isopropylamine

H224: Extremely flammable liquid and vapor [Danger Flammable liquids]

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H224 (99.9%): Extremely flammable liquid and vapor [Danger Flammable liquids]

H301+H311+H331 (16.7%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]

H301 (43.7%): Toxic if swallowed [Danger Acute toxicity, oral]

H311 (43.7%): Toxic in contact with skin [Danger Acute toxicity, dermal]

H314 (17.4%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H315 (82.6%): Causes skin irritation [Warning Skin corrosion/irritation]

H318 (12.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H319 (82.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H331 (43.6%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H335 (99.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 870 reports by companies from 28 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P308+P316, P316, P317, P319, P321, P330, P361+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H305: May be harmful if swallowed and enters airways [Warning Aspiration hazard]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P354+P338, P308+P316, P316, P317, P319, P321, P330, P331, P332+P317, P361+P364, P362+P364, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

H331: Toxic if inhaled [Danger Acute toxicity, inhalation]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P319, P321, P330, P361+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H333: May be harmful if inhaled [Warning Acute toxicity, inhalation]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P317, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P361+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention .

Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.

Rinse mouth. Give nothing to drink. Do NOT induce vomiting. Refer immediately for medical attention.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting. Thus, the risk of increasing the medical problems by inducing vomiting of a volatile corrosive chemical is very high. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Water flush immediately - If this chemical contacts the skin, immediately flush the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. Get medical attention promptly.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

Some of these materials may react violently with water.

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.

LARGE FIRE: Water spray, fog or alcohol-resistant foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Do not get water inside containers.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use water in large amounts, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Use water spray to cool unopened containers.

... Use dry chemical, carbon dioxide, or foam extinguishers. ... If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any digns of deforming), withdraw immediately to a secure position.

For more Fire Fighting Procedures (Complete) data for Isopropylamine (6 total), please visit the HSDB record page.

Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions.

Vapors are heavier than air and may travel to a source of ignition and flash back.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb with earth, sand or other non-combustible material.

· For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads).

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Evacuate danger area! Remove all ignition sources. Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Eliminate all ignition sources. Stop or control the leak, if this can be done without undue risk. Use water spray to cool and disperse vapors, protect personnel, and dilute spills to form nonflammable mixtures. Absorb in noncombustible material for proper disposal.

For more Cleanup Methods (Complete) data for Isopropylamine (8 total), please visit the HSDB record page.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.

... May be disposed of by atomizing in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device.

Incineration: Incinerate in a suitable combustion chamber with an afterburner and scrubber.

Use ventilation, local exhaust or breathing protection.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions:Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Use explosion-proof equipment. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.

Appropriate engineering controls: Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product

For more Preventive Measures (Complete) data for Isopropylamine (13 total), please visit the HSDB record page.

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb with earth, sand or other non-combustible material. For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads). Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Well closed. Fireproof. Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. See Chemical Dangers. Store in an area without drain or sewer access.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Isopropylamine must be stored to avoid contact with oxidizers (such as perchlorates, peroxides, permanganates, chlorates, and nitrates) and strong acids (such as hydrochloric, sulfuric, and nitric) since violent reactions occur. Store in tightly closed containers in a cool, well-ventilated area away from heat. Sources of ignition, such as smoking and open flames, are prohibited where isopropylamine is handled, used, or stored. Metal containers involving the transfer of 5 gallons or more of isopropylamine should be grounded and bonded. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only non-sparking tools and eqipment, especially when opening and closing containers of isopropylamine. Wherever isopropylamine is used, handled, manufactured, or stored, use explosion-proof electrical equipment and fittings. Isopropylamine will attack some forms of plastics, rubber, and coatings.

Store in a cool, dry, well-ventilated location. Separate from strong acids, oxidizing materials.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

5.0 [ppm], Ceiling = 10 ppm[German Research Foundation (DFG)]

5.0 [ppm]

130 [ppm]

750 [ppm]

See Appendix D

5 ppm (12 mg/m³)

TWA 5 ppm (12 mg/m3) See Appendix G

750 ppm (NIOSH, 2024)

750.0 [ppm]

Excerpts from Documentation for IDLHs: Other animal data: It has been reported that rats have survived an exposure to 4,000 ppm for 4 hours [Smyth et al. 1951]. Human data: Volunteers have complained of nose and throat irritation after brief exposures to concentrations ranging from 10 to 20 ppm [Amoore and Hautala 1983].

See: 75310

2.0 [ppm]

10.0 [ppm]

8 hr Time Weighted Avg (TWA): 5 ppm; 15 min Short Term Exposure Limit (STEL): 10 ppm.

2 ppm as TWA; 5 ppm as STEL; (skin).

5 ppm [1962]

10 ppm [1962]

· Some of these materials may react violently with water.

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

Large Fire

· Water spray, fog or alcohol-resistant foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

· Do not get water inside containers.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

Australia: 5 ppm, STEL 10 ppm (1990); Federal Republic of Germany: 5 ppm, short-term level 10 ppm, 30 min, 4 times per shift (1991)

A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. If swallowed the substance easily enters the airways and could result in aspiration pneumonitis. Exposure above the OEL could cause death.

Repeated or prolonged contact with skin may cause dermatitis.

Excerpt from NIOSH Pocket Guide for Isopropylamine:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Isopropylamine appears as a clear colorless liquid with an ammonia-like odor. Flash point -35 °F. Boiling point 90 °F. Less dense than water Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Used as a solvent and to make other chemicals.

Colorless liquid with an ammonia-like odor; Note: A gas above 91 degrees F; [NIOSH]

HYGROSCOPIC COLOURLESS LIQUID WITH AMMONIA ODOUR.

Colourless to yellow liquid; Fishy ammonia aroma

Colorless liquid with an ammonia-like odor.

Colorless liquid with an ammonia-like odor. [Note: A gas above 91 °F.]

Colorless liquid [Note: A gas above 91 degrees F]

Colorless, volatile liquid

Colorless to yellow liquid

Ammonia odor

High strength odor; fishy ammonia aroma

90.3 °F at 760 mmHg (NTP, 1992)

-150 °F (NTP, 1992)

-95.119 °C

-95.2 °C

-101.2 °C

-35 °F (NTP, 1992)

-18 °C (0 °F) (Closed cup)

-35 °F (-37 °C) (open cup)

-37 °C c.c.

-35 °F (open cup)

(oc) -35 °F

Very soluble (NTP, 1992)

In water, 1X10+6 mg/L at 20 °C /miscible/

Miscible with water

Miscible with ethanol, ether; very soluble in acetone; soluble in benzene, chloroform

Solubility in water: miscible

Soluble in water

Soluble (in ethanol)

Miscible

0.691 at 68 °F (est.) (USCG, 1999) - Less dense than water; will float

0.6891 g/cu cm at 20 °C

Bulk density: 5.7 lb/gal at 20 °C; refractive index; 1.377 at 15 C

0.7 g/cm³

Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.7

0.687-0.693

0.694 @ 15°C

2.04 (Air = 1)

Relative vapor density (air = 1): 2.0

940.94 mmHg (USCG, 1999)

Highly flammable. Water soluble.

Amines, Phosphines, and Pyridines

Highly Flammable

ISOPROPYLAMINE is a colorless, alkaline liquid, very volatile, moderately toxic, highly flammable. Dangerous fire hazard when exposed to heat, flame, sparks, or strong oxidizers. When heated to decomposition it emits toxic fumes of oxides of nitrogen [M. K.]. A mixture of isopropylamine and perchloryl fluoride resulted in an uncontrolled oxidation and/or explosion, [J. Org. Chem., 1980, 45, 4036]. The reaction of 1-chloro-2,3-epoxypropane and the amine and most probably other nitrogen bases, yields a violent exotherm, [Chem. & Ind., 1971, 994].

Incompatible materials: Oxidizing agents.

Reacts with acids, aldehydes, ketones, epoxides, and oxidizing agents.

Strong acids, strong oxidizers, aldehydes, ketones, epoxides.

Incompatible with 1-chloro-1,3-epoxypropane.

For more Hazardous Reactivities and Incompatibilities (Complete) data for Isopropylamine (9 total), please visit the HSDB record page.

Strong acids, strong oxidizers, aldehydes, ketones, epoxides

IDENTIFICATION AND USE: Isopropylamine is a colorless liquid (a gas above 91 degrees F). It is used as a solvent, intermediate in synthesis of rubber accelerators, pharmaceuticals, dyes, insecticides, bactericides, textile specialties, and surface-active agents, dehairing agent, solubilizer for 2,4-D acid. HUMAN STUDIES: Complaints of nose and throat irritation were reported by volunteer subjects after brief exposures at 10 to 20 ppm. Workers complained of transient visual disturbances (halos around lights) after exposure to the vapor for 8 hours, probably resulting from mild corneal edema, which usually cleared in 3 to 4 hours. ANIMAL STUDIES: A 4-hour exposure of 10,000 mg/cu m (4000 ppm) to 6 rats was not lethal, while all 6 rats died from exposure to 20,000 mg/cu m (8000 ppm). Exposure to a saturated vapor caused the death of all rats within 2 minutes. Isopropylamine produced a severe burn from application of 0.5 mL of a 1% solution. Instillation of 0.005 mL of undiluted compound resulted in severe corneal opacity while 0.5 mL of a 1% solution in water caused severe corneal opacity and iritis. In mice, isopropylamine is essentially an upper respiratory tract-irritating compound. In a one generation reproduction study rats were exposed to isopropylamine at analytical concentrations of 20, 100 or 499 mg/cu m for 6 hr per day (5 days/week) by inhalation (whole body exposure). Clinical signs included incidental fur discoloration and focal hair loss. There were no significant differences in mating and fertility parameters, number of corpora lutea, implantations and resorptions. The was a reduction in mean body weight gain in males in the high dose group. Negative results were reported in bacterial reverse mutation tests for mutagenicity in Salmonella typhimurium (strains included TA1535, TA1537, TA98 and TA100) with and without metabolic activation. The highest non-toxic dose tested was 3333 mg/plate.

Serious local effects by all routes of exposure.

inhalation, skin absorption, ingestion, skin and/or eye contact

Sore throat. Cough. Burning sensation. Shortness of breath. Laboured breathing.

Pain. Redness. Blisters. Skin burns.

Pain. Redness. Severe burns. Loss of vision.

Burning sensation. Burns in mouth and throat. Abdominal cramps. Shock or collapse.

irritation eyes, skin, nose, throat; pulmonary edema; visual disturbance; eye, skin burns; dermatitis

Eyes, skin, respiratory system

Dermatotoxin - Skin burns.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

LC50 (rat) = 4,000 ppm/4H

LC50 Rat inhalation 8.7 mg/L/4 hr

LD50 Rat oral 820 mg/kg

LD50 Rat (female) oral <173 mg/kg bw

LD50 Mouse oral 2200 mg/kg

For more Non-Human Toxicity Values (Complete) data for Isopropylamine (8 total), please visit the HSDB record page.

/While/ methyl and ethylamine in combination with nitrite were significantly mutagenic, the Escherichia coli mutagenicity test of carcinogenic isopropylamine in combination with nitrite did not yield a detectable increase in mutation frequency over that due to nitrite alone.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/Amines and related compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/Amines and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/Amines and related compounds/

Before a worker is placed in a job with a potential for exposure to isopropylamine, a licensed health care professional should evaluate and document the worker's baseline health status with thorough medical, environmental, and occupational histories, a physical examination, and physiologic and laboratory tests appropriate for the anticipated occupational risks. These should concentrate on the function and integrity of the eyes, skin, and respiratory system. Medical surveillance for respiratory disease should be conducted using the principles and methods recommended by the American Thoracic Society.

Occupational health interviews and physical examinations should be performed at regular intervals during the employment period, as mandated by any applicable Federal, State, or local standard. Where no standard exists and the hazard is minimal, evaluations should be conducted every 3 to 5 years or as frequently as recommended by an experienced occupational health physician. Additional examinations may be necessary if a worker develops symptoms attributable to isopropylamine exposure. The interviews, examinations, and medical screening tests should focus on identifying the adverse effects of isopropylamine on the eyes, skin, or respiratory system. Current health status should be compared with the baseline health status of the individual worker or with expected values for a suitable reference population.

/HUMAN EXPOSURE STUDIES/ Complaints of nose and throat irritation were reported by volunteer subjects after brief exposures at 10 to 20 ppm.

/SIGNS AND SYMPTOMS/ Workers complained of transient visual disturbances (halos around lights) after exposure to the vapor for 8 hours, probably resulting from mild corneal edema, which usually cleared in 3 to 4 hours.

/LABORATORY ANIMALS: Acute Exposure/ When rats (n=6/sex/group) were exposed to 5000 or 5100 mg/cu m (2050 and 2100 ppm), only one male animal exposed to 5100 mg/cu m died (on day 2). During exposure, labored breathing, discharges around nose and mouth, lachrymation, and hypoactivity were noted. Post-exposure observations included labored breathing, encrustation of the nose and eyes, opacity of eyes, urine-stained fur. Opacity of the eyes persisted throughout the 14-day observation period, as did one observation of labored respiration and encrustation of the nose. At day 2, there was a decrease in mean body weight. Although animals gained weight until sacrifice, only female animals had body weights comparable to control animals. At necropsy, only focal corneal opacity was found.

/LABORATORY ANIMALS: Acute Exposure/ A 4-hour exposure to 10,000 mg/cu m (4000 ppm) was not lethal to 6 out of 6 rats while all 6 rats died due to exposure to 20,000 mg/cu m (8000 ppm). Exposure to a saturated vapor caused the death of all rats within 2 minutes.

/LABORATORY ANIMALS: Acute Exposure/ ... Isopropylamine scored an injury grade of 10 (ie, a severe burn from 0.5 mL of a 1% solution) on a scale from 1 to 10.

/LABORATORY ANIMALS: Acute Exposure/ Instillation of 0.005 mL of undiluted compound resulted in severe corneal opacity while 0.5 mL of a 1% solution in water caused severe corneal opacity and iritis (no details available).

For more Non-Human Toxicity Excerpts (Complete) data for Isopropylamine (16 total), please visit the HSDB record page.

The following link will take the user to the National Toxicology Program (NTP) Test Status of Agents Search page, which tabulates the results and current status of tests such as "Short-Term Toxicity Studies", "Long-term Carcinogenicity Studies", "Developmental Studies", "Genetic Toxicology Studies", etc., performed with this chemical. Testing status for isopropylamine is available.[Available from, as of March 27, 2018: https://ntpsearch.niehs.nih.gov/?e=True&ContentType=Testing+Status]

EC50; Species: Chlorella ellipsoidea (Green algae); Conditions: freshwater, static 25 °C, pH 7.2; Concentration: 1X10-9 ug/cell for 90 min; Effect: decreased photosynthesis, oxygen production

EC50; Species: Anabaena catenula (Blue-Green Algae) exponential growth phase; Conditions: freshwater, static, 22 °C; Concentration: 1500 ug/L for 21 days; Effect: decreased population growth rate /98% purity/

EC50; Species: Microcystis aeruginosa (Blue-Green Algae) exponential growth phase; Conditions: freshwater, static, 22 °C; Concentration: 2500 ug/L for 21 days; Effect: decreased population growth rate /98% purity/

EC50; Species: Leptolyngbya boryana (Blue-Green Algae) exponential growth phase; Conditions: freshwater, static, 22 °C; Concentration: 2900 ug/L for 21 days; Effect: decreased population growth rate /98% purity/

For more Ecotoxicity Values (Complete) data for Isopropylamine (11 total), please visit the HSDB record page.

The substance is harmful to aquatic organisms.

Isopropylamine's production and use as a solvent, intermediate in synthesis of rubber accelerators, pharmaceuticals, dyes, insecticides, bactericides, textile specialities, and surface-active agents, dehairing agent, as a solubilizer for 2,4-D acid and flavoring agent may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 580 mm Hg at 25 °C indicates isopropylamine will exist solely as a vapor in the atmosphere. Vapor-phase isopropylamine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 3.3 hours. Isopropylamine does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, isopropylamine is expected to have very high mobility based upon an estimated Koc of 11. The pKa of isopropylamine is 10.6, indicating that this compound will exist almost entirely in cation form in the environment and cations generally absorb more strongly to soils containing organic carbon and clay than their neutral counterparts. Volatilization from moist soil is not expected because the compound exists as a cation and cations do not volatilize. Isopropylamine is expected to volatilize from dry soil surfaces based upon its vapor pressure. Utilizing the Manometric Respirometry test, 70-80% of the Theoretical BOD was reached in 4 weeks indicating that biodegradation is an important environmental fate process in soil and water. If released into water, isopropylamine is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. A pKa of 10.6 indicates isopropylamine will exist almost entirely in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process. An estimated BCF of 3.2 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions (pH 5 to 9). Occupational exposure to isopropylamine may occur through inhalation and dermal contact with this compound at workplaces where isopropylamine is produced or used. Monitoring and use data indicate that the general population may be exposed to isopropylamine via inhalation of tobacco smoke, ingestion of food, and dermal contact with consumer products containing isopropylamine. (SRC)

Isopropylamine has been detected in tobacco leaf(1). Decomposing animal manure has also been shown to release isopropylamine to the environment(2).

Isopropylamine's production and use as a solvent, intermediate in synthesis of rubber accelerators, pharmaceuticals, dyes, insecticides, bactericides, textile specialities, and surface-active agents, dehairing agent, as a solubilizer for 2,4-D acid(1), and flavoring agent(2) may result in its release to the environment through various waste streams(SRC). Isopropylamine has been identified as a constituent of tobacco, tobacco smoke, and tobacco substitute smoke(3).

EC50; Species: Chlorella ellipsoidea (Green algae); Conditions: freshwater, static 25 °C, pH 7.2; Concentration: 1X10-9 ug/cell for 90 min; Effect: decreased photosynthesis, oxygen production

EC50; Species: Anabaena catenula (Blue-Green Algae) exponential growth phase; Conditions: freshwater, static, 22 °C; Concentration: 1500 ug/L for 21 days; Effect: decreased population growth rate /98% purity/

EC50; Species: Microcystis aeruginosa (Blue-Green Algae) exponential growth phase; Conditions: freshwater, static, 22 °C; Concentration: 2500 ug/L for 21 days; Effect: decreased population growth rate /98% purity/

EC50; Species: Leptolyngbya boryana (Blue-Green Algae) exponential growth phase; Conditions: freshwater, static, 22 °C; Concentration: 2900 ug/L for 21 days; Effect: decreased population growth rate /98% purity/

For more Ecotoxicity Values (Complete) data for Isopropylamine (11 total), please visit the HSDB record page.

The substance is harmful to aquatic organisms.

Isopropylamine's production and use as a solvent, intermediate in synthesis of rubber accelerators, pharmaceuticals, dyes, insecticides, bactericides, textile specialities, and surface-active agents, dehairing agent, as a solubilizer for 2,4-D acid and flavoring agent may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 580 mm Hg at 25 °C indicates isopropylamine will exist solely as a vapor in the atmosphere. Vapor-phase isopropylamine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 3.3 hours. Isopropylamine does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, isopropylamine is expected to have very high mobility based upon an estimated Koc of 11. The pKa of isopropylamine is 10.6, indicating that this compound will exist almost entirely in cation form in the environment and cations generally absorb more strongly to soils containing organic carbon and clay than their neutral counterparts. Volatilization from moist soil is not expected because the compound exists as a cation and cations do not volatilize. Isopropylamine is expected to volatilize from dry soil surfaces based upon its vapor pressure. Utilizing the Manometric Respirometry test, 70-80% of the Theoretical BOD was reached in 4 weeks indicating that biodegradation is an important environmental fate process in soil and water. If released into water, isopropylamine is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. A pKa of 10.6 indicates isopropylamine will exist almost entirely in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process. An estimated BCF of 3.2 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions (pH 5 to 9). Occupational exposure to isopropylamine may occur through inhalation and dermal contact with this compound at workplaces where isopropylamine is produced or used. Monitoring and use data indicate that the general population may be exposed to isopropylamine via inhalation of tobacco smoke, ingestion of food, and dermal contact with consumer products containing isopropylamine. (SRC)

Isopropylamine has been detected in tobacco leaf(1). Decomposing animal manure has also been shown to release isopropylamine to the environment(2).

Isopropylamine's production and use as a solvent, intermediate in synthesis of rubber accelerators, pharmaceuticals, dyes, insecticides, bactericides, textile specialities, and surface-active agents, dehairing agent, as a solubilizer for 2,4-D acid(1), and flavoring agent(2) may result in its release to the environment through various waste streams(SRC). Isopropylamine has been identified as a constituent of tobacco, tobacco smoke, and tobacco substitute smoke(3).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 11(SRC), determined from a log Kow of 0.26(2) and a regression-derived equation(3), indicates that isopropylamine is expected to have very high mobility in soil(SRC). However, the pKa of isopropylamine is 10.6(4), indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization of isopropylamine from moist soil surfaces is not expected to be an important fate process because this compound exists almost entirely in the cation form at pH values of 5 to 9 and cations do not volatilize. Isopropylamine is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 580 mm Hg at 25 °C(6). A 70-80% of theoretical BOD using activated sludge in the Manometric Respirometry test(7) suggests that biodegradation is an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 11(SRC), determined from a log Kow of 0.26(2) and a regression-derived equation(3), indicates that isopropylamine is not expected to adsorb to suspended solids and sediment(SRC). A pKa of 10.6(4) indicates isopropylamine will exist almost entirely in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process(SRC). According to a classification scheme(5), an estimated BCF of 3.2(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A 70-80% of theoretical BOD using activated sludge in the Manometric Respirometry test(6) suggests that biodegradation is an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), isopropylamine, which has a vapor pressure of 580 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase isopropylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 3.3 hours(SRC), calculated from its rate constant of 3.9X10-13 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Isopropylamine does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: Isopropylamine was completely degraded within a 2 day period using an activated sludge inoculum in an aerobic screening test which suggests isopropylamine should biodegrade rapidly in the environment(1). Isopropylamine, present at 500 mg/L, reached approximately 26% of its theoretical BOD after 8 days in a closed bottle Warburg respirometer using an activated sludge, acclimated to aniline, at 2,500 mg/L(2). Isopropylamine, present at 100 mg/L, reached 70-80% of its theoretical BOD in 28 days using an activated sludge inoculum in the Manometric Respirometry test and was confirmed to be readily biodegradable(3). Isopropylamine reached greater than 95% degradation after 14 days using industrial, non-adapted sludge in an inherent Zahn-Wellens/EMPA test; based on the high degradation rate after 5 days, isopropylamine was considered readily biodegradable(3).

The rate constant for the vapor-phase reaction of isopropylamine with photochemically-produced hydroxyl radicals has been estimated as 3.9X10-13 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 3.3 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Isopropylamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). Isopropylamine does not contain chromophores that absorb at wavelengths >290 nm(2) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 3.2 was calculated in fish for isopropylamine(SRC), using a log Kow of 0.26(1) and a regression-derived equation(2). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of isopropylamine is estimated as 11(SRC), using a log Kow of 0.26(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that isopropylamine is expected to have very high mobility in soil. The pKa of isopropylamine is 10.6(4), indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

A pKa of 10.6(1) indicates that isopropylamine will exist almost entirely in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process. The potential for volatilization of isopropylamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 580 mm Hg(2).

SURFACE WATER: Isopropylamine was detected at a concentration of 4.2 ug/L in samples from the River Elbe, Germany; collection date not specified(1).

SOIL: Isopropylamine was detected in a mixture of soils from the Chuvash Autonomous Socialist Republic (Moscow) which contain chernozem, sandy, sandy loam, alluvial, dark grey forest and acid grey soils on unknown dates at unknown concentrations(1).

Isopropylamine was detected as a volatile component in boiled beef on unknown dates at unknown concentrations(1). Isopropylamine was detected in a sample of maize grain on unknown dates at a concentration of 2.3 mg/kg(2). Isopropylamine is reported as an odor and/or flavor used in cereal, fruit, meat, cheese and diary(3).

Isopropylamine has been identified as a constituent of tobacco, tobacco smoke, and tobacco substitute smoke(1).

According to the 2016 TSCA Inventory Update Reporting data, 3 reporting facilities estimate the number of persons reasonably likely to be exposed during the manufacturing, processing, or use of isopropylamine in the United States may be as low as 500 workers and as high as 9,999 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 8,134 workers (3,173 of these were female) were potentially exposed to isopropylamine in the US(1). Occupational exposure to isopropylamine may occur through inhalation and dermal contact with this compound at workplaces where isopropylamine is produced or used. Monitoring data indicate that the general population may be exposed to isopropylamine via dermal contact with this compound or other consumer products containing isopropylamine(SRC).

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.

... May be disposed of by atomizing in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device.

Incineration: Incinerate in a suitable combustion chamber with an afterburner and scrubber.

/GUIDE 132 FLAMMABLE LIQUIDS - CORROSIVE/ Fire or Explosion: Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

/GUIDE 132 FLAMMABLE LIQUIDS - CORROSIVE/ Health: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

/GUIDE 132 FLAMMABLE LIQUIDS - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind, uphill and/or upstream. Ventilate closed spaces before entering.

/GUIDE 132 FLAMMABLE LIQUIDS - CORROSIVE/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for Isopropylamine (8 total), please visit the HSDB record page.

UN 1221; Isopropylamine

IMO 3; Isopropylamine

49 081 94; Isopropylamine

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. Isopropylamine is included on the dangerous goods list.

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. Isopropylamine is included on the dangerous goods list.

Flammable Liquid Corrosive

Unbreakable packaging. Put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs.

Symbol: F+, Xi; R: 12-36/37/38; S: (2)-16-26-29

UN Hazard Class: 3; UN Subsidiary Risks: 8; UN Pack Group: I