English Safety Data Sheet Database 中文版 MSDS

2,2,2-trifluoroethanol

CAS No. 75-89-8 | PubChem CID 6409
Section 1. Identification
Chemical Name2,2,2-trifluoroethanol CAS No.75-89-8
Synonyms2,2,2-trifluoroet-hylalcohol Chinese Name2,2,2-三氟乙醇
Molecular FormulaC2H3F3O Molecular Weight100
UN No.1992 Data SourcePubChem (NIH/NLM)
GHS Hazard Classification
Signal Word DANGER
Pictograms GHS02 · Flammable GHS05 · Corrosive GHS06 · Acute Toxic GHS07 · Irritant GHS08 · Health Hazard
Hazard Statements H226H301H331H312H315H318H332H335H360H373
Precautionary Statements P203P210P233P240P241P242P243P260P261P264P264+P265P270P271P280P301+P316P302+P352P303+P361+P353P304+P340P305+P354+P338P316P317P318P319P321P330P332+P317P362+P364P370+P378P403+P233P403+P235P405P501

Section 2. Hazards Identification

This chemical does not meet GHS hazard criteria for 0.6% (1 of 169) of reports.

H226 (99.4%): Flammable liquid and vapor [Warning Flammable liquids]

H301+H331 (14.2%): Toxic if swallowed or if inhaled [Danger Acute toxicity, oral; acute toxicity, inhalation]

H301 (91.1%): Toxic if swallowed [Danger Acute toxicity, oral]

H312 (59.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H315 (55.6%): Causes skin irritation [Warning Skin corrosion/irritation]

H318 (91.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H331 (51.5%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H332 (39.6%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H335 (29%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H360 (20.1%): May damage fertility or the unborn child [Danger Reproductive toxicity]

H360F (17.8%): May damage fertility [Danger Reproductive toxicity]

H373 (62.7%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P330, P332+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 169 reports by companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 1 of 169 reports by companies.

There are 26 notifications provided by 168 of 169 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H226: Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501 (click each P-code to see the statement)

Section 8. Exposure Controls / Personal Protection

0.90 [ppm]

5.8 [ppm]

35 [ppm]

Section 9. Physical and Chemical Properties

Colorless liquid with an ethanol-like odor; bp = 74.1 deg C; [Merck Index]

1.288 @25 °C

71.3 [mmHg]

Schoenflies notation

Boiling point

Chemical bond

Chemical shift

Dielectric constant

Excess enthalpy

Excess volume

Heat of solution

Heat of sublimation

High pressure fluid phase equilibrium

Internuclear distance

Lineshape

Mixing enthalpy

Molecular structure

Optical coefficient

Phase diagram

Phase equilibrium

Point group

Refractive index

Rotational excitation cross section

Surface tension

Vapor pressure

Vapor-liquid equilibrium

Virial coefficient

Viscosity

Other Classes -> Halogenated Alcohols

Pharmaceuticals -> Listed in ZINC15

PFAS -> Suspected persistent, mobile, toxic (PMT) PFAS or PFAS-like compounds

PFAS -> PFAS identified in REACH Regulation EC No. 1272/2008

PFAS -> F-telomer alcohols (FTOH)

Section 11. Toxicological Information

Neurotoxin - Acute solvent syndrome

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

LC50 (rat) = 470 ppm/6h

Source: PubChem CID 6409 (NIH/NLM, public domain). Retrieved from PubChem, a public-domain chemistry database maintained by the U.S. National Library of Medicine. Last updated: 2026-08-02 09:17:40.
Disclaimer: This information is compiled for reference only and does not replace the manufacturer's official Safety Data Sheet. Always consult the supplier's SDS before handling any chemical.