Chlorotrimethylsilane

This chemical does not meet GHS hazard criteria for < 0.1% (1 of 2477) of reports.

H225 (99.2%): Highly Flammable liquid and vapor [Danger Flammable liquids]

H301 (95.4%): Toxic if swallowed [Danger Acute toxicity, oral]

H312 (99%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H314 (99.6%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H331 (95.9%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H351 (85.6%): Suspected of causing cancer [Warning Carcinogenicity]

P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P318, P321, P330, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 2477 reports by companies from 28 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 1 of 2477 reports by companies.

There are 27 notifications provided by 2476 of 2477 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H312: Harmful in contact with skin [Warning Acute toxicity, dermal]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H331: Toxic if inhaled [Danger Acute toxicity, inhalation]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P308+P316, P316, P317, P321, P330, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Give nothing to drink. Refer for medical attention .

Warning: In the presence of water, trimethylchlorosilane liberates hydrochloric acid, which is extremely corrosive. Caution is advised.

Signs and Symptoms of Acute Trimethylchlorosilane Exposure: Signs and symptoms of acute trimethylchlorosilane exposure may include increased salivation, intense thirst, difficulty swallowing, chills, pain, and shock. Oral, esophageal, and stomach burns are common. Vomitus generally has a coffee-ground appearance. Acute inhalation exposure may result in hoarseness, laryngitis, a feeling of suffocation, dyspnea (shortness of breath), choking, respiratory tract irritation, chest pain, and pulmonary edema. The potential for circulatory collapse is high following ingestion of trimethylchlorosilane. Sneezing, bleeding of the nose and gums, and ulceration of the nasal and oral mucosa may also occur. Renal toxicity has been observed in animals. If the eyes come in contact with trimethylchlorosilane, irritation, pain, swelling, corneal erosion, and blindness may result. Dermal exposure is generally followed by dermatitis (red, inflamed skin), severe burns, pain, and shock.

Emergency Life-Support Procedures: Acute exposure to trimethylchlorosilane may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:

1. Move victims to fresh air. Emergency personnel should avoid self-exposure to trimethylchlorosilane.

2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

4. RUSH to a health care facility.

Dermal/Eye Exposure:

1. Remove victims from exposure. Emergency personnel should avoid self- exposure to trimethylchlorosilane.

3. Remove contaminated clothing as soon as possible.

4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.

5. Wash exposed skin areas THOROUGHLY with soap and water.

6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

7. RUSH to a health care facility.

Ingestion Exposure:

1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

2. Rinse mouth with large amounts of water. Inform victims not to swallow this water.

3. DO NOT induce vomiting or attempt to neutralize! 4 Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

5. Activated charcoal is of no value.

6. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert.

7. RUSH to a health care facility. (EPA, 1998)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

Use acid-vapor-type respirator, rubber gloves, chemical worker's goggles, and other protective equipment as necessary to protect skin and eyes.

Extinguish with dry chemicals or carbon dioxide. Do not use water or foam. Cool exposed containers with water. Water spray, fog, or foam may be required to fight large fires. However, trimethylchlorosilane may react violently with water. Do not get water inside containers. (EPA, 1998)

Use AFFF, carbon dioxide, dry sand, special powder. NO hydrous agents. NO water. In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water.

Aqueous film forming foam (AFFF), carbon dioxide, dry sand, special powder. NO hydrous agents. NO water.

If material on fire or involved in fire: Do not extinguish the fire unless flow can be stopped. Use "alcohol" foam, dry chemical or carbon dioxide. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Do not use water on material itself. If large quantities of combustibles are involved, use water in flooding quantities as spray and fog. Use water spray to knock-down vapors.

Flashback along vapor trail may occur.

Behavior in fire: difficult to extinguish; re-ignition may occur.

The vapor is heavier than air and may travel along the ground; distant ignition possible ... Reacts violently with fire extinguishing agents such as water.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

· A vapor-suppressing foam may be used to reduce vapors.

· FOR CHLOROSILANES, use alcohol-resistant foam to reduce vapors.

· DO NOT GET WATER on spilled substance or inside containers.

· Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material.

· Prevent entry into waterways, sewers, basements or confined areas.

Small Spill

· Cover with DRY earth, DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain.

· Use clean, non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal.

HCl - when spill Trimethylchlorosilane into water.

Excerpt from ERG Guide 155 [Substances - Toxic and/or Corrosive (Flammable / Water-Sensitive)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 1298 datasheet.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

When spilled in water

Small spill:

- ISOLATE in all directions: 30 m (100 ft)

Large spill:

- PROTECT people from downwind during DAY time: 0.1 km (0.1 mi)

- PROTECT people from downwind during NIGHT time: 0.1 km (0.1 mi)

- PROTECT people from downwind during DAY time: 0.4 km (0.2 mi)

- PROTECT people from downwind during NIGHT time: 1.0 km (0.6 mi)

Evacuate danger area! Consult an expert! Collect leaking and spilled liquid in sealable dry non-plastic containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer. Personal protection: complete protective clothing including self-contained breathing apparatus.

Shut off ignition sources. Call fire department. Avoid contact with liquid. Keep people away. Stop discharge if possible. Isolate and remove discharged material. Notify local health and pollution control agencies.

Flush with water. Rinse with sodium bicarbonate or lime soln.

Evacuate danger area! Consult an expert! Collect leaking liquid in sealable dry containers; do not use plastic containers. Absorb remaining liquid in dry sand or inert absorbent and remove to safe place. Do NOT wash away into sewer. (Extra personal protection: complete protective clothing including self-contained breathing apparatus.)

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

It is good practice to install emergency showers at all strategic locations; these should ... be actuated automatically by pressure on foot plate; bath tubs filled with clean water can also provide valuable service in ... emergency. /Corrosive substances/

Excerpt from ERG Guide 155 [Substances - Toxic and/or Corrosive (Flammable / Water-Sensitive)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. A vapor-suppressing foam may be used to reduce vapors. FOR CHLOROSILANES, use alcohol-resistant foam to reduce vapors. DO NOT GET WATER on spilled substance or inside containers. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Prevent entry into waterways, sewers, basements or confined areas.

SMALL SPILL: Cover with DRY earth, DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain. Use clean, non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal. (ERG, 2024)

Fireproof. Separated from food and feedstuffs and other compounds. Cool. Dry. Well closed.

Storage temperature; ambient.

Venting: pressure-vacuum

Fireproof. Separated from other compounds, food and feedstuffs. Cool. Dry. Well closed.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: ppm)

AEGL 2: Irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape (Unit: ppm)

AEGL 3: Life-threatening health effects or death (Unit: ppm)

AEGLs Status: Final

1.8 [ppm]

22 [ppm]

100 [ppm]

· Note: Most foams will react with the material and release corrosive/toxic gases.

CAUTION: For Acetyl chloride (UN1717), use CO2 or dry chemical only.

Small Fire

· CO2, dry chemical, dry sand, alcohol-resistant foam.

Large Fire

· Water spray, fog or alcohol-resistant foam.

· FOR CHLOROSILANES, DO NOT USE WATER; use alcohol-resistant foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Avoid aiming straight or solid streams directly onto the product.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Do not get water inside containers.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

ERPG-1: 3 ppm - one hour exposure limit: 1 = mild transient health effects or objectionable odor [AIHA]

ERPG-2: 20 ppm - one hour exposure limit: 2 = impaired ability to take protective action [AIHA]

ERPG-3: 150 ppm - one hour exposure limit: 3 = life threatening health effects [AIHA]

Workplace Environmental Exposure Level (WEEL): Ceiling 5 ppm

Emergency Response Planning Guidelines (ERPG): ERPG(1) 3 ppm (no more than mild, transient effects) for up to 1 hr exposure; ERPG(2) 20 ppm (without serious, adverse effects) for up to 1 hr exposure; ERPG(3) 150 ppm (not life threatening) up to 1 hr exposure.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance and the vapour are corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. Exposure could cause death. Medical observation is indicated.

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

... Prevent, from outset, any planned or accidental contact with corrosive substances by utilizing only closed-circuit apparatus ... /otherwise/ corrosion-resistant & impervious suits or overalls, foot, ... hand & arm, ... head, ... eye & face protection ... /should be relied on/. /Corrosive substances/

... Where aprons are used ... these should have bibs; sleeves should be worn outside ... gloves, and ... trouser legs should cover tops of shoes ... When exposure ... is not severe ... barrier creams can often be used instead of gloves. /Corrosive substances/

Acid-vapor-type respiratory protection; rubber gloves; chemical worker's goggles; other protective equipment as necessary to protect skin and eyes.

Face shield, or eye protection in combination with breathing protection.

NO open flames, NO sparks and NO smoking. NO contact with hot surfaces. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.

STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR!

Trimethylchlorosilane appears as a colorless fuming liquid with a pungent odor. Boiling point 135 °F, Flash point -18 °F. Density 0.854 g / cm3. The vapor and liquid may cause burns. Vapors are heavier than air.

Colorless liquid with a pungent odor; [ICSC]

COLOURLESS LIQUID WITH PUNGENT ODOUR.

Colorless liquid

SHARP, HYDROCHLORIC ACID-LIKE ODOR; ACRID.

135 °F at 760 mmHg (EPA, 1998)

57 °C @760 [mm Hg]

-72 °F (EPA, 1998)

0 °F (EPA, 1998)

[ERG 2016] -28 °C

-18 °F (-28 °C) (Closed cup)

0 °F (Open cup)

Decomposes (NTP, 1992)

Sol in benzene, ether, perchloroethylene

Solubility in water: reaction

0.854 at 77 °F (EPA, 1998) - Less dense than water; will float

0.854 AT 25 °C/25 °C

Relative density (water = 1): 0.85

0.854 @25 °C

3.7 (EPA, 1998) - Heavier than air; will sink (Relative to Air)

3.75 (Air=1)

Relative vapor density (air = 1): 3.8

608 mmHg at 68 °F ; 40 mmHg at 11.5 °F; 100 mmHg at 42.8 °F (NTP, 1992)

234.0 [mmHg]

234 mm Hg at 25 °C

Vapor pressure, kPa at 20 °C: 26.7

743 °F (USCG, 1999)

743 °F (395 °C)

... /Trimethylchlorosilane/ decomposes on heating producing toxic and corrosive fumes including hydrogen chloride, phosgene.

When heated to decomposition it emits toxic fumes of /hydrogen chloride/.

126 BTU/LB

Index of refraction = 1.3870 at 25 °C/D

Readily hydrolyzed with liberation of hydrochloric acid

Organo-functional silanes are noted for their ability to bond organic polymer systems to inorganic substrates /Silane cmpd/

The reaction of organosilanes with halogens and halogen cmpd usually proceeds in good yield through cleavage of the Si--H bond and formation of the silicon-halogen bond. Reaction with fluorine, however, does not proceed satisfactorily because of cleavage of not only the Si--H but also C--Si and C--H bonds. Direct halogenation with chlorination, bromine, and iodine proceeds smoothly, however. /Organosilanes/

29Si nuclear magnetic resonance spectrum

Schoenflies notation

Boiling point

Chemical bond

Chemical shift

Highly flammable. Fumes in air. Reacts vigorously and exothermically with water. Products of the reaction include hydrogen chloride. The heat may be sufficient to ignite nearby combustible materials.

Trimethylchlorosilane reacts vigorously with water to generate gaseous HCl. Based on a scenario where the chemical is spilled into an excess of water (at least 5 fold excess of water), half of the maximum theoretical yield of Hydrogen Chloride gas will be created in 1.3 minutes. Experimental details are in the following: "Development of the Table of Initial Isolation and Protective Distances for the 2008 Emergency Response Guidebook", ANL/DIS-09-2, D.F. Brown, H.M. Hartmann, W.A. Freeman, and W.D. Haney, Argonne National Laboratory, Argonne, Illinois, June 2009.

Chlorosilanes

Highly Flammable

Water-Reactive

Air-Reactive

CSL00024

SODIUM AZIDE + CHLOROTRIMETHYLSILANE

explosion hazard

Explosive

ACS Safety Letters

TRIMETHYLCHLOROSILANE reacts vigorously and exothermically with water to produce hydrogen chloride.

Reacts with surface moisture to evolve hydrogen chloride, which will corrode common metals & form flammable hydrogen gas.

... They will react with water or steam to produce heat, toxic & corrosive fumes of hydrochloric acid. /Chlorosilanes/

Interaction of the lithium derivative /eg hexafluoroisopropylideneaminolithium/ with a range of chloro- and fluoro-derivatives of arsenic, boron, phosphorus, silicon and sulfur during warming to 25 °C tended to be violently exothermic in absence of solvent ...

Silane and chlorosilanes can explode when mixed with various halocarbons and ignited.

... Reacts violently with alcohols, amines causing fire and explosion hazard. Attacks many metals in presence of water.

The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Burning sensation. Cough. Sore throat. Laboured breathing. Shortness of breath. Symptoms may be delayed.

Redness. Pain. Blisters. Skin burns.

Redness. Pain. Severe deep burns.

Burning sensation. Abdominal pain. Shock or collapse.

Dermatotoxin - Skin burns.

Lacrimator (Lachrymator) - A substance that irritates the eyes and induces the flow of tears.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

LC50 (rat) = 13,175 mg/m3/1hr

LD50 Rabbit dermal 1780 uL/kg

LD50 Rabbit dermal 1500 mg/kg

LD50 Rabbit (female) dermal 1.78 (95% confidential limit 0.84 to 3.79) mL/kg

LD50 Rabbit (male) dermal 2.83 (95% confidential limit 1.56 to 3.63) mL/kg

For more Non-Human Toxicity Values (Complete) data for TRIMETHYLCHLOROSILANE (9 total), please visit the HSDB record page.

No specific antidote is available /for chlorosilanes/, but first aid treatment consists of copious irrigation with water, & subsequent treatment is as for chemical burns in general. /Chlorosilanes/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal (refer to ingestion protocol in Section Three ... . Cover skin burns with sterile dressings after decontamination ... . /Silane, Chlorosilane, and Related Compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Early intubation at the first sign of upper airway obstruction may be necessary. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Silane, Chlorosilane, and related compounds/

FIRST AID: Inhalation--Fresh air, rest. Half-upright position. Artificial respiration may be needed ... The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered ... Skin--Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention; Eyes--First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor; Ingestion--Rinse mouth. Do NOT induce vomiting. Give nothing to drink. Refer for medical attention.

/SIGNS AND SYMPTOMS/ Inhalation of vapor irritates mucous membranes. Contact of liq with eyes or skin causes severe burns. Ingestion causes severe burns of mouth and stomach. ... Vapors cause severe irritation of ... throat and can cause ... lung injury.

/SIGNS AND SYMPTOMS/ ... Chlorotrimethylsilane is a very irritative compound, probably due to its very fast hydrolysis to hydrogen chloride. ... Severe irritation of skin, eyes (from exposure to the liquid), and mucous membranes (by vapors), and severe burns of mouth and stomach following ingestion were mentioned.

/SIGNS AND SYMPTOMS/ ... /Trimethylchlorosilane/ and the vapor are corrosive to the eyes, the skin and the respiratory tract. Corrosive on ingestion. Inhalation of the vapor may cause lung edema ... The symptoms of lung edema often do not become manifest until a few hours have passed and they are aggravated by physical effort ... Exposure may result in death ...

/SIGNS AND SYMPTOMS/ ACUTE ... SYMPTOMS: Inhalation--Burning sensation. Cough. Sore throat. Labored breathing. Shortness of breath. Symptoms may be delayed ... Skin--Redness. Pain. Blisters. Skin burns; Eyes--Redness. Pain. Severe deep burns; Ingestion--Burning sensation. Abdominal pain. Shock or collapse.

/LABORATORY ANIMALS: Acute Exposure/ An intraperitoneal LDLo of 750 mg/kg bw has been reported in mice.[Health Council of the Netherlands: Dutch Expert Committee on Occupational Standards. Chlorotrimethylsilane; Health-based recommended occupational exposure limit. p. 31. The Hague: Health Council of the Netherlands, 2001; publication no. 2001/05OSH.]

/LABORATORY ANIMALS: Acute Exposure/ In rats, a 1-hr LC50 of approximately 13,175 mg/cu m (2928 ppm) has been determined after exposing male and female rats (n=5/sex/group) nose-only to vapour concentrations of approximately 10,415, 12,850, 14,790, and 16,840 mg/cu m (2314, 2855, 3289, 3742 ppm). The mortality observed in a fourteen-day observation period was 1/10 (female), 3/10 (all females), 10/10, and 10/10 for the 2314-, 2855-, 3289-, and 3742-ppm group, respectively. The animals exposed to the two highest concentration groups died on the first observation day. Because of this early dying, recording of clinical signs and body weights was limited to the two lower concentration groups showing nasal crust, rough coat as the main signs, and initial body weight loss and decreased total mean body weight gain. At necropsy, major findings included corneal opacity (in the three higher concentration groups) and diffuse or focal dark coloured areas of the lungs (in all treated groups).[Health Council of the Netherlands: Dutch Expert Committee on Occupational Standards. Chlorotrimethylsilane; Health-based recommended occupational exposure limit. p. 30. The Hague: Health Council of the Netherlands, 2001; publication no. 2001/05OSH.]

/LABORATORY ANIMALS: Acute Exposure/ When exposed to nearly satured vapors /estimated to be ca 250,000 ppm/, all exposed female Sprague-Dawley rats (n=5) died within twelve minutes. Toxic signs reported included lachrymation, hyperactivity, ataxia, and gasping. At necropsy, red patchy lungs and gas-filled stomachs and intestines were seen.[Health Council of the Netherlands: Dutch Expert Committee on Occupational Standards. Chlorotrimethylsilane; Health-based recommended occupational exposure limit. p. 31. The Hague: Health Council of the Netherlands, 2001; publication no. 2001/05OSH.]

/LABORATORY ANIMALS: Acute Exposure/ Trimethylchlorosilane is rated 9 on rabbit eyes /on a scale of 1 to 10 with 10 being the most severe/.[Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 1061]

For more Non-Human Toxicity Excerpts (Complete) data for TRIMETHYLCHLOROSILANE (27 total), please visit the HSDB record page.

Trimethylchlorosilane's production and use as an intermediate in silicone synthesis as well as use as a chain terminating agent and in imparting water repellence may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 234 mm Hg at 25 °C indicates trimethylchlorosilane will exist solely as a vapor in the atmosphere. Vapor-phase trimethylchlorosilane will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 12 days. Methyl silanes are transparent to UV radiation >290 nm and therefore trimethylchlorosilane is not expected to undergo direct photolytic degradation. All silicon chlorides are immediately and completely hydrolyzed and trimethylchlorosilane has been reported to hydrolyze instantaneously releasing hydrochloric acid. Hydrolysis is expected to be the most important fate process in soil and water. Biodegradation, bioconcentration, soil adsorption and volatilization will not be important fate processes when compared to hydrolysis. Trimethylchlorosilane may volatilize from dry soil surfaces based upon its vapor pressure. Due to rapid hydrolysis bioconcentration of trimethylchlorosilane is not expected. Occupational exposure to trimethylchlorosilane may occur through inhalation and dermal contact with this compound at workplaces where trimethylchlorosilane is produced or used. (SRC)

Trimethylchlorosilane's production and use as an intermediate in silicone synthesis as well as use as a chain terminating agent and imparting water repellence(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: All silicon chlorides are immediately and completely hydrolyzed by water(1) and trimethylchlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(2). Volatilization from moist soil surfaces, adsorption to soil and sediment as well as biodegradation are not expected to be important fate processes when compared to decomposition in water. Trimethylchlorosilane may volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 234 mm Hg(3).

AQUATIC FATE: All silicon chlorides are immediately and completely hydrolyzed by water(1) and trimethylchlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(2). Due to the rapid decomposition in water volatilization, bioconcentration and biodegradation are not expected to be important fate processes(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), trimethylchlorosilane, which has a vapor pressure of 234 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase trimethylchlorosilane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 12 days(SRC), calculated from its rate constant of 4.5X10-13 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Methyl silanes are transparent to UV radiation >290 nm(4) and therefore trimethylchlorosilane is not expected to undergo direct photolytic degradation(SRC).

The rate constant for the vapor-phase reaction of trimethylchlorosilane with photochemically-produced hydroxyl radicals has been estimated as 4.5X10-13 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 12 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). All silicon chlorides are immediately and completely hydrolyzed by water(2) and trimethylchlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(3). Methyl silanes are transparent to UV radiation >290 nm(4) and therefore trimethylchlorosilane is not expected to undergo direct photolytic degradation(SRC).

Trimethylchlorosilane has been reported to hydrolyze immediately upon contact with water(1) and therefore bioconcentration of trimethylchlorosilane is not expected(SRC).

All silicon chlorides are immediately and completely hydrolyzed by water(1) and trimethylchlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(2). Decomposition of trimethylcholorsilane is expected to occur more rapidly than adsorption(SRC).

All silicon chlorides are immediately and completely hydrolyzed by water(1) and trimethylchlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(2). Decomposition of trimethylchlorosilane is expected to occur more rapidly than volatilization(SRC.) Trimethylchlorosilane is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 234 mm Hg(3).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,876 workers (20 of these are female) are potentially exposed to trimethylchlorosilane in the US(1). Occupational exposure to trimethylchlorosilane may occur through inhalation and dermal contact with this compound at workplaces where trimethylchlorosilane is produced or used(SRC).

Trimethylchlorosilane's production and use as an intermediate in silicone synthesis as well as use as a chain terminating agent and in imparting water repellence may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 234 mm Hg at 25 °C indicates trimethylchlorosilane will exist solely as a vapor in the atmosphere. Vapor-phase trimethylchlorosilane will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 12 days. Methyl silanes are transparent to UV radiation >290 nm and therefore trimethylchlorosilane is not expected to undergo direct photolytic degradation. All silicon chlorides are immediately and completely hydrolyzed and trimethylchlorosilane has been reported to hydrolyze instantaneously releasing hydrochloric acid. Hydrolysis is expected to be the most important fate process in soil and water. Biodegradation, bioconcentration, soil adsorption and volatilization will not be important fate processes when compared to hydrolysis. Trimethylchlorosilane may volatilize from dry soil surfaces based upon its vapor pressure. Due to rapid hydrolysis bioconcentration of trimethylchlorosilane is not expected. Occupational exposure to trimethylchlorosilane may occur through inhalation and dermal contact with this compound at workplaces where trimethylchlorosilane is produced or used. (SRC)

Trimethylchlorosilane's production and use as an intermediate in silicone synthesis as well as use as a chain terminating agent and imparting water repellence(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: All silicon chlorides are immediately and completely hydrolyzed by water(1) and trimethylchlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(2). Volatilization from moist soil surfaces, adsorption to soil and sediment as well as biodegradation are not expected to be important fate processes when compared to decomposition in water. Trimethylchlorosilane may volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 234 mm Hg(3).

AQUATIC FATE: All silicon chlorides are immediately and completely hydrolyzed by water(1) and trimethylchlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(2). Due to the rapid decomposition in water volatilization, bioconcentration and biodegradation are not expected to be important fate processes(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), trimethylchlorosilane, which has a vapor pressure of 234 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase trimethylchlorosilane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 12 days(SRC), calculated from its rate constant of 4.5X10-13 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Methyl silanes are transparent to UV radiation >290 nm(4) and therefore trimethylchlorosilane is not expected to undergo direct photolytic degradation(SRC).

The rate constant for the vapor-phase reaction of trimethylchlorosilane with photochemically-produced hydroxyl radicals has been estimated as 4.5X10-13 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 12 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). All silicon chlorides are immediately and completely hydrolyzed by water(2) and trimethylchlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(3). Methyl silanes are transparent to UV radiation >290 nm(4) and therefore trimethylchlorosilane is not expected to undergo direct photolytic degradation(SRC).

Trimethylchlorosilane has been reported to hydrolyze immediately upon contact with water(1) and therefore bioconcentration of trimethylchlorosilane is not expected(SRC).

All silicon chlorides are immediately and completely hydrolyzed by water(1) and trimethylchlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(2). Decomposition of trimethylcholorsilane is expected to occur more rapidly than adsorption(SRC).

All silicon chlorides are immediately and completely hydrolyzed by water(1) and trimethylchlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(2). Decomposition of trimethylchlorosilane is expected to occur more rapidly than volatilization(SRC.) Trimethylchlorosilane is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 234 mm Hg(3).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,876 workers (20 of these are female) are potentially exposed to trimethylchlorosilane in the US(1). Occupational exposure to trimethylchlorosilane may occur through inhalation and dermal contact with this compound at workplaces where trimethylchlorosilane is produced or used(SRC).

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

If ... THERE IS NO FIRE, go directly to the Table of Initial Isolation and Protective Action Distances /(see table below)/ ... to obtain initial isolation and protective action distances. IF THERE IS A FIRE, or IF A FIRE IS INVOLVED, go directly to the appropriate guide /(see guide(s) below)/ and use the evacuation information shown under PUBLIC SAFETY.

Table: Table of Initial Isolation and Protective Action Distances for Trimethylchlorosilane (when spilled in water) [Table#2679]

Table of Water-Reactive Materials Which Produce Toxic Gases. Trimethylchlorosilane

Table: Materials Which Produce Large Amounts of Toxic-by-Inhalation (TIH) Gas(es) When Spilled in Water [Table#2680]

/GUIDE 155: SUBSTANCES - TOXIC and/or CORROSIVE (Flammable/Water-Sensitive)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

/GUIDE 155: SUBSTANCES - TOXIC and/or CORROSIVE (Flammable/Water-Sensitive)/ Health: TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

For more DOT Emergency Guidelines (Complete) data for TRIMETHYLCHLOROSILANE (10 total), please visit the HSDB record page.

UN 1298; Trimethylchlorosilane

IMO 3.2; Trimethylchlorosilane

49 076 80; Trimethylchlorosilane

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Liquid Corrosive

Do not transport with food and feedstuffs.

UN Hazard Class: 3; UN Subsidiary Risks: 8; UN Pack Group: II