heptachlor

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

H351: Suspected of causing cancer [Warning Carcinogenicity]

H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P203, P260, P262, P264, P270, P273, P280, P301+P316, P302+P352, P316, P318, P319, P321, P330, P361+P364, P391, P405, and P501 (click each P-code to see the statement)

H300 (93.8%): Fatal if swallowed [Danger Acute toxicity, oral]

H310 (93.8%): Fatal in contact with skin [Danger Acute toxicity, dermal]

H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]

H373 (100%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Aggregated GHS information provided per 48 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H310: Fatal in contact with skin [Danger Acute toxicity, dermal]

H360: May damage fertility or the unborn child [Danger Reproductive toxicity]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P203, P260, P262, P264, P270, P280, P301+P316, P302+P352, P308+P316, P316, P318, P319, P321, P330, P361+P364, P405, and P501 (click each P-code to see the statement)

P273, P391, and P501 (click each P-code to see the statement)

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give a slurry of activated charcoal in water to drink. Rest. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Soap wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

SMALL FIRE: Dry chemical, CO2 or water spray.

LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Avoid aiming straight or solid streams directly onto the product.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

In case of fire in the surroundings, use appropriate extinguishing media.

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire (material itself does not burn, or burns with difficulty). Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. If large quantities of combustibles are involved, use water in flooding quantities as spray and fog.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. If appropriate, moisten first to prevent dusting. Sweep spilled substance into covered sealable containers. Carefully collect remainder. Then store and dispose of according to local regulations.

A PROCESS FOR REMOVING POLLUTANTS FROM DU PONT'S CHAMBERS WORKS PLANT IN DEEPWATER, NJ IS DESCRIBED. PROCESS INVOLVES NEUTRALIZATION OF WASTES & SETTLING, FOLLOWED BY COMBINED POWDERED CARBON-BIOLOGICAL PROCESS. AMONG PESTICIDES LISTED AS PRIORITY POLLUTANTS ARE HEPTACHLOR & CHLORDANE.

Environmental considerations: Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be contained with a flexible impermeable membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.

... Liquid containing heptachlor should be absorbed in vermiculite, dry sand, earth, or a similar material.

Treatment technologies which are capable of removing heptachlor from drinking water include adsorption by granular activated carbon and ozone or ozone/ultraviolet radiation.

For more Cleanup Methods (Complete) data for HEPTACHLOR (7 total), please visit the HSDB record page.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste numbers P059; D031, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Heptachlor is a potential candidate for incineration by a rotary kiln with a temperature of 820-1600 °C with a residence time for liquids and gases: seconds; Solids: hours.

Group I Containers: Combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) should be disposed of in pesticide incinerators or in specified landfill sites. /Organic or metallo-organic pesticides/

Group II Containers: Non-combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) must first be triple-rinsed. Containers that are in good condition may be returned to the manufacturer or formulator of the pesticide product, or to a drum reconditioner for reuse with the same type of pesticide product, if such reuse is legal under Department of Transportation regulations (eg 49 CFR 173.28). Containers that are not to be reused should be punctured ... and transported to a scrap metal facility for recycling, disposal or burial in a designated landfill. /Organic or metallo-organic pesticides/

For more Disposal Methods (Complete) data for HEPTACHLOR (13 total), please visit the HSDB record page.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Wear appropriate equipment /clothing/ to prevent ... skin contact with heptachlor. ... Wash ... immediately when skin becomes contaminated. ... Work clothing should be changed daily if there is any possibility that it may be contaminated. ... Immediately remove non-impervious clothing that becomes contaminated. ... Wear eye protection to prevent ... eye contact. ... A quick drench eyewash /station/ should be available. ...

Personnel protection: Avoid breathing dust, and fumes from burning material. Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. ... If contact with the material anticipated, wear appropriate chemical protective clothing.

Persons not wearing protective equipment and clothing should be restricted from areas of spills until cleanup has been completed.

For more Preventive Measures (Complete) data for HEPTACHLOR (19 total), please visit the HSDB record page.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. For solids, prevent dust cloud and avoid inhalation of dust. (ERG, 2024)

Provision to contain effluent from fire extinguishing. Separated from strong oxidants, metals and food and feedstuffs. Well closed. Keep in a well-ventilated room. Dry. Store in an area without drain or sewer access.

Protect containers against physical damage. Outdoor or detached storage is preferred; in case of indoor storage, cool, well-ventilated, fire-proof place should be used and kept away from source of ignition.

PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

0.05 [mg/m3], inhalable fraction[German Research Foundation (DFG)]

0.40 [mg/m3]

14 [mg/m3]

700 [mg/m3]

0.5 mg/m³

Ca TWA 0.5 mg/m3 [skin] See Appendix A

0.5 [mg/m3]

TWA 0.5 mg/m3 [skin]

35 mg/m3 ; A potential occupational carcinogen. (NIOSH, 2024)

35.0 [mg/m3]

NIOSH considers heptachlor to be a potential occupational carcinogen. [35 mg/cu m]

35 mg/m³

Ca [35 mg/m3]

See: 76448

0.05 [mg/m3]

8 hr Time Weighted Avg (TWA): 0.05 mg/cu m, skin. /Heptachlor and heptachlor epoxide/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /Heptachlor and heptachlor epoxide/

A3; Confirmed animal carcinogen with unknown relevance to humans. /Heptachlor and heptachlor epoxide/

0.05 mg/m

0.05 mg/m³ [1990]

(inhalable fraction): 0.05 mg/m

Acute Oral: 0.0006 mg/kg/day (L134)

Intermediate Oral: 0.0001 mg/kg/day (L134)

Federal Republic of Germany: 500 ug/cu m (inhalation); USSR: 10 ug/ cu m (inhalation).

Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.

The substance may cause effects on the central nervous system.

The substance may have effects on the liver. This substance is possibly carcinogenic to humans.

Excerpt from NIOSH Pocket Guide for Heptachlor:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Wash skin:

• WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.

• DAILY - The worker should wash daily at the end of each work shift, and prior to eating, drinking, smoking, etc.

Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Change: DAILY - Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.

Provide:

• EYEWASH - Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substances; this is irrespective of the recommendation involving the wearing of eye protection.

• QUICK DRENCH - Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2024)

PROTECTIVE RESPIRATOR; RUBBER GLOVES; CLEAN CLOTHES.

Employees should be provided with and required to wear impervious clothing, gloves, and face shields (eight-inch minimum). ...

Heptachlor is a white to light tan waxy looking solid. Noncombustible. Insoluble in water. Can cause illness by inhalation, skin absorption and/or ingestion. The primary hazard is the threat posed to the environment. Immediate steps should be taken to limit its spread to the environment. Used as an insecticide.

White to light-tan crystals with a camphor-like odor. [insecticide]; [NIOSH]

WHITE CRYSTALS OR TAN WAXY SOLID WITH CHARACTERISTIC ODOUR.

White to light-tan crystals with a camphor-like odor.

White to light-tan crystals with a camphor-like odor. [insecticide]

White to light tan waxy solid

White to light tan crystals.

Camphor-like odor

Decomposes (NTP, 1992)

145 °C @ 1.5 MM HG

293 °F (decomposes)

293 °F (Decomposes)

203 to 205 °F (NTP, 1992)

95-96 °C

less than 0.1 mg/mL at 64 °F (NTP, 1992)

g/100 ml solvent @ 27 °C: acetone 75, benzene 106, carbon tetrachloride 112, cyclohexanone 119, alcohol 4.5, xylene 102

Soluble in hexane.

Soluble in ethyl ether, ethanol, ligroin

In water, 0.18 mg/l @ 25 °C

Solubility in water: none

1.66 at 68 °F (USCG, 1999) - Denser than water; will sink

1.57 @ 9 °C

1.6 g/cm³

1.57 @ 9°C

0.0003 mmHg at 77 °F (NTP, 1992)

0.0003 [mmHg]

4.0X10-4 mm Hg @ 25 °C

Vapor pressure, Pa at 25 °C: 0.053

0.0003 mmHg at 77 °F

(77 °F): 0.0003 mmHg

log Kow = 6.10

5.27/5.44

Henry's Law constant = 2.94X10-4 atm-cu m/mol @ 25 °C

STABLE TO DAYLIGHT, AIR, MOISTURE, AND MODERATE HEAT (UP TO 160 °C).

Decomposition products: Toxic gases and vapors which include: hydrogen chloride, and carbon monoxide.

Corrosive to metals.

0.02 PPM

155.14 Ų [M]+ [CCS Type: TW; Buffer gas: N2; Ionization: GC-APCI+]

NOT READILY DEHYDROCHLORINATED; SUSCEPTIBLE TO EPOXIDATION

HAS HIGH LIPID-WATER PARTITION COEFFICIENTS; FORMS PHOTOPRODUCT, PHOTOHEPTACHLOR.

Susceptible to epoxidation. Insoluble in water. Slowly losses hydrogen chloride in the presence of alkaline solution.

Halogenated Organic Compounds

Hydrocarbons, Aliphatic Unsaturated

HEPTACHLOR is incompatible with strong alkalis. Corrosive to metals. Can react with iron and rust to form toxic gases. Can react vigorously with oxidizing materials. Susceptible to epoxidation (NTP, 1992).

Halogenated aliphatic compounds, such as HEPTACHLOR, are moderately or very reactive. Halogenated organics generally become less reactive as more of their hydrogen atoms are replaced with halogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

Heptachlor can react with iron and rust to form ... hydrogen chloride gas.

Hazardous reactions with alkali metals.

Iron and rust.

Oxidized biologically to heptachlor epoxide.

Reacts with strong oxidants.

Iron, rust

IDENTIFICATION: Heptachlor is a chlorinated dicyclopentadiene insecticide that is persistent in the environment and accumulates in the food chain. Although its use has been banned or severely restricted in many countries since the 1980's, it is still detected as a contaminant in some food commodities. Heptachlor in its pure form at room temperature appears as a white or light tan crystalline solid with a mild camphor or cedar like odor. The technical product is a soft wax. The technical product usually contains about 72% heptachlor and about 28% related compounds such as trans-chlordane (20-22%) and trans-nonachlor (4-8%). HUMAN EXPOSURE: In humans placental transfer of heptachlor has been noted. Available epidemiological data do not show a clear relationship between adverse health effects and exposure to heptachlor. Consumption of foods containing pesticides such as heptachlor leads to an accumulation of these compounds in human tissues. Heptachlor has been detected in blood and serum samples, adipose tissue and breast milk. The most significant source of exposure of infants to heptachlor and its metabolites appears to be breast milk, in which concentrations can be much higher than those found in dairy milk. Heptachlor induced statistically significant increase in unscheduled DNA synthesis in human fibroblasts in the presence of metabolic activation and heptachlor inhibited junctional intracellular communication in cultured human cells. ANIMAL/PLANT/AVIAN/CRUSTACEAN/FISH/INVERTEBRATES STUDIES: In animals fed heptachlor by diet, gavage or sc injection, there is a sharp dose response curve for mortality. No marked differences were seen between treated animals and controls with respect to body weight and food consumption. Liver enlargement has been noted with accentuated lobulation; histopathological findings showed enlargement of centrilobular and midzonal hepatocytes. Fertility studies in rats injected with heptachlor sc resulted in suppression of reproductive hormone levels, disruptions in female cyclicity and delays in mating behavior. In developmental toxicity studies, there were usually no clinical signs of maternal toxicity (dose related alterations in weight gain) until mortality occurred. In one study reduced litter sizes was noted, postnatal mortality of the pups was the most obvious finding. No teratological effects was noted. The profile of effects produced by repeated heptachlor to female rats consisted of altered activity, hyperexcitability and autonomic effects. Neurotoxicological studies on perinatal heptachlor exposure in the rat suggested developmental delays, alterations in GABAergic neurotransmission and neurobehavioral changes which included cognitive deficits at all doses. Heptachlor and technical grade heptachlor have been tested for carcinogenicity by oral administration in several strains of rats and mice. Technical grade heptachlor was shown to be carcinogenic in male and female mice but not in rats. Heptachlor has been shown to be neurotoxic and immunotoxic in rats. Heptachlor shows mostly negative responses in vitro and in vivo genotoxicity testing. The acute toxicity of heptachlor was tested using a variety of aquatic species from different trophic levels. Heptachlor was shown to be toxic to fish and other species. Heptachlor appears to exhibit moderate toxic effects upon terrestrial vertebrates. Heptachlor has been found in tissues of water birds, amphibians, reptiles, seals and whales. Heptachlor is clearly toxic to a range of both freshwater and marine species, including algae. Growth of both freshwater marine species including algae and shrimp was effected by heptachlor exposure. Heptachlor is moderately toxic to birds.

Heptachlor is a central nervous system stimulant. It non-competitively blocks neurotransmitter action at gamma-amino butyric acid receptors, resulting in overstimulation of the nervous system. Heptachlor is also believed to exert carcinogenic effects by activating key kinases in signalling pathways and inhibiting apoptosis. (L118, A81, A82)

Heptachlor

5 x 10 ^-4 mg/kg-day

Pesticide

Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP

Evaluation: There is inadequate evidence in humans for the carcinogenicity of chlordane and heptachlor. There is sufficient evidence in experimental animals for the carcinogenicity of chlordane and heptachlor. Overall evaluation: Chlordane and heptachlor are possibly carcinogenic to humans (Group 2B).

Cancer Classification: Group B2 Probable Human Carcinogen

CLASSIFICATION: B2; probable human carcinogen. BASIS FOR CLASSIFICATION: Inadequate human data, but sufficient evidence exists from studies in which benign and malignant liver tumors were induced in three strains of mice of both sexes. Several structurally related compounds are liver carcinogens. HUMAN CARCINOGENICITY DATA: Inadequate. ANIMAL CARCINOGENICITY DATA: Sufficient.

A3; Confirmed animal carcinogen with unknown relevance to humans. /Heptachlor and heptachlor epoxide/

Group 2B: Possibly carcinogenic to humans

Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)

Volume 53: (1991) Occupational Exposures in Insecticide Application, and Some Pesticides

Volume 79: (2001) Some Thyrotropic Agents

TR-009: Bioassay of Heptachlor for Possible Carcinogenicity (CASRN 76-44-8) (1977 )

No Evidence

Equivocal Evidence

Clear Evidence

It is concluded that under the conditions of this bioassay, heptachlor is carcinogenic for the liver in mice.

2B, possibly carcinogenic to humans. (L135)

Exposure to heptachlor may cause damage to your liver, nervous system, and immune system. (L118)

The substance can be absorbed into the body by inhalation of dust, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

Oral (L116) ; inhalation (L116) ; dermal (L116)

Convulsions. Tremor.

MAY BE ABSORBED! See Inhalation.

See Inhalation.

In Animals: tremor, convulsions; liver damage; [potential occupational carcinogen]

Heptachlor poisoning may cause convulsions, vomiting, seizures, confusion, incoordination, excitability, coma, hypotension, and respiratory failure. (L118)

central nervous system,liver

[in animals: liver cancer]

Chemical: HEPTACHLOR

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Aplastic anemia - The presence of increased methemoglobin in the blood; the compound is classified as primary toxic effect.

Other Poison - Organochlorine

IARC Carcinogen - Class 3: Chemicals are not classifiable by the International Agency for Research on Cancer.

ACGIH Carcinogen - Confirmed Animal.

FAO/WHO ADI: 0.0001 mg/kg bw

IRIS Current

ATSDR Final

LC50 APLEXA HYPNORUM (SNAILS) 1450 UG/L/96 HR (95% CONFIDENCE LEVEL 1260-1680 UG/L). TECHNICAL GRADE HEPTACHLOR WAS USED IN THESE TESTS. /CONDITIONS OF BIOASSAY NOT SPECIFIED/

LC50 TANYTARSUS DISSIMILIS (CHIRONOMIDS) IS MORE THAN THE CONCN USED (2500 UG/L/48 HR). TECHNICAL GRADE HEPTACHLOR WAS USED IN THESE TESTS. /CONDITIONS OF BIOASSAY NOT SPECIFIED/

LC50 BOBWHITE QUAIL ORAL 92 PPM IN 5 DAY DIET (95% CONFIDENCE LIMIT 76-113 PPM), 23 DAYS OLD

LC50 RING-NECKED PHEASANT 224 PPM IN 5 DAY DIET (95% CONFIDENCE LIMIT 191-265 PPM), 8 DAYS OLD

For more Ecotoxicity Values (Complete) data for HEPTACHLOR (34 total), please visit the HSDB record page.

1.30e-01

6.30e-01

2.20e-03

9.40e-03

1.40e-03

4.00e-01

1.20e-04

3.30e-02

4.50e+00

1.30e-03

1.00e-04

Volatile

1.30e+01

6.30e+01

2.20e-01

9.40e-01

1.40e-01

The substance is very toxic to aquatic organisms. Bioaccumulation of this chemical may occur along the food chain, for example in fish and milk. The substance may cause long-term effects in the aquatic environment. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

Heptachlor was used extensively as an insecticide on many agricultural crops until its use was banned by EPA in 1974. Its production and former use in termite control, seed/seed furrow treatment, and wood treatment did result in its direct release to the environment. If released to air, a vapor pressure of 4.00X10-4 mm Hg at 25 °C indicates heptachlor will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase heptachlor will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and ozone; the half-life for these reactions in air are estimated to be 6.3 and 1.4 hours, respectively. Particulate-phase heptachlor will be removed from the atmosphere by wet and dry deposition. Direct and photosensitized photolysis of unabsorbed heptachlor may occur in the environment. Heptachlor at 1.35X10-7 to 1.0X10-5 mole/l in acetone irradiated with light for >180 min at >290 nm degraded by about 5 to 10%. If released to soil, heptachlor is expected to have no mobility based upon a range of Kocs of 13,330 to 661,000. Volatilization from moist soil surfaces is expected to be an important fate process based upon a Henry's Law constant of 2.94X10-4 atm-cu m/mole. Complete degradation of heptachlor in flooded Casiguran sandy loam and Louisiana clay occurred after 1 and 2 months, respectively, and was nearly complete in Maahas clay after 3 months. However, field dissipation half-lives for heptachlor can range from 40 days to 5.5 yrs. If released into water, heptachlor is expected to adsorb to suspended solids and sediment based upon the range of Koc's. In water, 95.3% of heptachlor was removed by an acclimated aerobic mixed microbial culture in 4 weeks. Anaerobic incubation of heptachlor with thick sewage sludge inoculum at 53 °C resulted in complete degradation in about 1 day. Volatilization from water surfaces is expected to be an important fate process based upon this compound's Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 6 hours and 9 days, respectively. However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 1.5 years if adsorption is considered. A range of BCF values of 200 to 37,000 suggest bioconcentration in aquatic organisms is high to very high. In water and moist soil, heptachlor readily undergoes hydrolysis to 1-hydrochlorodene which is then readily converted by microorganisms into heptachlor epoxide. The chemical hydrolysis half-life for heptachlor is 4.5 days at pH 7. Occupational exposure to heptachlor may occur through inhalation of dust particles and dermal contact with this compound at workplaces where heptachlor was produced or used. Monitoring data indicate that the general population may be exposed to heptachlor via inhalation of ambient air (especially indoor air of homes treated with heptachlor), ingestion of food (e.g., fish) and drinking water. (SRC)

Heptachlor's production and former(1) use in termite control, seed/seed furrow treatment, and wood treatment(2) has resulted in its direct release to the environment(SRC). Heptachlor was used extensively as an insecticide on many agricultural crops until its use was banned by EPA in 1974(3).

TERRESTRIAL FATE: Based on a classification scheme(1), Koc values for heptachlor from 13,330-661,000(2), indicates that heptachlor is expected to be immobile in soil(SRC). Volatilization of heptachlor from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 2.94X10-4 atm-cu m/mole(3). However, volatilization from moist soil surfaces is expected to be attenuated by adsorption to soil(SRC). When heptachlor was applied to orchard grass, approximately 90% was lost in 7 days(4). Six hours and 6 days after application of heptachlor to a moist soil surface, 50% and 90% of the heptachlor had volatilized, respectively(5). However, only 7% of heptachlor incorporated 7.5 cm into soil had volatilized after 167 days(5). Fifty hours following the application of heptachlor to a dry soil surface, 14 to 40% of the heptachlor had volatilized(5). In moist soil, heptachlor readily undergoes hydrolysis to 1-hydrochlorodene which is then readily converted by microorganisms into heptachlor epoxide(6). Chemical hydrolysis half-lives for heptachlor are 5.4, 4.3, 4.5, 4.5, and 3.0 days for pH 4.5,5.0, 6.0, 7.0, and 8.0, respectively(7). Heptachlor absorbs light weakly above 290 nm(8) and thin films of heptachlor have been shown to undergo direct photolysis when exposed to sunlight and artificial light sources >290 nm(9). Degradation of heptachlor in flooded Casiguran sandy loam after 1 month and Louisiana clay after 2 months was complete (initial concn about 13 ppm) and nearly complete in Maahas clay after 3 months(10). In Pila clay loam, degradation proceeded to only about 5 ppm from the initial level of about 13 ppm after 3 months(10). Biodegradation of heptachlor by soil microorganisms produced heptachlor epoxide and chlordene(11). Field dissipation half-lives for heptachlor can range from 40 days to 5.5 yrs(2).

AQUATIC FATE: Based on a classification scheme(1), a range of Koc values for heptachlor from 13,330 to 661,000(2), indicates that heptachlor is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 2.94X10-4 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 6 hours and 9 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column(SRC). The estimated volatilization half-life from a model pond is 1.5 years hours if adsorption is considered(5). The volatilization half-life of heptachlor was determined to be 0.73 days from static distilled water and 0.29 days from stirred river water(depth not specified)(6). According to a classification scheme(7), BCF values ranging from 200 to 37,000(8-13), suggests the potential for bioconcentration in aquatic organisms is high to very high(SRC). Heptachlor readily undergoes chemical hydrolysis to 1-hydrochlorodene which is then readily processed by microorganisms into heptachlor epoxide(14). Chemical hydrolysis half-lives for heptachlor are 5.4, 4.3, 4.5, 4.5, and 3.0 days for pH 4.5, 5.0, 6.0, 7.0, and 8.0, respectively(15). When heptachlor was aerobically incubated with acclimated, mixed microbial cultures, an average of 95.3% of the initial heptachlor was removed in 4 weeks(16). The products were chlordene, 1-hydroxy-2,3-epoxychlordene and heptachlor epoxide(17). Anaerobic incubation with thick sewage sludge inoculum at 53 °C resulted in complete degradation of 10 ppm heptachlor in about 1 day(18).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), heptachlor, which has a vapor pressure of 4.0X10-4 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase heptachlor is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and ozone(SRC). The half-life for reaction with hydroxyl radicals in air is estimated to be 6.3 hours(SRC), calculated from its rate constant of 6.11X10-11 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(3). The half-life for reaction with ozone in air is estimated to be 1.4 hour(SRC), calculated from its rate constant of 2.0X10-16 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(3). Particulate-phase heptachlor may be removed from the air by wet and dry deposition(SRC). Heptachlor absorbs weakly above 290 nm(4) and thin films of heptachlor have been shown to undergo direct photolysis when exposed to sunlight and artificial light sources >290 nm(4).

AEROBIC: Mixed cultures of Pseudomonas sp. in water were capable of growing on heptachlor(1). The products were chlordene, 1-hydroxy-2,3-epoxychlordene and heptachlor epoxide(1). When heptachlor was aerobically incubated with acclimated, mixed microbial cultures, 95.3% of the initial heptachlor was removed in 4 weeks(2); biodegradation of 1 mg/l heptachlor occurred immediately(2). The products resulting from the incubation of heptachlor with a mixed culture of soil microorganisms were chlordene(7%), 1-exohydroxychlordene, heptachlor epoxide (<0.04%) and chlordene epoxide (<0.02%) which were formed after 2 weeks(3). Biodegradation of heptachlor by soil microorganisms produced heptachlor epoxide and chlordene(4). Degradation of heptachlor in flooded Casiguran sandy loam after 1 month and Louisiana clay after 2 months was complete (initial level about 13 ppm) and nearly complete in Maahas clay after 3 months(5). In Pila clay loam, degradation proceeded to only about 5 ppm from the initial level of about 13 ppm (approx 38%) after 3 months(5).

ANAEROBIC: Anaerobic incubation of 10 ppm heptachlor with a thick anaerobically digested sewage sludge inoculum at 53 °C resulted in complete degradation in about 1 day(1); at 35 °C with the thick sludge, heptachlor was converted to an extractable degradation product which was more persistent than heptachlor(1).

The rate constant for the vapor-phase reaction of heptachlor with photochemically-produced hydroxyl radicals and ozone has been estimated as 6.11X10-11 cu cm/molecule-sec and 2.00X10-16 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 6.3 hrs and 1.4 hrs at an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm and 7X10+11 ozone molecules per cu cm, respectively(1). In water, heptachlor readily undergoes chemical hydrolysis to 1-hydrochlorodene which is then readily converted by microorganisms into heptachlor epoxide(2). Chemical hydrolysis half-lives for heptachlor are 5.4, 4.3, 4.5, 4.5, and 3.0 days for pH 4.5,5.0, 6.0, 7.0, and 8.0, respectively(3). Heptachlor absorbs weakly above 290 nm(4) and thin films of heptachlor have been shown to undergo direct photolysis when exposed to sunlight and artificial light sources >290 nm(5). The products were two dechlorinated photoproducts and heptachlor epoxide(5). Heptachlor at 1.35X10-7 mol/l to 1.0X10-5 mol/l in acetone irradiated for >180 min at >290 nm degraded by about 5 to 10%(6). Photoheptachlor was the photoproduct(6). Heptachlor also undergoes photosensitized photolysis in the presence of benzophenone(5). Photolysis of heptachlor can take place on plant leaves in the presence of sunlight or UV light(7). Thus, direct and photosensitized photolysis of unabsorbed heptachlor may occur in the environment(SRC).

BCF values for several fish, molluscs, and other aquatic species range from 200 to 37,000 for heptachlor(1-6). According to a classification scheme(7), these BCF values suggest that bioconcentration in aquatic organisms ranges from high to very high(SRC). Bioaccumulation factors (BAFs) for heptachlor have been measured for aquatic molluscs (250 to 2,500), oysters (17,600), pelecypod (3,900 to 8,500), decapod (200 to 700), Cyprinodon variegatus (7,400 to 21,300), Lagodon rhomboides (2,800 to 7,700), Leiostomus xanthurus (3,000 to 13,800), Cyprinodon variegatus (3,700 to 4,600), trout(300), and fathead minnow(6,310 to 20,000)(2). BCFs of heptachlor are 3,800 in mosquito fish(3); 3,600 to 7,400 in spot(3); 21,379 in sheepshead minnows(4); 37,000 in snails(3); 21,000 in alga(3); 18,000 in oysters(6); and 17,400 in unidentified fish species(5). At Mar Meno Lagoon (SE Spain), the BCF of heptachlor was measured in plant and aquatic organisms(8): algae (470), red algae (3,220), bivalve mollusc (1,770), and isopods (56,030). The bioaccumulation (ie, concn in biota/concn in soil) of heptachlor by earthworms ranges from 0.92 to 2.7(9). The BCF of heptachlor in vegetation is 0.033(2). Biomagnification of heptachlor in the aquatic food chain is significant, however because it is readily metabolized to heptachlor epoxide by higher tropic level organisms, biomagnification of heptachlor itself is not significant(10).

The Koc values for heptachlor range from 13,330 to 661,000(1,2). According to a classification scheme(3), these Koc values suggest that heptachlor is expected to be immobile in soil(SRC). Heptachlor was added to soil columns containing Hagerstown silty clay loam and Lakeland sandy loam which were then subjected to the upward movement of water at an undisclosed rate(3). After 3 days, all the heptachlor was detected in the initial column depth, indicating no tendency to leach in these soils(4).

The Henry's Law constant for heptachlor is 2.94X10-4 atm-cu m/mole(1). This Henry's Law constant indicates that heptachlor is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 6 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 9 days(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column(SRC). The estimated volatilization half-life from a model pond is 1.5 years if adsorption is considered(3). The volatilization half-life of heptachlor from glass surfaces was determined to be 0.73 days from static distilled water and 0.29 days from stirred river water(4). Heptachlor's Henry's Law constant(1) indicates that volatilization from moist soil surfaces may occur(SRC). When heptachlor was applied to orchard grass, approximately 90% was lost in 7 days(5). Six hours and 6 days after application of heptachlor to a moist soil surface, 50% and 90% of the heptachlor had volatilized, respectively(6). However, only 7% of heptachlor incorporated 7.5 cm into soil had volatilized after 167 days(6). Fifty hours following the application of heptachlor to a dry soil surface, 14 to 40% of the heptachlor had volatilized(6).

DRINKING WATER: The mean concn of heptachlor was 0.06 ug/l (5 of 19 stations) and 0.06 ug/l (1 of 7 stations) in public water systems from surface water and ground water sources, respectively(1). Heptachlor and heptachlor epoxide have been detected in private drinking wells at concns <0.02 ug/l(2).

SURFACE WATER: The mean and range of concns of total heptachlor (both suspended and dissolved) in surface water was 0.67 ug/l and 0.001 to 2.3 ug/l, respectively(1). Of the 4650 stations reporting heptachlor in ambient water in EPA's STORET database, 34.0% contained detectable levels of the chemical with a median concn of 0.001 ug/l(2). Heptachlor was listed as a contaminant of the Great Lakes including Lakes Ontario, Erie, Huron, Michigan and Superior(3). In 1980, heptachlor was detected in the waters of Lake Pontchartrain Inner Harbor Navigation Canal at a concn of 0.6 ng/l at an ebb tide of 1.5 m and at concns ranging from 9.1 to 9.3 ng/l at flood tides of 1.5 to 10 m(4). Heptachlor was detected with a 21.4% frequency of occurrence for 604 samples of surface waters from New Jersey collected from 1977 to 1979(5). Heptachlor was detected in Mississippi River water at Louisiana at concns ranging from undetected levels to 2.4 ng/l for the summer to winter of 1974(6). Mediterranean waters off the coast of Morocco contained heptachlor at concns ranging from trace quantities to 11 ppb, trace quantities to 100 ppb and trace quantities to 3 ppb with mean concns of 5, 20 and 2 ppb for 8 samples each collected during the autumn, winter and spring, respectively(7). Throughout 1982, surface waters of the Donana National Park, Spain contained Heptachlor at concn ranging from 0.002 to 0.006 ppb(8). Heptachlor was detected at two locations in the Shatt al-Arab river (Iraq) at mean concns of 10 ng/l (range, 2 to 19 ng/l) and 79 ng/l (range, 50 to 91 ng/l), respectively(9). Heptachlor was detected in the Tigris and Euphrates rivers (Iraq) at mean concns of 19 ng/l (range, 10 to 39 ng/l) and 4 ng/l (range, not detected to 7 ng/l), respectively(9).

SURFACE WATER: The concn of heptachlor in water samples from River Nile (Cairo, Egypt) ranged from 2.4 to 3.5 ng/l and 5.9 to 10.3 ng/l in the winter and summer of 1991, respectively(1). The concn of heptachlor in water samples from Manzala Lake (Egypt) ranged from 6.0 to 15.6 ng/l and 6.5 to 30.0 ng/l in the winter and summer of 1991, respectively(1).

GROUNDWATER: The mean and range of concns of total heptachlor (both suspended and dissolved) in ground water was 0.12 ug/l and 0.09 to 0.15 ug/l, respectively(1). According to the EPA's Pesticides in Groundwater Database, heptachlor was detected in the groundwater supplies of the states of Kansas, Illinois, and Massachusetts at mean concns of 0.03, 0.19, and 0.05 ppb, respectively(2). In New Jersey, the max concn of heptachlor in groundwater was 1.0 ppb (21.2% of 1,075 samples)(3). In a statewide survey (Dec 1985 to Feb 1986) conducted in Kansas, heptachlor was detected in 1% of farm wells at an avg concn of 0.025 ppb (range, 0.023 to 0.026 ppb)(4).

RAIN/SNOW: Heptachlor was detected in wet precipitation samples (rain/snow) from Lake Erie at a volume-weighted mean concn (based on total volume collected over a 12-month period) of 0.1 ng/l(1). Rain water samples were collected in Dec 1995 and Apr 1996 in Egypt where chlorinated hydrocarbon pesticides have been used for over two decades(2); the concn of heptachlor residues in these samples were 3.4 ug/l and 3.1 ug/l, respectively(2).

Of the 671 stations reporting heptachlor in industrial effluents in EPA's STORET database, 3.0% contained detectable levels of this chemical with a median concn of <0.007 ug/l(1). Heptachlor residues were detected in treated wastewater effluents from coal mining, foundry, and nonferrous manufacturing industries at a mean concns of 2.2 ug/l (4.3% of 47 samples), 8.7 ug/l (range, 5 to 31 ug/l; 11 samples), and 0.1 ug/l (range, not detected to 0.7 ug/l; 55 samples), respectively(2). Heptachlor was detected in leachate from the Love Canal hazardous waste site at concns less than 10 ug/l(3). Findings from the Nationwide Urban Runoff Program priority pollutant samples collected in 1982 showed that heptachlor was detected at a concn of 0.1 ppb in 5% of urban runoff samples from 15 cites(4). In New York City from 1989 to 1993, heptachlor was detected in municipal water treatment facilities influent and effluent at concns ranging from 0.021 to 0.35 ug/l and 0.02 to 0.447 ug/l, respectively(5).

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste numbers P059; D031, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Heptachlor is a potential candidate for incineration by a rotary kiln with a temperature of 820-1600 °C with a residence time for liquids and gases: seconds; Solids: hours.

Group I Containers: Combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) should be disposed of in pesticide incinerators or in specified landfill sites. /Organic or metallo-organic pesticides/

Group II Containers: Non-combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) must first be triple-rinsed. Containers that are in good condition may be returned to the manufacturer or formulator of the pesticide product, or to a drum reconditioner for reuse with the same type of pesticide product, if such reuse is legal under Department of Transportation regulations (eg 49 CFR 173.28). Containers that are not to be reused should be punctured ... and transported to a scrap metal facility for recycling, disposal or burial in a designated landfill. /Organic or metallo-organic pesticides/

For more Disposal Methods (Complete) data for HEPTACHLOR (13 total), please visit the HSDB record page.

/GUIDE 131 FLAMMABLE LIQUIDS - TOXIC/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /Organochlorine pesticide, liquid, flammable, poisonous; Organochlorine pesticide, liquid, flammable, toxic; Organochlorine pesticide, liquid, poisonous, flammable; Organochlorine pesticide, liquid, toxic, flammable/

/GUIDE 131 FLAMMABLE LIQUIDS - TOXIC/ Health: TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. /Organochlorine pesticide, liquid, flammable, poisonous; Organochlorine pesticide, liquid, flammable, toxic; Organochlorine pesticide, liquid, poisonous, flammable; Organochlorine pesticide, liquid, toxic, flammable/

/GUIDE 131 FLAMMABLE LIQUIDS - TOXIC/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering. /Organochlorine pesticide, liquid, flammable, poisonous; Organochlorine pesticide, liquid, flammable, toxic; Organochlorine pesticide, liquid, poisonous, flammable; Organochlorine pesticide, liquid, toxic, flammable/

/GUIDE 131 FLAMMABLE LIQUIDS - TOXIC/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Organochlorine pesticide, liquid, flammable, poisonous; Organochlorine pesticide, liquid, flammable, toxic; Organochlorine pesticide, liquid, poisonous, flammable; Organochlorine pesticide, liquid, toxic, flammable/

For more DOT Emergency Guidelines (Complete) data for HEPTACHLOR (16 total), please visit the HSDB record page.

2761 151(organochlorine pesticide, solid)

UN 2762; Organochlorine pesticides, liquid, flammable, toxic, flashpoint less than 23 °C

UN 2761; Organochlorine pesticides, solid, toxic

IMO 3.0; Organochlorine pesticide, liquid, flammable, toxic, flashpoint less than 23 °C

UN 2995; Organochlorine pesticides, liquid, toxic, flammable, flashpoint not less than 23 °C

For more Shipping Name/ Number DOT/UN/NA/IMO (Complete) data for HEPTACHLOR (7 total), please visit the HSDB record page.

49 606 30; Heptachlor

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. Organochlorine pesticide, liquid, flammable, toxic, flash point less than 23 °C; organochlorine pesticide, liquid, toxic; organochlorine pesticide, liquid, toxic, flammable, flash point 23 °C or more; and organochlorine pesticide, solid, toxic are included on the dangerous goods list.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. Organochlorine pesticide, solid, toxic; organochlorine pesticide, liquid, flammable, toxic, flash point less than 23 °C; organochlorine pesticide, liquid, toxic, flammable, flash point not less than 23 °C; and organochlorine pesticide, liquid, toxic are included on the dangerous goods list.

PRECAUTIONS FOR "CARCINOGENS": Procurement ... of unduly large amt ... should be avoided. To avoid spilling, carcinogens should be transported in securely sealed glass bottles or ampoules, which should themselves be placed inside strong screw-cap or snap-top container that will not open when dropped & will resist attack from the carcinogen. Both bottle & the outside container should be appropriately labelled. ... National post offices, railway companies, road haulage companies & airlines have regulations governing transport of hazardous materials. These authorities should be consulted before ... material is shipped. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": When no regulations exist, the following procedure must be adopted. The carcinogen should be enclosed in a securely sealed, watertight container (primary container), which should be enclosed in a second, unbreakable, leakproof container that will withstand chem attack from the carcinogen (secondary container). The space between primary & secondary container should be filled with absorbent material, which would withstand chem attack from the carcinogen & is sufficient to absorb the entire contents of the primary container in the event of breakage or leakage. Each secondary container should then be enclosed in a strong outer box. The space between the secondary container & the outer box should be filled with an appropriate quantity of shock-absorbent material. Sender should use fastest & most secure form of transport & notify recipient of its departure. If parcel is not received when expected, carrier should be informed so that immediate effort can be made to find it. Traffic schedules should be consulted to avoid ... arrival on weekend or holiday ... /Chemical Carcinogens/

Do not transport with food and feedstuffs. Severe marine pollutant.

Symbol: T, N; R: 24/25-33-40-50/53; S: (1/2)-36/37-45-60-61

UN Hazard Class: 6.1; UN Pack Group: II