Tris(2-ethylhexyl) phosphate

This chemical does not meet GHS hazard criteria for 52.7% (260 of 493) of all reports.

H315 (42%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (36.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)

Aggregated GHS information provided per 493 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 260 of 493 reports by companies.

There are 6 notifications provided by 233 of 493 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P264, P273, P280, P302+P352, P321, P332+P317, P362+P364, P391, and P501 (click each P-code to see the statement)

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Fresh air, rest. Refer for medical attention.

Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give one or two glasses of water to drink. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)

Use water spray, powder, foam, carbon dioxide.

Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should store this chemical under ambient temperatures and keep it away from oxidizing materials. (NTP, 1992)

Separated from strong oxidants. Well closed. Keep in a well-ventilated room.

110 [mg/m3]

1200 [mg/m3]

7300 [mg/m3]

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is irritating to the eyes and skin.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

NO open flames.

PREVENT GENERATION OF MISTS!

Use ventilation.

Protective gloves.

Wear safety goggles.

Do not eat, drink, or smoke during work.

Tris(2-ethylhexyl)phosphate is a clear colorless to pale yellow liquid with a slight sharp odor. (NTP, 1992)

Other Solid; Liquid

COLOURLESS VISCOUS LIQUID.

374 to 451 °F at 760 mmHg (decomposes) (NTP, 1992)

at 0.7kPa: 220 °C

226.9 °C @760 [mm Hg]

-94 °F (NTP, 1992)

305 °F (NTP, 1992)

less than 1 mg/mL at 64 °F (NTP, 1992)

Solubility in water at 20 °C: none

0.9262 at 68 °F (NTP, 1992) - Less dense than water; will float

Relative density (water = 1): 0.93

0.9077 @25 °C

14.95 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

Relative vapor density (air = 1): 15

1.9 mmHg at 392 °F (NTP, 1992)

Vapor pressure, Pa at 20 °C:

0.03 [mm Hg] @20 °C

698 °F (NTP, 1992)

231.9 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID0021414]

221.61 Ų [M+H]+ [CCS Type: TW; Buffer gas: N2; Ionization: GC-APCI+]

231.8 Ų [M+Na]+

315.91 Ų [2M+H]+

327.65 Ų [2M+Na]+

219.15 Ų [M+H]+

Organophosphate

Flame Retardants -> Organophosphorus flame retardant (OP)

FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

Insoluble in water.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

TRIS(2-ETHYLHEXYL)PHOSPHATE is incompatible with oxidizing materials. It may soften or deteriorate certain plastics and elastomers. It is incompatible with cellulose acetate and cellulose acetate butyrate. (NTP, 1992)

Tris(2-ethylhexyl) phosphate

TR-274: Toxicology and Carcinogenesis Studies of Tris(2-ethylhexyl)phosphate (CASRN 78-42-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1984 )

10/28/83

Equivocal Evidence

No Evidence

Some Evidence

Under the conditions of these studies, a comparison of concurrent and historical controls indicated that there was equivocal evidence of carcinogenicity in male F344/N rats receiving 2,000 and 4,000 mg/kg tris(2-ethylhexyl)phosphate, as evidenced by increased incidences of pheochromocytomas of the adrenal glands. There was no evidence of carcinogenicity in female F344/N rats or in male B6C3F1 mice receiving tris(2-ethylhexyl)phosphate. There was some evidence of carcinogenicity in female B6C3F1 mice that received 1,000 mg/kg tris(2-ethylhexyl)phosphate, as shown by an increased incidence of hepatocellular carcinoma. Tris(2-ethylhexyl)phosphate was associated with increased incidences of follicular cell hyperplasia of the thyroid gland in male and female B6C3F1 mice.

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Redness. Pain.

Tris(2-ethylhexyl)phosphate

1 x 10^-1 mg/kg-day

PDF Document

Suggestive evidence of carcinogenic potential

PPRTV Current

1.70e+02

7.20e+02

2.40e+01

5.00e+01

1.20e+02

3.20e-03

1.00e-01

Volatile

1.70e+04

7.20e+04

2.40e+03

Avoid release to the environment in circumstances different to normal use.

1.70e+02

7.20e+02

2.40e+01

5.00e+01

1.20e+02

3.20e-03

1.00e-01

Volatile

1.70e+04

7.20e+04

2.40e+03

Avoid release to the environment in circumstances different to normal use.