Chlorine trifluoride

H270 (100%): May cause or intensify fire; oxidizer [Danger Oxidizing gases]

H280 (100%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

P220, P244, P260, P264, P271, P273, P280, P284, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P320, P321, P363, P370+P376, P391, P403, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 117 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H270: May cause or intensify fire; oxidizer [Danger Oxidizing gases]

H280: Contains gas under pressure; may explode if heated [Warning Gases under pressure]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H330: Fatal if inhaled [Danger Acute toxicity, inhalation]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P220, P244, P260, P264, P264+P265, P270, P271, P280, P284, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P308+P316, P316, P317, P319, P320, P321, P363, P370+P376, P403, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement)

Fresh air, rest. Half-upright position. Refer for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Excerpt from NIOSH Pocket Guide for Chlorine trifluoride:

Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: WATER FLUSH IMMEDIATELY - If this chemical contacts the skin, immediately flush the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. Get medical attention promptly.

Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.

Swallow: MEDICAL ATTENTION IMMEDIATELY (LIQUID) - If this chemical in liquid form has been swallowed, get medical attention immediately. (NIOSH, 2024)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Clothing frozen to the skin should be thawed before being removed.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Water flush immediately - If this chemical contacts the skin, immediately flush the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. Get medical attention promptly.

Breathing: Respiratory support

Swallow: Medical attention immediately (liquid)

Excerpt from ERG Guide 124 [Gases - Toxic and/or Corrosive - Oxidizing]:

CAUTION: These materials do not burn but will support combustion. Some will react violently with water.

SMALL FIRE: Contain fire and let burn. If fire must be fought, water spray or fog is recommended. Water only; no dry chemical, CO2 or Halon®. Do not get water inside containers. If it can be done safely, move undamaged containers away from the area around the fire. Damaged cylinders should be handled only by specialists.

FIRE INVOLVING TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devices; icing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep cylinder cool by spraying with water. NO direct contact with water. Combat fire from a sheltered position.

Do not use water water. Violent reaction may result. Use appropriate extinguishing agents on nearby combustible fires. Use of dry chemical or carbon dioxide preferred.

If material involved in fire: Do not use water on material itself. Use dry chemical or carbon dioxide. Cool all affected containers with flooding quantities of water. If large quantities of combustibles are involved, use water in flooding quantities as spray and fog. Use water spray to knock-down vapors.

Wear chemical protective suit with self-contained breathing apparatus. Combat fires from safe distance or protected location. Extinguish with dry chemicals or carbon dioxide. DO NOT USE WATER OR FOAM ON ADJACENT FIRES.

This chemical will attack (react with)...fire fighter's ordinary protective clothing. ... Be very careful not to enter spill area or contact the chemical with the body or clothing.

If released from container, can increase the intensity of fire. Containers may explode.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Many gases are heavier than air and will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· Do not touch or walk through spilled material.

· Keep combustibles (wood, paper, oil, etc.) away from spilled material.

· Stop leak if you can do it without risk.

· Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material.

· Do not direct water at spill or source of leak.

· If possible, turn leaking containers so that gas escapes rather than liquid.

· Prevent entry into waterways, sewers, basements or confined areas.

· Isolate area until gas has dispersed.

· Ventilate the area.

Excerpt from ERG Guide 124 [Gases - Toxic and/or Corrosive - Oxidizing]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 1749 datasheet.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 100 meters (330 feet) in all directions.

· See Table 1 - Initial Isolation and Protective Action Distances.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Small spill:

- ISOLATE in all directions: 30 m (100 ft)

Large spill:

- ISOLATE in all directions: 300 m (1000 ft)

- PROTECT people from downwind during DAY time: 0.2 km (0.2 mi)

- PROTECT people from downwind during NIGHT time: 1.1 km (0.7 mi)

- PROTECT people from downwind during DAY time: 1.4 km (0.9 mi)

- PROTECT people from downwind during NIGHT time: 3.7 km (2.3 mi)

Evacuate danger area! Consult an expert! Personal protection: complete protective clothing SPECIFICALLY RECOMMENDED AS EFFECTIVE AGAINST Chlorine trifluoride, including self-contained breathing apparatus. Ventilation. Turn off gas at source if possible. NEVER direct water jet on liquid.

1) Ventilate area of spill or leak. 2) If in gaseous form, stop flow of gas. If source of leak is cylinder & leak cannot be stopped in place, remove...to safe place in open air, & repair leak or allow cylinder to empty. 3) If in liquid form, evacuate persons not wearing protective equipment from spill area. Allow chlorine trifluoride to evaporate while providing all available ventilation.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.

...SUBSTITUTION OF LESS IRRITATING SUBSTANCES...REDESIGN OF OPERATIONS...PREVENT CONTACT, PROVISION OF A PHYSICAL BARRIER AGAINST CONTACT, PROPER WASHING FACILITIES, WORK CLOTHING AND STORAGE FACILITIES, PROTECTIVE CLOTHING, AND BARRIER CREAMS. MEDICAL CONTROL...

Chlorine trifluoride should always be removed from the cylinder as a gas. Cylinders...should never be connected directly to apparatus containing a liquid absorbing medium. A trap should be inserted in the line between the cylinder & the reaction vessel adequate to contain the entire volume of liquid that might be drawn into the chlorine trifluoride line. ... Thorough flushing with an inert gas should precede any opening of apparatus that has contained chlorine trifluoride.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

For more Preventive Measures (Complete) data for CHLORINE TRIFLUORIDE (11 total), please visit the HSDB record page.

Excerpt from ERG Guide 124 [Gases - Toxic and/or Corrosive - Oxidizing]:

Do not touch or walk through spilled material. Keep combustibles (wood, paper, oil, etc.) away from spilled material. Stop leak if you can do it without risk. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Do not direct water at spill or source of leak. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Isolate area until gas has dispersed. Ventilate the area. (ERG, 2024)

Fireproof. Separated from combustible substances, reducing agents and food and feedstuffs. Cool. Dry.

Store in a cool, dry, well-ventilated location. Keep cylinders restrained. Separate from water, organic matter, glass, asbestos, sand, chlorofluorocarbons, acids, alkalies, halogens, slats, metal oxides. Outside or detached storage is preferred.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: ppm)

AEGL 2: Irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape (Unit: ppm)

AEGL 3: Life-threatening health effects or death (Unit: ppm)

AEGLs Status: Final

0.12 [ppm]

2.0 [ppm]

21 [ppm]

0.1 ppm (0.4 mg/m³)

C 0.1 ppm (0.4 mg/m³)

12 ppm (NIOSH, 2024)

20.0 [ppm]

Excerpts from Documentation for IDLHs: Other animal data: No mortality occurred among 2 dogs and rats exposed to 21 ppm for 6 hours but the dogs became nauseated, coughed up a small amount of mucous material, and had rapid respiration and salivation [Horn and Weir 1955]. . . . Human data: It has been reported that 50 ppm or more may be fatal in 30 minutes to 2 hours [Deichmann and Gerarde 1969].

See: 2020-124

0.1 [ppm]

Ceiling Limit: 0.1 ppm.

0.1 ppm as STEL

CAUTION: These materials do not burn but will support combustion. Some will react violently with water.

Small Fire

· Contain fire and let burn. If fire must be fought, water spray or fog is recommended.

· Water only; no dry chemical, CO2 or Halon®.

· Do not get water inside containers.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Damaged cylinders should be handled only by specialists.

Fire Involving Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Do not direct water at source of leak or safety devices; icing may occur.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

ERPG-1: 0.1 ppm - one hour exposure limit: 1 = mild transient health effects or objectionable odor [AIHA]

ERPG-2: 1 ppm - one hour exposure limit: 2 = impaired ability to take protective action [AIHA]

ERPG-3: 10 ppm - one hour exposure limit: 3 = life threatening health effects [AIHA]

Table: AEGLs for CHLORINE TRIFLUORIDE (ppm) [Table#2597]

Emergency Response Planning Guidelines (ERPG): ERPG(1) 0.1 ppm (no more than mild, transient effects) for up to 1 hr exposure; ERPG(2) 1 ppm (without serious, adverse effects) for up to 1 hr exposure; ERPG(3) 10 ppm (not life threatening) up to 1 hr exposure.

A harmful concentration of this gas in the air will be reached very quickly on loss of containment.

Chlorine trifluoride appears as a colorless gas or green liquid with a pungent odor. Boils at 53 °F. It reacts with water to form chlorine and hydrofluoric acid with release of heat. Contact with organic materials may result in spontaneous ignition. It is corrosive to metals and tissue. Prolonged exposure to low concentrations or short term exposure to high concentrations may result in adverse health effects. Under prolonged exposure to fire or intense heat the container may violently rupture and rocket.

Colorless gas or a greenish-yellow liquid (below 53 degrees F) with a somewhat sweet, suffocating odor; Note: Shipped as a liquefied compressed gas; [NIOSH]

NEARLY COLOURLESS COMPRESSED LIQUEFIED GAS WITH CHARACTERISTIC ODOUR.

Colorless gas or a greenish-yellow liquid (below 53 °F) with a somewhat sweet, suffocating odor.

Colorless gas or a greenish-yellow liquid (below 53 °F) with a somewhat sweet, suffocating odor. [Note: Shipped as a liquefied compressed gas.]

COLORLESS GAS; LIQUID IS YELLOW-GREEN IN COLOR; SOLID IS WHITE

Colorless gas or a greenish-yellow liquid (below 53 degrees F) [Note: Shipped as a liquefied compressed gas].

SOMEWHAT SWEET, SUFFOCATING ODOR

Sweet, irritating odor.

Somewhat sweet, suffocating odor.

53 °F at 760 mmHg (USCG, 1999)

11.75 °C

11.75 °C @760 [mm Hg]

-105 °F (USCG, 1999)

-76.34 °C

Reacts with water (NIOSH, 2024)

decomposes in cold and hot water

Solubility in water: reaction

1.85 at 51.8 °F (USCG, 1999) - Denser than water; will sink

1.825 g/mL @ boiling point (liquid)

DENSITY OF GAS 3.14 g/L (AIR= 1.29)

Density of the solid = 2.530 g/cu cm @ 153 deg K

1.85 at 51.8 °F

3.779 @25 °C

1.77 (Liquid at 53 °F)

3.21(relative gas density)

3.21 (NIOSH, 2024) - Heavier than air; will sink (Relative to Air)

More than three times that of air

Relative vapor density (air = 1): 3.18

1.4 atm (NIOSH, 2024)

10 mm Hg at -71.8 °C; 400 mm Hg at -4.9 °C; 760 mm Hg at 11.5 °C

750 [mm Hg] @11.4 °C

.../Unstable/ in moist air...

In the vapor phase, chlorine trifluoride decomposes into a variety of substances, Cl2, ClF, ClOF, CLO2F, ClO2, & HF, depending upon the availability of water; of these chlorine, hydrogen fluoride & chlorine dioxide are probably of greatest toxicologic significance.

Chlorine trifluoride decomposes above 220 °C (428 °F) and may explode container.

0.448 mPa-s @ 290 deg K (liquid)

Corrosive; Attacks quartz if traces of moisture are present

27.50 kJ/mol

26.6 mN/m (=dyn/cm) @ 273 deg K

13.00 eV

A violent reaction occurs with water or ice generating acidic HF and chlorine, [Sidgwick, 1156(1950)]. The release of Chlorine Trifluoride to the atmosphere rapidly generates two toxic reaction products: HF and Chlorine Dioxide, [Lombardi, D.A. and M.D. Cheng 1996. "Modeling Accidental Releases of Chlorine Trifluoride to the Atmosphere," Paper No. 96-WP66B.02, presented at the 89th Annual Meeting of the Air and Waste Management Association, Nashville, Tennessee, June 23-26].

Oxidizing Agents, Strong

Halogenating Agents

Strong Oxidizing Agent

Water-Reactive

CHLORINE TRIFLUORIDE is a low-boiling liquid (b.p. 12 °C) which is irritating and toxic in the gaseous state. A highly reactive oxidant, it is spontaneously flammable and used as a rocket propellant. It is incompatible with fuels and nitro compounds. Interaction with water is violent and may be explosive, even with ice [Sidgwick, 1950, p. 1156]. It undergoes an immediate explosive reaction on contact with hydrocarbons or halocarbons even at -70 °C [Brower, K. R., J. Fluorine Chem., 1986, 31, p. 333]. Solutions with carbon tetrachloride are capable of detonation, while solutions with nitroaryl compounds (TNT, hexanitrobiphenyl) or highly chlorinated compounds are extremely shock-sensitive. Violent, sometimes explosive reaction with hydrogen containing materials, e.g., acetic acid, ammonia, benzene, ether, coal gas, hydrogen, hydrogen sulfide, methane, or fluoroamino compounds. Ignition with fibrous materials (cotton, paper, wood). [Mellor, 1956, vol. 2, suppl. 1, p. 155]. Explosive gaseous products (chlorodifluoroamine) are formed with ammonium fluoride or ammonium hydrogen fluoride [Gardner, D. M. et al., Inorg., Chem., 1963, 2, p. 413]. Ignition occurs on contact with iodine, boron-containing materials (boron powder, tetraboron carbide, boron-aluminum), fibrous or finely divided refractory materials (asbestos, glass, wool, sand, tungsten carbide). Violent reactions occur with mineral acids (nitric acid, sulfuric acid), chromium trioxide, ruthenium metal, selenium tetrafluoride. [Bretherick, 5th ed., 1995, p. 1235]. Chlorine trifluoride is a hypergolic oxidizer and contact with a number of metals and their oxides (aluminum, antimony, arsenic, calcium, copper, iridium, iron, lithium, lead, magnesium, molybdenum, osmium, potassium, rhodium, sodium, selenium, silver, tellurium, tin, tungsten, zinc), nonmetals (phosphorus, silicon, sulfur), salts (mercury iodide, potassium iodide, silver, nitrate, potassium carbonate) will result in a violent reaction often followed by ignition [Mellor, 1956, vol. 2, suppl. 1, p. 155; Sidgwick, 1950, p. 1156].

Incompatibilities: acids; ammonium fluoride; carbon tetrachloride; fluorinated polymers; fuels, hydrogen-containing materials; iodine; metals, or metal oxides, or metal salts or non-metals, or non-metal oxides; nitrocompounds; organic material; polychlorotrifluoroethylene; refractory material; water.

...ON CONTACT WITH ACID OR ACID FUMES EMITS HIGHLY TOXIC FUMES; WILL REACT WITH WATER OR STEAM TO PRODUCE MUCH HEAT AND TOXIC AND CORROSIVE FUMES; REACTS VIGOROUSLY WITH REDUCING MATERIALS.

While chlorine trifluoride was being passed through Kel-F Oil (chlorotrifluoroethylene polymer) for disposal the inadvertent introduction of moisture set up the exothermic water-plus-chlorine trifluoride reaction. Heat evolved initiated a violent reacton with Kel-F Oil. Chlorine trifluoride & chromic anhydride react violently with evolution of brown fumes. /It/ produces a violent reaction without flame in presence of arsenic trioxide, bismuth trioxide, lanthanum oxide, phosphorus pentoxide or stannic oxide. Combination of chlorine trifluoride & fuming nitric acid, potassium carbonate, potassium iodide, silver nitrate, 10% sodium hydroxide or sulfuric acid results in a violent reaction. Chlorine trifluoride is compatible with other oxidizers such as OF2 & ClO3F, but reacts violently with organics.

When...in contact with rubber a violent reaction occurs.

For more Hazardous Reactivities and Incompatibilities (Complete) data for CHLORINE TRIFLUORIDE (12 total), please visit the HSDB record page.

Oxidizers, water, acids, combustible materials, sand, glass, metals (corrosive) [Note: Reacts with water to form chlorine & hydrofluoric acid.]

The substance can be absorbed into the body by inhalation.

inhalation, ingestion (liquid), skin and/or eye contact

Burning sensation. Cough. Sore throat. Laboured breathing. Shortness of breath.

Redness. Serious skin burns. Pain. Blisters.

Redness. Pain. Severe deep burns. Loss of vision.

Eye, skin burns (liquid or high vapor concentration); resp irritation; In Animals: lacrimation (discharge of tears), corneal ulcer; pulmonary edema

Skin, eyes, respiratory system

Dermatotoxin - Skin burns.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

LC50 (rat) = 299 ppm/1H

LC50 Mouse inhalation 178 ppm/1 hr

Fluoride is protoplasmic poison that binds with calcium, inhibits enzyme systems, and activates glycolic and proteolytic mechanisms. Management consists of symptomatic and supportive care, plus the administration of calcium and the treatment of hyperkalemia. Hemodialysis may be useful in severe cases. Prognosis is largely dictated by the clinical course over the first several hours. Survival beyond 4 hours is generally associated with a favorable outcome. /Fluoride/

/Protect/ from exposure those individuals with pulmonary diseases.

The following medical procedures should be made available to each employee who is exposed to chlorine trifluoride at potentially hazardous levels: 1. ... A complete history and physical examination: The purpose is to detect pre-existing conditions that might place the exposed employee at increased risk, and to establish a baseline for future health monitoring. Examination of the respiratory system should be stressed. The skin and eyes should be examined for evidence of chronic disorders; 14" X 17" chest roentgenogram ... ; FVC and FEV (1 sec). ... 2. ... The aforementioned medical examinations should be repeated on an annual basis, except that an x-ray is necessary only when indicated by the results of pulmonary function testing, or when signs and symptoms of respiratory disease occur.

Liquid chlorine trifluoride causes deep penetrating burns on contact with body. The effect may be delayed & progressive, as in the case of burns by hydrogen fluoride.

INHALATION EXPOSURE OF RATS AT 800 PPM ... FOR 15 MIN WAS UNIFORMLY LETHAL; HOWEVER, REDUCING EXPOSURE TIME TO 13 MIN PERMITTED SURVIVAL IN MOST TESTS. EXPOSURE AT 400 PPM FOR 35 MIN WAS ALSO UNIFORMLY LETHAL. CHLORINE TRIFLUORIDE EXPOSURES RESULTED IN INFLAMMATION OF MUCOSAL SURFACES, BURNING OF THE SKIN, AND CORNEAL ULCERATION. LUNG DAMAGE WAS ESTABLISHED FROM A DECREASED RELEASE OF CARBON DIOXIDE FROM THE LUNG FOLLOWING ADMIN OF BICARBONATE & FROM LOWERED BLOOD PH. THE ACUTE TOXICITY OF CHLORINE TRIFLUORIDE WAS CONSIDERED TO BE COMPARABLE TO THAT OF HYDROGEN FLUORIDE ON A FLUORINE-EQUIVALENT BASIS. OF THE MAJOR DECOMPOSITION PRODUCTS OF TOXICOLOGIC INTEREST, CHLORINE DIOXIDE HAD BEEN FOUND PREVIOUSLY TO BE THE MOST TOXIC; ITS ACUTE TOXICITY WAS CONSIDERED TO BE COMPARABLE TO THAT OF CHLORINE TRIFLUORIDE ON A CHLORINE EQUIVALENT BASIS.

... TWO DOGS & 20 RATS /WERE EXPOSED/ AT AN AVG CONCN OF 1.17 PPM ... FOR ... 6 MO ON A 6 HR/DAY, 5 DAY/WK BASIS. AN ADDNL 2 DOGS & 20 RATS SERVED AS CONTROLS. EARLY SIGNS OF TOXICITY IN THE DOGS WERE COUGHING, SNEEZING, RHINORRHEA, SALIVATION, PANTING RESPIRATION, AND OCCASIONAL EXPULSION OF FROTHY FLUID FROM THE MOUTH & NOSE. AFTER ABOUT 2 MO, BOTH DOGS HAD RECURRENT BOUTS OF PNEUMONIA. ONE DOG DIED ON THE 115TH DAY. SIGNS WERE NOT AS PRONOUNCED IN THE RATS; HOWEVER, AFTER SEVERAL WK, A BLOOD-TINGED DISCHARGE APPEARED ABOUT THE NARES AND EYES. SIX RATS DIED DURING THE COURSE OF THE EXPT. PATHOLOGIC FINDINGS WERE SEVERE PULMONARY IRRITATION IN BOTH SPECIES AMONG THE SURVIVORS AS WELL AS AMONG THE ANIMALS THAT DIED COMPARED WITH UNREMARKABLE PATHOLOGY IN THE CONTROLS.

Chlorine trifluoride is an extremely reactive, corrosive and irritating gas which experimentally has been observed to cause a severe reaction in the lungs and in all exposed mucous membranes. It it highly irritating to the skin and eyes, and has caused severe corneal ulcers in dogs.

Persons with impaired pulmonary function may be at increased risk from exposure.

The hazard of exposure to chlorine trifluoride in atmosphere is at least as great as that of chlorine.

The hazard of exposure to chlorine trifluoride in atmosphere is at least as great as that of chlorine.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

If ... THERE IS NO FIRE, go directly to the Table of Initial Isolation and Protective Action Distances /(see table below)/ ... to obtain initial isolation and protective action distances. IF THERE IS A FIRE, or IF A FIRE IS INVOLVED, go directly to the appropriate guide /(see guide(s) below)/ and use the evacuation information shown under PUBLIC SAFETY.

Table: Table of Initial Isolation and Protective Action Distances for Chlorine trifluoride [Table#2596]

/GUIDE 124: GASES - TOXIC and/or CORROSIVE - OXIDIZING/ Fire or Explosion: Substance does not burn but will support combustion. Vapors from liquefied gas are initially heavier than air and spread along ground. These are strong oxidizers and will react vigorously or explosively with many materials including fuels. May ignite combustibles (wood, paper, oil, clothing, etc.). Some will react violently with air, moist air and/or water. Cylinders exposed to fire may vent and release toxic and/or corrosive gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket.

/GUIDE 124: GASES - TOXIC and/or CORROSIVE - OXIDIZING/ Health: TOXIC; may be fatal if inhaled or absorbed through skin. Fire will produce irritating, corrosive and/or toxic gases. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Runoff from fire control may cause pollution.

/GUIDE 124: GASES - TOXIC and/or CORROSIVE - OXIDIZING/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Many gases are heavier than air and will spread along ground and collect in low or confined areas (sewers, basements, tanks). Keep out of low areas. Ventilate closed spaces before entering.

For more DOT Emergency Guidelines (Complete) data for CHLORINE TRIFLUORIDE (9 total), please visit the HSDB record page.

UN 1749; CHLORINE TRIFLUORIDE

IMO 2.3; Chlorine trifluoride

49 205 29; Chlorine trifluoride

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Poison Gas Oxidizer Corrosive

Do not transport with food and feedstuffs and combustible materials.

UN Hazard Class: 2.3; UN Subsidiary Risks: 5.1 and 8