Trichloromethylsilane

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for < 0.1% (2 of 2308) of reports.

H225 (> 99.9%): Highly Flammable liquid and vapor [Danger Flammable liquids]

H315 (97%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (97%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335 (97.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Aggregated GHS information provided per 2308 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 2 of 2308 reports by companies.

There are 13 notifications provided by 2306 of 2308 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H312: Harmful in contact with skin [Warning Acute toxicity, dermal]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Give nothing to drink. Refer for medical attention .

Warning: In the presence of water, methyltrichlorosilane liberates hydrochloric acid, which is extremely corrosive. Caution is advised.

Signs and Symptoms of Acute Methyltrichlorosilane Exposure: Signs and symptoms of acute ingestion of methyltrichlorosilane may include excessive salivation, intense thirst, difficulty in swallowing, chills, pain, and shock. Oral, esophageal, and stomach burns are common. Vomitus generally has a coffee-ground appearance. The potential for circulatory collapse is high following ingestion of methyltrichlorosilane. Acute inhalation exposure may result in hoarseness, laryngitis, a feeling of suffocation, dyspnea (shortness of breath), choking, respiratory tract irritation, chest pain, and pulmonary edema. Sneezing, bleeding of the nose and gums, and ulceration of the nasal and oral mucosa may also occur. Renal toxicity has been observed in animals. If the eyes have come in contact with methyltrichlorosilane, then irritation, pain, swelling, corneal erosion, and blindness may result. Dermatitis (red, inflamed skin), severe burns, pain, and shock generally follow dermal exposure.

Emergency Life-Support Procedures: Acute exposure to methyltrichlorosilane may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:

1. Move victims to fresh air. Emergency personnel should avoid self-exposure to methyltrichlorosilane.

2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

4. RUSH to a health care facility.

Dermal/Eye Exposure:

1. Remove victims from exposure. Emergency personnel should avoid self- exposure to methyltrichlorosilane.

3. Remove contaminated clothing as soon as possible.

4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.

5. Wash exposed skin areas THOROUGHLY with soap and water.

6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

7. RUSH to a health care facility.

Ingestion Exposure:

1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

2. Rinse mouth with large amounts of water. Inform victims not to swallow this water.

3. DO NOT induce vomiting or attempt to neutralize!

4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

5. Activated charcoal is of no value.

6. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert.

7. RUSH to a health care facility. (EPA, 1998)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

Self-contained breathing apparatus is required as combustion/decomposition yields acid gases/pulmonary irritants. Corrosion-resistant protective clothing, as well as appropriate foot, hand, arm, head, eye, and face protection are required where contact is possible.

Dry chemical or carbon dioxide may be used for small fires. Water may be used for large fires if firefighters are protected from violent reaction of methyltrichlorosilane with water. Water may be used to keep containers cool. (EPA, 1998)

Use AFFF, powder, carbon dioxide. NO hydrous agents. NO water. In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water.

If material on fire or involved in fire: do not extinguish fire unless flow can be stopped. Use "alcohol" foam, dry chemical or carbon dioxide. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Do not use water on material itself. If large quantities of combustibles are involved, use water in flooding quantities as spray and fog. Use water spray to knock-down vapors.

Use dry chemical, foam, carbon dioxide, or water spray. Water may be ineffective. Use water spray to keep fire exposed containers cool. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products.

Aqueous film forming foam (AFFF). Powder. Carbon dioxide. NO hydrous agents. NO water.

Vapors are heavier than air and may travel to a source of ignition and flash back.

Containers may explode in fire.

Reacts violently with fire extinguishing agents such as water.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

· A vapor-suppressing foam may be used to reduce vapors.

· FOR CHLOROSILANES, use alcohol-resistant foam to reduce vapors.

· DO NOT GET WATER on spilled substance or inside containers.

· Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material.

· Prevent entry into waterways, sewers, basements or confined areas.

Small Spill

· Cover with DRY earth, DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain.

· Use clean, non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal.

HCl - when spill Methyltrichlorosilane into water.

Excerpt from ERG Guide 155 [Substances - Toxic and/or Corrosive (Flammable / Water-Sensitive)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 1250 datasheet.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

When spilled in water

Small spill:

- ISOLATE in all directions: 30 m (100 ft)

Large spill:

- ISOLATE in all directions: 60 m (200 ft)

- PROTECT people from downwind during DAY time: 0.1 km (0.1 mi)

- PROTECT people from downwind during NIGHT time: 0.1 km (0.1 mi)

- PROTECT people from downwind during DAY time: 0.6 km (0.4 mi)

- PROTECT people from downwind during NIGHT time: 1.9 km (1.2 mi)

Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable dry non-plastic containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.

Evacuate danger area! Consult an expert! Collect leaking liquid in sealable, dry containers; do not use plastic containers. Absorb remaining liquid in dry sand or inert absorbent and remove to safe place. Do NOT wash away into sewer. (Extra personal protection: complete protective clothing including self-contained breathing apparatus.)

Eliminate all ignition sources. Stop or control the leak, if this can be done without undue risk. Use water spray to cool and disperse vapors and protect personnel. Control runoff and isolate discharged material for proper disposal.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

... Preventive measures should be directed primarily at preventing or minimizing contact between corrosive substances & skin, mucous membranes & eyes. ... Adequate ventilation & exhaust arrangements, whether general or local, should be provided whenever corrosive gases or dusts are present. /Corrosive substances/

Excerpt from ERG Guide 155 [Substances - Toxic and/or Corrosive (Flammable / Water-Sensitive)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. A vapor-suppressing foam may be used to reduce vapors. FOR CHLOROSILANES, use alcohol-resistant foam to reduce vapors. DO NOT GET WATER on spilled substance or inside containers. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Prevent entry into waterways, sewers, basements or confined areas.

SMALL SPILL: Cover with DRY earth, DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain. Use clean, non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal. (ERG, 2024)

Fireproof. Separated from oxidants. Cool. Dry. Well closed.

Fireproof ... Well closed.

Store in a cool, dry, well-ventilated location. Separate from acids, alkalies, oxidizing materials, and water. Outside or detached storage is preferred.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: ppm)

AEGL 2: Irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape (Unit: ppm)

AEGL 3: Life-threatening health effects or death (Unit: ppm)

AEGLs Status: Final

0.60 [ppm]

7.3 [ppm]

33 [ppm]

· Note: Most foams will react with the material and release corrosive/toxic gases.

CAUTION: For Acetyl chloride (UN1717), use CO2 or dry chemical only.

Small Fire

· CO2, dry chemical, dry sand, alcohol-resistant foam.

Large Fire

· Water spray, fog or alcohol-resistant foam.

· FOR CHLOROSILANES, DO NOT USE WATER; use alcohol-resistant foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Avoid aiming straight or solid streams directly onto the product.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Do not get water inside containers.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

ERPG-1: 0.5 ppm - one hour exposure limit: 1 = mild transient health effects or objectionable odor [AIHA]

ERPG-2: 3 ppm - one hour exposure limit: 2 = impaired ability to take protective action [AIHA]

ERPG-3: 15 ppm - one hour exposure limit: 3 = life threatening health effects [AIHA]

Emergency Response Planning Guidelines (ERPG): ERPG(1) 0.5 ppm (no more than mild, transient effects) for up to 1 hr exposure; ERPG(2) 3 ppm (without serious, adverse effects) for up to 1 hr exposure; ERPG(3) 15 ppm (not life threatening) up to 1 hr exposure.

Workplace Environmental Exposure Level (WEEL): Short-term Exposure Limit (STEL) 1 ppm, ceiling.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema. Exposure could cause death. Medical observation is indicated.

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

... /Protective/ equipment should ... /include/ corrosion-resistant & impervious suits ... foot, ... hand & arm, ... head, ... and eye & face protection; where corrosive gases may be expected ... Respiratory protective equipment is required... Natural rubbers, synthetic rubbers, polyvinyl chloride, polypropylene or polyethylene either in sheet form or with fabric backing are suitable /for personal protective equipment/. /Corrosive substances/

... Acid-vapor type respiratory protection ...

... Positive pressure self-contained breathing apparatus.

Face shield, or eye protection in combination with breathing protection.

NO open flames, NO sparks and NO smoking. NO contact with hot surfaces. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.

STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR!

Methyltrichlorosilane appears as a colorless fuming liquid with a pungent odor. Flash point 8 °F. Vapor and liquid may cause burns. Denser than water. Vapors are heavier than air.

Colorless liquid with a sharp, irritating odor; [CHRIS]

COLOURLESS LIQUID WITH PUNGENT ODOUR.

COLORLESS LIQUID

ACRID ODOR, SHARP LIKE HYDROCHLORIC ACID

152 °F at 760 mmHg (EPA, 1998)

65.6 °C @760 [mm Hg]

-108 °F (EPA, 1998)

15 °F (EPA, 1998)

45 °F (Open cup); 15 °F (Closed cup)

Decomposes in ethanol

Decomposes instantly in water

Solubility in water: reaction

1.27 at 77 °F (EPA, 1998) - Denser than water; will sink

1.270 at 25 °C/25 °C

Relative density (water = 1): 1.3

1.273 @ 20°C

5.17 (EPA, 1998) - Heavier than air; will sink (Relative to Air)

5.17 (Air = 1)

Relative vapor density (air = 1): 5.2

167.0 [mmHg]

167 mm Hg at 25 °C

Vapor pressure, kPa at 20 °C: 17.9

75 [mm Hg] @7 °C

Decomp in moist air, creating hydrochloric acid with odor threshold of 1 ppm.

greater than 760 °F (USCG, 1999)

>760 °F (>404 °C)

Rapid hydrolysis precludes measurements. Possible toxic effects may be due to formation of hydrochloric acid.

When heated to decomposition it emits toxic fumes of /hydrogen chloride/.

Decomposes in moist air, creating hydrochloric acid with odor threshold of 1 ppm.

89.3 BTU/LB

20.3 DYNES/CM= 0.0203 N/M @ 20 °C

Index of refraction: 1.4085 at 25 °C/D

Organo-functional silanes are noted for their ability to bond organic polymer systems to inorganic substrates. /Silane cmpd/

The reaction of organosilanes with halogens and halogen cmpd usually proceeds in good yield through cleavage of the Si--H bond and formation of the silicon-halogen bond. Reaction with fluorine, however, does not proceed satisfactorily because of cleavage of not only the Si--H but also C--Si and C--H bonds. Direct halogenation with chlorination, bromine, and iodine proceeds smoothly, however. /Organosilanes/

29Si nuclear magnetic resonance spectrum

Dunham energy parameter

Schoenflies notation

Boiling point

Centrifugal distortion

Highly flammable. Fumes in air. Reacts violently with water, steam, moist air, alcohols, acetone, light metals with generation of heat and combustible (H2) and corrosive (HCl) gases. On contact with air it gives off HCl gas. [Handling Chemicals Safely 1980. p. 924].

Methyltrichlorosilane reacts vigorously with water to generate gaseous HCl. Based on a scenario where the chemical is spilled into an excess of water (at least 5 fold excess of water), half of the maximum theoretical yield of Hydrogen Chloride gas will be created in 1.4 minutes. Experimental details are in the following: "Development of the Table of Initial Isolation and Protective Distances for the 2008 Emergency Response Guidebook", ANL/DIS-09-2, D.F. Brown, H.M. Hartmann, W.A. Freeman, and W.D. Haney, Argonne National Laboratory, Argonne, Illinois, June 2009.

Chlorosilanes

Highly Flammable

Water-Reactive

Air-Reactive

Chlorosilanes, such as METHYLTRICHLOROSILANE, are compounds in which silicon is bonded to from one to four chlorine atoms with other bonds to hydrogen and/or alkyl groups. Chlorosilanes react with water, moist air, or steam to produce heat and toxic, corrosive fumes of hydrogen chloride. They may also produce flammable gaseous H2. They can serve as chlorination agents. Chlorosilanes react vigorously with both organic and inorganic acids and with bases to generate toxic or flammable gases.

Silane and chlorosilanes can explode when mixed with various halocarbons and ignited.

... Can react vigorously with oxidizing materials.

Methyl trichlorosilane evolves white fumes with moist air. It reacts violently with water with the evolution of heat and white acid fumes.

... Reacts violently with water and moist air to produce hydrogen chloride ... Attacks metals like aluminium and magnesium.

The substance can be absorbed into the body by inhalation and by ingestion.

Burning sensation. Cough. Sore throat. Laboured breathing. Shortness of breath. Symptoms may be delayed.

Redness. Blisters. Pain. Skin burns.

Redness. Pain. Severe deep burns.

Burning sensation. Abdominal pain. Shock or collapse.

Dermatotoxin - Skin burns.

Lacrimator (Lachrymator) - A substance that irritates the eyes and induces the flow of tears.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

LC50 (rat) = 450 ppm/4H

LD50 Rat oral 0.8 g/kg /From table/

LD50 Rat ip approx 0.06 g/kg /From table/

No specific antidote is available /for chlorosilanes/, but first aid treatment consists of copious irrigation with water, & subsequent treatment is as for chemical burns in general. /Chlorosilanes/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... Anticipate seizures and treat if necessary ... Monitor for shock and treat if necessary ... For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... Cover skin burns with sterile dressings after decontamination ... /Silane, Chlorosilane, and Related Compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Early intubation at the first sign of upper airway obstruction may be necessary. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... Monitor cardiac rhythm and treat arrhythmias if necessary ... Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... Treat seizures with diazepam or lorazepam ... Use proparacaine hydrochloride to assist eye irrigation ... /Silane, Chlorosilane, and related compounds/

FIRST AID: Inhalation--Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention ... The symptoms of lung edema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate ... /aerosol/, by a doctor or a person authorized by him/her, should be considered ... Skin--Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention; Eyes--First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor; Ingestion--Rinse mouth. Do NOT induce vomiting. Give nothing to drink. Refer for medical attention.

/SIGNS AND SYMPTOMS/ Causes severe eye and skin burns. May be harmful if absorbed through skin or inhaled. Irritating to skin, eyes, and respiratory system ...

/SIGNS AND SYMPTOMS/ If inhaled will cause difficult breathing. ... Ingestion causes severe burns of mouth and stomach.

/SIGNS AND SYMPTOMS/ Corrosive. Causes severe eye and skin burns. May be harmful if absorbed through skin or inhaled. Irritating to skin, eyes, and respiratory system. Symptoms of overexposure include coughing, wheezing, laryngitis, headache, nausea, vomiting, spasm, pulmonary inflammation, and edema.

/SIGNS AND SYMPTOMS/ ACUTE ... SYMPTOMS: Inhalation--Burning sensation. Cough. Sore throat. Labored breathing. Shortness of breath. Symptoms may be delayed ... Skin--Redness. Blisters. Pain. Skin burns; Eyes--Redness. Pain. Severe deep burns; Ingestion--Burning sensation. Abdominal pain. Shock or collapse.

/SIGNS AND SYMPTOMS/ ... /Methyltrichlorosilane/ is corrosive to the eyes, the skin and the respiratory tract. Corrosive on ingestion. Inhalation of this substance may cause lung edema ... The symptoms of lung edema often do not become manifest until a few hours have passed and they are aggravated by physical effort ... Exposure may result in death ...

/LABORATORY ANIMALS: Acute Exposure/ Methyl trichlorosilane has been tested by application of a small drop to rabbit eyes and has been found to cause severe damage.

/LABORATORY ANIMALS: Acute Exposure/ All these cmpd, even in very low doses ... caused severe burns of cornea and eyelids. ... /After/ application to the skin of the rabbit the region attacked by chlorosilanes blanches and then blisters appear ... /Chlorosilanes/

/LABORATORY ANIMALS: Acute Exposure/ Tests by application of a drop to rabbit eyes have been made on tetrachlorosilane, dichloridimethyl silane, dichlorodiethylsilane, methyltrichlorosilane, and ethyl trichlorosilane. All the chlorosilanes were found to cause severe damage of the cornea and lids. More severe damage was caused by the alkylchlorosilanes than by tetrachlorosilane (silicone tetrachloride). The principal danger is from splash contamination. /Chlorosilanes/

/GENOTOXICITY/ The synthetic and degradative intermediates of polydimethylsiloxanes were assessed for genotoxic potential using in vitro microbial assay techniques. The compounds were tested with and without S-9 activation. Salmonella typhimurium strains TA 1535, TA 1537, TA 1538, TA 98, and TA 100 were used for reverse mutation assays according the method of Ames. Saccharomyces cerevisiae strain D4 provided a parallel for the Ames mutation assay in diploid eukaryotic cells. The Escherichia coli pol-A repair assay tested for chemically induced DNA damage using the mutant strain P3078. Tissue culture assays were performed using Fischer L5178Y mouse lymphoma cells. The test compounds included hydrochloric acid, trimethylchlorosilane, trimethylsilanol, dimethyldichlorosilane, dimethyldiethoxysilane, methyltrichlorosilane, methyltriethoxysilane, silicon tetrachloride, hexamethyldisiloxane, silane hydrolysate, hexamethylcyclotrisiloxane, octamethylcyclotetrasiloxane, and decamethylcyclopentasiloxane. None of the organosilicon test compounds produced any significant increase in the incidence of reverse mutation, mitotic recombination, or DNA damage as assessed by the microbial assays, nor did any agent produce a significant increase in mutant colonies in the mouse lymphoma studies. Dose related increases in sister chromatid exchanges were observed for trimethylsilanol without S-9 activation, methyltriethoxysilane with S-9 activation, and for dimethyldiethoxysilane, methyltrichlorosilane, silicon tetrachloride, and hexamethylcyclotrisiloxane in the presence and absence of S-9. Dose related increases in chromosome aberrations were observed after treatment with trimethylchlorosilane in the absence of S-9 and after trimethylsilanol and dimethyldichlorosilane with and without S-9. /It was/ concluded that none of the compounds tested are mutagenic although some exhibit in vitro clastogenic activity.

/GENOTOXICITY/ The clastogenic activity of several organosilicon compounds was investigated using in-vivo cytogenetic tests. The test compounds included methyltrichlorosilane, dimethyldichlorosilane, trimethylchlorosilane, trimethylsilanol, hexamethyldisiloxane, and hexamethylcyclotrisiloxane (541059). Male Sprague-Dawley-rats received intraperitoneal injections of the test chemicals, and bone marrow samples were collected at 6, 24, and 48 hours. Chromosomes were prepared using standard air drying methods. Confirmatory bone marrow chromosome assays and the dominant lethal test were used to evaluate the in-vivo clastogenic potential of trimethylsilanol. Chromosomes were harvested after intraperitoneal injections of the agent at concentrations of 300, 400, and 500 mg/kg, and a 9 week dosing schedule prior to mating was used for the dominant lethal study. No significant, dose related increase in chromosome damage was observed for any of the agents tested. Simple chromatid gaps and breaks were the predominant type of damage. Neither the bone marrow chromosome assay nor the dominant lethal test revealed any clastogenic activity for trimethylsilanol. The authors conclude that all the agents tested lack clastogenic activity.

/OTHER TOXICITY INFORMATION/ Rapid hydrolysis precludes measurements. Possible toxic effects may be due to formation of hydrochloric acid.

Methyltrichlorosilane's production and use as an intermediate in silicone synthesis may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 167 mm Hg at 25 °C indicates methyltrichlorosilane will exist solely as a vapor in the atmosphere. Vapor-phase methyltrichlorosilane will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 36 days. Methyl silanes are transparent to UV radiation >290 nm and therefore methyltrichlorosilane is not expected to undergo direct photolytic degradation. All silicon chlorides are immediately and completely hydrolyzed and methyltrichlorosilane has been reported to hydrolyze instantaneously releasing hydrochloric acid. Volatilization from moist soil surfaces, adsorption to soil and sediment, as well as biodegradation, are not expected to be important fate processes when compared to rapid hydrolysis in water. Methyltrichlorosilane may volatilize from dry soil surfaces based upon its vapor pressure. Due to the rapid hydrolysis, bioconcentration of methyltrichlorosilane is not expected. Occupational exposure to methyltrichlorosilane may occur through inhalation and dermal contact with this compound at workplaces where methyltrichlorosilane is produced or used. (SRC)

Methyltrichlorosilane's production and use as an intermediate in silicone synthesis(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: All silicon chlorides are immediately and completely hydrolyzed by water(1) and methyltrichlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(2). Volatilization from moist soil surfaces, adsorption to soil and sediment as well as biodegradation are not expected to be important fate processes when compared to decomposition in water. Methyltrichlorosilane may volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 167 mm Hg(3).

AQUATIC FATE: All silicon chlorides are immediately and completely hydrolyzed by water(1) and methyltrichlorosilane has been reported to hydrolyze in water, releasing hydrochloric acid(2). Due to the rapid decomposition in water volatilization, bioconcentration and biodegradation are not expected to be important fate processes(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methyltrichlorosilane, which has a vapor pressure of 167 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase methyltrichlorosilane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 36 days(SRC), calculated from its rate constant of 1.5X10-13 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Methyl silanes are transparent to UV radiation >290 nm(4) and therefore methyltrichlorosilane is not expected to undergo direct photolytic degradation(SRC).

The rate constant for the vapor-phase reaction of methyltrichlorosilane with photochemically-produced hydroxyl radicals has been estimated as 1.5X10-13 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 36 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). All silicon chlorides are immediately and completely hydrolyzed by water(2) and methyltrichlorosilane has been reported to hydrolyze in water, releasing hydrochloric acid(3). Methyl silanes are transparent to UV radiation >290 nm(4) and therefore methyltrichlorosilane is not expected to undergo direct photolytic degradation(SRC).

Methyltrichlorosilane has been reported to hydrolyze immediately upon contact with water(1) and therefore bioconcentration of methyltrichlorosilane is not expected.

All silicon chlorides are immediately and completely hydrolyzed by water(1) and methyltrichlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(2). Decomposition of methyltricholorsilane is expected to occur more rapidly than adsorption(SRC).

All silicon chlorides are immediately and completely hydrolyzed by water(1) and methyltrichlorosilane has been reported to hydrolyze in water, releasing hydrochloric acid(2). Decomposition of methyltricholorsilane is expected to occur more rapidly than volatilization(SRC). Methyltrichlorosilane may volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 167 mm Hg(3).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,755 workers (1,191 of these are female) are potentially exposed to methyltrichlorosilane in the US(1). Occupational exposure to methyltrichlorosilane may occur through inhalation and dermal contact with this compound at workplaces where methyltrichlorosilane is produced or used(SRC).

/OTHER TOXICITY INFORMATION/ Rapid hydrolysis precludes measurements. Possible toxic effects may be due to formation of hydrochloric acid.

Methyltrichlorosilane's production and use as an intermediate in silicone synthesis may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 167 mm Hg at 25 °C indicates methyltrichlorosilane will exist solely as a vapor in the atmosphere. Vapor-phase methyltrichlorosilane will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 36 days. Methyl silanes are transparent to UV radiation >290 nm and therefore methyltrichlorosilane is not expected to undergo direct photolytic degradation. All silicon chlorides are immediately and completely hydrolyzed and methyltrichlorosilane has been reported to hydrolyze instantaneously releasing hydrochloric acid. Volatilization from moist soil surfaces, adsorption to soil and sediment, as well as biodegradation, are not expected to be important fate processes when compared to rapid hydrolysis in water. Methyltrichlorosilane may volatilize from dry soil surfaces based upon its vapor pressure. Due to the rapid hydrolysis, bioconcentration of methyltrichlorosilane is not expected. Occupational exposure to methyltrichlorosilane may occur through inhalation and dermal contact with this compound at workplaces where methyltrichlorosilane is produced or used. (SRC)

Methyltrichlorosilane's production and use as an intermediate in silicone synthesis(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: All silicon chlorides are immediately and completely hydrolyzed by water(1) and methyltrichlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(2). Volatilization from moist soil surfaces, adsorption to soil and sediment as well as biodegradation are not expected to be important fate processes when compared to decomposition in water. Methyltrichlorosilane may volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 167 mm Hg(3).

AQUATIC FATE: All silicon chlorides are immediately and completely hydrolyzed by water(1) and methyltrichlorosilane has been reported to hydrolyze in water, releasing hydrochloric acid(2). Due to the rapid decomposition in water volatilization, bioconcentration and biodegradation are not expected to be important fate processes(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methyltrichlorosilane, which has a vapor pressure of 167 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase methyltrichlorosilane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 36 days(SRC), calculated from its rate constant of 1.5X10-13 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Methyl silanes are transparent to UV radiation >290 nm(4) and therefore methyltrichlorosilane is not expected to undergo direct photolytic degradation(SRC).

The rate constant for the vapor-phase reaction of methyltrichlorosilane with photochemically-produced hydroxyl radicals has been estimated as 1.5X10-13 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 36 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). All silicon chlorides are immediately and completely hydrolyzed by water(2) and methyltrichlorosilane has been reported to hydrolyze in water, releasing hydrochloric acid(3). Methyl silanes are transparent to UV radiation >290 nm(4) and therefore methyltrichlorosilane is not expected to undergo direct photolytic degradation(SRC).

Methyltrichlorosilane has been reported to hydrolyze immediately upon contact with water(1) and therefore bioconcentration of methyltrichlorosilane is not expected.

All silicon chlorides are immediately and completely hydrolyzed by water(1) and methyltrichlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(2). Decomposition of methyltricholorsilane is expected to occur more rapidly than adsorption(SRC).

All silicon chlorides are immediately and completely hydrolyzed by water(1) and methyltrichlorosilane has been reported to hydrolyze in water, releasing hydrochloric acid(2). Decomposition of methyltricholorsilane is expected to occur more rapidly than volatilization(SRC). Methyltrichlorosilane may volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 167 mm Hg(3).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,755 workers (1,191 of these are female) are potentially exposed to methyltrichlorosilane in the US(1). Occupational exposure to methyltrichlorosilane may occur through inhalation and dermal contact with this compound at workplaces where methyltrichlorosilane is produced or used(SRC).

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

If ... THERE IS NO FIRE, go directly to the Table of Initial Isolation and Protective Action Distances /(see table below)/ ... to obtain initial isolation and protective action distances. IF THERE IS A FIRE, or IF A FIRE IS INVOLVED, go directly to the appropriate guide /(see guide(s) below)/ and use the evacuation information shown under PUBLIC SAFETY.

Table: Table of Initial Isolation and Protective Action Distances for Methyltrichlorosilane (when spilled in water) [Table#2264]

Table of Water-Reactive Materials Which Produce Toxic Gases

Table: Materials Which Produce Large Amounts of Toxic-by-Inhalation Gas(es) When Spilled in Water [Table#2265]

/GUIDE 155: SUBSTANCES - TOXIC AND/OR CORROSIVE (FLAMMABLE/WATER-SENSITIVE)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.

/GUIDE 155: SUBSTANCES - TOXIC AND/OR CORROSIVE (FLAMMABLE/WATER-SENSITIVE)/ Spill or Leak: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. A vapor suppressing foam may be used to reduce vapors. ... DO NOT GET WATER on spilled substance or inside containers. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Prevent entry into waterways, sewers, basements or confined areas. Small spills: Cover with DRY earth, DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain. Use clean non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal.

For more DOT Emergency Guidelines (Complete) data for METHYLTRICHLOROSILANE (10 total), please visit the HSDB record page.

UN 1250; Methyltrichlorosilane

IMO 3.1; Metyltrichlorosilane

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Liquid Corrosive

Airtight. Unbreakable packaging. Put breakable packaging into closed unbreakable container.

Symbol: F, Xi; R: 11-14-36/37/38; S: (2)-26-39

UN Hazard Class: 3; UN Subsidiary Risks: 8; UN Pack Group: I