arsenictriiodide

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

H331 (100%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H400 (90.9%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 44 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:

Refer to the "General First Aid" section. Specific First Aid: Removal of solidified molten material from skin requires medical assistance. (ERG, 2024)

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:

SMALL FIRE: Dry chemical, CO2 or water spray.

LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Avoid aiming straight or solid streams directly onto the product.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. Do not use water on arsenic triiodide. If large quantities of combustibles are involved, use water in flooding quantities as spray and fog. Use water spray to knock down vapors.

Wear positive pressure self-contained breathing apparatus when fighting fires involving this material.

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, liquid, NOS/

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, solid, NOS/

Personnel protection: ... Wear positive pressure self-contained breathing apparatus when fighting fires involving this material. /Arsenical cmpd, solid, NOS/

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Prompt cleanup and removal are necessary. Control runoff and isolate discharged material for proper disposal.

Floors and other accessible surfaces contaminated with inorganic arsenic may not be cleaned by the use of compressed air, and shoveling and brushing may be used only where vacuuming or other relevant methods have been tried and found not to be effective. /Inorganic arsenic compounds/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Chemical Treatability of Arsenic; Concentration Process: Chemical Precipitation; Chemical Classification: Metal; Scale of Study: Pilot Scale; Type of Wastewater Used: Domestic Wastewater + Pure Compound; Results of Study: 5ppm @ 4gpm @ pH= 7.0. Iron system-90% reduction; low lime system-80% reduction; high lime system-76% reduction; (3 coagulant systems were used; Iron system used 45 ppm as Fe of Fe2(SO4)3 @ pH= 6.0. Low lime system used 20 ppm Fe of Fe2(SO4)3 and 260 ppm of CaO @ pH= 10.0. High lime system used 600 ppm of CaO @ pH= 11.5. Chemical coagulation was followed by multimedia filtration). /Arsenic cmpd/

Chemical Treatability of Arsenic; Concentration Process: Chemical Precipitation; Chemical Classification: Metal; Scale of Study: Full Scale Continuous Flow; Type of Wastewater Used: Domestic Wastewater; Results of Study: Effluent character (ppb): 2.5, 56% reduction with lime; 3.3, 24% reduction with lime; (lime dose of 350-400 ppm as calcium oxide @ pH= 11.3). /Arsenic cmpd/

If material not involved in fire: Use water spray to knock down vapors. Do not use water on material itself. Neutralize spilled material with crushed limestone, soda ash, or lime. Avoid breathing dusts, and fumes from burning material. Keep upwind. Do not handle broken packages without protective equipment.

Avoid bodily contact with the material. Wash away any material which may have contacted the body with copious amounts of water or soap and water.

WELL VENTILATED & ALL POISONOUS FUME ... CONDENSED & DUST CONTENT REMOVED. ... EXHAUST HOODS ... WORKTABLES ... EQUIPPED WITH DOWN-DRAUGHT ... VENTILATION. /ARSENIC CMPD/

IN ... /FACTORIES/ WITH ARSENIC HAZARD, FLOORS ... SHOULD BE ... IMPERMEABLE ... TO PREVENT ABSORPTION & ... FLUSHED DOWN FREQUENTLY WITH WATER. /ARSENIC CMPD/

For more Preventive Measures (Complete) data for ARSENIC TRIIODIDE (19 total), please visit the HSDB record page.

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024)

Store in airtight containers. Protect from light.

Protect container against physical damage. Store in well ventilated area away from food or food products and combustible materials. /Inorganic arsenic cmpd/

Biological Exposure Indices (BEI) [ACGIH] - Inorganic arsenic plus methylated metabolites in urine = 35 ug As/L; end of workweek;

0.01 [mg/m3], as As

5 mg As/m3 ; A potential occupational carcinogen. (NIOSH, 2024)

5.0 [mg/m3], as As

5 mg/cu m (as AS); NIOSH considers arsenic (inorganic cmpd, as As) to be a potential occupational carcinogen. /Arsenic (inorganic cmpd, as As)/

0.01 [mg/m3], as As (0.01 ppm, inhalable fraction and vapor (iodides))

8 hr Time weighted Avg (TWA) 0.01 mg/cu m /Arsenic and inorganic compounds, as As/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /Arsenic and inorganic compounds, as As/

A1: Confirmed human carcinogen. /Arsenic and inorganic compounds, as As/

BEI (Biological Exposure Index): Determinant: Inorganic arsenic plus methylated metabolites in urine; Sampling Time: end of workweek; BEI: 35 ug As/L. The determinant may be present in biological specimens collected from subjects who have not been occupationally exposed, at a concentration which could affect interpretation of the result. Such background concentrations are incorporated in the BEI value. /Arsenic, elemental and soluble inorganic compounds/

Acute Oral: 0.005 mg/kg/day (L134)

Chronic Oral: 0.0003 mg/kg/day (L134)

Chronic Inhalation: 0.01 mg/m3 (L134)

... The following countries had adopted the ... TLV of 0.5 mg/cu m: Austria, Belgium, Finland, Japan, and Holland. Czechoslavakia, East Germany, Hungary and Poland ... USSR ... 0.3 mg/cu m; Romania and Switzerland, 0.2 mg/cu m; Sweden 0.05 mg/cu m; and Italy 0.25 mg/cu m. /Arsenic and sol cmpd/

Tolerances for total residues of combined arsenic (calculated as As) in food are established as follows: (a) In edible tissues & in eggs of chickens & turkeys: 0.5 ppm in uncooked muscle tissue; 2 ppm in uncooked edible by-products; & 0.5 ppm in eggs. (b) In edible tissues of swine: 2 ppm in uncooked liver & kidney; 0.5 ppm in uncooked muscle tissue & by-products other than liver & kidney. /Arsenic/

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:

Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)

Workers should be supplied with suitable protective clothing, protective boots and when there is a risk that the exposure limit for airborne arsenic will be exceeded, respiratory protective equipment. /Arsenic cmpd/

Where there is occupational exposure to inorganic arsenic compounds, protective clothing shall be provided by the employers. This may include underwear, gloves, coveralls, and a hood over the head and neck. /Inorganic arsenic/

Wear appropriate personal protective clothing to prevent skin contact. /Arsenic (inorganic cmpd, as As)/

Wear appropriate eye protection to prevent eye contact. /Arsenic (inorganic cmpd, as As)/

For more Personal Protective Equipment (PPE) (Complete) data for ARSENIC TRIIODIDE (6 total), please visit the HSDB record page.

Arsenic iodide, solid appears as orange-red rhombohedral crystals (from acetone). Density 4.69 g / cm3. Melting point 285.6 °F (140.9 °C). Red as a liquid.

Orange red solid; Oxygen form air slowly liberates iodine; [Merck Index] Red or orange powder; [MSDSonline]

Orange-red, trigonal rhombohedra from acetone; aq soln is yellow

Red hexagonal crystals

140.9 °C

6 g/100 ml water at 25 °C

5.2 g/100 ml carbon disulfide

Freely sol in chloroform, benzene, toluene, xylene; less sol in ether

1 in 42 /parts/ of alc

30 g/100 ml hot water (decomp)

4.688 @ 25 °C/4 °C

REACTS SLOWLY WITH O2 FROM AIR, LIBERATING IODINE

Arsenic iodide is decomposed by water to form arsenic acid & hydriodic acid, a corrosive material.

When heated to decomposition it emits very toxic fumes of /iodide/ & arsenic.

DANGEROUS WHEN HEATED TO DECOMP ... IT EMITS TOXIC FUMES OF ARSENIC /SRP: INCLUDING ARSINE/. /ARSENIC CMPD/

1.1 (aq 0.1 N soln)

INDEX OF REFRACTION: APPROX 2.59, APPROX 2.23

Some tendency to sublime below 100 °C; forms red liq on melting; does not hydrolyze rapidly and may be recovered from water soln unchanged in 5 hr; aq soln form hydrogen iodide (HI) and arsenic trioxide (As203).

dielectric constant

pseudobinary system

crystal structure

fusion temperature

enthalpy

effective mass

isothermal section

Gibbs energy

phase equilibrium

positional coordinate

temperature-composition section

space group

enthalpy change

phase diagram

unit cell parameter

melting temperature

heat capacity

electronic structure

Schoenflies notation

photoemission spectroscopy

excitation energy

fusion entropy

Reacts slowly with oxygen from the air, liberating iodine [Merck]. Water soluble. Aqueous solutions are strongly acidic (pH of 0.1N solution about 1.1) and ultimately form HI and As2O3, although an equilibrium AsI3 + 3H2O = H3AsO3 + 3HI has been observed [Merck 1989].

Acyl Halides, Sulfonyl Halides, and Chloroformates

Halogenating Agents

Water-Reactive

Air-Reactive

ARSENIC IODIDE gives acidic solutions in water. These solutions neutralize bases exothermically. Can react as either an oxidizing agent or reducing agent.

Can form a shock sensitive cmpd with sodium or potassium.

... WHEN WATER SOLN OF ARSENICALS ARE IN CONTACT WITH ACTIVE METALS SUCH AS ARSENIC, IRON, ALUMINUM, ZINC, ... HIGHLY TOXIC FUMES OF ARSENIC /INCLUDING ARSINE ARE RELEASED/. /ARSENIC CMPD/

Strong oxidizers, bromide azide [Note: Hydrogen gas can react with inorganic arsenic to form the highly toxic gas arsine.] /Arsenic (inorganic compounds, as As)/

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

Classification of carcinogenicity: 1) evidence in humans: sufficient; 2) evidence in animals: limited. Overall summary evaluation of carcinogenic risk to humans is Group 1: Carcinogenic to humans. NOTE: This evaluation applies to the group of chemicals as a whole and not necessarily to all individual chemicals within the group. /Arsenic and arsenic compounds/

CLASSIFICATION: A; human carcinogen. BASIS FOR CLASSIFICATION: Based on sufficient evidence from human data. An increased lung cancer mortality was observed in multiple human populations exposed primarily through inhalation. Also, increased mortality from multiple internal organ cancers (liver, kidney, lung, and bladder) and an increased incidence of skin cancer were observed in populations consuming drinking water high in inorganic arsenic. HUMAN CARCINOGENICITY DATA: Sufficient. ANIMAL CARCINOGENICITY DATA: Inadequate. /Inorganic Arsenic/ /based on former classification system/

A1: Confirmed human carcinogen. /Arsenic and inorganic compounds, as As/

Evaluation: There is sufficient evidence in humans that arsenic in drinking-water causes cancers of the urinary bladder, lung and skin ... Overall evaluation: Arsenic in drinking-water is carcinogenic to humans (Group 1). /Arsenic in drinking-water/

Arsenic compounds, inorganic: known to be a human carcinogen.

1, carcinogenic to humans. (L135)

Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20)

Oral (L2) ; inhalation (L2) ; dermal (L2)

Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of

Neurotoxin - Sensorimotor

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Aplastic anemia - The presence of increased methemoglobin in the blood; the compound is classified as primary toxic effect.

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

IARC Carcinogen - Class 1: International Agency for Research on Cancer classifies chemicals as established human carcinogens.

NTP Carcinogen - Known to be a human carcinogen.

ACGIH Carcinogen - Confirmed Human.

WHO= 0.002 mg/kg /Inorganic arsenic cmpd, as As; from table/

Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Chemical Treatability of Arsenic; Concentration Process: Chemical Precipitation; Chemical Classification: Metal; Scale of Study: Pilot Scale; Type of Wastewater Used: Domestic Wastewater + Pure Compound; Results of Study: 5ppm @ 4gpm @ pH= 7.0. Iron system-90% reduction; low lime system-80% reduction; high lime system-76% reduction; (3 coagulant systems were used; Iron system used 45 ppm as Fe of Fe2(SO4)3 @ pH= 6.0. Low lime system used 20 ppm Fe of Fe2(SO4)3 and 260 ppm of CaO @ pH= 10.0. High lime system used 600 ppm of CaO @ pH= 11.5. Chemical coagulation was followed by multimedia filtration). /Arsenic cmpd/

Chemical Treatability of Arsenic; Concentration Process: Chemical Precipitation; Chemical Classification: Metal; Scale of Study: Full Scale Continuous Flow; Type of Wastewater Used: Domestic Wastewater; Results of Study: Effluent character (ppb): 2.5, 56% reduction with lime; 3.3, 24% reduction with lime; (lime dose of 350-400 ppm as calcium oxide @ pH= 11.3). /Arsenic cmpd/

/GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Health: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Arsenic compound, solid, NOS (Arsenic(III) iodide)/

/GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. /Arsenic compound, solid, NOS (Arsenic(III) iodide)/

/GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. /Arsenic compound, solid, NOS (Arsenic(III) iodide)/

/GUIDE 152: SUBSTANCES - TOXIC (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Arsenic compound, solid, NOS (Arsenic(III) iodide)/

For more DOT Emergency Guidelines (Complete) data for ARSENIC TRIIODIDE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.