2-Chloro-1,1,1-trifluoroethane

H280 (100%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]

P410+P403</a, and a href="https://pubchem.ncbi.nlm.nih.gov/ghs/#P410+P403">P410+P403 (click each P-code to see the statement)

Aggregated GHS information provided per 25 reports by companies from 2 notifications to the ECHA C&L Inventory.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H280: Contains gas under pressure; may explode if heated [Warning Gases under pressure]

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

H360: May damage fertility or the unborn child [Danger Reproductive toxicity]

P203, P261, P271, P280, P304+P340, P318, P319, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement)

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Refer to the "General First Aid" section. Specific First Aid: In case of contact with liquefied gas, only medical personnel should attempt thawing frosted parts. (ERG, 2024)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· In case of contact with liquefied gas, only medical personnel should attempt thawing frosted parts.

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Use extinguishing agent suitable for type of surrounding fire.

SMALL FIRE: Dry chemical or CO2.

LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Damaged cylinders should be handled only by specialists.

FIRE INVOLVING TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devices; icing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. Some of these materials, if spilled, may evaporate leaving a flammable residue. (ERG, 2024)

In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep cylinder cool by spraying with water.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Many gases are heavier than air and will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Do not direct water at spill or source of leak.

· Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material.

· If possible, turn leaking containers so that gas escapes rather than liquid.

· Prevent entry into waterways, sewers, basements or confined areas.

· Allow substance to evaporate.

· Ventilate the area.

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 500 meters (1/3 mile).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

Large Spill

· Consider initial downwind evacuation for at least 500 meters (1/3 mile).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Ventilation. NEVER direct water jet on liquid. Do NOT let this chemical enter the environment. Personal protection: chemical protection suit including self-contained breathing apparatus.

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Do not touch or walk through spilled material. Stop leak if you can do it without risk. Do not direct water at spill or source of leak. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Allow substance to evaporate. Ventilate the area. (ERG, 2024)

Fireproof if in building. Cool.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

· Use extinguishing agent suitable for type of surrounding fire.

Small Fire

· Dry chemical or CO2.

Large Fire

· Water spray, fog or regular foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Damaged cylinders should be handled only by specialists.

Fire Involving Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Do not direct water at source of leak or safety devices; icing may occur.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· Some of these materials, if spilled, may evaporate leaving a flammable residue.

A harmful concentration of this gas in the air will be reached very quickly on loss of containment.

Rapid evaporation of the liquid may cause frostbite. Exposure at high levels could cause unconsciousness.

Animal tests show that this substance possibly causes toxic effects upon human reproduction.

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)

AVOID EXPOSURE OF (PREGNANT) WOMEN!

Use ventilation.

Cold-insulating gloves.

Wear safety goggles or eye protection in combination with breathing protection.

Do not eat, drink, or smoke during work.

1-Chloro-2,2,2-trifluoroethane is a colorless, odorless gas. It is shipped as a liquid under its own vapor pressure. Contact with the liquid may cause frostbite to unprotected skin. It can asphyxiate by the displacement of air. Exposure of the container to fire or heat can cause it to rupture violently and rocket.

Gas Vapor; Liquid

A colorless gas; Shipped as a liquid under its own vapor pressure; [CAMEO]

COMPRESSED LIQUEFIED GAS.

-105.3 °C

-105.5 °C

In water, 9,200 mg/l @ 25 °C

Solubility in water, g/100ml at 25 °C: 0.89

1.389 g/cu cm @ 0 °C

Relative density (water = 1): 1.4

Relative vapor density (air = 1): 4.1

Vapor pressure, kPa at 20 °C: 180

When heated to decomposition it emits toxic fumes of /fluorides/.

Index of refraction= 1.3092 @ 0 °C

Hydroxyl radical reaction rate constant= 1.62X10-14 cu cm/molecule-sec @ 25 °C

Coriolis coupling

Schoenflies notation

Boiling point

Centrifugal distortion

Chemical bond

Chemical shift

Equilibrium structure

Heat of sublimation

Internuclear distance

Molecular structure

Nuclear quadrupole coupling

Nuclear quadrupole resonance spectroscopy

Optical coefficient

Phase diagram

Phase equilibrium

Point group

Quadrupole coupling

Refractive index

Rotation-vibration spectrum

Rotational excitation cross section

Spin-spin coupling constant

Thermal expansion coefficient

Vapor pressure

Vapor-liquid equilibrium

Viscosity

No rapid reaction with air. No rapid reaction with water.

Fluorinated Organic Compounds

1-CHLORO-2,2,2-TRIFLUOROETHANE is chemically inert in many situations, but can react violently with strong reducing agents such as the very active metals and the active metals. Undergoes oxidation with strong oxidizing agents and under extremes of temperature.

No data are available in humans. Limited evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans. /From table/

2-Chloro-1,1,1-trifluoroethane

Group 3: Not classifiable as to its carcinogenicity to humans

Volume 41: (1986) Some Halogenated Hydrocarbons and Pesticide Exposures

Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)

Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Part 1, Part 2, Part 3)

The substance can be absorbed into the body by inhalation.

Unconsciousness. Suffocation.

ON CONTACT WITH LIQUID: FROSTBITE.

See Skin.

Neurotoxin - Acute solvent syndrome

Other Poison - Simple Asphyxiant

LC50 (mice) = 150,000 ppm/1h

LC50 Mouse inhalation 15 pph/1 hr

Groups of 36 male & 36 female SPR Alpk/Ap (Wistar-derived) rats, 6 wk old, received 300 mg/kg bw 2-chloro-1,1,1-trifluoroethane (FC 133a; purity, 99.5%) as a 3% w/v soln in corn oil by gavage on 5 day/wk for 52 wk. Two vehicle-control groups (one of which was housed separately) & one untreated control group were available. The study was terminated after 125 wk. Body-weight gain was significantly reduced in treated males; mortality rates were comparable between the groups. The incidence of uterine carcinomas was 1/104 in the combined controls & 15/35 in treated females [p<0.001]. the incidence of benign (often bilateral) interstitial-cell neoplasms of the testes was 16/104 in the combined controls & 29/36 in treated males [p<0.001].

The toxicity of 2-chloro-1,1,1-trifluoroethane was reviewed ... which concluded that, in an inhalation experiment, the compound produced nasal & lung damage & atrophy of the thymus, spleen, testes & ovaries. In addn, thyroid weight was increased in male rats. ... /It/ is embryotoxic at exposure concns that did not produce clear evidence of maternal toxicity & that there was evidence of teratogenicity.

Groups of 36 male & 36 female Alpk/Ap rats were exposed to 0 or 300 mg/kg bw 2-chloro-1,1,1-trifluoroethane by gavage on 5 days/wk for one yr. Reduced growth & increased aggressive behavior, arrest of spermatogenesis & seminiferous tubular atrophy were observed in males.

2-Chloro-1,1,1-trifluoroethane was not mutagenic to Salmonella typhimurium TA98 or TA100, in the presence & absence of a rat-liver metabolic system (S9) when incubated at concns of 0.1-50% for 48 hr, or at 0.5-10% for 8 hr. ... No mutagenic effect /was reported/ in S. typhimurium TA1535 or TA100 in the presence or absence of S9, when incubated for 72 hr at concns up to 50%.

For more Non-Human Toxicity Excerpts (Complete) data for 1,1,1-TRIFLUORO-2-CHLOROETHANE (6 total), please visit the HSDB record page.

Avoid release to the environment because of its impact on the ozone layer. Avoid release to the environment in circumstances different to normal use.

1,1,1-Trifluoro-2-chloroethane's (HCFC-133a) production and use as a blowing agent, refrigerant and chemical intermediate may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 950 mm Hg at 25 °C indicates 1,1,1-trifluoro-2-chloroethane will exist solely as a gas in the ambient atmosphere. Gas-phase 1,1,1-trifluoro-2-chloroethane will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 2.7 years. Stratospheric photolysis of 1,1,1-trifluoro-2-chloroethane releases chlorine radicals which can participate in ozone-destroying reactions. If released to soil, 1,1,1-trifluoro-2-chloroethane is expected to have very high mobility based upon an estimated Koc of 30. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 0.27 atm-cu m/mole. 1,1,1-Trifluoro-2-chloroethane may volatilize from dry soil surfaces based upon its vapor pressure. If released into water, 1,1,1-trifluoro-2-chloroethane is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 1 hour and 4 days, respectively. 1,1,1-Trifluoro-2-chloroethane is not expected to undergo hydrolysis since it lacks hydrolyzable functional groups. An estimated BCF of 4 suggests the potential for bioconcentration in aquatic organisms is low. Occupational exposure to 1,1,1-trifluoro-2-chloroethane may occur through inhalation and dermal contact with this compound at workplaces where 1,1,1-trifluoro-2-chloroethane is produced or used. (SRC)

1,1,1-Trifluoro-2-chloroethane's production and use as a blowing agent, refrigerant and chemical intermediate(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 30(SRC), determined from a measured water solubility of 9,200 mg/l(2) and a regression-derived equation(3), indicates that 1,1,1-trifluoro-2-chloroethane is expected to have very high mobility in soil(SRC). Volatilization of 1,1,1-trifluoro-2-chloroethane from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.27 atm-cu m/mole(SRC), using a fragment constant estimation method(4). The potential for volatilization of 1,1,1-trifluoro-2-chloroethane from dry soil surfaces may exist(SRC) based upon an estimated vapor pressure of 950 mm Hg(SRC), determined from a fragment constant method(5).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 30(SRC), determined from a measured water solubility of 9,200 mg/l(2) and a regression-derived equation(3), indicates that 1,1,1-trifluoro-2-chloroethane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 0.27 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 1 hour and 4 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 4(SRC), from its water solubility and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,1,1-trifluoro-2-chloroethane, which has an estimated vapor pressure of 950 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a gas in the ambient atmosphere. Gas-phase 1,1,1-trifluoro-2-chloroethane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2.7 years(SRC), calculated from its rate constant of 1.62X10-14 cu cm/molecule-sec at 25 °C(3). Stratospheric photolysis of 1,1,1-trifluoro-2-chloroethane releases chlorine radicals which can participate in ozone-destroying reactions(4).

The rate constant for the vapor-phase reaction of 1,1,1-trifluoro-2-chloroethane with photochemically-produced hydroxyl radicals has been measured as 1.62X10-14 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 2.7 years at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 1,1,1-Trifluoro-2-chloroethane is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2) but can become environmentally significant in the stratosphere where released chlorine radicals may participate in ozone-destroying reactions(3).

An estimated BCF of 4 was calculated for 1,1,1-trifluoro-2-chloroethane(SRC), using a water solubility of 9,200 mg/l(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of 1,1,1-trifluoro-2-chloroethane is estimated as 30(SRC), using a measured water solubility of 9,200 mg/l(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 1,1,1-trifluoro-2-chloroethane is expected to have very high mobility in soil.

The Henry's Law constant for 1,1,1-trifluoro-2-chloroethane is estimated as 0.27 atm-cu m/mole(SRC) calculated using a fragment constant estimation method(1). This Henry's Law constant indicates that 1,1,1-trifluoro-2-chloroethane is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 1 hour(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 4 days(SRC). 1,1,1-Trifluoro-2-chloroethane's Henry's Law constant(1) indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of 1,1,1-trifluoro-2-chloroethane from dry soil surfaces may exist(SRC) based upon an estimated vapor pressure of 950 mm Hg(SRC), determined from a fragment constant method(3).

Occupational exposure to 1,1,1-trifluoro-2-chloroethane may occur through inhalation and dermal contact with this compound at workplaces where 1,1,1-trifluoro-2-chloroethane is produced or used. (SRC)

Avoid release to the environment because of its impact on the ozone layer. Avoid release to the environment in circumstances different to normal use.

1,1,1-Trifluoro-2-chloroethane's (HCFC-133a) production and use as a blowing agent, refrigerant and chemical intermediate may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 950 mm Hg at 25 °C indicates 1,1,1-trifluoro-2-chloroethane will exist solely as a gas in the ambient atmosphere. Gas-phase 1,1,1-trifluoro-2-chloroethane will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 2.7 years. Stratospheric photolysis of 1,1,1-trifluoro-2-chloroethane releases chlorine radicals which can participate in ozone-destroying reactions. If released to soil, 1,1,1-trifluoro-2-chloroethane is expected to have very high mobility based upon an estimated Koc of 30. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 0.27 atm-cu m/mole. 1,1,1-Trifluoro-2-chloroethane may volatilize from dry soil surfaces based upon its vapor pressure. If released into water, 1,1,1-trifluoro-2-chloroethane is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 1 hour and 4 days, respectively. 1,1,1-Trifluoro-2-chloroethane is not expected to undergo hydrolysis since it lacks hydrolyzable functional groups. An estimated BCF of 4 suggests the potential for bioconcentration in aquatic organisms is low. Occupational exposure to 1,1,1-trifluoro-2-chloroethane may occur through inhalation and dermal contact with this compound at workplaces where 1,1,1-trifluoro-2-chloroethane is produced or used. (SRC)

1,1,1-Trifluoro-2-chloroethane's production and use as a blowing agent, refrigerant and chemical intermediate(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 30(SRC), determined from a measured water solubility of 9,200 mg/l(2) and a regression-derived equation(3), indicates that 1,1,1-trifluoro-2-chloroethane is expected to have very high mobility in soil(SRC). Volatilization of 1,1,1-trifluoro-2-chloroethane from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.27 atm-cu m/mole(SRC), using a fragment constant estimation method(4). The potential for volatilization of 1,1,1-trifluoro-2-chloroethane from dry soil surfaces may exist(SRC) based upon an estimated vapor pressure of 950 mm Hg(SRC), determined from a fragment constant method(5).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 30(SRC), determined from a measured water solubility of 9,200 mg/l(2) and a regression-derived equation(3), indicates that 1,1,1-trifluoro-2-chloroethane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 0.27 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 1 hour and 4 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 4(SRC), from its water solubility and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,1,1-trifluoro-2-chloroethane, which has an estimated vapor pressure of 950 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a gas in the ambient atmosphere. Gas-phase 1,1,1-trifluoro-2-chloroethane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2.7 years(SRC), calculated from its rate constant of 1.62X10-14 cu cm/molecule-sec at 25 °C(3). Stratospheric photolysis of 1,1,1-trifluoro-2-chloroethane releases chlorine radicals which can participate in ozone-destroying reactions(4).

The rate constant for the vapor-phase reaction of 1,1,1-trifluoro-2-chloroethane with photochemically-produced hydroxyl radicals has been measured as 1.62X10-14 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 2.7 years at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 1,1,1-Trifluoro-2-chloroethane is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2) but can become environmentally significant in the stratosphere where released chlorine radicals may participate in ozone-destroying reactions(3).

An estimated BCF of 4 was calculated for 1,1,1-trifluoro-2-chloroethane(SRC), using a water solubility of 9,200 mg/l(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of 1,1,1-trifluoro-2-chloroethane is estimated as 30(SRC), using a measured water solubility of 9,200 mg/l(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 1,1,1-trifluoro-2-chloroethane is expected to have very high mobility in soil.

The Henry's Law constant for 1,1,1-trifluoro-2-chloroethane is estimated as 0.27 atm-cu m/mole(SRC) calculated using a fragment constant estimation method(1). This Henry's Law constant indicates that 1,1,1-trifluoro-2-chloroethane is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 1 hour(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 4 days(SRC). 1,1,1-Trifluoro-2-chloroethane's Henry's Law constant(1) indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of 1,1,1-trifluoro-2-chloroethane from dry soil surfaces may exist(SRC) based upon an estimated vapor pressure of 950 mm Hg(SRC), determined from a fragment constant method(3).

Occupational exposure to 1,1,1-trifluoro-2-chloroethane may occur through inhalation and dermal contact with this compound at workplaces where 1,1,1-trifluoro-2-chloroethane is produced or used. (SRC)

Non-Flammable Gas

UN Hazard Class: 2.2