perchloryl fluoride

H270 (100%): May cause or intensify fire; oxidizer [Danger Oxidizing gases]

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]

P220, P244, P260, P264, P264+P265, P271, P280, P284, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P320, P321, P363, P370+P376, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 2 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Fresh air, rest. Half-upright position. Refer for medical attention.

ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Excerpt from NIOSH Pocket Guide for Perchloryl fluoride:

Eye: FROSTBITE - If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.

Skin: FROSTBITE - If frostbite has occurred, seek medical attention immediately; do NOT rub the affected areas or flush them with water. In order to prevent further tissue damage, do NOT attempt to remove frozen clothing from frostbitten areas. If frostbite has NOT occurred, immediately and thoroughly wash contaminated skin with soap and water.

Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible. (NIOSH, 2024)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Clothing frozen to the skin should be thawed before being removed.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Frostbite - If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.

Skin: Frostbite - Compressed gases may create low temperatures when they expand rapidly. Leaks and uses that allow rapid expansion may cause a frostbite hazard. Wear appropriate personal protective clothing to prevent the skin from becoming frozen.

Breathing: Respiratory support

Excerpt from ERG Guide 124 [Gases - Toxic and/or Corrosive - Oxidizing]:

CAUTION: These materials do not burn but will support combustion. Some will react violently with water.

SMALL FIRE: Contain fire and let burn. If fire must be fought, water spray or fog is recommended. Water only; no dry chemical, CO2 or Halon®. Do not get water inside containers. If it can be done safely, move undamaged containers away from the area around the fire. Damaged cylinders should be handled only by specialists.

FIRE INVOLVING TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devices; icing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep cylinder cool by spraying with water.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Many gases are heavier than air and will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· Do not touch or walk through spilled material.

· Keep combustibles (wood, paper, oil, etc.) away from spilled material.

· Stop leak if you can do it without risk.

· Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material.

· Do not direct water at spill or source of leak.

· If possible, turn leaking containers so that gas escapes rather than liquid.

· Prevent entry into waterways, sewers, basements or confined areas.

· Isolate area until gas has dispersed.

· Ventilate the area.

Excerpt from ERG Guide 124 [Gases - Toxic and/or Corrosive - Oxidizing]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 3083 datasheet.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

· See Table 1 - Initial Isolation and Protective Action Distances.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Small spill:

- ISOLATE in all directions: 30 m (100 ft)

Large spill:

- ISOLATE in all directions: 1000 m (3000 ft)

- PROTECT people from downwind during DAY time: 0.2 km (0.2 mi)

- PROTECT people from downwind during NIGHT time: 1.1 km (0.7 mi)

- PROTECT people from downwind during DAY time: 5.5 km (3.4 mi)

- PROTECT people from downwind during NIGHT time: 10.9 km (6.8 mi)

Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. NEVER direct water jet on liquid.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

AVOID INHALATION, INGESTION & SKIN CONTACT. TAKE SPECIAL MEASURES IN CASES OF LEAK. /FROM TABLE/

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Excerpt from ERG Guide 124 [Gases - Toxic and/or Corrosive - Oxidizing]:

Do not touch or walk through spilled material. Keep combustibles (wood, paper, oil, etc.) away from spilled material. Stop leak if you can do it without risk. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Do not direct water at spill or source of leak. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Isolate area until gas has dispersed. Ventilate the area. (ERG, 2024)

Fireproof if in building.

USUALLY STORED IN CYLINDERS AS LIQUID UNDER PRESSURE.

HANDLE WITH CARE. DO NOT BRING IN DIRECT CONTACT WITH REDUCING AGENTS, ALCOHOLS, ETC.

IN GENERAL, MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS...SHOULD BE STORED IN A COOL, WELL-VENTILATED PLACE, OUT OF DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, & SHOULD BE PERIODICALLY INSPECTED... INCOMPATIBLE MATERIALS SHOULD BE ISOLATED FROM EACH OTHER.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: ppm)

AEGL 2: Irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape (Unit: ppm)

AEGL 3: Life-threatening health effects or death (Unit: ppm)

AEGLs Status: Final

1.5 [ppm]

4.0 [ppm]

12 [ppm]

3 ppm (14 mg/m³)

6 ppm (28 mg/m³)

TWA 3 ppm (14 mg/m3) ST 6 ppm (28 mg/m3)

3.0 [ppm]

3 ppm (13.5 mg/m³)

TWA 3 ppm (13.5 mg/m3) See Appendix G

100 ppm (NIOSH, 2024)

100.0 [ppm]

See: 7616946

0.5 [ppm]

8 hr Time Weighted Avg (TWA): 3 ppm; 15 min Short Term Exposure Limit (STEL): 6 ppm.

0.5 ppm as TWA

3 ppm [1962]

6 ppm [1962]

CAUTION: These materials do not burn but will support combustion. Some will react violently with water.

Small Fire

· Contain fire and let burn. If fire must be fought, water spray or fog is recommended.

· Water only; no dry chemical, CO2 or Halon®.

· Do not get water inside containers.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Damaged cylinders should be handled only by specialists.

Fire Involving Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Do not direct water at source of leak or safety devices; icing may occur.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

A harmful concentration of this gas in the air will be reached very quickly on loss of containment.

Perchloryl fluoride is a colorless, non corrosive gas with a characteristic sweet odor. Contact with the material may cause irritation to skin, eyes, and mucous membranes. It is very toxic by inhalation and skin absorption. Under prolonged exposure to fire or intense heat the containers may violently rupture and rocket.

Colorless gas with a characteristic, sweet odor. [Note: Shipped as a liquefied compressed gas.]; [NIOSH]

COLOURLESS GAS OR COMPRESSED LIQUEFIED GAS WITH CHARACTERISTIC ODOUR.

Colorless gas with a characteristic, sweet odor.

Colorless gas with a characteristic, sweet odor. [Note: Shipped as a liquefied compressed gas.]

COLORLESS GAS

Colorless gas [Note: Shipped as a liquefied compressed gas].

CHARACTERISTIC SWEET ODOR

Characteristic, sweet odor.

-52 °F at 760 mmHg (NIOSH, 2024)

-46.8 °C

Liquid molar volume = 0.060457 cu m/kmol (determined at normal boiling point)

-46.7 °C

-46.8 °C @760 [mm Hg]

-234 °F (NIOSH, 2024)

Heat of Fusion at Melting Point = 3.834E+6 Joules/kmol

-147.7 °C

0.06 % (NIOSH, 2024)

MISCIBLE WITH WATER

Solubility in water, g/100ml at 20 °C: 0.06

0.637 (GAS); 1.434 @ 20 °C (LIQ)

Relative density (water = 1): 1.4 (liquid)

1.434 (L)

3.64(relative gas density)

3.64 (NIOSH, 2024) - Heavier than air; will sink (Relative to Air)

10.5 atm (NIOSH, 2024)

8943.88 mm Hg @ 25 °C

10.5 atm

8943.9 [mm Hg] @25 °C

WHEN HEATED TO DECOMP, IT EMITS HIGHLY TOXIC FUMES OF CHLORIDES & FLUORIDES.

3.91X10-3 Pa.s (liq) @ melting point

DOES NOT CORRODE BASE METALS WHEN ANHYDROUS

4.6 KCAL/MOL

13.60 eV

Odor Threshold Low: 10.0 [ppm]

Odor threshold from "Quick Guide: The Electronic NIOSH Pocket Guide to Chemical Hazards"

DIPOLE MOMENT 0.03; HEAT OF FORMATION OF GAS @ 25 °C -5.12 KCAL/MOL; TROUTON CONSTANT: 20.4; SPECIFIC HEAT OF LIQ: 0.229 CAL/G/DEG C @ -40 °C, 0.290 @ +50 °C; SHOWS GREATEST RESISTANCE TO ELECTRICAL BREAKDOWN KNOWN FOR ANY GAS

IG Heat of Formation = -2.38x10+7 Joules/kmol

nuclear quadrupole moment

dielectric constant

Slightly soluble in water.

Oxidizing Agents, Strong

Halogenating Agents

Strong Oxidizing Agent

PERCHLORYL FLUORIDE is a propellant; a powerful oxidant. It ignites upon contact with alcohols, amines, ammonia, beryllium alkyls, boranes, dicyanogen, hydrazines, hydrocarbons, hydrogen, nitroalkanes, powdered metals, silanes, or thiols [Bretherick 1979. p.174].

It may generate hydrofluoric acid if it comes into contact with water.

POWERFUL OXIDIZING AGENT.

Preparation of dimethylaminomethyl-2-fluoroferrocene, by interaction of the lithio compound in THF at -70 °C with perchloryl fluoride diluted with helium, unexpectedly exploded violently.

Combustibles, strong bases, amines, finely divided metals, reducing agents, alcohols.

Combustibles, strong bases, amines, finely divided metals, reducing agents, alcohols

The substance can be absorbed into the body by inhalation.

inhalation, skin and/or eye contact (liquid)

Cough. Sore throat. Laboured breathing. Shortness of breath.

ON CONTACT WITH LIQUID: FROSTBITE.

irritation respiratory system; liquid: frostbite; In Animals: methemoglobinemia; cyanosis; lassitude (weakness, exhaustion), dizziness, headache; pulmonary edema; pneumonitis; anoxia

Skin, respiratory system, blood

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

LC50 (rat) = 385 ppm/4H

Acute inhalation LC50 values for rodents exposed to perchloryl fluoride for 4 hours were 385 ppm in rats and 630 ppm in mice.

MUCOUS MEMBRANE, SKIN, LUNG, CORNEA IRRITATION & CYANOSIS. /FROM TABLE/

...MEN EXPOSED TO UNKNOWN CONCN OF CMPD /PERCHLORYL FLUORIDE/ FOR BRIEF PERIODS REPORTED SYMPTOMS OF UPPER RESP IRRITATION.

CAUSES METHEMOGLOBINEMIA...

Perchloryl fluoride is a strong irritant of the eyes, mucous membranes, and lungs. In high concn it can produce pulmonary edema as well as methemoglobinemia. Exposure to toxic concn can produce weakness, syncope, and headache as well as severe respiratory tract irritation and pulmonary edema. Skin contact from the liquid form can produce burns.

Clinical symptomatology includes dizziness, headache, cyanosis, and syncope.

DOGS, RATS & MICE EXPOSED TO VAPOR DEVELOPED METHEMOGLOBINEMIA. DOGS EXPOSED... @ 220 TO 450 PPM FOR 4 HR & @ 620 PPM FOR 2.5 HR WERE CYANOTIC & HYPERPNEIC... IN DOGS, DYING FROM EXPOSURE, THERE WERE...PIGMENT DEPOSITION IN LIVER, SPLEEN & BONE MARROW; AREAS OF ALVEOLAR HEMORRHAGE, OF ALVEOLAR COLLAPSE & EMPHYSEMA.

IN REPEATED INHALATION EXPOSURES TO PERCHLORYL FLUORIDE @ 185 PPM FOR 6 HR/DAY, 5 DAYS/WK FOR 7 WK, 18 OF 20 RATS, 20 OF 39 MICE & 10 OF 10 GUINEA PIGS DIED...SIGNS OF TOXICITY & PATHOLOGICAL CHANGES WERE...DYSPNEA; CYANOSIS & METHEMOGLOBINEMIA; FLUOROSIS (PIGMENT ALTERATION IN INCISOR TEETH); PATCHY AREAS OF CONSOLIDATION IN RAT LUNG; SPLENOMEGALY; HEMOSIDEROSIS OF THE SPLEEN, LIVER AND KIDNEY; AND ALVEOLAR EDEMA FOLLOWING THE FIRST EXPOSURE WHICH DEVELOPED INTO BRONCHOPNEUMONIA.

ON SIMILAR EXPOSURES AT 104 PPM FOR 6 WKS, ALL 10 GUINEA PIGS AND 1 OF 20 RATS DIED. SIMILAR SIGNS AND ANATOMIC CHANGES WERE OBSERVED. CIRCULATING /BLOOD/ FLUORIDE CONCENTRATIONS INCREASED FROM 20- TO 30-FOLD, URINARY FLUORIDE LEVELS FROM 5- TO 8-FOLD, & RAT FEMUR FLUORIDE CONCENTRATIONS INCREASED 10-FOLD.

After inhaling perchloryl fluoride for 6 mo @ 24 ppm, 14 of 30 exposed and 1 of 30 control guinea pigs died, but these deaths in exposed animals were attributed to infection by bordetella bronchiseptica; there were no deaths in rats and dogs. Bone fluoride concentrations were increased to four times the control in guinea pigs and almost three times the control value in rats. Dogs had about 50% increase in bone fluoride. All species had congested spleens containing iron-bearing pigments. In guinea pigs, there was an increase in normoblasts and a slight but nonsignificant decrease in total hemoglobin. In dogs, a two fold increase in the indirect fraction of serum bilirubin was demonstrated. There was no evidence of irritation observed in these animals that were exposed to 24 ppm.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Poison Gas Oxidizer

UN Hazard Class: 2.3; UN Subsidiary Risks: 5.1