Cyclohexanone peroxide

H240: Heating may cause an explosion [Danger Self-reactive substances and mixtures; Organic peroxides]

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P210, P234, P235, P240, P260, P264, P270, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P363, P370+P372+P380+P373, P403, P405, P410, P411, P420, and P501 (click each P-code to see the statement)

H242: Heating may cause a fire [Danger Self-reactive substances and mixtures; Organic peroxides]

P210, P234, P235, P240, P260, P264, P270, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P363, P370+P378, P403, P405, P410, P411, P420, and P501 (click each P-code to see the statement)

H240 (70.9%): Heating may cause an explosion [Danger Self-reactive substances and mixtures; Organic peroxides]

H242 (38%): Heating may cause a fire [Danger Self-reactive substances and mixtures; Organic peroxides]

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318 (76%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H335 (76.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H361d (11.2%): Suspected of damaging the unborn child [Warning Reproductive toxicity]

H412 (76%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P203, P210, P234, P235, P240, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P330, P363, P370+P372+P380+P373, P370+P378, P403, P403+P233, P405, P410, P411, P420, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 179 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H240 (70.4%): Heating may cause an explosion [Danger Self-reactive substances and mixtures; Organic peroxides]

Aggregated GHS information provided per 54 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]:

Refer to the "General First Aid" section. Specific First Aid: Contaminated clothing may be a fire risk when dry. (ERG, 2024)

EYES: flush with water for at least 15 min.; get medical attention.

SKIN: wipe off and wash with soap and water; get medical attention if irritation occurs.

INGESTION: induce vomiting; get medical attention. (USCG, 1999)

Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]:

SMALL FIRE: Water spray or fog is preferred; if water not available use dry chemical, CO2 or regular foam.

LARGE FIRE: Flood fire area with water from a distance. Use water spray or fog; avoid aiming straight or solid streams directly onto the product. Do not move cargo or vehicle if cargo has been exposed to heat. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Fire Extinguishing Agents: Water, foam, dry chemical, carbon dioxide (USCG, 1999)

In case of fire, water should be applied by the sprinkler system or by hose from a safe distance, preferably with a fog nozzle. Foam may be necessary instead if the peroxide is diluted in a low density flammable solvent. Portable extinguishers should not be used except for very small fires. Peroxides threatened by fire should be wetted from a safe distance for cooling. /Peroxides, Organic and Inorganic/

Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

LARGE SPILL: Consider initial evacuation for at least 250 meters (800 feet) in all directions.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Excerpt from ERG Guide 146 [Organic Peroxides (Heat, Contamination and Friction Sensitive)]:

Spills should be cleaned up promptly using non-sparking tools and an inert, moist diluent such as vermiculite or sand. Sweepings may be placed in open containers or polyethylene bags and the area washed with water and detergent. Spilled, contaminated, waste or questionable peroxides should be destroyed. /Peroxides, Organic and Inorganic/

Most peroxides can be hydrolyzed by adding them slowly with stirring to about ten times their weight of cold 10% sodium hydroxide solution. The reaction may require several hours. /Peroxides, Organic and Inorganic/

Dilute and drain into the sewer with abundant water. /Hydrogen peroxide/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Keep combustibles (wood, paper, oil, etc.) away from spilled material. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Keep substance wet using water spray. Stop leak if you can do it without risk.

SMALL SPILL: Pick up with inert, damp, non-combustible material using clean, non-sparking tools and place into loosely covered plastic containers for later disposal.

LARGE SPILL: Wet down with water and dike for later disposal. Prevent entry into waterways, sewers, basements or confined areas. DO NOT CLEAN-UP OR DISPOSE OF, EXCEPT UNDER SUPERVISION OF A SPECIALIST. (ERG, 2024)

Excerpt from ERG Guide 146 [Organic Peroxides (Heat, Contamination and Friction Sensitive)]:

...SHOULD BE STORED IN COOL, VENTILATED, ISOLATED AREA AWAY FROM ORG OR OTHER EASILY OXIDIZABLE MATERIALS &...ACUTE FIRE HAZARDS. CONTAINERS SHOULD BE KEPT CLOSED & CLEARLY LABELED. /PEROXIDES, ORG/

BECAUSE OF THEIR INSTABILITY, MANY PEROXIDES ARE STORED & HANDLED IN AN INERT VEHICLE SUCH AS DIMETHYLPHTHALATE. ... STORAGE TEMP SHOULD NOT EXCEED 30 °C. /PEROXIDES, ORG/

Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]:

Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)

Goggles or face shield; rubber gloves; protective clothing. (USCG, 1999)

...STRONGLY RECOMMENDED THAT WORKMEN WEAR SAFETY GOGGLES, AN APRON, & RUBBER BOOTS. /ORG PEROXIDES/

RECOMMENDED...RESPIRATOR TO AVOID INHALATION OF EXTENSIVE AMT...IN VAPOR FORM... /ORG PEROXIDES/

Persons handling peroxides should use safety glasses with side shields, goggles or face shield for eye protection. Emergency eyewash facilities should be provided. Gloves, aprons and other protective clothing as necessary should be used to prevent skin contact. Clothing and equipment that generate static electricity should be avoided. Smoking should be prohibited. /Peroxides, Organic and Inorganic/

Cyclohexanone peroxide, not more than 72% in solution is a white solid dissolved in some unkown organic solvent. Responders should try to identify the solvent being used. Solvent is added to lessen explosion hazard.

1-hydroxy-1'-hydroperoxy dicyclohexyl peroxide is an odorless thick white liquid. Sinks in water. (USCG, 1999)

Odorless thick white liquid or paste; [CAMEO] Moist white solid; [MSDSonline]

Grayish paste

76-77 °C

315 °F Combustible solution) (dibutyl phthalate) (USCG, 1999)

OFF-WHITE THICK PASTE; INSOL IN WATER; SOL IN COMMON ORG SOLVENTS /PASTE WITH DIBUTYL PHTHALATE/

Insoluble in water; soluble in most organic solvents

1.05 at 68 °F (USCG, 1999) - Denser than water; will sink

0.00000071 [mmHg]

757 °F (USCG, 1999)

Other Classes -> Peroxides, Organic

Combines with water to form grayish paste. Insoluble in water.

No rapid reaction with air. No rapid reaction with water.

Alcohols and Polyols

Peroxides, Organic

Acetals, Ketals, Hemiacetals, and Hemiketals

Explosive

Strong Oxidizing Agent

Peroxides, such as CYCLOHEXANONE PEROXIDE, are good oxidizing agents. Organic compounds can ignite on contact with concentrated peroxides. Strongly reduced material such as sulfides, nitrides, and hydrides may react explosively with peroxides. There are few chemical classes that do not at least produce heat when mixed with peroxides. Many produce explosions or generate gases (toxic and nontoxic). Generally, dilute solutions of peroxides (<70%) are safe, but the presence of a catalyst (often a transition metal such as cobalt, iron, manganese, nickel, or vanadium) as an impurity may even then cause rapid decomposition, a buildup of heat, and even an explosion. Solutions of peroxides often become explosive when evaporated to dryness or near-dryness. Danger of explosion when dry. May ignite combustibles (wood, paper, oil, clothing, etc.). May be ignited by heat, sparks or flames. May burn rapidly with flare-burning effect. Containers may explode when heated.

Peroxides, such as 1-HYDROXY-1'-HYDROPEROXY DICYCLOHEXYL PEROXIDE, are good oxidizing agents. Organic compounds can ignite on contact with concentrated peroxides. Strongly reduced material such as sulfides, nitrides, and hydrides may react explosively with peroxides. There are few chemical classes that do not at least produce heat when mixed with peroxides. Many produce explosions or generate gases (toxic and nontoxic). Generally, dilute solutions of peroxides (<70%) are safe, but the presence of a catalyst (often a transition metal such as cobalt, iron, manganese, nickel, or vanadium) as an impurity may even then cause rapid decomposition, a buildup of heat, and even an explosion. Solutions of peroxides often become explosive when evaporated to dryness or near-dryness. May explode from heat or contamination. May ignite combustibles (wood, paper, oil, clothing, etc.). May be ignited by heat, sparks or flames. May burn rapidly with flare-burning effect. Behavior in Fire: May explode (USCG, 1999).

Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

Dermatotoxin - Skin burns.

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

PROMPT WASHING OF AFFECTED AREAS IS ESSENTIAL. /PEROXIDES, ORG/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool .... . Do not attempt to neutralize because of exothermic reaction. Cover skin burns with dry, sterile dressings after decontamination ... . /Organic peroxides/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Early intubation, at the first sign of upper airway obstruction, may be necessary. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic peroxides/

Peroxides should be washed promptly from the skin to prevent irritation. In the case of eye contact, the eyes should be flushed immediately with large amounts of water, and medical attention should be obtained. ... Medical attention should also be obtained in case of accidental ingestion. ... /Peroxides, Organic and Inorganic/

...AN ALLERGEN RESPONSIBLE FOR SKIN SENSITIZATION IN MAN.

INDUSTRIALLY IT HAS CAUSED OCULAR IRRITATION...

PROLONGED INHALATION OF VAPORS RESULTS IN HEADACHE & THROAT IRRITATION... PROLONGED SKIN CONTACT WITH CLOTHING CONTAMINATED WITH PEROXIDES MAY CAUSE IRRITATION & BLISTERING. /ORG PEROXIDES/

In the workplace the peroxide has caused eye irritation and skin sensitization. Prolonged inhalation of vapors result in headache and throat irritation. Prolonged skin contact with clothing contaminated with peroxides may cause irritation and blistering.

The main toxic effect of most peroxides is irritation of skin, mucous membranes and eyes. Prolonged or intense skin contact or splashes in the eyes may cause severe injury. ... /Peroxides, Organic and Inorganic/

MIGHT BE EXPECTED TO HAVE CORROSIVE ACTION ON SKIN & MUCOUS MEMBRANE.

...TESTS ON RABBIT EYES BY APPLICATION OF 40-50% SOLN IN CYCLOHEXANONE OR IN DIMETHYL PHTHALATE...CAUSE MODERATELY SEVERE CORNEAL INJURY WITH SUPERFICIAL OPACITY & ASSOCIATED CONJUNCTIVAL INFLAMMATION.

CYCLOHEXANONE PEROXIDE TREATMENT OF MALE RATS INCR INCIDENCE OF EMBRYONIC DEATH & DECR AVG WT OF 1ST GENERATION OFFSPRING, BUT DID NOT AFFECT % OF FEMALES IMPREGNATED OR NUMBER OF EMBRYOS/FEMALE.

CYCLOHEXANONE PEROXIDE ADMIN TO RATS ORALLY @ 10% LD50 (0.072 G/KG) DAILY FOR 30 DAYS DECR MOBILITY PERIOD OF SPERMATOZOIDS, PRODUCED VIBRATIONAL MOVEMENT & SOME 2-TAILED SPERMATOZOIDS.

For more Non-Human Toxicity Excerpts (Complete) data for CYCLOHEXANONE PEROXIDE (7 total), please visit the HSDB record page.

Individuals with eye, skin, and chronic respiratory diseases /may be/ at an increased risk. /Hydrogen peroxide/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

/GUIDE 145: ORGANIC PEROXIDES (HEAT AND CONTAMINATION SENSITIVE)/ Fire or Explosion: May explode from heat or contamination. May ignite combustibles (wood, paper, oil, clothing, etc.). May be ignited by heat, sparks or flames. May burn rapidly with flare-burning effect. Containers may explode when heated. Runoff may create fire or explosion hazard. /Organic peroxide type D, liquid; Organic peroxide type D, solid/

/GUIDE 145: ORGANIC PEROXIDES (HEAT AND CONTAMINATION SENSITIVE)/ Health: Fire may produce irritating, corrosive and/or toxic gases. Ingestion or contact (skin, eyes) with substance may cause severe injury or burns. Runoff from fire control or dilution water may cause pollution. /Organic peroxide type D, liquid; Organic peroxide type D, solid/

/GUIDE 145: ORGANIC PEROXIDES (HEAT AND CONTAMINATION SENSITIVE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. /Organic peroxide type D, liquid; Organic peroxide type D, solid/

/GUIDE 145: ORGANIC PEROXIDES (HEAT AND CONTAMINATION SENSITIVE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing will only provide limited protection. /Organic peroxide type D, liquid; Organic peroxide type D, solid/

For more DOT Emergency Guidelines (Complete) data for CYCLOHEXANONE PEROXIDE (16 total), please visit the HSDB record page.

UN 3103; Organic peroxide type C, liquid.

UN 3104; Organic peroxide type C, solid.

UN 3105; Organic peroxide type D, liquid.

UN 3106; Organic peroxide type D, solid.

For more Shipping Name/ Number DOT/UN/NA/IMO (Complete) data for CYCLOHEXANONE PEROXIDE (9 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Organic Peroxide