.s (liquid) @ -23.15 °C

3.5348X10-2 N/m at melting point

Index of refraction: 1.4251 at 20 °C/D

Liquid molar volume = 0.0959 cu meter/kmol

IG Heat of formation = -9.7069X10+7 J/kmol

Hydroxyl radical reaction rate constant = 8.8X10-13 cu cm/molec-sec at 25 °C

Coriolis coupling

Schoenflies notation

Boiling point

Centrifugal distortion

Chemical bond

Chemical diffusion

Diamagnetic susceptibility

Dielectric constant

Diffusion

Diffusive flux

Electric dipole moment

Equilibrium structure

Fusion temperature

Heat of sublimation

Hindering potential

Organobromide compounds, especially alkylbromides are strong alkylating agents. Consequently they can randomly modify the surfaces of proteins and lipids, leading to the disruption of enzyme, transporter or membrane functions. One of the most probable protein targets is the TRPA1 ion channel that is expressed in sensory nerves (trigeminal nerve) of the eyes, nose, mouth and lungs. Alkylation of DNA by alkylbromides may also lead to mutations. 2-bromopropane triggers the mitochondrion-dependent apoptotic pathway via ROS (reactive oxygen species) generation. 2-bromopropane has also been shown to induce DNA damage, impair functional antioxidant cellular defenses, and enhance the lipid peroxidation in cultured Leydig cells.

2-Bromopropane

Group 2A: Probably carcinogenic to humans

Volume 133: (2024) Anthracene, 2-Bromopropane, Butyl Methacrylate, and Dimethyl Hydrogen Phosphite

2024 online

No indication of carcinogenicity to humans (not listed by IARC).

2-Bromopropane is a strong lachrymator. Chronic exposure has been shown to have teratogenic effects in mouse and rat embryos. Very high chronic doses led to developmental toxicity which included an increase in the fetal deaths, a decrease in the litter size, and a reduction in the fetal body weight. In addition, an increase in the incidence of fetal external, visceral, and skeletal abnormalities was seen. Chronic exposure to 2-bromopropane depletes spermatogenic cells in male rats and oocytes in female rats. Humans exposed to 2-bromopropane exhibited oligospermia, amenorrhea and other reproductive toxic effects.

Oral (L626) ; inhalation (L626) ; dermal (L626)

May cause skin, eye and respiratory tract irritation. May affect behavior/central nervous system (central nervous system depression, excitement fatigue, headache, dizziness, stupor,unconsciousness and possible coma). If ingested, 2-bromopropane may cause gastrointestinal tract irritation with nausea, and vomiting. It may also affect behavior/central nervous system with symptoms similar to those for inhalation. May also cause kidney damage and liver damage.

Neurotoxin - Acute solvent syndrome

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

LC50 (mouse) = 31,171 ppm/4H

LD50: 4837 mg/kg (Intraperitoneal, Mouse) (T14)

LD50: >2000 mg/kg (Oral, Rat) (T43)

LC50: 31 171 ppm over 4 hours (Inhalation, Mouse) (T43)

LD50 Mouse ip 4837 mg/kg

LD50 Rat oral >2000 mg/kg

LC50 Mouse (ICR) inhalation 31,171 ppm/4 hr

EYES: irrigate opened eyes for several minutes under running water.

INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice.

SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention.

INHALATION: supply fresh air. If required provide artificial respiration.

/HUMAN EXPOSURE STUDIES/ An outbreak of reproductive and hematopoietic toxicities occurred in Korean electronics workers in 1995 exposed to solvents containing 2-BP that were used as alternatives to chlorofluorocarbons for cleaning tactile switches. Seventeen of 25 female workers showed ovarian dysfunction accompanied by amenorrhea and severe anemia, and 6 of 8 male workers had oligospermia or azospermia. The mean ambient 2-BP concentration in the work area was 12.4 ppm, and the 2-BP concentration inside the hood of the cleaning baths was 4141 ppm. Some workers had skin contact with 2-BP. Two of the affected female workers regained normal ovarian function within 2 years following exposure.

/HUMAN EXPOSURE STUDIES/ Sixteen Korean female laborers who had been exposed to a cleaning solvent composed mainly of 2-bromopropane developed primary ovarian failure. Histologic findings from these patients' ovaries were similar to those observed in ovarian failure caused by radiation or chemotherapy, i.e., reduced number and developmental arrest of primary follicles, interstitial fibrosis and hyalinization of blood vessels. We followed their clinical course for 2 years and found that two patients recovered normal ovarian function spontaneously: one became pregnant and delivered a normal full-term baby, and the other resumed regular menstrual periods with normal hormonal values. Our observations support the idea that the increasing prevalence of ovarian failure in recent years might be due to an increase in presently unidentified environmental toxic agents.

/HUMAN EXPOSURE STUDIES/ A study of 25 workers in a Chinese 2-BP manufacturing plant found amenorrhea or polymenorrhea in 4 female workers exposed at >10 ppm (TWA) 2-BP.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Male Sprague-Dawley rats were given daily intraperitoneal injections of 125, 250, or 500 mg/kg 2-BP in olive oil for 28 days. The rats exhibited dose-dependent decreases in body weight and testicular weight, with histopathological evidence of testicular necrosis. The NOEL was 125 mg/kg body weight.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Male Sprague-Dawley rats given oral 2-BP at 100, 330, or 1000 mg/kg daily for 28 days exhibited decreased body and thymus weights at the highest dose. White and red blood cell and platelet numbers were reduced, suggesting an immunotoxic potential of 2-BP.

/LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ Male Wistar rats were exposed 8 hours/day, 7 days/week for 9 weeks at 300 or 1000 ppm 2-BP. Exposures at 3000 ppm were terminated after 9 to 11 days due to morbidity. The rats exhibited decreased testicular and epididymal weights, decreased sperm count and motility, and decreased erythrocytes and platelets, indicating testicular and hematopoietic toxicity from 2-BP. Hypoplasia of bone marrow was observed at exposures of 1000 ppm 2-BP. Female Wistar rats exposed at 100, 300, or 1000 ppm 2-BP for 9 weeks developed irregular estrous cycling due to the destruction of primordial follicles and their oocytes.

/LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ Treatment of female Sprague-Dawley rats by intraperitoneal injection of 300, 600, or 900 mg/kg 2-BP for 21 days produced delayed estrous cycle and decreased the number of pups born in the high-dose group.

For more Non-Human Toxicity Excerpts (Complete) data for 2-BROMOPROPANE (21 total), please visit the HSDB record page.

Isopropyl bromide's production and use in the synthesis of pharmaceuticals, dyes, and other organics may result in its release to the environment through various waste streams. If released to air, an extrapolated vapor pressure of 216 mm Hg at 25 °C indicates isopropyl bromide will exist solely as a vapor in the ambient atmosphere. Vapor-phase isopropyl bromide will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 18 days. If released to soil, isopropyl bromide is expected to have moderate mobility based upon an estimated Koc of 350. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 0.011 atm-cu m/mole. The potential for volatilization of isopropyl bromide from dry soil surfaces exists based upon its extrapolated vapor pressure. An aqueous screening study using an activated sludge indicated that isopropyl bromide is readily biodegradable. If released into water, isopropyl bromide is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 1 hour and 4 days, respectively. The hydrolysis half-life of isopropyl bromide was reported as 2.1 days at 25 °C (pH 7). An estimated BCF of 9 suggests the potential for bioconcentration in aquatic organisms is low. Occupational exposure to isopropyl bromide may occur through inhalation and dermal contact with this compound at workplaces where isopropyl bromide is produced or used. (SRC)

Isopropyl bromide's production and use in the synthesis of pharmaceuticals, dyes, and other organics(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 350(SRC), determined from a measured log Kow of 2.14(2) and a regression derived equation(3), indicates that isopropyl bromide is expected to have moderate mobility in soil(SRC). Volatilization of isopropyl bromide from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.011 atm-cu m/mole(SRC) derived from its extrapolated vapor pressure of 216 mm Hg(4) and water solubility of 3180 mg/L(5). The potential for volatilization of isopropyl bromide from dry soil surfaces exists(SRC) based upon its extrapolated vapor pressure(4). No terrestrial biodegradation data were located for isopropyl bromide(SRC, 2005); however, an aqueous aerobic screening study using an activated sludge inoculum indicated that this compound is readily biodegradable(6).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 350(SRC), determined from a measured log Kow of 2.14(2) and a regression derived equation(3), indicates that isopropyl bromide is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 0.011 atm-cu m/mole(SRC), derived from an extrapolated vapor pressure of 216 mm Hg(4) and water solubility of 3180 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 1 hour and 4 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 9(SRC), from a log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). The hydrolysis half-life of isopropyl bromide was reported as 2.1 days at 25 °C(8). No aquatic biodegradation data were located for isopropyl bromide(SRC, 2005); however, an aqueous aerobic screening study using an activated sludge inoculum indicated that this compound is readily biodegradable(9).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), isopropyl bromide, which has an extrapolated vapor pressure of 216 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase isopropyl bromide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 18 days(SRC), calculated from its rate constant of 8.8X10-13 cu cm/molecule-sec at 25 °C(3).

Isopropyl bromide present at 100 mg/L, reached 73-89% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(1). Half-lives for the biodehalogenation of isopropyl bromide are 35 (oxygen insertion), 279 (substitution), and 40 hours (substitution) by the bacterial strains Pseudomonas putida, Pseudomonas sp., and Flavobacterium sp., respectively(2).

The rate constant for the vapor-phase reaction of isopropyl bromide with photochemically produced hydroxyl radicals has been measured as 8.8X10-13 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 18 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm. A hydrolysis half-life of about 2.1 days was reported for isopropyl bromide at 25 °C and pH 7(2). Isopropyl bromide is not expected to undergo direct photolysis in the environment since it lacks functional groups that absorb light at wavelengths greater than 290 nm(SRC).

An estimated BCF of 9 was calculated for isopropyl bromide (SRC), using a measured log Kow of 2.14(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of isopropyl bromide is estimated as 350(SRC), using a measured log Kow of 2.14(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that isopropyl bromide is expected to have moderate mobility in soil(SRC).

The Henry's Law constant for isopropyl bromide is estimated as 0.011 atm-cu m/mole(SRC) derived from its extrapolated vapor pressure, 216 mm Hg(1), and water solubility, 3180 mg/L(2). This Henry's Law constant indicates that isopropyl bromide is expected to volatilize rapidly from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 1 hour(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 4 days(SRC). Isopropyl bromide's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of isopropyl bromide from dry soil surfaces may exist(SRC) based upon its extrapolated vapor pressure(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,583 workers (323 of these are female) are potentially exposed to isopropyl bromide in the USA(1). Occupational exposure to isopropyl bromide may occur through inhalation and dermal contact with this compound at workplaces where isopropyl bromide is produced or used(SRC).

Isopropyl bromide's production and use in the synthesis of pharmaceuticals, dyes, and other organics may result in its release to the environment through various waste streams. If released to air, an extrapolated vapor pressure of 216 mm Hg at 25 °C indicates isopropyl bromide will exist solely as a vapor in the ambient atmosphere. Vapor-phase isopropyl bromide will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 18 days. If released to soil, isopropyl bromide is expected to have moderate mobility based upon an estimated Koc of 350. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 0.011 atm-cu m/mole. The potential for volatilization of isopropyl bromide from dry soil surfaces exists based upon its extrapolated vapor pressure. An aqueous screening study using an activated sludge indicated that isopropyl bromide is readily biodegradable. If released into water, isopropyl bromide is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 1 hour and 4 days, respectively. The hydrolysis half-life of isopropyl bromide was reported as 2.1 days at 25 °C (pH 7). An estimated BCF of 9 suggests the potential for bioconcentration in aquatic organisms is low. Occupational exposure to isopropyl bromide may occur through inhalation and dermal contact with this compound at workplaces where isopropyl bromide is produced or used. (SRC)

Isopropyl bromide's production and use in the synthesis of pharmaceuticals, dyes, and other organics(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 350(SRC), determined from a measured log Kow of 2.14(2) and a regression derived equation(3), indicates that isopropyl bromide is expected to have moderate mobility in soil(SRC). Volatilization of isopropyl bromide from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.011 atm-cu m/mole(SRC) derived from its extrapolated vapor pressure of 216 mm Hg(4) and water solubility of 3180 mg/L(5). The potential for volatilization of isopropyl bromide from dry soil surfaces exists(SRC) based upon its extrapolated vapor pressure(4). No terrestrial biodegradation data were located for isopropyl bromide(SRC, 2005); however, an aqueous aerobic screening study using an activated sludge inoculum indicated that this compound is readily biodegradable(6).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 350(SRC), determined from a measured log Kow of 2.14(2) and a regression derived equation(3), indicates that isopropyl bromide is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 0.011 atm-cu m/mole(SRC), derived from an extrapolated vapor pressure of 216 mm Hg(4) and water solubility of 3180 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 1 hour and 4 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 9(SRC), from a log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). The hydrolysis half-life of isopropyl bromide was reported as 2.1 days at 25 °C(8). No aquatic biodegradation data were located for isopropyl bromide(SRC, 2005); however, an aqueous aerobic screening study using an activated sludge inoculum indicated that this compound is readily biodegradable(9).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), isopropyl bromide, which has an extrapolated vapor pressure of 216 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase isopropyl bromide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 18 days(SRC), calculated from its rate constant of 8.8X10-13 cu cm/molecule-sec at 25 °C(3).

Isopropyl bromide present at 100 mg/L, reached 73-89% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(1). Half-lives for the biodehalogenation of isopropyl bromide are 35 (oxygen insertion), 279 (substitution), and 40 hours (substitution) by the bacterial strains Pseudomonas putida, Pseudomonas sp., and Flavobacterium sp., respectively(2).

The rate constant for the vapor-phase reaction of isopropyl bromide with photochemically produced hydroxyl radicals has been measured as 8.8X10-13 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 18 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm. A hydrolysis half-life of about 2.1 days was reported for isopropyl bromide at 25 °C and pH 7(2). Isopropyl bromide is not expected to undergo direct photolysis in the environment since it lacks functional groups that absorb light at wavelengths greater than 290 nm(SRC).

An estimated BCF of 9 was calculated for isopropyl bromide (SRC), using a measured log Kow of 2.14(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of isopropyl bromide is estimated as 350(SRC), using a measured log Kow of 2.14(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that isopropyl bromide is expected to have moderate mobility in soil(SRC).

The Henry's Law constant for isopropyl bromide is estimated as 0.011 atm-cu m/mole(SRC) derived from its extrapolated vapor pressure, 216 mm Hg(1), and water solubility, 3180 mg/L(2). This Henry's Law constant indicates that isopropyl bromide is expected to volatilize rapidly from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 1 hour(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 4 days(SRC). Isopropyl bromide's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of isopropyl bromide from dry soil surfaces may exist(SRC) based upon its extrapolated vapor pressure(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,583 workers (323 of these are female) are potentially exposed to isopropyl bromide in the USA(1). Occupational exposure to isopropyl bromide may occur through inhalation and dermal contact with this compound at workplaces where isopropyl bromide is produced or used(SRC).

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.

For more DOT Emergency Guidelines (Complete) data for 2-BROMOPROPANE (8 total), please visit the HSDB record page.

UN 2344; Bromopropanes

IMO 3.2; Bromopropanes

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.