Methyl Ethyl Ketone

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for < 0.1% (2 of 4539) of reports.

H225 (> 99.9%): Highly Flammable liquid and vapor [Danger Flammable liquids]

H319 (> 99.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H336 (99.5%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

Aggregated GHS information provided per 4539 reports by companies from 78 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 2 of 4539 reports by companies.

There are 77 notifications provided by 4537 of 4539 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P317, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H303: May be harmful if swallowed [Warning Acute toxicity, oral]

H305: May be harmful if swallowed and enters airways [Warning Aspiration hazard]

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

H333: May be harmful if inhaled [Warning Acute toxicity, inhalation]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P303+P361+P353, P304+P317, P304+P340, P305+P351+P338, P308+P316, P319, P321, P331, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Give nothing to drink. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Wash skin with soap and water.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Water wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and wash the skin with water. If symptoms occur after washing, get medical attention immediately.

Breathing: Fresh air

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient. CAUTION: For fire involving UN1170, UN1987 or UN3475, alcohol-resistant foam should be used. CAUTION: Ethanol (UN1170) can burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.).

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.

LARGE FIRE: Water spray, fog or alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use alcohol-resistant foam, water, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

In case of fire: keep drums, etc., cool by spraying with water. Powder, AFFF, foam, carbon dioxide.

Alc foam, dry chemical, or carbon dioxide

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use alcohol foam, dry chemical or carbon dioxide.

Flammable. Flashback along vapor trail may occur. Vapor may explode if ignited in an enclosed area. Extinguish with dry chemical, alcohol foam, or carbon dioxide. Water may be ineffective on fire. Cool exposed containers with water.

Flashback along vapor trail may occur.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· Consider initial downwind evacuation for at least 300 meters (1000 feet).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: self-contained breathing apparatus. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Establish forced ventilation to keep levels below explosive limit. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or similar material and deposit in sealed containers. Oil-skimming equipment and sorbent foams can be applied to slick if done immediately. Keep this chemical out of a confined space ... because of the possibility of an explosion ... It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable.

Environmental considerations-air spill: Apply water spray or mist to knock down vapors

Environmental considerations-water spill: Use natural barriers or oil spill control booms to limit spill travel. Remove trapped material with suction hoses.

Environmental considerations-land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Absorb bulk liquid with fly ash, cement powder, or commercial sorbents.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste numbers U159, D035 and F005, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Incineration. Recommendable methods: Incineration, open burning, use as a fuel, evaporation, discharge to sewer. Peer-review: Potentially contains peroxides which may be explosive. Evaporate small amt only. (Peer-review conclusions of an IRPTC expert consultation (May 1985))

A good candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids. A good candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A good candidate for liquid injection incineration at a temperature range of 650 to 1,600 °C and a residence time of 0.1 to 2 seconds.

The following wastewater treatment technologies have been investigated for methyl ethyl ketone: solvent extraction and activated carbon.

For more Disposal Methods (Complete) data for METHYL ETHYL KETONE (6 total), please visit the HSDB record page.

Work practices and industrial hygiene techniques should minimize the volatilization of ketones in the workroom air in order to ensure that the exposure limits are not exceeded. /Ketones/

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without hazard. Use water spray to disperse vapors and dilute standing pools of liquid.

Evacuation: If material leaking (not on fire) consider evacuation from downwind area based on amount of material spilled, location and weather conditions.

Personnel protection: Avoid breathing vapors. Keep upwind. ... Do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.

For more Preventive Measures (Complete) data for METHYL ETHYL KETONE (10 total), please visit the HSDB record page.

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Fireproof. Separated from strong oxidants and strong acids. Cool. Well closed. Store in an area without drain or sewer access.

Methyl ethyl ketone must be stored to avoid contact with strong oxidizers (such as chlorine, bromine, and fluorine) since violent reactions may occur. Store in tightly closed containers in a cool, well ventilated area away from sources of heat, sparks, or flame. Sources of ignition such as smoking and open flames are prohibited where methyl ethyl ketone is handled, used or stored in a manner that could create a potential fire or explosion hazard. Metal containers involving the transfer of 5 gallons or more of diethyl ketone should be grounded and bonded. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only non-sparking tools and equipment, especially when opening and closing containers of methyl ethyl ketone.

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

Biological Exposure Indices (BEI) [ACGIH] - MEK in urine = 2 mg/L; sample at end of shift; The determinant is nonspecific since it is also observed after exposure to other chemicals.

200.0 [ppm]

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: ppm)

AEGL 2: Irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape (Unit: ppm)

AEGL 3: Life-threatening health effects or death (Unit: ppm)

Lower Explosive Limit (LEL) = 18,000 ppm * = >10% LEL; ** = >50% LEL AEGL 3 - 10 min/30 min = ** 10,000 ppm For values denoted as * safety considerations against the hazard(s) of explosion(s) must be taken into account. For values denoted as ** extreme safety considerations against the hazard(s) of explosion(s) must be taken into account.

AEGLs Status: Final

200 [ppm]

2700 [ppm]

4000 [ppm]

200 ppm (500 mg/m³)

300 ppm (885 mg/m³)

TWA 200 ppm (590 mg/m3) ST 300 ppm (885 mg/m3)

200 ppm (590 mg/m³)

TWA 200 ppm (590 mg/m3) See Appendix G

3000 ppm (NIOSH, 2024)

3000.0 [ppm]

Excerpts from Documentation for IDLHs: It has been reported that 3,000 ppm is irritating to the eyes and nose [Patty et al. 1935].

3000 ppm

See: 78933

75.0 [ppm]

150.0 [ppm]

8 hr Time Weighted Avg (TWA): 200 ppm; 15 min Short Term Exposure Limit (STEL): 300 ppm.

Biological Exposure Index (BEI): Determinant: methyl ethyl ketone in urine; Sampling Time: end of shift; BEI: 2 mg/L.

200 ppm as TWA; 300 ppm as STEL; BEI issued.

600 mg/m

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

CAUTION: For fire involving UN1170, UN1987 or UN3475, alcohol-resistant foam should be used.

CAUTION: Ethanol (UN1170) can burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.)

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

Large Fire

· Water spray, fog or alcohol-resistant foam.

· Avoid aiming straight or solid streams directly onto the product.

· If it can be done safely, move undamaged containers away from the area around the fire.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

Methyl ethyl ketone appears as colorless fairly volatile liquid with a pleasant pungent odor. Flash point 20 °F. Vapors heavier than air. Does not react with water or many common materials. Stable in normal transportation. Irritates the nose, eyes, and throat. Combustion may produce toxic materials. Density 6.7 lb / gal. Used as a solvent, for making other chemicals, and for production of wax from petroleum.

Liquid; Gas Vapor; CBI

Colorless liquid with a moderately sharp, fragrant, mint- or acetone-like odor; [NIOSH]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

colourless, mobile liquid with an ethereal, nauseating odour

Colorless liquid with a moderately sharp, fragrant, mint- or acetone-like odor.

Colorless liquid

Acetone-like odor

Sweet, pleasant, pungent

Moderately sharp, fragrant, mint- or acetone-like odor

175.3 °F at 760 mmHg (NTP, 1992)

79.59 °C

78.60 to 80.00 °C. @ 760.00 mm Hg

78.6-80 °C

79.59 °C @760 [mm Hg]

-123.3 °F (NTP, 1992)

-86.67 °C

-86.6 °C

-86.64 °C

26 °F (NTP, 1992)

16 °F (-9 °C) (Closed cup)

-9 °C (closed cup)

-9 °C c.c.

greater than or equal to 100 mg/mL at 66 °F (NTP, 1992)

Constant boiling mixture with water, BP 73.4 °C, contains 88.7% methyl ethyl ketone (MEK); Solubility of water in MEK is 12.5% at 25 °C

In water, 2.23X10+5 mg/L at 25 °C

In water, 3.13X10+5 mg/L at 10 °C; 2.11X10+5 mg/L at 25 °C; 1.6X10+5 mg/L at 90 °C

Soluble in benzene, alcohol, and ether; miscible with oils

Miscible with ethanol, ether, acetone, benzene, chloroform

223.0 mg/mL

Solubility in water, g/100ml at 20 °C: 29 (good)

miscible with alcohol, ether, most fixed oils; 1 ml in 4 ml water

(in ethanol)

0.806 at 68 °F (USCG, 1999) - Less dense than water; will float

0.805 at 20 °C/4 °C; 0.7997 at 25 °C/4 °C; 0.8255 at 0 °C/4 °C

Bulk density: 6.71 lb/gal at 20 °C

Relative density (water = 1): 0.8

0.801-0.803

0.7999 @25 °C

2.42 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

Highly flammable. Soluble in water.

Highly Flammable

METHYL ETHYL KETONE is explosive in the form of vapor when exposed to heat, flame or sparks. Ignition on contact with potassium tert-butoxide. Reactive with strong oxidizing materials, and will dissolve or soften some plastics. Mixture with 2-propanol will form explosive peroxides during storage. Vigorous reaction with chloroform in the presence of alkali (sodium hydroxide, potassium hydroxide), chlorosulfonic acid, fuming sulfuric acid (oleum) [Lewis, 3rd ed., 1993, p. 855]. Reaction with hydrogen peroxide in the presence of nitric acid forms heat- and shock-sensitive explosive acetone peroxides. [Bjorklund, G. H. et al., Trans. R. Soc. Can, 1950, 44, p. 25].

Reacts violently with strong oxidants and inorganic acids causing fire and explosion hazard. Attacks some plastic.

Incompatible with chloroform, hydrogen peroxide, nitric acid, potassium t-butoxide, and 2-propanol.

forms exposive mixture with air. Violent reaction with strong oxidizers, amines, ammonia, inorganic acids. caustics, isocyanates, pyridines. Incompatible with potassium teret-butoxide, 2-propanol, chlorosulfonice acid, oleum. Attacks some plastics.

Strong oxidizers, amines, ammonia, inorganic acids, caustics, copper, isocyanates, pyridines.

Reaction with hydrogen peroxide + nitric acid forms a heat- and shock-sensitive explosive product. Ignition on contact with potassium t-butoxide. Mixture with 2-propanol will produce explosive peroxides during storage. Vigorous reaction with chloroform + alkali. Incompatible with chlorosulfonic acid; oleum.

Strong oxidizers, amines, ammonia, inorganic acids, caustics, isocyanates, pyridines

2-Butanone

B*: Compounds that form peroxides on concentration (distillation/evaporation)

9 samples, 1-&gt; 100 ppm, 1-10+ yrs

Bretherick's

Mixtures with 2-propanol will form explosive peroxides during storage.

https://toxnet.nlm.nih.gov/cgi-bin/sis/search/r?dbs+hsdb:@term+@rn+@rel+78-93-3

https://cameochemicals.noaa.gov/chemical/1105

CDC-ATSDR Toxicological Profile

IDENTIFICATION AND USE: Methyl ethyl ketone (MEK) is a colorless liquid with acetone-like odor. It is used as an organic solvent, in the surface coating industry, in the manufacture of smokeless powder, and in colorless synthetic resins. MEK is not registered for current use in pesticides in the U.S. MEK is also used as an extraction solvent in the processing of foodstuffs and food ingredients, e.g., in fractionation of fats and oils, decaffeination of tea and coffee, and extraction of flavorings. HUMAN EXPOSURE AND TOXICITY: At high concentrations MEK is irritating to the eyes, nose, and throat. Other symptoms of exposure include headache, dizziness, vomiting, or numbness of the extremities. Prolonged exposure produces neurotoxic effects, as in the case of a 27-year-old man who was exposed occupationally (through dermal and inhalation pathways) over a 2-year period to solvents containing 100% MEK. The patient reported symptoms of dizziness, anorexia, and involuntary muscle movement, beginning about 1 month prior to admission. Neurological examination confirmed multifocal myoclonus, ataxia, and tremor. Symptoms of solvent toxicity disappeared after 1 month of cessation of exposure and treatment with clonazepam and propranolol. Symptoms did not reappear after withdrawal of the drugs. ANIMAL STUDIES: Acute exposures to MEK in mice showed a 75 to 100% decrease in response rate to light stimuli at concentration of 1,000 to 10,000 ppm. Guinea pigs exposed to MEK vapor (10,000 to 100,000 ppm) for up to 13.5 hr showed that the acute effects of MEK advanced through several distinct phases as the exposure proceeded with nose irritation, eye irritation, lacrimation, incoordination, CNS depression, labored breathing, and death occurring in succession. Vapor concentrations of 33,000 ppm or greater caused death in the animals after 45-260 min of exposure. In subcronic studies rats were exposed to 0, 1250, 2500, or 5000 ppm MEK vapors 6 hours per day, 5 days per week for 90 days. The 5000 ppm animals had a slight but significant increase in liver weight, liver weight/body weight ratio, and liver weight/brain weight ratio at necropsy. Serum glutamicpyruvic transaminase (SGPT) activity in the 2500 ppm female rats was elevated while the 5000 ppm female rats exhibited significantly decreased SGPT activity. In addition, alkaline phosphatase, potassium and glucose values for the 5000 ppm female rats were increased. Pregnant mice were relatively insensitive to the toxic effects of MEK at the inhaled concentrations 0, 400, 1000, or 3000 ppm 7 hr/day on days 6-15 of gestation. However, the offspring of the mice exhibited significant signs of developmental toxicity at the 3000 ppm exposure level. MEK was negative in all genotoxic and mutagenicity assays, including the Salmonella/microsome (Ames) assay, the L5178/TK+/- mouse lymphoma (M/L) assay, the BALB/3T3 cell transformation (CT) assay, unscheduled DNA synthesis (UDS) and the CHO micronucleus test. ECOTOXICITY STUDIES: MEK is toxic to wheat and lettuce seeds and did not produce alarm behavior in ants or honey bees.

Methyl ethyl ketone (MEK)

Developmental

Musculoskeletal

6 x 10 ^-1 mg/kg-day

5 mg/m^3

Methyl Ethyl Ketone

Volatile Organic Compound (VOC)

Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP

Cancer Classification: Group D Not Classifiable as to Human Carcinogenicity

CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: Based on no human carcinogenicity data and inadequate animal data. HUMAN CARCINOGENICITY DATA: None. ANIMAL CARCINOGENICITY DATA: Inadequate.

No indication of carcinogenicity to humans (not listed by IARC).

The substance can be absorbed into the body by inhalation, by ingestion and through the skin.

inhalation, ingestion, skin and/or eye contact

Cough. Headache. Dizziness. Nausea. Vomiting. Drowsiness. Numbness. Laboured breathing.

Dry skin.

Redness. Pain.

See Inhalation. Unconsciousness.

irritation eyes, skin, nose; headache; dizziness; vomiting; dermatitis

Neurological (Nervous System), Ocular (Eyes), Respiratory (From the Nose to the Lungs)

Eyes, skin, respiratory system, central nervous system

Neurotoxin - Acute solvent syndrome

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

... An Acceptable Daily Intake (ADI), defined as the amount of a chemical to which humans can be exposed on a daily basis over an extended period of time (usually a lifetime) without suffering a deleterious effect, for methyl ethyl ketone is 3.2 mg/day for oral exposure. ...

ATSDR Final

IRIS Current

HEAST Current

LC50 (rat) = 23,500mg/m3/8H

LC50 Rat inhalation >5000 ppm/6 hr

LD50 Rat oral 3400 mg/kg bw

LD50 Rat oral 2900 (95% C.I. 2300-3500) mg/kg /From table/

LD50 Rat (female) oral 5520 (95% C.I. 4500-6800) mg/kg /From table/

For more Non-Human Toxicity Values (Complete) data for METHYL ETHYL KETONE (11 total), please visit the HSDB record page.

... A total of 32 male Wistar rats were divided into 4 groups of 8 each and were then exposed to fresh air only, 2000 ppm n-hexane only, 2000 ppm n-hexane plus 200 ppm MEK, and 2000 ppm n-hexane plus 2000 ppm MEK, respectively. Inhalation exposures were performed 12 hr/day, 6 days/week, for 20 weeks. Motor nerve conduction velocity (MCV), distal latency (DL), and urinary 2,5-hexanedione were measured every 4 weeks.... The MCV decreased, the DL increased, and urinary levels of 2,5-hexanedione increased in the 2000-ppm n-hexane plus 200 ppm MEK group in comparison with the 2000-ppm n-hexane only group following 4 weeks' exposure. On the 1st day of exposure, however, coexposure to MEK decreased urinary levels of 2,5-hexanedione dose-dependently. ... The present study showed that urinary concentrations of 2,5-hexanedione increased with potentiation of n-hexane neurotoxicity. Urinary 2,5-hexanedione concentration does not necessarily reflect the exposure concentration of n-hexane in coexposure to n-hexane along with MEK or other solvents, but it may be useful as a marker in the assessment of neurotoxicity in coexposure to n-hexane and other solvents.

It does not appear to be neurotoxic by itself, it potentiates neurotoxicity of other hexacarbons; reported in humans exposed to methyl ethyl ketone (MEK) and n-hexane.

The effects of the solvents n-hexane, butanone (methyl ethyl ketone, MEK) and a mixture of both in the intrapulmonary nerve system of rats were studied by light and electron microscopy. The alteration in the fine structures of the tissues consisted in a disseminated swelling of axons due to a striking multiplication of neurofilaments. Nonspecific axonal alterations could be demonstrated as well. The latter consisted in clusters of phospholipid material within the axoplasm of nerve fibers and the cytoplasm of Schwann cells plus an accumulation of glycogen granules in the axoplasm. Additionally, single degenerative changes of Schwann cells were observed.

Methyl ethyl ketone potentiates carbon tetrachloride hepatoxicity in rats. Oral dosing with methyl ethyl ketone at 1.87, 2.4, or 1.2 mL/kg followed by ip injection with carbon tetrachloride at 0.1 mL/kg significantly enhanced the hepatotoxicity of carbon tetrachloride as measured by increased serum glutamic pyruvic transaminase activity and hepatic triglyceride concentration and decreased hepatic glucose-6-phosphatase activity.

For more Interactions (Complete) data for METHYL ETHYL KETONE (21 total), please visit the HSDB record page.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Ketones and related compounds/

LC50; Species: Leuciscus idus /Orfe/; Conditions: freshwater, static; Concentration: 4600 mg/L for 48 hr

LC50; Species: Lepomis macrochirus (bluegill); Concentration: 5,640-1,690 mg/L for 24 to 96 hr /Conditions of bioassay not specified/

LC50; Species: Artemia salina (brine shrimp); Concentration: 1,950 mg/L for 24 hr /From table; bottles not sealed and may have lost MEK during experiment; water pH, temp, and hardness not specified/

LC50; Species: Daphnia magna (water flea); Concentration: <520 mg/L for 48 hr /From table; pH 8 and hardness 173; temp not specified/

For more Ecotoxicity Values (Complete) data for METHYL ETHYL KETONE (19 total), please visit the HSDB record page.

/OTHER TERRESTRIAL SPECIES/ The effect of MEK on the alarm behavior of social insects has been studied. It was considered inactive in producing alarm behavior in the ant Iridomyrmex preinosus ... the harvester ant Pogonomyrmex badius ... and the honeybee Apis mellifera ...

/PLANTS/ MEK has an effect on the germination of seeds of several plant species. /Researchers/ observed that the germination of wheat seeds was inhibited when the seeds were treated with 6.4 mg MEK/g seed. At this level, 10% of the experimental seeds germinated versus 60% of the control seeds. Germination of lettuce was inhibited 50% by MEK at 12.5 (+ or - 4) mmol/liter (equivalent to 900 + or - 288 mg/liter) dissolved in agar. /The authors/ reported, however, that a mixture of acetone and MEK had no inhibitory effect on the growth of rye grass at concentrations up to 1 g/liter.

2.70e+04

1.90e+05

5.20e+03

2.20e+04

5.60e+03

4.00e+01

1.20e+00

6.00e-01

5.00e+00

Volatile

2.84e+04

8.10e+04

5.80e+05

1.60e+04

6.60e+04

1.70e+04

Avoid release to the environment in circumstances different to normal use.

Methyl ethyl ketone's production and use as a solvent for coatings, resins, paint removers, pharmaceuticals, adhesives and cements and as an intermediate in organic synthesis may result in its release to the environment through various waste streams. Methyl ethyl ketone can be released directly to the atmosphere, via evaporation, through its use as a solvent in commercial products such as latex paint and from automobile exhaust. Its use as an inert ingredient (solvent) in pesticides will result in its direct release to the environment. Methyl ethyl ketone occurs naturally as a metabolic byproduct of plants and animals and is released into the atmosphere by volcanoes and forest fires. If released to air, a vapor pressure of 90.6 mm Hg at 25 °C indicates methyl ethyl ketone will exist solely as a vapor in the atmosphere. Vapor-phase methyl ethyl ketone will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 13 days. Methyl ethyl ketone has been detected in rain, clouds and fog; therefore, it may be removed from the air by wet deposition. Methyl ethyl ketone is susceptible to direct photolysis by sunlight. The atmospheric lifetime based on direct photolysis from direct overhead sunlight has been approximated as 4 days; however, rates under typical atmospheric conditions may be slower by a factor of 2-3. If released to soil, methyl ethyl ketone is expected to have very high mobility based upon Koc values of 29 and 34 measured in silt loam soils. Volatilization from moist soil surfaces is expected to be an important fate process based upon a Henry's Law constant of 4.67X10-5 atm-cu m/mole. Methyl ethyl ketone is expected to volatilize from dry soil surfaces based upon its vapor pressure. The volatilization half-life of methyl ethyl ketone from silt and sandy loam soils was measured as 4.9 days. Utilizing the Japanese MITI test, >60% of the Theoretical BOD was reached in 4 weeks indicating that biodegradation is an important environmental fate process. If released into water, methyl ethyl ketone is not expected to adsorb to suspended solids and sediment based upon the Koc values. Methyl ethyl ketone was shown to biodegrade 89% in 20 days in fresh water and 69% in 20 days in salt water. Numerous screening studies indicate methyl ethyl ketone is expected to biodegrade under aerobic and anaerobic conditions in soil and water. Volatilization from water surfaces is expected to be an important fate process based upon this compound's Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 18 hours and 8.2 days, respectively. An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to methyl ethyl ketone may occur through inhalation and dermal contact with this compound at workplaces where methyl ethyl ketone is produced or used. Monitoring data indicate that the general population may be exposed to methyl ethyl ketone via inhalation of ambient air, ingestion of food and drinking water, and dermal contact with consumer products containing methyl ethyl ketone. (SRC)

Methyl ethyl ketone occurs as a metabolic byproduct of plants and animals and is released into the atmosphere by volcanoes and forest fires(1). Methyl ethyl ketone is emitted from pencil cedar, Zeravshan juniper, European firs, Evergreen Cyprus(2), blooming rape(3), and southern pea seeds(4). Methyl ethyl ketone occurs in plants such as catmint, bell pepper, tomato, myrtle and black currant(5).

Methyl ethyl ketone's production and use as a solvent for coatings, resins, paint removers, pharmaceuticals, adhesives and cements and as an intermediate in organic synthesis(1,2) may result in its release to the environment through various waste streams(SRC). Methyl ethyl ketone can be released directly to the atmosphere, via evaporation, through its use as a solvent in commercial products such as latex paint and from automobile exhaust(3). Its use as an inert ingredient (solvent) in pesticides(4) will result in its direct release to the environment(SRC). [

TERRESTRIAL FATE: Based on a classification scheme(1), measured Koc values of 29 and 34(2), indicate that methyl ethyl ketone is expected to have very high mobility in soil(SRC). Volatilization of methyl ethyl ketone from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 4.67X10-5 atm-cu m/mole(3). Methyl ethyl ketone is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 90.6 mm Hg(4). The volatilization half-life of methyl ethyl ketone from silt and sandy loams was measured as 4.9 days(5). A >60% of theoretical BOD using activated sludge in the Japanese MITI test(6) suggests that biodegradation is an important environmental fate process in soil(SRC). Methyl ethyl ketone is expected to biodegrade under both aerobic and anaerobic conditions as indicated by numerous screening tests(7-12). Methyl ethyl ketone is susceptible to direct photolysis by sunlight(13,14); therefore, direct photolysis is expected to occur on soil surfaces exposed to sunlight(SRC).

AQUATIC FATE: Based on a classification scheme(1), measured Koc values of 29 and 34(2), indicate that methyl ethyl ketone is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 4.67X10-5 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 18 hours and 8.2 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from a log Kow of 0.29(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Methyl ethyl ketone was shown to biodegrade 89% in 20 days in fresh water and 69% in 20 days in salt water(8). A variety of screening studies using a microbial seed from domestic waste treatment plants have indicated that methyl ethyl ketone has a 5-day biological oxygen demand (BOD5) which is between 59% and 74% of the theoretical amount after a short lag period(9). Methyl ethyl ketone is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). Methyl ethyl ketone is susceptible to direct photolysis by sunlight(10,11); therefore, direct photolysis may occur at water surfaces exposed to sunlight(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methyl ethyl ketone, which has a vapor pressure of 90.6 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase methyl ethyl ketone is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 13 days(SRC), calculated from its rate constant of 1.2X10-12 cu cm/molecule-sec at 25 °C(3). Methyl ethyl ketone is expected to undergo direct photolysis in the atmosphere(4-8). The atmospheric lifetime of methyl ethyl ketone, based on direct photolysis from direct overhead sunlight, has been approximated as 4 days(5); however, rates under typical atmospheric conditions are a factor of 2-3 slower than estimates using quantum yields for methyl ethyl ketone and similar ketones(8). Methyl ethyl ketone has been detected in rain, clouds and fog(9,10); therefore, methyl ethyl ketone may be removed from the air by wet deposition(SRC).

AEROBIC: Methyl ethyl ketone (MEK) is readily oxidized by microorganisms in activated sludge following selection and/or adaptation, with over 80% being removed in 24 hr. Metabolism in unacclimated sludges is slow.

AEROBIC: Biological oxygen demand (BOD) after 5 days at 20 °C: 59% theoretical (acclimated); after 5 days, temp not specified: 46; 62; 74; 79; 92% theoretical (std dilution sewage); after 20 days: 74% theoretical at 10 mg/L, unadapted sewage: lag period 1 day; after 20 days: 79% theoretical, unadapted sewage; Chemical oxygen demand (COD): 90; 95; 100% theoretical.

AEROBIC: Using standard BOD and COD dilution techniques and a sewage inoculum, a theoretical BOD of 83% and a theoretical COD of 95% was reported over a 5 day incubation period for methyl ethyl ketone(1). The percent theoretical BOD of methyl ethyl ketone in freshwater was reported as 76%, 82%, 84% and 89% over 5, 10 15 and 20 day incubation periods respectively(2). The percent theoretical BOD of methyl ethyl ketone in synthetic saltwater was reported as 32%, 62%, 63% and 69% over 5, 10 15 and 20 day incubation periods respectively(2). 92-95% Biodegradation was reported when 0.25 mg/L of methyl ethyl ketone was fed through an activated sludge from a wastewater treatment plant over a 3 week incubation period(3). Methyl ethyl ketone was biodegraded 100% on 3 in-situ field sites with added oxygen, nitrogen and methane in Monroe County, NY, July 20th through Dec 5th, 1994(4). Methyl ethyl ketone biodegraded 81-87% in 40 days at a rate of 0.24/h in a respirometry study(5). Using a pilot-scale treatment processes using activated sludge and with daily mass loadings of COD/bacterial mass ratios of 0.1, 0.36 and 0.48, methyl ethyl ketone, present at influent concentrations of <25, 110 and 110 ug/L, was detected at concentrations of <10, <10 and <10 ug/L, respectively, in plant effluents(6). Methyl ethyl ketone, present at 100 mg/L, reached >60% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test which classified the compound as readily biodegradable(7). A variety of screening studies using a microbial seed from domestic waste treatment plants have indicated that methyl ethyl ketone has a 5-day biological oxygen demand (BOD5) which is between 59% and 74% of the theoretical amount after a short lag period(8).

ANAEROBIC: The percent theoretical methane recovery of methyl ethyl ketone in an anaerobic aquifer was 89% over a 3 week incubation period following a 15 day acclimation period(1).

The rate constant for the vapor-phase reaction of methyl ethyl ketone with photochemically-produced hydroxyl radicals is 1.2X10-12 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 13 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Methyl ethyl ketone absorbs at wavelengths >290 nm, and is expected to undergo direct photolysis in the atmosphere(3-6). The atmospheric lifetime of methyl ethyl ketone, based on direct photolysis from overhead sunlight, has been approximated as 4 days(3); however, rates under typical atmospheric conditions are a factor of 2-3 slower than estimates using quantum yields for methyl ethyl ketone and similar ketones(6). Methyl ethyl ketone is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(7).

An estimated BCF of 3 was calculated in fish for methyl ethyl ketone(SRC), using a log Kow of 0.29(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Measured Koc values of 29 and 34 were obtained for methyl ethyl ketone in a silt loam and sandy loam soil respectively(1). A measured Koc value of 3.55 has also been reported(2). According to a classification scheme(3), these Koc values suggest that methyl ethyl ketone is expected to have very high mobility in soil(SRC).

The Henry's Law constant for methyl ethyl ketone is 4.67X10-5 atm-cu m/mole(1). This Henry's Law constant indicates that methyl ethyl ketone is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 18 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 8.2 days(SRC). Methyl ethyl ketone's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Methyl ethyl ketone is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 90.6 mm Hg(3). The volatilization half-life of methyl ethyl ketone from silt and sandy loams was measured as 4.9 days(4).

GROUNDWATER: Methyl ethyl ketone was detected in groundwater at a coal strip-mine in Ohio at a concn of 650 mg/L(1). Methyl ethyl ketone was identified, not quantified, in on-site and off-site groundwater near a landfill in New Jersey(2). Methyl ethyl ketone was detected in the groundwater of a coal strip-mine in Lackawanne, PA at a maximum concentration of 29,000 ppb(3). Methyl ethyl ketone was detected at an average concentration of 12 ug/L in the groundwater of 19 solid waste disposal facilities in Wisconsin(4) and in the range of 0-91 ug/L in the groundwater of a landfill located in New Castle, DE(5). Methyl ethyl ketone was detected at an average concentration of 60 ug/L in the groundwater of a chemical manufacturing facility in Alabama(6). For samples collected from 1981 to 1986, methyl ethyl ketone was detected in 4.3%, 19.4%, 3.3%, 12.7%, 0.7%, 38.5% and 8.5% of the hazardous waste site groundwater samples in EPA regions 1, 2, 3, 4, 5, 8 and 10, respectively(7). Methyl ethyl ketone was found at 2.78 ug/L in 1 of 9 sites tested 1990-1992 in Laquna Asososca area, Managua, Nicaragua(8). Methyl ethyl ketone was detected in 1.5% of 214 ground water samples from 30 industrial sites in Taiwan tested Mar-Apr 1999(9).

DRINKING WATER: A Federal survey of public groundwater supplies detected methyl ethyl ketone in less than 5% of the samples(1). Methyl ethyl ketone was identified, not quantified, in drinking water supplies from 7 cities from varied sources and with different types of pollutant sources(2-4). Methyl ethyl ketone was listed as a contaminant found in drinking water for a survey of US cities including Miami, FL, Cincinnati, OH, Philadelphia, PA, Ottumwa, IA, and Seattle, WA(5). Methyl ethyl ketone was identified as a ozone disinfection by-product in drinking water(6). A national sampling conducted by the US Geological Survey of randomly selected community water systems (CWSs) in the US detected methyl ethyl ketone at concentrations of 2.0 ug/L (the detection limit) or higher in 0.6% of 955 samples(7).

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste numbers U159, D035 and F005, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Incineration. Recommendable methods: Incineration, open burning, use as a fuel, evaporation, discharge to sewer. Peer-review: Potentially contains peroxides which may be explosive. Evaporate small amt only. (Peer-review conclusions of an IRPTC expert consultation (May 1985))

A good candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids. A good candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A good candidate for liquid injection incineration at a temperature range of 650 to 1,600 °C and a residence time of 0.1 to 2 seconds.

The following wastewater treatment technologies have been investigated for methyl ethyl ketone: solvent extraction and activated carbon.

For more Disposal Methods (Complete) data for METHYL ETHYL KETONE (6 total), please visit the HSDB record page.

/GUIDE 127: FLAMMABLE LIQUIDS (Polar/Water-Miscible)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

/GUIDE 127: FLAMMABLE LIQUIDS (Polar/Water-Miscible)/ Health: Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution.

/GUIDE 127: FLAMMABLE LIQUIDS (Polar/Water-Miscible)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 127: FLAMMABLE LIQUIDS (Polar/Water-Miscible)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.

For more DOT Emergency Guidelines (Complete) data for METHYL ETHYL KETONE (8 total), please visit the HSDB record page.

UN 1193; Ethyl methyl ketone or Methyl ethyl ketone

IMO 3; Ethyl methyl ketone or Methyl ethyl ketone

49 092 43; Methyl ethyl ketone

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Liquid

Symbol: F, Xi; R: 11-36-66-67; S: (2)-9-16; Note: 6

UN Hazard Class: 3; UN Pack Group: II