Nitrogen trifluoride

H270 (100%): May cause or intensify fire; oxidizer [Danger Oxidizing gases]

H280 (100%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]

H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H373 (33.3%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P220, P244, P260, P261, P271, P304+P340, P317, P319, P370+P376, P403, P410+P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 87 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H270: May cause or intensify fire; oxidizer [Danger Oxidizing gases]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

P220, P244, P260, P261, P264, P270, P271, P304+P340, P308+P316, P317, P319, P370+P376, P403, P405, and P501 (click each P-code to see the statement)

Fresh air, rest.

Remove contaminated clothes.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Excerpt from NIOSH Pocket Guide for Nitrogen trifluoride:

Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible. (NIOSH, 2024)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Clothing frozen to the skin should be thawed before being removed.

· In case of contact with liquefied gas, only medical personnel should attempt thawing frosted parts.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Breathing: Respiratory support

Excerpt from ERG Guide 122 [Gases - Oxidizing (Including Refrigerated Liquids)]:

Use extinguishing agent suitable for type of surrounding fire.

SMALL FIRE: Dry chemical or CO2.

LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Damaged cylinders should be handled only by specialists.

FIRE INVOLVING TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devices; icing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep cylinder cool by spraying with water.

Do not extinguish the fire unless the flow of gas can be stopped and any remaining gas is out of the line. Specially trained personnel may use fog lines to cool exposures and let the fire burn itself out. Vapors are heavier than air and will collect in low areas. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminates waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure location. ... The only respirators recommended for firefighting are self-contained breathing apparatuses that have full face-pieces and are operated in a pressure-demand or other positive-pressure mode.

If material on fire or involved in fire: Solid streams of water may be ineffective. Extinguish fire using agent suitable for type of surrounding fire (Material itself does not burn or burns with difficulty.) Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.

Turn leaking cylinder with the leak up to prevent escape of gas in liquid state.

Heating will cause rise in pressure with risk of bursting.

Poisonous gases, including fluorine, are produced in fire.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Many gases are heavier than air and will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· Keep combustibles (wood, paper, oil, etc.) away from spilled material.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· If possible, turn leaking containers so that gas escapes rather than liquid.

· Do not direct water at spill or source of leak.

· Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material.

· Prevent entry into waterways, sewers, basements or confined areas.

· Allow substance to evaporate.

· Isolate area until gas has dispersed.

CAUTION: When in contact with refrigerated/cryogenic liquids, many materials become brittle and are likely to break without warning.

Excerpt from ERG Guide 122 [Gases - Oxidizing (Including Refrigerated Liquids)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 500 meters (1/3 mile).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

Large Spill

· Consider initial downwind evacuation for at least 500 meters (1/3 mile).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Ventilation. NEVER direct water jet on liquid. Personal protection: self-contained breathing apparatus.

If in a building, evacuate building and confine vapors by closing doors and shutting down HVAC systems. Restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Ventilate area of spill or leak to disperse the gas. Wear chemical protective suit with self-contained breathing apparatus to combat spills. Stay upwind and use water spray to "knock down" vapor; contain runoff. Stop the flow of gas, if it can be done safely from a distance. If source is a cylinder and the leak cannot be stopped in place, remove the leaking cylinder to a safe place, and repair leak or allow cylinder to empty. Keep this chemical out of confined spaces, such as a sewer, because of the possibility of explosion, unless the sewer is designed to prevent the buildup of explosive concentrations.

Persons not wearing protective equipment and clothing should be restricted from areas of leaks until cleanup has been completed. ... 1. Ventilate area of leak to disperse gas. 2. Stop flow of gas. If source of leak is a cylinder and the leak cannot be stopped in place, remove the leaking cylinder to a safe place in the open air, and repair the leak or allow the cylinder to empty.

Gas leakage: Pass through a reducing agent (sodium bisulfite) and sodium bicarbonate solution with a trap in the line, when the valve can not be closed.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Spillage Disposal: Ventilation. NEVER direct water jet on liquid. Personal protection: self-contained breathing apparatus.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

If material not on fire and not involved in fire: Keep material out of water sources and sewers. Attempt to stop leak if without undue personnel hazard.

Personnel protection: Avoid breathing vapors. Keep upwind. ... Do not handle broken packages unless wearing appropriate personal protective equipment.

Excerpt from ERG Guide 122 [Gases - Oxidizing (Including Refrigerated Liquids)]:

Keep combustibles (wood, paper, oil, etc.) away from spilled material. Do not touch or walk through spilled material. Stop leak if you can do it without risk. If possible, turn leaking containers so that gas escapes rather than liquid. Do not direct water at spill or source of leak. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Prevent entry into waterways, sewers, basements or confined areas. Allow substance to evaporate. Isolate area until gas has dispersed. CAUTION: When in contact with refrigerated/cryogenic liquids, many materials become brittle and are likely to break without warning. (ERG, 2024)

Fireproof if in building. Separated from combustible substances and reducing agents. Cool.

Store separately in an area isolated from flammables, combustibles, or other yellow coded materials. ... High concentrations cause a deficiency of oxygen with the risk of unconsciousness or death. Check that oxygen content is at least 19% before entering storage or spill area.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

· Always wear thermal protective clothing when handling refrigerated/cryogenic liquids.

Biological Exposure Indices (BEI) [ACGIH] - Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: ppm)

AEGL 2: Irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape (Unit: ppm)

AEGL 3: Life-threatening health effects or death (Unit: ppm)

AEGLs Status: Interim

200 [ppm]

530 [ppm]

860 [ppm]

10 ppm (29 mg/m³)

TWA 10 ppm (29 mg/m3)

10.0 [ppm]

1000 ppm (NIOSH, 2024)

1000.0 [ppm]

Excerpts from Documentation for IDLHs: Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse 4­hour LC50 of 2,000 ppm cited by Deichmann and Gerarde [1969]. Deichmann and Gerarde [1969] also stated that nitrogen trifluoride is a pulmonary irritant comparable in toxicity to the oxides of nitrogen. . . . Human data: None relevant for use in determining the revised IDLH.

1000 ppm

See: 7783542

8 hr Time Weighted Avg (TWA): 10 ppm.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

Biological Exposure Index (BEI): Determinant: methemoglobin in blood; Sampling Time: during or end of shift; BEI: 1.5% of hemoglobin. The determinant may be present in biological specimens collected from subjects who have not been occupationally exposed, at a concentration which could affect interpretation of the result. Such background concentrations are incorporated in the BEI value. The determinant is nonspecific, since it is also observed after exposure to other chemicals. The biological determinant is an indicator of exposure to the chemical, but the quantitative interpretation of the measurement is ambiguous. These determinants should be used as a screening test if a quantitative test is not practical or as a confirmatory test if the quantitative test is not specific and the origin of the determinant is in question. /Methemoglobin inducers/

10 ppm as TWA; BEI issued

10 ppm [1992]

· Use extinguishing agent suitable for type of surrounding fire.

Small Fire

· Dry chemical or CO2.

Large Fire

· Water spray, fog or regular foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Damaged cylinders should be handled only by specialists.

Fire Involving Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Do not direct water at source of leak or safety devices; icing may occur.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

ERPG-1: Not appropriate - one hour exposure limit: 1 = mild transient health effects or objectionable odor [AIHA]

Nitrogen trifluoride appears as a colorless gas with a moldy odor. Very toxic by inhalation. Slightly soluble in water. Corrosive to tissue. Under prolonged exposure to fire or heat the containers may rupture violently and rocket. Used to make other chemicals and as a component of rocket fuels.

Gas Vapor; CBI

Colorless gas with a moldy odor. [Note: Shipped as a nonliquefied compressed gas.]; [NIOSH]

COLOURLESS GAS WITH CHARACTERISTIC ODOUR.

Colorless gas with a moldy odor.

Colorless gas with a moldy odor. [Note: Shipped as a nonliquefied compressed gas.]

Colorless gas [Note: Shipped as a nonliquified compressed gas]

Moldy odor

High purity nitrogen trifluoride has little odor, but material contaminated with traces of active fluorides may have a pungent, musty odor.

-200 °F at 760 mmHg (NIOSH, 2024)

-128.75 °C

Trouton constant: 19.9; decomposed by electric sparks; inert chemically; liquid at boiling point

-129 °C @760 [mm Hg]

-340 °F (NIOSH, 2024)

-208.79 °C

Heat of fusion at the melting point = 3.9794x10+5 J/kmol

-208.5 °C

-343.8 °F

-206.79 °C

Slight (NIOSH, 2024)

Water solubility = 1.4X10-5 mol NF3/mol H2O at 25 °C and 101.3 kPa

Insoluble in water

Solubility in water: none

2.902 g/L

Liquid density = 1.533 at -129 °C; Heat of formation = -131.5 kJ/mol; Heat capacity = 53.39 J/(mol*K)

Relative density (water = 1):

2.46(relative gas density)

2.46 (NIOSH, 2024) - Heavier than air; will sink (Relative to Air)

greater than 1 atm (NIOSH, 2024)

33,400 mm Hg at 233 K

Decomposed by electric sparks.

When heated to decomposition it emits highly toxic fumes of /flouride/.

Does not attack glass, mercury

11.56 kJ/mol at -128.75 °C

12.97 eV

Refractive Index determined in the gaseous state = 1.0004

Global Warming Potential (100 yr) = 17,200 /CO2 = 1/

Critical volume: 167 cu cm/mol

Reactivity: ... strong oxidzer; reacts explosively with reducing agents; decomposed by electric sparks. Conversion factors at 25 °C and 760 torr: 1 ppm = 2.90 g/cu m; 1 mg/cu m = 0.344 ppm

Heat of formation = -132.1 kJ/mol; Standard molar Gibbs energy of formation = -90.6 kJ/mol; Standard molar entropy = 260.8 kJ/mol; Molar heat capacity at constant pressure, 298.15 K = 53.5 J/mol

Slightly soluble in water.

Oxidizing Agents, Strong

Halogenating Agents

Explosive

Strong Oxidizing Agent

NITROGEN TRIFLUORIDE is a very powerful oxidizing agent. Presents dangerous fire hazard in the presence of reducing agents. Etches glass in the presence of moisture. Emits toxic and corrosive fumes of fluoride when heated to decomposition [Lewis, 3rd ed., 1993, p. 937]. Can react violently with hydrogen, ammonia, carbon monoxide, diborane, hydrogen sulfide, methane, tetrafluorohydrazine, charcoal. Explosive reaction with chlorine dioxide. A severe explosion may occur when exposed to reducing agents under pressure [Bretherick, 5th ed., 1995, p. 1427].

Can react violently with /ammonia/, /carbon monoxide/, diborane, /hydrogen/, /hydrogen sulfide/, /methane/, tetrafluorohydrazine. Can react vigorously with reducing materials.

Incompatible with charcoal, hydrogen-containing compounds, tetrafluorihydrazine.

NO contact with flammables. NO contact with reducing agents.

Attacks metals.

For more Hazardous Reactivities and Incompatibilities (Complete) data for NITROGEN TRIFLUORIDE (11 total), please visit the HSDB record page.

Water, oil, grease, oxidizable materials, ammonia, carbon monoxide, methane, hydrogen, hydrogen sulfide, activated charcoal, diborane

IDENTIFICATION AND USE: Nitrogen trifluoride is a colorless gas with a moldy odor. It is used as a chamber-cleaning gas in the manufacture of electronics. Nitrogen trifluoride is preferred to F2 in high-power chemical lasers because of its ease of handling at ambient temperatures. It is also an oxidizer for high-energy fuels, chemical synthesis. HUMAN EXPOSURE AND TOXICITY: Nitrogen trifluoride is a simple asphyxiant. Five volunteers were exposed to nitrogen trifluoride at concentrations of 100 and 500 ppm for 2 to 3 minutes. No odor was detected at 100 ppm, but one of the five reported the odor detectable at 500 ppm. ANIMAL STUDIES: Nitrogen trifluoride has a moderate acute inhalation toxicity causing anoxic deaths due to methemoglobinemia. Acute inhalation also results in slight histologic changes in the liver and kidneys of some rats and enlargement and darkening of the spleen. Serum glutamic-oxaloacetic transaminase levels in the rats were essentially unaffected after acute inhalation. Dogs surviving exposure at 9600 ppm for 60 minutes exhibited Heinz body-included hemolysis, anemia, decreased hematocrit, decreased hemoglobin, reduced red blood cell count, and clinical signs consistent with histotoxic anoxia as a result of methemoglobin formation. Rabbits that received 9 intraperitoneal injections of 10 mL of nitrogen trifluoride gas in 29 days showed enlarged spleens, pathologic changes in the liver, and myocardial degeneration.

The substance can be absorbed into the body by inhalation.

inhalation

In Animals: anoxia, cyanosis; methemoglobinemia; lassitude (weakness, exhaustion), dizziness, headache; liver, kidney injury

Blood, liver, kidneys

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.

Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

LC50 (rat) = 6,700 ppm/1H

LC50 Mouse inhalation 7500 ppm/1 hr

LC50 Rat inhalation 6700 ppm/1 hr

LC50 Mouse inhalation 2000 pm/4 hr

LC50 Dog inhalation 9600 ppm/1 hr

LC50 Monkey inhalation 7500 ppm/1hr

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Fluorine and Related Compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Fluorine and Related Compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... .

First Aid: If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. If frostbite has occurred, seek medical attention immediately; do NOT rub the affected areas or flush them with water. In order to prevent further tissue damage, do NOT attempt to remove frozen clothing from frostbitten areas. If frostbite has NOT occurred, immediately and thoroughly wash contaminated skin with soap and water.

For more Antidote and Emergency Treatment (Complete) data for NITROGEN TRIFLUORIDE (7 total), please visit the HSDB record page.

The following medical procedures should be made available to each employee who is exposed to nitrogen trifluoride at potentially hazardous levels: A complete history and physical examination /should be performed/ to detect pre-existing conditions that might place the exposed employee at increased risk, and to establish a baseline for future health monitoring. Examination of the blood, cardiovascular system, nervous system, liver, and kidneys should be stressed; ... a complete blood count should be performed including a red cell count, a white cell count, a differential count of a stained smear, as well as hemoglobin and hematocrit. ... The aforementioned medical examinations should be repeated on an annual basis. Methemoglobin determinations should be performed if overexposure is suspected or signs and symptoms of toxicity occur.

/LABORATORY ANIMALS: Acute Exposure/ Rats that had received single intraperitoneal injections of nitrogen trifluoride gas (8-15 mL/kg) became cyanotic and developed enlarged spleens, possibly as a secondary response to the methemoglobinemia.

/LABORATORY ANIMALS: Acute Exposure/ Nitrogen trifluoride has a moderate acute inhalation toxicity causing anoxic deaths due to methemoglobinemia. Acute inhalation also results in slight histologic changes in the liver and kidneys of some rats and enlargement and darkening of the spleen. Serum glutamic-oxaloacetic transaminase levels in the rats were essentially unaffected after acute inhalation.

/LABORATORY ANIMALS: Acute Exposure/ When rats inhaled 1000 ppm nitrogen trifluoride for 4 hours, a substantial increase in circulating methemoglobin was detectable; however, inhalation of 3000 ppm for 10 minutes failed to show such an effect. When rats inhaled 2500 ppm nitrogen trifluoride for 4 hours, deaths were commonplace. Eighty-seven percent of the rats died after inhalation of 10,000 ppm nitrogen trifluoride for 60 to 70 minutes; the methemoglobin concentrations at the time of death were equivalent to 60% to 70% of the total blood pigment.

/LABORATORY ANIMALS: Acute Exposure/ Dogs surviving exposure at 9600 ppm for 60 minutes exhibited Heinz body-induced hemolysis, anemia, decreased hematocrit, decreased hemoglobin, reduced red blood cell count, and clinical signs consistent with histotoxic anoxia as a result of methemoglobin formation.

For more Non-Human Toxicity Excerpts (Complete) data for NITROGEN TRIFLUORIDE (8 total), please visit the HSDB record page.

Persons with blood disorders may be at increased risk from exposure.

Nitrogen trifluoride does not occur naturally in the environment(1).

Nitrogen trifluouride's production and use in high energy fuels and as a chemical intermediate(1) may result in its release to the environment through various waste streams(SRC).

Unlike many other greenhouse gases, fluorinated gases /such as nitrogen trifluoride/ have no natural sources and only come from human-related activities. They are emitted through a variety of industrial processes such as aluminum and semiconductor manufacturing. ... Like other long-lived greenhouse gases, fluorinated gases are well-mixed in the atmosphere, spreading around the world after they're emitted. Fluorinated gases are removed from the atmosphere only when they are destroyed by sunlight in the far upper atmosphere. In general, fluorinated gases are the most potent and longest lasting type of greenhouse gases emitted by human activities(1).

Atmospheric Lifetime = 740 years

According to the 2012 TSCA Inventory Update Reporting data, 3 reporting facilities estimate the number of persons reasonably likely to be exposed during the manufacturing, processing, or use of nitrogen trifluoride in the United States may be as low as <10 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,096 workers (140 of these are female) were potentially exposed to nitrogen trifluoride in the US(1). Occupational exposure to nitrogen trifluoride may occur through inhalation and dermal contact with this compound at workplaces where nitrogen trifluoride is produced or used. (SRC)

Nitrogen trifluoride does not occur naturally in the environment(1).

Nitrogen trifluouride's production and use in high energy fuels and as a chemical intermediate(1) may result in its release to the environment through various waste streams(SRC).

Unlike many other greenhouse gases, fluorinated gases /such as nitrogen trifluoride/ have no natural sources and only come from human-related activities. They are emitted through a variety of industrial processes such as aluminum and semiconductor manufacturing. ... Like other long-lived greenhouse gases, fluorinated gases are well-mixed in the atmosphere, spreading around the world after they're emitted. Fluorinated gases are removed from the atmosphere only when they are destroyed by sunlight in the far upper atmosphere. In general, fluorinated gases are the most potent and longest lasting type of greenhouse gases emitted by human activities(1).

Atmospheric Lifetime = 740 years

According to the 2012 TSCA Inventory Update Reporting data, 3 reporting facilities estimate the number of persons reasonably likely to be exposed during the manufacturing, processing, or use of nitrogen trifluoride in the United States may be as low as <10 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,096 workers (140 of these are female) were potentially exposed to nitrogen trifluoride in the US(1). Occupational exposure to nitrogen trifluoride may occur through inhalation and dermal contact with this compound at workplaces where nitrogen trifluoride is produced or used. (SRC)

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Spillage Disposal: Ventilation. NEVER direct water jet on liquid. Personal protection: self-contained breathing apparatus.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

/GUIDE 122 GASES - OXIDIZING (Including Refrigerated Liquids)/ Fire or Explosion: Substance does not burn but will support combustion. Some may react explosively with fuels. May ignite combustibles (wood, paper, oil, clothing, etc.). Vapors from liquefied gas are initially heavier than air and spread along ground. Runoff may create fire or explosion hazard. Containers may explode when heated. Ruptured cylinders may rocket.

/GUIDE 122 GASES - OXIDIZING (Including Refrigerated Liquids)/ Health: Vapors may cause dizziness or asphyxiation without warning. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire may produce irritating and/or toxic gases.

/GUIDE 122 GASES - OXIDIZING (Including Refrigerated Liquids)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Many gases are heavier than air and will spread along ground and collect in low or confined areas (sewers, basements, tanks). Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 122 GASES - OXIDIZING (Including Refrigerated Liquids)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. Always wear thermal protective clothing when handling refrigerated/cryogenic liquids.

For more DOT Emergency Guidelines (Complete) data for NITROGEN TRIFLUORIDE (8 total), please visit the HSDB record page.

UN 2451; Nitrogen trifluoride

IMO 2.2; Nitrogen trifluoride

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. Nitrogen trifluoride is included on the dangerous goods list.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. Nitrogen trifluoride is included on the dangerous goods list.

Non-Flammable Gas Oxidizer

UN Hazard Class: 2.2; UN Subsidiary Risks: 5.1