bromotrifluoromethane

H280 (99.6%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]

H315 (15%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (15%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335 (15%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H336 (39.7%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

H420 (54.3%): Harms public health and the environment by destroying ozone in the upper atmosphere [Warning Hazardous to the ozone layer]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, P410+P403, P501, and P502 (click each P-code to see the statement)

Aggregated GHS information provided per 267 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H420: Harms public health and the environment by destroying ozone in the upper atmosphere [Warning Hazardous to the ozone layer]

P260, P261, P264, P270, P271, P304+P340, P308+P316, P319, P321, P403+P233, P405, P501, and P502 (click each P-code to see the statement)

H280: Contains gas under pressure; may explode if heated [Warning Gases under pressure]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P261, P264+P265, P271, P280, P304+P340, P305+P351+P338, P319, P337+P317, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement)

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Excerpt from NIOSH Pocket Guide for Trifluorobromomethane:

Eye: FROSTBITE - If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.

Skin: FROSTBITE - If frostbite has occurred, seek medical attention immediately; do NOT rub the affected areas or flush them with water. In order to prevent further tissue damage, do NOT attempt to remove frozen clothing from frostbitten areas. If frostbite has NOT occurred, immediately and thoroughly wash contaminated skin with soap and water.

Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible. (NIOSH, 2024)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· In case of contact with liquefied gas, only medical personnel should attempt thawing frosted parts.

(General first aid procedures)

Eye: Frostbite - If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.

Skin: Frostbite - Compressed gases may create low temperatures when they expand rapidly. Leaks and uses that allow rapid expansion may cause a frostbite hazard. Wear appropriate personal protective clothing to prevent the skin from becoming frozen.

Breathing: Respiratory support

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Use extinguishing agent suitable for type of surrounding fire.

SMALL FIRE: Dry chemical or CO2.

LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Damaged cylinders should be handled only by specialists.

FIRE INVOLVING TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devices; icing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. Some of these materials, if spilled, may evaporate leaving a flammable residue. (ERG, 2024)

In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep cylinder cool by spraying with water.

If material involved in fire: Extingiush fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty). Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Many gases are heavier than air and will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Do not direct water at spill or source of leak.

· Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material.

· If possible, turn leaking containers so that gas escapes rather than liquid.

· Prevent entry into waterways, sewers, basements or confined areas.

· Allow substance to evaporate.

· Ventilate the area.

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 500 meters (1/3 mile).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

Large Spill

· Consider initial downwind evacuation for at least 500 meters (1/3 mile).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Ventilation. NEVER direct water jet on liquid. Personal protection: chemical protection suit including self-contained breathing apparatus.

If trifluoromonobromomethane is leaked, the following steps should be taken: 1. Ventilate area of leak. 2. Stop flow of gas.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced.

Because of recent discovery of potential ozone decomposition in the stratosphere by fluorotrichloromethane, this material should be released to the environment only as a last resort. Waste material should be /recovered and/ returned to the vendor, or to licensed waste disposal company.

Persons not wearing protective equipment and clothing should be restricted from areas of leaks until cleanup has been completed.

If material not involved in fire: Attempt to stop leak if without undue personnel hazard.

Personnel protection: Avoid breathing vapors. Keep upwind. Wear appropriate chemical protective gloves and goggles. Do not handle broken packages unless wearing appropriate personal protective equipment.

SUFFICIENT EXHAUST & GENERAL VENTILATION SHOULD BE PROVIDED TO KEEP VAPOR CONCN BELOW RECOMMENDED LEVELS. /FLUOROCARBONS/

For more Preventive Measures (Complete) data for BROMOTRIFLUOROMETHANE (10 total), please visit the HSDB record page.

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Do not touch or walk through spilled material. Stop leak if you can do it without risk. Do not direct water at spill or source of leak. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Allow substance to evaporate. Ventilate the area. (ERG, 2024)

Fireproof if in building. Cool.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

1000.0 [ppm]

3,000 [ppm]

25,000 [ppm]

40,000 [ppm]

1000 ppm (6100 mg/m³)

TWA 1000 ppm (6100 mg/m3)

40000 ppm (NIOSH, 2024)

40000.0 [ppm]

Excerpts from Documentation for IDLHs: Human data: Volunteers exposed to 70,000 ppm for 3 minutes experienced lightheadedness and disturbances in balance and ability to respond to visual stimulus [Reinhardt and Reinke 1972]; 3 hours to 70,000 ppm caused decrements in mental performance tests [Harrison et al. 1982]. Exposure to 50,000 ppm for 20 to 25 minutes caused drowsiness, light­headedness, and a slight effect on judgment [Hine et al. 1968]. Three volunteers experienced mild nose and throat discomfort after 28 minutes of exposure to 71,000 ppm [Stewart et al. 1978]. Others reported that a 30­minute exposure at 43,000 to 45,000 ppm caused dizziness, light­headedness, euphoria, and disturbances in equilibrium and coordination [Stewart et al. 1978].

40,000 ppm

See: 75638

8 hr Time Weighted Avg (TWA): 1000 ppm.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

1000 ppm as TWA.

1000 ppm [1979]

6200 mg/m

· Use extinguishing agent suitable for type of surrounding fire.

Small Fire

· Dry chemical or CO2.

Large Fire

· Water spray, fog or regular foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Damaged cylinders should be handled only by specialists.

Fire Involving Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Do not direct water at source of leak or safety devices; icing may occur.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· Some of these materials, if spilled, may evaporate leaving a flammable residue.

Australia: 1000 ppm (1990); Federal Republic of Germany: 1000 ppm, short-term level 2000 ppm, 60 min, 3 times per shift, Pregnancy Group C, no reason to fear a risk of damage to the developing embryo or fetus when MAK and BAT values are adhered to (1992); United Kingdom: 1000 ppm, 10-min STEL 1200 ppm (1991).

A harmful concentration of this gas in the air will be reached very quickly on loss of containment.

The substance is irritating to the eyes. Rapid evaporation of the liquid may cause frostbite. The substance may cause effects on the central nervous system.

Excerpt from NIOSH Pocket Guide for Trifluorobromomethane:

Skin: FROSTBITE - Compressed gases may create low temperatures when they expand rapidly. Leaks and uses that allow rapid expansion may cause a frostbite hazard. Wear appropriate personal protective clothing to prevent the skin from becoming frozen.

Eyes: FROSTBITE - Wear appropriate eye protection to prevent eye contact with the liquid that could result in burns or tissue damage from frostbite.

Wash skin: No recommendation is made specifying the need for washing the substance from the skin (either immediately or at the end of the work shift).

Bromotrifluoromethane appears as a colorless, odorless gas at room conditions Shipped as a liquid confined under its own vapor pressure. Noncombustible. Nontoxic but can asphyxiate by the displacement of air. Contact with the unconfined liquid can cause frostbite by evaporative cooling. Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket.

Gas Vapor

Colorless, odorless gas. [Note: Shipped as a liquefied compressed gas.]; [NIOSH]

COLOURLESS COMPRESSED LIQUEFIED GAS.

Colorless, odorless gas.

Colorless, odorless gas. [Note: Shipped as a liquefied compressed gas.]

Colorless gas [Note: Shipped as a liquefied compressed gas.]

Odorless gas.

-72 °F at 760 mmHg (NIOSH, 2024)

-57.8 °C @ 760 mm Hg

-57.8 °C @760 [mm Hg]

-267 °F (NIOSH, 2024)

0.03 % (NIOSH, 2024)

Sol in chloroform

0.03% in water

Solubility in water: none

1.5800 g/ml @ 20 °C (liq)

Critical volume: 200 cu m/mol; critical density: 0.745 g/cu cm; specific heat of liquid: 0.208 cal/g at 25 °C; specific heat of vapor: 0.112 cal/g at 25 °C and 1 atm.

Relative density (water = 1): 1.5

1.58 @ 20°C

5.14(relative gas density)

5.14 (NIOSH, 2024) - Heavier than air; will sink (Relative to Air)

3.8 (AIR= 1)

Relative vapor density (air = 1): 5.1

greater than 1 atm (NIOSH, 2024)

1.22X10+4 mm Hg @ 25 °C

Vapor pressure, kPa at 20 °C: 1434

750 [mm Hg] @-58.1 °C

log Kow= 1.86

Henry's Law constant= 0.4994 atm-cu m/mole at 25 °C

Conditions contributing to instability: heat

THE FIRE EXTINGUISHER HALON 1301 BEGINS TO DECOMP AT 400-500 DEG TO HALOGEN GASES, WHICH REACT WITH HYDROGEN TO FORM HYDROGEN HALIDES. IN OXYGEN, CARBON DIOXIDE, CARBONYL FLUORIDE & CARBONYL BROMIDE MAY FORM. HAZARDS FROM DECOMP PRODUCTS ARE NEGLIGIBLE AS COMPARED TO THOSE OF OTHER HAZARDS ASSOCIATED WITH A FIRE.

Toxic gases and vapors (such as hydrogen bromide, ... hydrogen fluoride, and carbon monoxide) may be released when trifluoromonobromomethane decomposes.

UNDER CERTAIN CONDITIONS, FLUOROCARBON VAPORS MAY DECOMPOSE ON CONTACT WITH FLAMES OR HOT SURFACES, CREATING THE POTENTIAL HAZARD OF INHALATION OF TOXIC DECOMPOSITION PRODUCTS. /FLUOROCARBONS/

0.157 mPa.s @ 25 °C (liq); 0.0154 mPa.s @ 25 °C - 101.3 kPa (vapor)

Noncorrosive

118.7 kJ/kg @ boiling point

4 mN/m @ 25 °C

11.78 eV

Index of refraction: 1.238 @ 25 °C/D

Slightly soluble in water.

Fluorinated Organic Compounds

BROMOTRIFLUOROMETHANE may react with aluminum to produce substantial heat. Other halogenated hydrocarbons, such as fluorotrichloromethane, dichlorodifluoromethane, chlorodifluoromethane, tetrafluoromethane produce sufficient heat in this way to melt aluminum pieces. The vigor of the reaction appears to depend on the degree of fluorination and the vapor pressure [Chem. Eng. News 39(27):44 1961].

Incompatible with chemically-active metals such as calcium, powdered aluminum, zinc & magnesium.

Chemically-active metals (such as calcium, powdered aluminum, zinc & magnesium)

The substance can be absorbed into the body by inhalation.

inhalation, skin and/or eye contact (liquid)

Dizziness. Headache. Unconsciousness.

ON CONTACT WITH LIQUID: FROSTBITE.

Redness. See Skin.

dizziness; cardiac arrhythmias; liquid: frostbite

central nervous system, heart

Neurotoxin - Acute solvent syndrome

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Other Poison - Simple Asphyxiant

LC50 (rat) = 84,000 ppm/15 min

LC50 Rat ihl 84,000 ppm/15 mos

LC50 Guinea pig ihl 88,000 ppm/15 mos

IF INHALATION OCCURS, EPINEPHRINE OR OTHER SYMPATHOMIMETIC AMINES & ADRENERGIC ACTIVATORS SHOULD NOT BE ADMIN SINCE THEY WILL FURTHER SENSITIZE HEART TO DEVELOPMENT OF ARRHYTHMIAS. /FLUOROCARBONS/

If the diagnosis of solvent abuse is suspected it can be confirmed by biochemical examination of the blood or urine. Emergency treatment is supportive and includes decontamination, oxygen, and any specific therapy required in a particular case such as antiarrhythmics or anticonvulsants. A few patients may require intermittent positive-pressure ventilation, dialysis, or treatment for hepatic failure. /Solvent abuse/

... In persons who are intoxicated with fluorocarbons, steps can be taken to lessen the risk of arrhythmias. ... Before evaluation at the hospital, patients should be advised to avoid strenuous exercise. In the hospital, patients can be placed in a quiet, nonthreatening environment and sedated if necessary. If hypoxic, oxygen should be administered and metabolic abnormalities corrected. Sympathomimetic drugs should be avoided. Ventricular arrhythmias are best treated with beta-blocking agents. /Fluorocarbons/

Patients with fluorohydrocarbon poisoning should not be given epinephrine (Adrenalin) or similar drugs because of the tendency of fluorohydrocarbon to induce cardiac arrhythmias, including ventricular fibrillation. /Fluorohydrocarbons/

Victims of Freon inhalation require management for hypoxic, CNS anesthetic, and cardiac symptoms. Patients must be removed from the exposure environment, and high-flow supplemental oxygen should be utilized. The respiratory system should be evaluated for injury, aspiration, or pulmonary edema and treated appropriately. CNS findings should be treated supportively. A calm environment with no physical exertion is imperative to avoid increasing endogenous adrenegic levels. Exogenous adrenergic drugs must not be used to avoid inducing sensitized myocardial dysrhythmias. Atropine is ineffective in treating bradyarrhythmias. For ventricular dysrhythmias, diphenylhydantoin and countershock may be effective. Cryogenic dermal injuries should be treated by water bath rewarming at 40 to 42 °C until vasodilatory flush has returned. Elevation of the limb and standard frostbite management with late surgical debridement should be utilized. Ocular exposure requires irrigation and slit-lamp evaluation for injury. /Freons/

For more Antidote and Emergency Treatment (Complete) data for BROMOTRIFLUOROMETHANE (7 total), please visit the HSDB record page.

Consider the points of attack /heart, central nervous system/ in preplacement and periodic physical examinations.

The following medical procedures should be made available to each employee who is exposed to trifluoromonobromomethane at potentially hazardous levels: 1. Initial Medical Screening: Employees should be screened for history of certain medical conditions ... which might place the employee at increased risk from trifluoromonobromomethane exposure. /These include/ cardiovascular disease. In persons with impaired cardiovascular function, especially those with a history of cardiac arrythmias, the breathing of trifluoromonobromomethane might cause exacerbation of symptoms due to its sensitizing properties. 2. Periodic Medical Examination: Any employee developing /these/ conditions should be referred for further medical examination.

... TEN TO FIFTEEN PERCENT TRIFLUOROBROMOMETHANE IN AIR CAUSED A DECR IN HUMAN SUBJECT'S PERFORMANCE OF 5 OF 6 PSYCHOMOTOR TASKS. AT 15%, A FEELING OF IMPENDING UNCONSCIOUSNESS DEVELOPED. ... SLIGHT INCR IN REACTION TIME DURING 3 MIN EXPOSURES AT 4% & 7% TRIFLUOROBROMOMETHANE. LIGHT HEADEDNESS, PARESTHESIA, & DIMINISHED PERFORMANCE ... DURING EXPOSURES UP TO 10% TRIFLUOROBROMOMETHANE. ... NO CARDIAC ARRHYTHMIAS WERE REPORTED DURING HUMAN EXPOSURES AT 4% TO 7% TRIFLUOROBROMOMETHANE FOR 3 MIN IN HYPOBARIC CHAMBERS OR AT 5% TO 7% FOR 5 MIN AT PRESSURIZED ALTITUDES OF 1,000-20,000 FEET IN AIRCRAFT FLIGHT TESTS.

Possible adverse effects of exposure to Halon 1301 during firefighting in confined spaces were investigated. Halon 1301 (7%) did not affect the normal sleep pattern or the general health of human subjects. No Halon-induced changes in serum enzymes or serum albumin or total protein levels were observed suggesting that liver function was not altered. Subjects experienced transient light-headness and mild euphoria. Mental performance was decr, but returned to normal 1/2 hr after exposure. Apparently, Halon 1301 is a medically safe agent for use in fire fighting in confined spaces.

EXPOSURE OF HUMANS TO HALON 1301 UNDER HYPOBARIC CONDITIONS DID NOT PRODUCE SIGNIFICANT CHANGES IN THE CARDIAC OR CENTRAL NERVOUS SYSTEMS. VOLUNTEERS WERE EXPOSED FOR 3 MIN TO 4 OR 7% HALON 1301 IN AIR IN A HYPOBARIC CHAMBER MAINTAINED AT 632 OR 380 MM HG.

FLUOROCARBON VAPORS ARE FOUR TO FIVE TIMES HEAVIER THAN AIR. THUS HIGH CONCN TEND TO ACCUMULATE IN LOW-LYING AREAS, RESULTING IN HAZARD OF INHALATION OF CONCENTRATED VAPORS, WHICH MAY BE FATAL. ... THE HIGHEST EXPOSURE IN THE PLANT OCCURS WITH VENTING OF GASES FROM RETURNABLE CYLINDERS. /FLUOROCARBONS/

For more Human Toxicity Excerpts (Complete) data for BROMOTRIFLUOROMETHANE (21 total), please visit the HSDB record page.

... EXPOSURES TO TRIFLUOROBROMOMETHANE OF 20-25% RESULTED IN PERFORMANCE DECREMENTS FOR OPERANT-TRAINED MONKEYS. ... DOGS AND RATS /EXPOSED/ DAILY FOR 18 WEEKS AT AN AVERAGE CONCENTRATION OF 23000 /PPM/ TRIFLUOROBROMOMETHANE SHOWED NO SIGNS OF INTOXICATION AND NO PATHOLOGIC CHANGE WAS DETECTABLE AT NECROPSY.

... APPROX LETHAL CONCN ... WAS 5070 MG/L AIR ... FOR 15 MIN EXPOSURE OF RATS. ... /AFTER DECOMP/ @ 800 °C ... APPROX LETHAL CONCN WAS 90 MG/L ... FOR A 15 MIN EXPOSURE OF RATS. RESPONSE WAS PRIMARILY RESPIRATORY DAMAGE WITH IRRITATION & EDEMA OF LUNGS. ... CONGESTION OF LIVER, SPLEEN & KIDNEY BUT NO CHANGES IN CIRCULATORY SYSTEM.

ADMIN TO CATS @ 228 MM HG IN AIR ATMOSPHERE FOR 5 MIN @ 73 PSIG (EQUIV TO 165 FT OF SEAWATER) PRODUCED FREQUENT NODAL HEART BEATS, INCR QRS INTERVAL FROM 0.05-0.06 SEC, & PRODUCED LUNG VACUOLIZATION & MINIMAL ALVEOLAR CAPILLARY ENGORGEMENT & INFLAMMATION.

ANESTHETIZED DOGS EXPOSED TO BROMOTRIFLUOROMETHANE SHOWED A SIGNIFICANT DECREASE IN TOTAL PERIPHERAL RESISTANCE AND MYOCARDIAL CONTRACTILITY PRODUCED A REVERSIBLE HYPOTENSION DURING THE EXPOSURE.

For more Non-Human Toxicity Excerpts (Complete) data for BROMOTRIFLUOROMETHANE (11 total), please visit the HSDB record page.

Bromotrifluoromethane (CAS # 75-63-8) was evaluated for acute inhalation toxicity and cardiac sensitization in groups of beagle dogs (12/group, sex unspecified) exposed by facemask to historically sensitizing concentrations (7.5% and 10% v/v in air) and a non-sensitizing concentration (5% v/v in air) for 30 or 60 minutes. The same group of 12 dogs was used for trials at all exposure levels. The test material, a vapor at the experimental temperature and pressure, was released from a pressurized storage tank into the metered air supply to the facemasks, which was sampled and analyzed by thermal conductivity gas chromatograph every 5 minutes during exposures. Five minutes prior to the exposures, the dogs received a control intravenous injection of epinephrine (0.008 mg/kg), with an identical injection administered as challenge after the appropriate exposure interval. The exposures extended 5 minutes beyond the challenge injection for observation of subsequent recovery. Upon the challenge epinephrine injection, 1 dog each receiving 7.5 for 30 and 60 minutes, respectively, showed marked response (life-threatening arrhythmia) to treatment. One questionable and 1 definite marked response were also observed in 1 dog each in the 10% group after 30 minutes (there was no 60-minute, 10% exposure group). All marked responses were characterized by short bursts of multiple ventricular beats of up to 4 seconds in duration. One dog each responding seriously to 30-minute exposures to 7.5% and 10%, respectively, also exhibited atrial flutter. No response was noted after epinephrine challenge during a 5% exposure. The authors noted that only 1 dog of 12 showed more than one response in repeat experiments.

Bromotrifluoromethane (CBrF3, CAS # 75-63-8) was evaluated for subchronic inhalation toxicity in 4 female rhesus monkeys and 2 female baboons repeatedly exposed by inhalation to 10-80% v/v in oxygen for 10-minute intervals. Both anesthetized (2 monkeys and 2 baboons) and conscious primates inhaled from CBrF3/oxygen-filled bags of 300-400 L capacity supplied from pressurized steel cylinders, and exhaled to the outside atmosphere by means of a Pink valve or by endotracheal catheters (anesthetized animals). Cardiac function (ECG), arterial blood pressure and content, and cardiac output were monitored throughout the study. In the conscious animals, treatment was associated with evidence of cortical depression, including shivering, sedation, half-closed eyes, and lack of an inducible aggressive response. Intravenous injection of epinephrine (10 ug/kg bodyweight) induced a short sequence of ventricular fibrillation bursts from which all animals recovered spontaneously. Cardiac arrest could not be induced by further increasing the doses of epinephrine. Universal arrhythmias at 5-40 seconds after initiation of 20-80% exposures were intractable to the introduction of anesthesia. In monkeys, a 3-4 ug/kg bodyweight injection of epinephrine also elicited halved pressor responses during (but not after) 80% exposure. Similarly, during 80% exposures, no rise in blood pressure accompanied electrical stimulation of the femoral nerve (5 Hz, 10v, 2.5 msec). An identical stimulation regimen produced a 20 mm Hg elevation in blood pressure in untreated monkeys. Electrical stimulation of the femoral nerve in the arrhythmic monkeys of the 80% exposure group gave rise to incomplete or complete heart block of about 2-3 minute duration, which reverted spontaneously to bizarre arrhythmias dominated by ectopic beats. Arrhythmias were also noted to change without stimulation. Changes in heart rate occasionally heralded onset of arrhythmia during exposures to 20-80% CBrF3. Within the first minute of treatment, blood pressure rose slightly or was unchanged, and heart rates rose 10-15%. The authors attributed a 25% drop in mean blood pressure associated with ectopic beats and other ensuing treatment-related phenomena to an interference with the dynamic efficiency of the heart.

The pharmacokinetics of bromotrifluoromethane (CBrF3, CAS # 75-63-8) was investigated in 7 catheterized male volunteers exposed to 0.5% vapor by inhalation from Tedlar bags for 30 minutes. A nonbreathing valve inhalation device and mass spectrometry continuously analyzed inspired and end alveolar expired concentrations, while blood samples were collected for substance level analysis at 1/2-minute intervals for 5 minutes, and at 5-minute intervals thereafter. No effects on cardiac function (continuous ECG), blood pressure or pulse rate were noted throughout treatment, and venous blood concentrations among respective study participants ranged approximately 7-fold (from 0.19-1.24 mg/L) at the end of the exposure.

IT IS POSSIBLE THAT PT WITH CARDIAC OR RESP DISORDERS MAY PROVE ESP SUSCEPTIBLE. /FLUOROCARBONS/

Avoid release to the environment because of its impact on the ozone layer.

ALthough bromotrifluoromethane is no longer produced in the United States, it may still be used in fire extinguishers which may result in its release to the environment through various waste streams. However, the production of bromotrifluoromethane has to be stopped in accordance with the Montreal Protocol of 1987 as it plays an important role in the destruction of the earth's ozone layer. If released to air, a vapor pressure of 1.22X10+4 mm Hg at 25 °C indicates bromotrifluoromethane will exist solely in the gas phase in the ambient atmosphere. Gas-phase bromotrifluoromethane will be degraded slowly in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life of this reaction in air is estimated to be greater than 44 years. The primary decomposition process to occur in the stratosphere is UV photolysis. It has an estimated photolysis half-life of 72 yrs in the ambient atmosphere. If released to soil, bromotrifluoromethane is expected to have very high mobility based upon an estimated Koc of 49. Volatilization from moist soil surfaces is expected to be an important fate process based upon a Henry's Law constant of 0.499 atm-cu m/mole. If released into water, bromotrifluoromethane is not expected to adsorb to suspended solids and sediment in the water based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 1.2 hrs and 4.8 days, respectively. An estimated BCF of 5.4 suggests the potential for bioconcentration in aquatic organisms is low. Based upon the high degree of stability, bromotrifluoromethane biodegradation is expected to be slow. Hydrolysis is not expected to occur due to the lack of hydrolyzable functional groups. Occupational exposure to bromotrifluoromethane may occur through inhalation and dermal contact with this compound at workplaces where bromotrifluoromethane is still or used. The general population may be exposed to bromotrifluoromethane via inhalation of ambient air and from fire extinguishing products containing bromotrifluoromethane. Bromotrifluoromethane is widely detected in the atmosphere due to its high stability. (SRC)

Bromotrifluoromethane's production and use in fire extinguishers(1) and suggested use as a possible refrigerant for liquified natural gas(2) may result in its release to the environment through various waste streams(SRC). However, the production of bromotrifluoromethane has to be stopped in accordance with the Montreal Protocol of 1987 as it plays an important role in the destruction of the earth's ozone layer(1). The Montreal Protocol stipulates that the production and consumption of compounds that deplete ozone in the stratosphere including halons, are to be phased out by 2000(1).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 49(SRC), determined from a structure estimation method(2), indicates that bromotrifluoromethane is expected to have very high mobility in soil(SRC). Volatilization of bromotrifluoromethane from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 0.499 atm-cu m/mole(3). Volatilization of bromotrifluoromethane from dry soil surfaces is expected to be rapid(SRC) based upon a vapor pressure of 1.22X10+4 mm Hg(4). Based upon the highly halogenated structure of bromotrifluoromethane, biodegradation is expected to be slow(5).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 49(SRC), determined from a structure estimation method(2), indicates that bromotrifluoromethane is not expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 0.499 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 1.2 hrs and 4.8 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 5.4(SRC), from its log Kow of 1.86(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to occur due to the lack of hydrolyzable functional groups(SRC). Based upon the highly halogenated structure of bromotrifluoromethane, biodegradation is expected to be slow(9).

Avoid release to the environment because of its impact on the ozone layer.

ALthough bromotrifluoromethane is no longer produced in the United States, it may still be used in fire extinguishers which may result in its release to the environment through various waste streams. However, the production of bromotrifluoromethane has to be stopped in accordance with the Montreal Protocol of 1987 as it plays an important role in the destruction of the earth's ozone layer. If released to air, a vapor pressure of 1.22X10+4 mm Hg at 25 °C indicates bromotrifluoromethane will exist solely in the gas phase in the ambient atmosphere. Gas-phase bromotrifluoromethane will be degraded slowly in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life of this reaction in air is estimated to be greater than 44 years. The primary decomposition process to occur in the stratosphere is UV photolysis. It has an estimated photolysis half-life of 72 yrs in the ambient atmosphere. If released to soil, bromotrifluoromethane is expected to have very high mobility based upon an estimated Koc of 49. Volatilization from moist soil surfaces is expected to be an important fate process based upon a Henry's Law constant of 0.499 atm-cu m/mole. If released into water, bromotrifluoromethane is not expected to adsorb to suspended solids and sediment in the water based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 1.2 hrs and 4.8 days, respectively. An estimated BCF of 5.4 suggests the potential for bioconcentration in aquatic organisms is low. Based upon the high degree of stability, bromotrifluoromethane biodegradation is expected to be slow. Hydrolysis is not expected to occur due to the lack of hydrolyzable functional groups. Occupational exposure to bromotrifluoromethane may occur through inhalation and dermal contact with this compound at workplaces where bromotrifluoromethane is still or used. The general population may be exposed to bromotrifluoromethane via inhalation of ambient air and from fire extinguishing products containing bromotrifluoromethane. Bromotrifluoromethane is widely detected in the atmosphere due to its high stability. (SRC)

Bromotrifluoromethane's production and use in fire extinguishers(1) and suggested use as a possible refrigerant for liquified natural gas(2) may result in its release to the environment through various waste streams(SRC). However, the production of bromotrifluoromethane has to be stopped in accordance with the Montreal Protocol of 1987 as it plays an important role in the destruction of the earth's ozone layer(1). The Montreal Protocol stipulates that the production and consumption of compounds that deplete ozone in the stratosphere including halons, are to be phased out by 2000(1).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 49(SRC), determined from a structure estimation method(2), indicates that bromotrifluoromethane is expected to have very high mobility in soil(SRC). Volatilization of bromotrifluoromethane from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 0.499 atm-cu m/mole(3). Volatilization of bromotrifluoromethane from dry soil surfaces is expected to be rapid(SRC) based upon a vapor pressure of 1.22X10+4 mm Hg(4). Based upon the highly halogenated structure of bromotrifluoromethane, biodegradation is expected to be slow(5).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 49(SRC), determined from a structure estimation method(2), indicates that bromotrifluoromethane is not expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 0.499 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 1.2 hrs and 4.8 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 5.4(SRC), from its log Kow of 1.86(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to occur due to the lack of hydrolyzable functional groups(SRC). Based upon the highly halogenated structure of bromotrifluoromethane, biodegradation is expected to be slow(9).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), bromotrifluoromethane, which has a vapor pressure of 1.22X10+4 mm Hg at 25 °C(2), is expected to exist solely in the gas phase in the ambient atmosphere. Gas-phase bromotrifluoromethane is slowly degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life of this reaction in air is estimated to be greater than 44 years(3), calculated from it's rate constant of <1.0X10-16 cu cm/molecule-sec at 25 °C(3). Bromotrifluoromethane has a maximum UV absorbance at 205 nm and does not appear to absorb UV light above 270 nm(4). It has an estimated photolysis lifetime in the atmosphere of 72 years(4). The primary decomposition process to occur in the stratosphere is UV photolysis(5). The stratospheric lifetime of bromotrifluoromethane has been estimated to range from 62 to 112 years(6). Therefore, when bromotrifluoromethane is released in the troposphere, it will diffuse gradually into the upper limits of the troposphere, and eventually, into the stratosphere above the ozone layer where it will degrade slowly via photolysis, contributing to ozone depletion(SRC).

Based upon the highly halogenated structure of bromotrifluoromethane, biodegradation is expected to be slow(1).

The rate constant for the gas-phase reaction of bromotrifluoromethane with photochemically-produced hydroxyl radicals has been estimated as <1.0X10-16 cu cm/molecule-sec at 25 °C(1). This corresponds to an estimated atmospheric half-life greater than 44 years at an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm(1). Bromotrifluoromethane has a maximum UV absorbance at 205 nm and does not appear to absorb UV light above 270 nm(2). It has an estimated photolysis lifetime in the atmosphere of 72 years(2). Therefore, photolysis will not be an important fate process in the troposphere(SRC). The stratospheric lifetime of bromotrifluoromethane has been estimated to range from 62 to 112 years with direct photolysis being the dominant removal mechanism(3). Hydrolysis is not expected to occur due to the lack of hydrolyzable functional groups(SRC).

An estimated BCF of 5.4 was calculated for bromotrifluoromethane(SRC), using a log Kow of 1.86(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

The Koc of bromotrifluoromethane is estimated as 49(SRC), using a log Kow of 1.86(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that bromotrifluoromethane is expected to have very high mobility in soil.

The Henry's Law constant for bromotrifluoromethane is 0.499 atm-cu m/mole(1). This Henry's Law constant indicates that bromotrifluoromethane is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 1.2 hrs(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 4.8 days(SRC). Bromotrifluoromethane's Henry's Law constant(1) indicates that volatilization from moist soil surfaces may occur(SRC). Volatilization of bromotrifluoromethane from dry soil surfaces is expected to be rapid(SRC) based upon a vapor pressure of 1.22X10+4 mm Hg(3).

INDOOR: Bromotrifluoromethane was detected in the payload bay of the shuttle (concn not specified) from 28 separate missions(1).

RURAL/REMOTE: The concn of bromotrifluoromethane in the atmosphere at altitudes ranging from about 10 to 34 km was found to be approximately 1 part per trillion/V during 1980 monitoring(1). Bromotrifluoromethane was found at concns of 0.8 and 0.7 parts per trillion in monitoring studies conducted over the northern and southern hemisphere of the eastern Pacific Ocean, respectively(2). Bromotrifluoromethane is the main source of bromine radicals in the atmosphere above 25 km(3).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 32 workers (0 of these are female) are potentially exposed to bromotrifluoromethane in the US(1). However, production of bromotrifluoromethane has since been banned in the U.S. and therefore occupational exposure will only occur in the use of fire extinguishers containing bromotrifluoromethane as an ingredient(2). Occupational exposure to bromotrifluoromethane may occur through inhalation and dermal contact with this compound at workplaces where bromotrifluoromethane is used(SRC). The general population may be exposed to bromotrifluoromethane via inhalation of ambient air(3,4) and from fire extinguishing products(5) containing bromotrifluoromethane. Due to its ozone depleting potential in the stratosphere(6), its use is decreasing.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced.

Because of recent discovery of potential ozone decomposition in the stratosphere by fluorotrichloromethane, this material should be released to the environment only as a last resort. Waste material should be /recovered and/ returned to the vendor, or to licensed waste disposal company.

/GUIDE 126: GASES - COMPRESSED or LIQUEFIED (Including Refrigerant Gases)/ Fire or Explosion: Some may burn but none ignite readily. Containers may explode when heated. Ruptured cylinders may rocket.

/GUIDE 126: GASES - COMPRESSED or LIQUEFIED (Including Refrigerant Gases)/ Health: Vapors may cause dizziness or asphyxiation without warning. Vapors from liquefied gas are initially heavier than air and spread along ground. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire may produce irritating, corrosive and/or toxic gases.

/GUIDE 126: GASES - COMPRESSED or LIQUEFIED (Including Refrigerant Gases)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Many gases are heavier than air and will spread along ground and collect in low or confined areas (sewers, basements, tanks). Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 126: GASES - COMPRESSED or LIQUEFIED (Including Refrigerant Gases)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing will only provide limited protection.

For more DOT Emergency Guidelines (Complete) data for BROMOTRIFLUOROMETHANE (8 total), please visit the HSDB record page.

UN 1009; Bromotrifluoromethane

IMO 2.2; Bromotrifluoromethane

49 045 49; Bromotrifluoromethane

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Non-Flammable Gas

UN Hazard Class: 2.2