Calcium arsenate

H301+H331 (81.5%): Toxic if swallowed or if inhaled [Danger Acute toxicity, oral; acute toxicity, inhalation]

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

H331 (100%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H350 (100%): May cause cancer [Danger Carcinogenicity]

H400 (96.3%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P203, P261, P264, P270, P271, P273, P280, P301+P316, P304+P340, P316, P318, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 27 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H350: May cause cancer [Danger Carcinogenicity]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P203, P260, P264, P264+P265, P270, P280, P301+P316, P305+P351+P338, P308+P316, P318, P319, P321, P330, P337+P317, P405, and P501 (click each P-code to see the statement)

H300: Fatal if swallowed [Danger Acute toxicity, oral]

H313: May be harmful in contact with skin [Warning Acute toxicity, dermal]

H316: Causes mild skin irritation [Warning Skin corrosion/irritation]

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

P203, P260, P264, P264+P265, P270, P280, P301+P316, P302+P317, P305+P351+P338, P308+P316, P318, P319, P321, P330, P332+P317, P337+P317, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Seek medical attention if you feel unwell.

Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.

Rinse mouth. Refer immediately for medical attention.

Warning: Effects usually appear within 30 minutes of exposure but may be delayed for several hours. Caution is advised.

Signs and Symptoms of Acute Calcium Arsenate Exposure: Hypotension (low blood pressure), tachycardia (rapid heart rate), dehydration, intense thirst, difficulty swallowing, vomiting, abdominal pain, and diarrhea are among the first signs and symptoms noticed following acute calcium arsenate exposure. Headache, conjunctivitis (red, inflamed eyes), runny nose, and lacrimation (tearing) are also common. Garlic odor of breath and feces may be noted. Cardiovascular effects include shock, tachycardia (rapid heart rate), ventricular fibrillation, and other cardiac abnormalities. Pulmonary edema may occur. Altered mental status, seizures, and delirium are further complications of calcium arsenate exposure. Intense muscle cramping is common. Exposure to airborne dust is generally accompanied by irritation of exposed skin, eyes, and mucous membranes.

Emergency Life-Support Procedures: Acute exposure to calcium arsenate may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:

1. Move victims to fresh air. Emergency personnel should avoid self-exposure to calcium arsenate.

2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

3. RUSH to a health care facility!

4. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

Dermal/Eye Exposure:

1. Remove victims from exposure. Emergency personnel should avoid self- exposure to calcium arsenate.

3. Remove contaminated clothing as soon as possible.

4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.

5. THOROUGHLY wash exposed skin areas with soap and water.

6. RUSH to a health care facility!

7. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

Ingestion Exposure:

1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.

2. RUSH to a health care facility!

3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

4. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of calcium arsenate is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step

5.Ipecac should not be administered to children under 6 months of age.Warning: Ingestion of calcium arsenate may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step

5.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.

5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.

6. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. (EPA, 1998)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

Stay upwind; keep out of low areas. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing.

Not flammable. For small fires, use dry chemical, water spray, or foam. For large fires, use water spray, fog, or foam. (EPA, 1998)

In case of fire in the surroundings, use appropriate extinguishing media.

Personnel protection: ... Wear positive pressure self contained breathing apparatus when fighting fires involving this material.

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, liquid, NOS/

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, solid, NOS/

Personnel protection: ... Wear positive pressure self-contained breathing apparatus when fighting fires involving this material. /Arsenical cmpd, solid, NOS/

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· Cover with plastic sheet to prevent spreading.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· DO NOT GET WATER INSIDE CONTAINERS.

· For solids, prevent dust cloud and avoid inhalation of dust.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Vacuum with specialist equipment or carefully sweep into containers. Carefully collect remainder. Then store and dispose of according to local regulations.

Prompt cleanup and removal are necessary. Control runoff and isolate discharged material for proper disposal.

Both arsenate and arsenite can be removed from the water column by co-precipitation or adsorption onto iron oxides. Arsenate species can also be removed by adsorption onto aluminum hydroxide and clays, while arsenite is readily adsorbed onto metal sulfides. /Arsenate and arsenite/

Floors and other accessible surfaces contaminated with inorganic arsenic may not be cleaned by the use of compressed air, and shoveling and brushing may be used only where vacuuming or other relevant methods have been tried and found not to be effective. /Inorganic arsenic compounds/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Recycling: Dissolve in a minimum amt of concentrated hydrochloric acid. Add to water until the appearance of white precipitate. Add 6 M-HCl /6 M-hydrochloric acid/ just to dissolve again. Saturate with hydrogen sulfide. After filtration, wash the precipitate and return to suppliers. Recommendable methods: Chemical treatment, solidification /hazardous waste/, landfill. Not recommendable methods: Thermal destruction, discharge to sewer.

Dissolve in HCl, precipitate as sulfide using H2S, dry, and return to supplier.

Chemical Treatability of Arsenic; Concentration Process: Chemical Precipitation; Chemical Classification: Metal; Scale of Study: Pilot Scale; Type of Wastewater Used: Domestic Wastewater + Pure Compound; Results of Study: 5ppm @ 4gpm @ pH= 7.0. Iron system-90% reduction; low lime system-80% reduction; high lime system-76% reduction; (3 coagulant systems were used; Iron system used 45 ppm as Fe of Fe2(SO4)3 @ pH= 6.0. Low lime system used 20 ppm Fe of Fe2(SO4)3 and 260 ppm of CaO @ pH= 10.0. High lime system used 600 ppm of CaO @ pH= 11.5. Chemical coagulation was followed by multimedia filtration). /Arsenic cmpd/

For more Disposal Methods (Complete) data for CALCIUM ARSENATE (6 total), please visit the HSDB record page.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Personnel protection: Avoid breathing dusts, and fumes from burning material. Keep upwind. Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. ... If contact with calcium arsenate is anticipated, wear appropriate chemical protective clothing.

Lockers should be provided with separate compartments for work & personal clothes, & adjacent sanitary facilities of a high standard should be made available. Smoking, eating, & drinking at the workplace should not be allowed. /Arsenic/

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. All contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

For more Preventive Measures (Complete) data for CALCIUM ARSENATE (27 total), please visit the HSDB record page.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. For solids, prevent dust cloud and avoid inhalation of dust. (ERG, 2024)

Separated from acids and food and feedstuffs. Well closed. Store in an area without drain or sewer access.

Long-term storage in large, weatherproof, and sift proof storage bins or silos; small amounts may be disposed in a chemical waste landfill.

Protect container against physical damage. Store in well ventilated area away from food or food products and combustible materials. /Inorganic arsenic cmpd/

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

Biological Exposure Indices (BEI) [ACGIH] - Inorganic arsenic plus methylated metabolites in urine = 35 ug As/L; end of workweek;

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

2.0 [mg/m3]

10 [mg/m3]

16 [mg/m3]

Ca C 0.002 mg/m3 [15-minute] See Appendix A

0.01 [mg/m3], as As

[1910.1018] TWA 0.010 mg/m3

5 mg As/m3 ; A potential occupational carcinogen. (NIOSH, 2024)

5.0 [mg/m3], as As

Excerpts from Documentation for IDLHs: No inhalation toxicity data are available on which to base an IDLH for calcium arsenate. Therefore, the revised IDLH for calcium arsenate is 5 mg As/m3 based on acute oral toxicity data in animals [Lehman 1951] and to be consistent with the revised IDLH for other inorganic arsenic compounds which have a revised IDLH of 5 mg As/m3.

NIOSH considers calcium arsenate, as As, to be a potential occupational carcinogen.

5 mg/cu m (as AS); NIOSH considers arsenic (inorganic cmpd, as As) to be a potential occupational carcinogen. /Arsenic (inorganic cmpd, as As)/

Ca [5 mg/m3 (as As)]

See: 7778441

8 hr Time weighted Avg (TWA) 0.01 mg/cu m /Arsenic and inorganic compounds, as As/

A1: Confirmed human carcinogen. /Arsenic and inorganic compounds, as As/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /Arsenic and inorganic compounds, as As/

BEI (Biological Exposure Index): Determinant: Inorganic arsenic plus methylated metabolites in urine; Sampling Time: end of workweek; BEI: 35 ug As/L. The determinant may be present in biological specimens collected from subjects who have not been occupationally exposed, at a concentration which could affect interpretation of the result. Such background concentrations are incorporated in the BEI value. /Arsenic, elemental and soluble inorganic compounds/

(inhalable fraction): 0.01 mg/m

skin absorption (H); carcinogen category: 1; germ cell mutagen group: 3A.

Acute Oral: 0.005 mg/kg/day (L134)

Chronic Oral: 0.0003 mg/kg/day (L134)

Chronic Inhalation: 0.01 mg/m3 (L134)

Small Fire

· Dry chemical, CO2 or water spray.

Large Fire

· Water spray, fog or regular foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Dike runoff from fire control for later disposal.

· Avoid aiming straight or solid streams directly onto the product.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Do not get water inside containers.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

... The following countries had adopted the ... TLV of 0.5 mg/cu m: Austria, Belgium, Finland, Japan, and Holland. Czechoslavakia, East Germany, Hungary and Poland ... USSR ... 0.3 mg/cu m; Romania and Switzerland, 0.2 mg/cu m; Sweden 0.05 mg/cu m; and Italy 0.25 mg/cu m. /Arsenic and sol cmpd/

Calcium arsenate is a white powder. Slightly soluble in water. Toxic by inhalation and ingestion. Used as an insecticide and germicide.

Colorless to white, odorless solid. [insecticide/herbicide]; [NIOSH]

COLOURLESS-TO-WHITE AMORPHOUS POWDER.

Colorless to white, odorless solid. [insecticide/herbicide]

White powder

Colorless to white solid.

Odorless

Decomposes (NIOSH, 2024)

No boiling point at normal pressure; decomposes on heating

Decomposes

2651 °F (EPA, 1998)

1.455 °C

0.01 % at 77 °F (NIOSH, 2024)

Sol in dil acids

Insol in organic solvents

0.013 G/100 CC OF WATER AT 25 °C

Solubility in water: very poor

(77 °F): 0.01%

3.62 (EPA, 1998) - Denser than water; will sink

3.62 g/cm³

3.62 @25 °C

0 mmHg (approx) (NIOSH, 2024)

0 mm Hg @ 20 °C (approx)

0 mmHg (approx)

Moisture and carbon dioxide cause slow decomp to calcium carbonate and (phytotoxic) dicalcium hydrogen arsenate. In the presence of acids, water sol, strongly phytotoxic arsenic acid is produced.

WHEN HEATED TO DECOMP IT EMITS TOXIC FUMES OF ARSENIC.

DANGEROUS WHEN HEATED TO DECOMP ... IT EMITS TOXIC FUMES OF ARSENIC /SRP: INCLUDING ARSINE/. /ARSENIC CMPD/

Slight corrosive action on metals

Decomp on heating

Metals -> Arsenic Compounds, Inorganic

Carcinogens

Slightly soluble in water.

Salts, Basic

Oxidizing Agents, Weak

Has only weak oxidizing power but redox reactions can still occur. Soluble in dilute acids. [Hawley]. Produces toxic fumes of arsenic when heated to decomposition (NIOSH, 2024).

Reacts with acids to produce toxic arsine gas [International Chemical Safety Card 0765].

... WHEN WATER SOLN OF ARSENICALS ARE IN CONTACT WITH ACTIVE METALS SUCH AS ARSENIC, IRON, ALUMINUM, ZINC, ... HIGHLY TOXIC FUMES OF ARSENIC /INCLUDING ARSINE ARE RELEASED/. /ARSENIC CMPD/

Strong oxidizers, bromide azide [Note: Hydrogen gas can react with inorganic arsenic to form the highly toxic gas arsine.] /Arsenic (inorganic compounds, as As)/

None reported [Note: Produces toxic fumes of arsenic when heated to decomposition.]

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

Classification of carcinogenicity: 1) evidence in humans: sufficient; 2) evidence in animals: limited. Overall summary evaluation of carcinogenic risk to humans is Group 1: Carcinogenic to humans. NOTE: This evaluation applies to the group of chemicals as a whole and not necessarily to all individual chemicals within the group. /Arsenic and arsenic compounds/

CLASSIFICATION: A; human carcinogen. BASIS FOR CLASSIFICATION: Based on sufficient evidence from human data. An increased lung cancer mortality was observed in multiple human populations exposed primarily through inhalation. Also, increased mortality from multiple internal organ cancers (liver, kidney, lung, and bladder) and an increased incidence of skin cancer were observed in populations consuming drinking water high in inorganic arsenic. HUMAN CARCINOGENICITY DATA: Sufficient. ANIMAL CARCINOGENICITY DATA: Inadequate. /Inorganic Arsenic/ /Based on former classification system/

A1: Confirmed human carcinogen. /Arsenic and inorganic compounds, as As/

Evaluation: There is sufficient evidence in humans that arsenic in drinking-water causes cancers of the urinary bladder, lung and skin ... Overall evaluation: Arsenic in drinking-water is carcinogenic to humans (Group 1). /Arsenic in drinking-water/

For more Evidence for Carcinogenicity (Complete) data for CALCIUM ARSENATE (6 total), please visit the HSDB record page.

1, carcinogenic to humans. (L135)

Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, especially in skin, liver, bladder and lung cancers. (T1, L20)

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

Oral (L2) ; inhalation (L2) ; dermal (L2)

Cough. Sore throat.

Redness. Pain.

Abdominal pain. Diarrhoea. Vomiting. Burning sensation in the throat and chest. Headache. Weakness. Shock or collapse.

lassitude (weakness, exhaustion); gastrointestinal disturbance; peripheral neuropathy; skin hyperpigmentation, palmar planter hyperkeratoses; dermatitis; ; In Animals: liver damage [potential occupational carcinogen]

Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels.

Eyes, respiratory system, liver, skin, central nervous system, lymphatic system

[lymphatic & lung cancer]

Neurotoxin - Sensorimotor

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Aplastic anemia - The presence of increased methemoglobin in the blood; the compound is classified as primary toxic effect.

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

IARC Carcinogen - Class 1: International Agency for Research on Cancer classifies chemicals as established human carcinogens.

NTP Carcinogen - Known to be a human carcinogen.

ACGIH Carcinogen - Confirmed Human.

WHO= 0.002 mg/kg /Inorganic arsenic cmpd, as As; from table/

LD50: 20 mg/kg (Oral, Rat) (T14)

LD50: 2400 mg/kg (Dermal, Rat) (T14)

LD50 Rat female oral 298 mg/kg

LD50 Mouse oral 794 mg/kg

LD50 Rat oral 20 mg/kg

LD50 Rat skin 2400 mg/kg

For more Non-Human Toxicity Values (Complete) data for CALCIUM ARSENATE (6 total), please visit the HSDB record page.

Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)

Vineyard workers in Germany and France have received heavy exposure to arsenical insecticides through inhalation of lead, calcium, and copper arsenate dust and through the ingestion of contaminated wine. The concurrence of arsenicism and lung cancer was observed in post mortem studies of those vineyard workers who showed cutaneous stigmata of arsenic toxicity at death: lung cancer occurred in 12 out of 27 men autopsied and liver hemangioendothelioma in two.

... OF COMPOUNDS TO WHICH SPRAYERS OF ORCHARDS ARE EXPOSED, CALCIUM ARSENATE IS THE MOST TOXIC; NEXT IS LEAD ARSENATE; & THIRD IS LEAD CARBONATE.

GROUP OF ... 25 MALE BD IX RATS, 12 WK OLD ... GIVEN SINGLE INTRATRACHEAL INSTILLATION OF 0.1 ML OF ARSENIC CONTAINING MIXT (CALCIUM ARSENATE, COPPER SULFATE & CALCIUM HYDROXIDE) ... 10 ... DIED ... REMAINING 15 ... OBSERVED FOR ... (455-500 DAYS), & 9 ... /HAD/ LUNG TUMORS ... WORKING GROUP NOTED ... NO CU-CONTAINING CMPD ... TESTED ALONE.

PARAFFIN PELLETS (250 MG) CONTAINING 30% CALCIUM ARSENATE WERE IMPLANTED SUBCUTANEOUSLY INTO 60 RANDOM-BRED MALE ALBINO RATS. IN AN ADDITIONAL EXPT, 100 MG CALCIUM ARSENATE DISSOLVED IN 0.5 ML OF SUNFLOWER OIL WERE INJECTED SC INTO 50 RATS. NO TUMORS WERE REPORTED AFTER 2.5 YR.

CALCIUM ARSENATE IS STOMACH POISON, ITS LIABILITY TO CAUSE PHYTOTOXICITY IS ASCRIBED TO THE FORMATION OF WATER SOL ARSENIC COMPOUNDS.

500 ppm calcium arsenate applied to clay increases yield of corn and cotton; 196 ppm calcium arsenate applied to an unspecified soil type decreased yield of cotton; 246-371 ppm calcium arsenate applied to an unspecified soil type depressed yield of oats.

For more Non-Human Toxicity Excerpts (Complete) data for CALCIUM ARSENATE (10 total), please visit the HSDB record page.

This substance may be hazardous to the environment. Special attention should be given to aquatic organisms. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

INORGANIC ARSENICALS SUCH AS ... CALCIUM ARSENATE CA3(ASO4)2 HAVE BEEN USED FOR MANY YR AS SOIL STERILANTS ... THESE CMPD ARE MOST PERSISTENT SOIL STERILANTS & MAY REMAIN EFFECTIVE FOR ... AS LONG AS 5-8 YR ESPECIALLY IN AREAS OF LOW RAINFALL.

ARSENIC WAS FOUND IN SIGNIFICANT CONCN IN DRAINAGE & RUNOFF WHERE CALCIUM ARSENATE HAD BEEN APPLIED. DRAINAGE FROM PLOTS PREVIOUSLY CORED FOR SOIL SAMPLES CONTAINED CONCN OF 8 PPM. AFTER HEAVY RAIN, SHORTLY AFTER APPLICATION, RUNOFF WAS AS GREAT AS 14 PPM.

ADVERSE HEALTH EFFECTS HAVE BEEN REPORTED IN WORKERS INVOLVED IN THE PRODUCTION, PACKAGING, AND USE OF LEAD AND CALCIUM ARSENATE PESTICIDES.

Workers engaged in manufacture, formulation, and application of pesticides containing calcium arsenate.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Recycling: Dissolve in a minimum amt of concentrated hydrochloric acid. Add to water until the appearance of white precipitate. Add 6 M-HCl /6 M-hydrochloric acid/ just to dissolve again. Saturate with hydrogen sulfide. After filtration, wash the precipitate and return to suppliers. Recommendable methods: Chemical treatment, solidification /hazardous waste/, landfill. Not recommendable methods: Thermal destruction, discharge to sewer.

Dissolve in HCl, precipitate as sulfide using H2S, dry, and return to supplier.

Chemical Treatability of Arsenic; Concentration Process: Chemical Precipitation; Chemical Classification: Metal; Scale of Study: Pilot Scale; Type of Wastewater Used: Domestic Wastewater + Pure Compound; Results of Study: 5ppm @ 4gpm @ pH= 7.0. Iron system-90% reduction; low lime system-80% reduction; high lime system-76% reduction; (3 coagulant systems were used; Iron system used 45 ppm as Fe of Fe2(SO4)3 @ pH= 6.0. Low lime system used 20 ppm Fe of Fe2(SO4)3 and 260 ppm of CaO @ pH= 10.0. High lime system used 600 ppm of CaO @ pH= 11.5. Chemical coagulation was followed by multimedia filtration). /Arsenic cmpd/

For more Disposal Methods (Complete) data for CALCIUM ARSENATE (6 total), please visit the HSDB record page.

/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Health: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.

/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at lease 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas.

/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.

For more DOT Emergency Guidelines (Complete) data for CALCIUM ARSENATE (8 total), please visit the HSDB record page.

UN 1573; Calcium arsenate

IMO 6.1; Calcium arsenate

49 232 17; Calcium arsenate

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Do not transport with food and feedstuffs. Marine pollutant.

Symbol: T, N; R: 45-23/25-50/53; S: 53-45-60-61; Note: A, E

UN Hazard Class: 6.1; UN Pack Group: II