aluminiumfluoride

This chemical does not meet GHS hazard criteria for 95.2% (360 of 378) of all reports.

Not Classified

Reported as not meeting GHS hazard criteria by 360 of 378 companies (only 4.8% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 378 reports by companies from 11 notifications to the ECHA C&L Inventory.

Reported as not meeting GHS hazard criteria per 360 of 378 reports by companies.

There are 9 notifications provided by 18 of 378 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P203, P260, P261, P264, P264+P265, P270, P271, P280, P301+P316, P304+P340, P305+P351+P338, P318, P319, P321, P330, P337+P317, P403+P233, P405, and P501 (click each P-code to see the statement)

P203, P260, P264, P270, P280, P301+P316, P318, P319, P321, P330, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer for medical attention.

Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

For acute poisoning, oral administration of limewater, intravenous infusion of glucose, and intravenous injections of calcium gluconates. (USCG, 1999)

In case of fire in the surroundings, use appropriate extinguishing media.

Stop flow of liquid before extinguishing fire. Use dry chemical or carbon dioxide. DO NOT use water as straight stream directly on spilled material. Water fog can be used to control fire. DO NOT use halogenated extinguishing agents on spilled material. Violent reaction may result. Use water spray to keep fire-exposed containers cool. Fight fire from protected location or maximum possible distance. /Aluminum Alkyls/

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.

Aluminum compounds are treated under anhydrous conditions to prevent violent reactions, recover solvent, and form Al compounds suitable for landfill by reaction with anhydrous hydrolysis agent, eg calcium hydroxide. /Aluminum compounds/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Work clothing that becomes wet or significantly contaminated should be removed and replaced. /Aluminum (soluble salts and alkyls, as Al)/

Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises. /Aluminum (soluble salts and alkyls, as Al)/

The worker should immediately wash the skin when it becomes contaminated. /Aluminum (soluble salts and alkyls, as Al)/

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

Dry. Well closed.

Extremely reactive with air, moisture and compounds containing active hydrogen and therefore must be kept under a blanket of inert gas. /Aluminum alkyls/

In general, materials ... toxic as stored or which can decompose into toxic components ... Should be stored in cool ... ventilated place, out of ... sun, away from ... fire hazard ... be periodically inspected and monitored. Incompatible materials should be isolated ...

All possibility of contact with water must be avoided. Solution containing not more than 20% of these compounds in non-reactive solvents, however, can be handled without risk of spontaneous ignition. /Aluminum alkyls/

Must be stored in an inert atmosphere; sensitive to oxidation and hydrolysis in air. /Trialkylaluminums/

Separate from air, water, halocarbons, alcohols. Store in a cool, dry, well-ventilated location. Outside or detached storage is preferred. Inside storage should be in a standard flammable liquid storage warehouse, room, or cabinet. /Aluminum alkyls/

Biological Exposure Indices (BEI) [ACGIH] - Fluorides in urine = 2 mg/L prior to shift or 3 mg/L at end of shift; (Repeated measurements recommended.)

1.0 [mg/m3], inhalable fraction, as F[German Research Foundation (DFG)]

3.0 [mg/m3]

33 [mg/m3]

200 [mg/m3]

2.5 [mg/m3], as F

8 hr Time Weighted Avg (TWA): 2.5 mg/cu m. /Fluorides, as F/

Biological Exposure Index (BEI): Determinant: fluorides in urine; Sampling Time: prior to shift; BEI: 3 mg/g creatinine. Determinant: fluorides in urine; Sampling Time: end of shift; BEI: 10 mg/g creatinine. The determinant may be present in biological specimens collected from subjects who have not been occupationally exposed, at a concentration which could affect interpretation of the result. Such background concentrations are incorporated in the BEI value. The determinant is nonspecific, since it is also observed after exposure to other chemicals. /Fluorides/

A4; Not classifiable as a human carcinogen. /Fluorides, as F/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /Fluorides, as F/

For more Threshold Limit Values (TLV) (Complete) data for ALUMINUM FLUORIDE (7 total), please visit the HSDB record page.

(as F): 2.5 mg/m

(as F): 2,5 mg/m

(as F, inhalable fraction): 1 mg/m

USSR: 1 mg/cu m /Fluorides/

Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly.

The aerosol is irritating to the eyes, skin and respiratory tract.

Repeated or prolonged inhalation may cause asthma. The substance may have effects on the bone and central nervous system. This may result in bone alterations (fluorosis) and nervous system impairment.

Goggles to protect against airborne particles and possibly respirator for intermittent heavy dust exposures. (USCG, 1999)

Wear appropriate personal protective clothing to prevent skin contact. /Aluminum (soluble salts and alkyls, as Al/

Wear appropriate eye protection to prevent eye contact. /Aluminum (soluble salts and alkyls, as Al)/

Protective clothing and a high standard of training in the necessary precautionary measures are essential for the handling of the materials. /Aluminum alkyls/

PREVENT DISPERSION OF DUST!

Use local exhaust or breathing protection.

Protective gloves.

Wear safety goggles.

Do not eat, drink, or smoke during work. Wash hands before eating.

Aluminum fluoride appears as odorless white powder or granules. Denser than water. Solubility in water at 25 °C equals 0.559 g / 100 mL.

Other Solid; Dry Powder

White solid; [Hawley] Hygroscopic; [ICSC] Odorless powder; [MSDSonline]

HYGROSCOPIC WHITE OR COLOURLESS CRYSTALS.

White, hexagonal crystals

1272 °C @760 [mm Hg]

Loses water at 100 °C, more at 200 °C. ... slight solubility. /Trihydrate/

In water, 0.559 g/100 mL @ 25 °C

Sparingly soluble in acids and alkalies, even hot concentrated H2SO4 has little effect.

INSOL IN ALC & ACETONE

Solubility in water, g/100ml at 20 °C: 0.5

2.88 at 77 °F (USCG, 1999) - Denser than water; will sink

2.9 g/cm³

3.1 @25 °C

1 mm Hg @ 1238 °C

Vapor pressure, Pa at 1238 °C: 133

Low melting solids or colorless, volatile liquids. /Alkylaluminum halides/

Less sensitive than trialkylaminums to oxidation upon exposure to air. /Alkylaluminum halides/

Not flammable (USCG, 1999)

When heated to decomposition it emits highly toxic fumes of /hydrogen fluoride/.

Sublimes at 1272 °C, 760 mmHg

Heat of formation: -1510.4 (crystalline); -1204.6 (gas) kJ/mol @ 298.15 K; Gibbs energy of formation: -1431.1 (crystalline); -1188.2 (gas) kJ/mol @ 298.15 K; standard molar entropy: 66.5 (crystaline); 277.1 (gas) J/mol K @ 298.15 K; molar heat capacity at constant pressure: 75.1 (crystalline); 62.6 (gas) J/mol K @ 298.15 K

Enthalpy of fusion: 98 kJ/mol @ triple point

Hydrolyzed by superheated steam at 300-400 °C

Metals -> Metals, Inorganic Compounds

Corrosives

Antiplaque; Oral care

Slightly soluble in water

Salts, Basic

ALUMINUM FLUORIDE when heated to sublimation condition, emits toxic fumes of fluoride (USCG, 1999).

Violently impact-sensitive when in contact with sodium and potassium.

... On contact with acid or acid fumes, they emit highly toxic fumes. /Fluorides/

Extremely reactive with air, moisture, and compounds containing active hydrogen... /Alkyl aluminum compounds/

Reacts violently with a broad range of materials including air & water. /Aluminum alkyls/

A4: Not classifiable as a human carcinogen. /Aluminum metal and insouble compound/

A4; Not classifiable as a human carcinogen. /Fluorides as F/

The substance can be absorbed into the body by inhalation of dust and by ingestion.

Cough. Shortness of breath. Sore throat.

Pain. Redness.

Redness. Pain.

Dermatotoxin - Skin burns.

Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

4 mg/L (Adjusted Acceptable Daily Intake) /Fluoride/

LD50 Mouse oral 103 mg/kg

In the gut, antacids form insoluble compounds with numerous substances. Interactions are especially prominent with aluminum-containing antacids. Aluminum forms insoluble aluminum phosphate, which decreases the bioavailability of phosphate. Although aluminum fluoride is somewhat soluble, aluminum-containing antacids interfere with the absorption of fluoride, probably through the formation of more complex compounds, such as fluoroapatite. Aluminum-containing antacids adsorb bile acids, lysolecithin, and various proteins. /Aluminum-Containing antacids/

... Pretreatment of rats with fluoride increased their sensitivity to succinylcholine, demeton and parathion. /Fluoride/

/Exposure to aluminum fluoride/ dust: If inhaled, irritating to nose and throat. Move to fresh air.

Fluoride levels in urine should be checked periodically and all workers should be subjected to periodical skeletal X-ray exam particularly of the pelvis. /Fluoride and cmpd/

/SIGNS AND SYMPTOMS/ /Anhydrous aluminum fluoride is a/ strong irritant to tissue.

/SIGNS AND SYMPTOMS/ Symptoms Following Exposure /to aluminum fluoride/: Acute: respiratory irritation, possible nose bleeding or vomiting: Chronic: aggravates bronchitis/ asthma; increased bone density.

/SIGNS AND SYMPTOMS/ Fluorosis. Inhalation of fluoride poses a potential hazard in workers in primary aluminium production, but the majority of workers are clinically unaffected. Clinical fluorosis, which is rare, commences with stiffness in the lower back followed by pain and then limitation of rotation of the trunk. Later, the spine becomes rigid and stiff, with restriction of chest movement and of the large joints, particularly the hip, that is accompanied by osteosclerosis. /Aluminum fluorides/

/SIGNS AND SYMPTOMS/ Variable degrees of bony fluorosis have been seen. The first stage of this condition consists simply of an increase in bone density, particularly marked in the vertebral bodies and pelvis. As fluoride is further absorbed into bone, calcification of the ligaments of the pelvis may be seen ... In the event of extreme and protracted exposure to fluoride, calcification of the paraspinal and other ligamentous structures as well as about joints are noted. /Aluminum fluorides/

For more Human Toxicity Excerpts (Complete) data for ALUMINUM FLUORIDE (12 total), please visit the HSDB record page.

/LABORATORY ANIMALS: Acute Exposure/ /Acute poisoning/ if sufficient fluoride is absorbed ... Fluoride ion increases capillary permeability and also produces a coagulation defect. These actions lead to hemorrhagic gastroenteritis and hemorrhages, congestion, and edema in various organs including the brain. Clinical manifestations include excitability, muscle tremors, weakness, urination, defecation, salivation, emesis, sudden collapse, clonic convulsions, coma, and death due to respiratory and cardiac failure. Cyanosis and early rigor mortis ... /Fluoride/

/LABORATORY ANIMALS: Acute Exposure/ After intraperitoneal administration of a single large dose of fluoride (sodium fluoride, 35 mg/kg body weight), the calcium contents of the renal cortex and medulla of fluoride intoxicated rats were increased by 33 and 10 times, respectively. /Sodium Fluoride/

/LABORATORY ANIMALS: Acute Exposure/ The ionic fluoride levels in plasma following intraperitoneal administration of 15, 20, or 25 mg of fluoride per kg body weight to 200 g rats /was studied/. In animals given 25 mg/kg, the mean ionic fluoride level in plasma was 38 mg/liter after 10 min and the animals invariably died within 1 hr. All animals receiving 15 or 20 mg/kg survived, despite mean ionic fluoride levels in plasma of 22.9 and 29.2 mg/l, respectively. /Sodium Fluoride/

/LABORATORY ANIMALS: Acute Exposure/ The acute and subacute physiological and pathological effects of fluoride (as sodium fluoride) administered intravenously and orally to male and female dogs /were described/. When fluoride was infused intravenously in four dogs at the rate of 5.4 mg Fluoride/min, the mean acute lethal dose was 36.0 + or - 0.5 mg Fluoride/kg with death occurring after 59 to 64 minutes of infusion. The principal effects observed were a progressive decline in blood pressure, heart rate, central nervous system activity (pupil size, response to light, tendon reflexes) with vomiting and defecation. /Sodium Fluoride/

For more Non-Human Toxicity Excerpts (Complete) data for ALUMINUM FLUORIDE (14 total), please visit the HSDB record page.

Populations that appear to be at increased risk from the effects of fluoride are individuals that suffer from diabetes insipidus or some forms of renal impairment. /Fluoride/

LC50 Chlorella vulgaris (Green algae) 100 uM/3 days; static /technical product/

LC50 Chlorella vulgaris (Green algae) 180 uM/15 days; static /technical product/

Chronic fluorosis generally develops after prolonged (10-20 years) exposure to industrial dusts, insecticides, or water where fluorides exceed 3 to 4 ppm. This is especially true in workers involved in the production of aluminum, steel, or glass. /Aluminum fluorides/

Production of aluminum sulfate and aluminum fluoride is associated with exposure to several irritant substances. Such production has been connected with reversible bronchial obstruction or asthma. In an aluminum plant in Sweden, 6 cases of asthma occurred in 1975, and 7 in 1976. The number of exposed workers was 35-40. The levels of aluminum fluoride (personal sampling) were measured during these two years, and the mean concentrations were 3-6 mg/cu m. In 1977, improvements were made at this plant thereby reducing the mean levels of aluminum fluoride to 0.4-1.0 mg/cu m. During the years 1978-1980, only two cases of asthma occurred. /Aluminum fluorides/

Electrolytic production of aluminum can lead to a substantial exposure to fluorides and carcinogenic tar oils, including polyaromatic hydrocarbons. /Aluminum fluorides/

Primary aluminum production plants are located in about 40 countries. The two main methods used for aluminum production are Soderberg and prebake, which encompass a number of processes and job categories. Substantial exposures to airborne polynuclear aromatic compounds have been measured in certain occupational settings in this industry. Exposures have been higher in potrooms of plants using the Soderberg process than in those using the prebake process; some workers may have exposed to both process. Exposures to fluorides and a variety of other contaminants also occur in potrooms. /Aluminum fluorides/

LC50 Chlorella vulgaris (Green algae) 100 uM/3 days; static /technical product/

LC50 Chlorella vulgaris (Green algae) 180 uM/15 days; static /technical product/

Chronic fluorosis generally develops after prolonged (10-20 years) exposure to industrial dusts, insecticides, or water where fluorides exceed 3 to 4 ppm. This is especially true in workers involved in the production of aluminum, steel, or glass. /Aluminum fluorides/

Production of aluminum sulfate and aluminum fluoride is associated with exposure to several irritant substances. Such production has been connected with reversible bronchial obstruction or asthma. In an aluminum plant in Sweden, 6 cases of asthma occurred in 1975, and 7 in 1976. The number of exposed workers was 35-40. The levels of aluminum fluoride (personal sampling) were measured during these two years, and the mean concentrations were 3-6 mg/cu m. In 1977, improvements were made at this plant thereby reducing the mean levels of aluminum fluoride to 0.4-1.0 mg/cu m. During the years 1978-1980, only two cases of asthma occurred. /Aluminum fluorides/

Electrolytic production of aluminum can lead to a substantial exposure to fluorides and carcinogenic tar oils, including polyaromatic hydrocarbons. /Aluminum fluorides/

Primary aluminum production plants are located in about 40 countries. The two main methods used for aluminum production are Soderberg and prebake, which encompass a number of processes and job categories. Substantial exposures to airborne polynuclear aromatic compounds have been measured in certain occupational settings in this industry. Exposures have been higher in potrooms of plants using the Soderberg process than in those using the prebake process; some workers may have exposed to both process. Exposures to fluorides and a variety of other contaminants also occur in potrooms. /Aluminum fluorides/

Aluminum compounds are treated under anhydrous conditions to prevent violent reactions, recover solvent, and form Al compounds suitable for landfill by reaction with anhydrous hydrolysis agent, eg calcium hydroxide. /Aluminum compounds/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./