Methyl Methacrylate

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H317: May cause an allergic skin reaction [Warning Sensitization, Skin]

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P233, P240, P241, P242, P243, P261, P264, P271, P272, P280, P302+P352, P303+P361+P353, P304+P340, P319, P321, P332+P317, P333+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for < 0.1% (1 of 4537) of reports.

H225 (> 99.9%): Highly Flammable liquid and vapor [Danger Flammable liquids]

H315 (> 99.9%): Causes skin irritation [Warning Skin corrosion/irritation]

H317 (98.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H335 (98.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Aggregated GHS information provided per 4537 reports by companies from 64 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 1 of 4537 reports by companies.

There are 63 notifications provided by 4536 of 4537 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]

H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P284, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P317, P319, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P370+P378, P403, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

H333: May be harmful if inhaled [Warning Acute toxicity, inhalation]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P272, P280, P284, P302+P352, P303+P361+P353, P304+P317, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P370+P378, P403, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital. (NTP, 1992)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

· Wash skin with soap and water.

· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.

In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.

(General first aid procedures)

Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.

Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.

Breathing: Respiratory support

Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious); polymerization hazard]:

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam. Do not use dry chemical extinguishers to control fires involving nitromethane (UN1261) or nitroethane (UN2842).

LARGE FIRE: Water spray, fog or alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Use foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Use dry chemical, carbon dioxide, or foam extinguishers. Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any signs of deforming), withdraw immediately to a secure position.

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. /Methyl methacrylate monomer, stabilized and uninhibited/

Evacuation: If fire becomes uncontrollable or container is exposed to direct flame-consider evacuation of one-half (1/2) mile radius. If material leaking (not on fire) consider evacuation from downwind area based on amount of material spilled, location, and weather conditions. /Methyl methacrylate monomer, stabilized/

Evacuation: If fire becomes uncontrollable or container is exposed to direct flame-consider evacuation of one-third (1/3) mile radius. If material leaking (not on fire) consider evacuation from downwind area based on amount of material spilled, location, and weathre conditions. /Methyl methacrylate monomer, uninhibited/

Vapor is heavier than air and may travel a considerable distance to a source of ignition and flash back.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch or walk through spilled material.

· Stop leak if you can do it without risk.

· Prevent entry into waterways, sewers, basements or confined areas.

· A vapor-suppressing foam may be used to reduce vapors.

· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.

· Use clean, non-sparking tools to collect absorbed material.

Large Spill

· Dike far ahead of liquid spill for later disposal.

· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious); polymerization hazard]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

· Consider initial downwind evacuation for at least 300 meters (1000 feet).

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

Personal protection: chemical protection suit and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Remove all ignition sources. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. For small quantities, absorb on paper towels. Evaporate in safe place (such as fume hood). Burn paper in suitable location away from combustible materials. Large quantities can be collected and atomized in suitable combustion chamber. Methyl methacrylate should not be allowed to enter confined space, such as sewer, because of possibility of an explosion.

Spill Handling: Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Establish forced ventilation to keep levels below explosive limit. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. Keep this chemical out of a confined space, such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the build-up of explosive concentrations. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters.

Environmental considerations: Air spill: Apply water spray or mist to knock down vapors. /Methyl methacrylate monomer, stabilized and uninhibited/

For more Cleanup Methods (Complete) data for Methyl methacrylate (6 total), please visit the HSDB record page.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U162, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

1.By absorbing it in vermiculite, dry sand, earth or similar material ... 2. By atomizing in suitable combustion chamber.

Do not empty into drains.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

SRP: Contaminated protective clothing should be segregated in a manner that results in no direct personal contact by personnel who handle, dispose of, or clean the clothing. Quality assurance procedures to confirm the efficacy of the cleaning procedures should be implemented prior to the decontaminated protective clothing being returned for reuse by the workers. Contaminated clothing (including shoes/socks) should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water to knock-down vapors. /Methyl methacrylate monomer, stabilized and uninhibited/

For more Preventive Measures (Complete) data for Methyl methacrylate (18 total), please visit the HSDB record page.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious); polymerization hazard]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)

Fireproof. Separated from strong oxidants, strong bases and strong acids. Cool. Keep in the dark. Keep in a well-ventilated room. Store only if stabilized.

Before entering confined space where this chemical may be present, check to make sure that an explosive concentration does not exist. Methyl methacrylate must be stored to avoid contact with oxidizers, such as nitrates, permanganates, perchlorates, chlorates, and peroxides; strong alkalis, such as sodium hydroxide and potassium hydroxide, and strong acids, such as nitric acid, hydrochloric acid, and sulfuric acid, since violent reactions occur. Store in tightly closed containers in a cool, well ventilated area away from light, heat, and ionizing radiation, because methyl methacrylate will react and release heat quickly causing an explosion. Store with an appropriate inhibitor. Lack of an appropriate inhibitor may cause an explosive reaction.

Keep container in a well-ventilated place. Keep away from sources of ignition. ... Take precautionary measures against static discharges.

Temp during storage must be kept low to minimize formation of peroxides and other oxidation products. ... Storage temp below 30 °C are recommended for the polyfunctional methacrylates. ... the methacrylate monomers should not be stored for longer than one year. Shorter storage times are recommended for the aminomethacrylates, ie, three months, and the polyfunctional methacrylates, ie, six months. Many of these cmpd are sensitive to UV light and should, therefore, be stored in the dark. The methacrylic esters may be stored in mild steel, stainless steel, or aluminum. /Methacrylic acid & derivatives/

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

50.0 [ppm]

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: ppm)

AEGL 2: Irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape (Unit: ppm)

AEGL 3: Life-threatening health effects or death (Unit: ppm)

Level of Distinct Odor Awareness (LOA) = 0.11 ppm

AEGLs Status: Interim

17 [ppm]

120 [ppm]

570 [ppm]

100 ppm (410 mg/m³)

TWA 100 ppm (410 mg/m3)

100.0 [ppm]

1000 ppm (NIOSH, 2024)

1000.0 [ppm]

1000 ppm

See: 80626

8 hr Time Weighted Avg (TWA): 50 ppm; 15 min Short Term Exposure Limit (STEL): 100 ppm. Sensitization.

A4; Not classifiable as a human carcinogen.

50 ppm as TWA; 100 ppm as STEL; (SEN); A4 (not classifiable as a human carcinogen).

50 ppm [1992]

100 ppm [1992]

50 ppm as TWA; 100 ppm as STEL

210 mg/m

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.

Small Fire

· Dry chemical, CO2, water spray or alcohol-resistant foam.

· Do not use dry chemical extinguishers to control fires involving nitromethane (UN1261) or nitroethane (UN2842).

Large Fire

· Water spray, fog or alcohol-resistant foam.

· Avoid aiming straight or solid streams directly onto the product.

· If it can be done safely, move undamaged containers away from the area around the fire.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.

Australia: 100 ppm, sensitizer (1990); Federal Republic of Germany: 50 ppm, short-term level 100 ppm, 5 min, 8 times per shift, sensitizer, Pregnancy group C, no reason to fear a risk of damage to the developing embryo or fetus when MAK and BAT values are adhered to (1992); Sweden: 50 ppm, short-term value 150 ppm, 15 min, skin, sensitizer (1990); United Kingdom: 100 ppm, 10-min STEL 125 ppm (1991).

Methyl methacrylate monomer appears as a clear colorless liquid. Slightly soluble in water and floats on water. Vapors heavier than air. Vapors irritate the eyes and respiratory system. Containers must be heavily insulated or shipped under refrigeration. An inhibitor such as hydroquinone, hydroquinone methyl ester and dimethyl t-butylphenol is added to keep the chemical from initiating polymerization. The chemical may polymerize exothermically if heated or contaminated with strong acid or base. If the polymerization takes place inside a container, the container may rupture violently. Used to make plastics.

Liquid; Dry Powder; Liquid; Liquid; Wet Solid; CBI; Wet Solid

Colorless liquid with an acrid, fruity odor; [NIOSH]

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

Clear colourless liquid; Fruity aroma

Colorless liquid with an acrid, fruity odor.

Colorless volatile liquid

Characteristic quality: sulfur-like, sweet, sharp; hedonic tone: unpleasant

Acrid, fruity odor

213.8 °F at 760 mmHg (NTP, 1992)

100.5 °C

99-100 °C

100.5 °C @760 [mm Hg]

-54 °F (NTP, 1992)

-47.55 °C

50 °F (NTP, 1992)

50 °F; 10 °C (open cup)

55 °F (Tag open cup)

10 °C o.c.

50 °F (open cup)

(oc) 50 °F

1 to 10 mg/mL at 63.5 °F (NTP, 1992)

Soluble in methyl ethyl ketone, tetrahydrofuran, esters, aromatic and chlorinated hydrocarbons

Miscible with ethanol, ethyl ether, acetone; soluble in chloroform

1.500 lb/100 lb water at 68.02 °F

Sol in chloroform

For more Solubility (Complete) data for Methyl methacrylate (8 total), please visit the HSDB record page.

15 mg/mL at 25 °C

Solubility in water, g/100ml at 20 °C: 1.6

Slightly soluble in water; soluble in ether and acetone

Soluble (in ethanol)

0.945 at 68 °F (USCG, 1999) - Less dense than water; will float

0.9337 g/cu cm at 25 °C

Liquid heat capacity: 0.448 BTU/lb-F at 70 °F; Liquid thermal conductivity: 1.023 BTU-in/hr-sq ft-F at 70 °F; Saturated vapor density: 0.01119 lb/cu ft at 70 °F; Ideal gas heat capacity: 0.361 BTU/lb-F at 75 °F

Relative density (water = 1): 0.94

0.934-0.938

0.9377 @25 °C

3.45 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

3.45 (Air = 1)

Relative vapor density (air = 1): 3.5

Highly flammable. Very slightly soluble in water.

Acrylates and Acrylic Acids

Polymerizable Compounds

Highly Flammable

Polymerizable

Peroxidizable Compound

METHYL METHACRYLATE MONOMER, may polymerize if contaminated or subjected to heat. If polymerization takes place in a container, the container is subject to violent rupture. Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick 1979. p.151-154, 164]. Peroxides may also initiate exothermic polymierization of the bulk material [Bretherick 1979. p. 160]. Benzoyl peroxide was weighed into a beaker that had previously been rinsed with methyl methacrylate. The peroxide catalyzed polymerization of the methyl methacrylate and the build-up of heat ignited the remaining peroxide [MCA Case History 996. 1964].

... Can react with oxidizing materials.

Benzoyl peroxide was weighed into a stainless steel beaker that had been rinsed previously with methyl methacrylate. The peroxide catalyzed polymerization of the methacrylate and the build-up of heat was sufficient to ignite the remainder of the peroxide.

Incompatibile with nitrates, oxidizers, peroxides, strong acids, strong alkalies, reducing agents, amines, moisture. Contact with benzoyl peroxide may cause ignition, fire, and explosion.

Following an incident in which a drum containing bulked drainings (from other drums awaiting reconditioning) fumed and later exploded after sealing, it was found that methyl methacrylate and propionaldehyde can, under certain conditions of mixing, lead to a rapid exothermic reaction.

Potentially violent reaction with the polymerization initiators azoisobutyronitrile; dibenzoyl peroxide; di-tert-butyl peroxide; propionaldehyde.

Nitrates, oxidizers, peroxides, strong alkalis, moisture [Note: May polymerize if subjected to heat, oxidizers, or ultraviolet light. Usually contains an inhibitor such as hydroquinone.]

Methyl methacrylate

C: Compounds that autopolymerize due to peroxide formation if inhibitors are depleated or not present

1 samples had &lt; 10 ppm, age &gt; 9 yr

IDENTIFICATION: Methyl methacrylate is a volatile synthetic chemical that is used principally in the production of cast acrylic sheet, acrylic emulsions, and molding and extrusion resins. HUMAN EXPOSURE: Data on absorption following dermal exposure are limited. In humans, methyl methacrylate is rapidly metabolized to methacrylic acid. This compound is a mild skin irritant in humans and has the potential to induce skin sensitization in susceptible individuals. Although occupational asthma associated with methyl methacrylate has also been reported, there is no conclusive evidence that this compound is a respiratory sensitizer. Epidemiological studies do not provide strong or consistent evidence of a carcinogenic effect of methyl methacrylate on any target organ in humans, nor can it be inferred with any degree of confidence that the possibility of an increased risk has been disapproved. ANIMAL/PLANT STUDIES: Methyl methacrylate is rapidly absorbed and distributed following inhalation or oral administration to experimental animals. Data on absorption following dermal exposure are limited. In experimental animals, methyl methacrylate is rapidly metabolized to methacrylic acid. Following inhalation, 16-20% of the chemical is deposited in the upper respiratory tract of rats, where it is primarily metabolized by local tissue esterases. The acute toxicity of this compound is low. Irritation of the skin, eye and nasal cavity has been observed in rodents and rabbits exposed to relatively high concentrations of methyl methacrylate. The chemical is a mild skin sensitizer in animals. The effect observed most frequently at the lowest concentration after repeated inhalation exposure to this compound is irritation of the nasal cavity. Effects on the kidney and liver at higher concentrations have been reported. The lowest reported effect level for irritation was 410 mg/cu m in rats exposed to this material for 2 yr (based upon inflammatory degeneration of the nasal epithelium); the no observed effect level (NOEL) in this investigation was approximately 100 mg/cu m. In a study in rats, there were no developmental effects, although there were decreases in maternal body weight following inhalation of concentrations up to 8,315 mg/cu m. There was no reduction in fertility in a dominant lethal assay in mice exposed to this compound at concentrations up to 36,900 mg/cu m and no adverse effects on reproductive organs in repeated dose studies conducted to date. Available data on the neurotoxicity of methyl methacrylate are limited; impairment of locomotor activity and learning and behavioral effects on the brain were observed in rats exposed orally to 500 mg/kg bw/day for 21 days. Methyl methacrylate was not carcinogenic in an extensive well documented 2 yr bioassay in rats and mice exposed by inhalation and in additional chronic inhalation studies in rats and hamsters. This substance is not mutagenic in in vitro bacterial systems, this compound is mutagenic and clastogenic in mammalian cells in vitro. In in vivo studies (primarily by the inhalation route) in which there has been clear evidence of toxicity within the target tissue, there has been limited evidence of the genotoxicity of methyl methacrylate. The toxicity of methyl methacrylate to aquatic organisms is low. No chronic studies on aquatic organisms were identified. Acute tests have been conducted on fish, Daphnia magna and algae. The most sensitive effect was the onset of inhibition of cell multiplication by the green alga Scenedesmus quadricauda at 37 mg/l following an 8 day exposure period. The lowest EC50 for immobilization in Daphnia was 720 mg/L. The 96 hr LC50 for juvenile bluegill sunfish (Lepomis macrochirus) under flow through conditions was 191 mg/L, whereas LC50 values for durations 1-24 hr ranged from 420-356 mg/L, respectively. The 96 hr LC50 for rainbow trout (Oncorhynchus mykiss) under flow through conditions was > 79 mg/L, the highest concentration tested. Sublethal/behavioral responses were noted among the fish at 40 mg/L.

Methyl methacrylate

Respiratory

1.4 mg/kg-day

7 x 10 ^-1 mg/m^3

Volatile Organic Compound (VOC)

Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP

Evaluation: There is inadequate evidence in humans for the carcinogenicity of methyl methacrylate. There is evidence suggesting lack of carcinogenicity of methyl methacrylate in experimental animals. Overall evaluation: Methyl methacrylate is not classifiable as to its carcinogenicity to humans (Group3).

WEIGHT OF EVIDENCE CHARACTERIZATION: Under EPA's 1986 Guidelines for Carcinogen Risk Assessment, MMA would be classified as evidence of non-carcinogenicity for humans or a Group E chemical. Under the Proposed Guidelines for Carcinogenic Risk Assessment, MMA is considered not likely to be carcinogenic to humans by any route of exposure because it has been evaluated in four well-conducted chronic inhalation studies in three appropriate animal species without demonstrating carcinogenic effects. Basis - The results of the 2-year inhalation studies conducted for NTP showed no evidence of carcinogenicity of MMA for male F344/N rats exposed at 500 or 1,000 ppm, for female F344/N rats exposed at 250 or 500 ppm, or for female B6C3F1 mice exposed at 500 or 1,000 ppm. In addition, no increase was seen in the number or type of tumors in either rats or hamsters from the chronic inhalation study performed by Hazelton Laboratories /in 1979/. No carcinogenic activity was reported in a chronic oral study. Fewer animals were used and the experimental protocol and results of this oral study were not as well documented as for the inhalation study. However, acute oral exposure studies and structure-activity relationship comparisons with other acrylates suggest that the introduction of a methyl group to the acrylate moiety (e.g., EC to MMA) negates carcinogenic activity. Epidemiology studies show no clear excess of cancer. Though a report suggesting increased colon cancer among ethyl acrylate/MMA-exposed workers exists, a high background for this effect has been documented for the location and time of this study, the effects were not reproduced in other similar and more recent studies, a clear relationship between exposure and effect was not demonstrated, and the extent that ethyl acrylate concurrent exposure confounded results could not be determined. Given these structure-activity relationship considerations, the low potential for cancer from MMA exposure indicated in genotoxicity, laboratory animal and epidemiology studies suggests that MMA does not represent a carcinogenic hazard to humans. HUMAN CARCINOGENICITY DATA: Inadequate. ANIMAL CARCINOGENICITY DATA: No evidence.

A4; Not classifiable as a human carcinogen.

Group 3: Not classifiable as to its carcinogenicity to humans

Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)

Volume 60: (1994) Some Industrial Chemicals

Methyl Methacrylate

TR-314: Toxicology and Carcinogenesis Studies of Methyl Methacrylate (CASRN 80-62-6) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) (1986 )

12/09/85

No Evidence

Under the conditions of these 2-year inhalation studies, there was no evidence of carcinogenicityof methyl methacrylate for male F344/N rats exposed at 500 or 1,000 ppm, for female F344/N rats exposed at 250 or 500 ppm, or for male and female B6C3F1 mice exposed at 500 or 1,000 ppm. Inhalation of methyl methacrylate was associated with inflammation of the nasal cavity and degeneration of the olfactory sensory epithelium in male and female rats and mice; epithelial hyperplasia of the nasal cavity was also observed in exposed mice.

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

inhalation, ingestion, skin and/or eye contact

Cough. Shortness of breath. Sore throat.

Redness.

Redness. Pain.

Nausea. Vomiting. Abdominal pain.

irritation eyes, skin, nose, throat; dermatitis

Eyes, skin, respiratory system

Dermatotoxin - Skin burns.

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents.

ACGIH Carcinogen - Not Classifiable.

AN ADI /ACCEPTABLE DAILY INTAKE/ OF 0.1 MG/KG/DAY WAS CALCULATED ON BASIS OF AVAILABLE CHRONIC TOXICITY DATA.

IRIS Current

HEAST Current

LC50 (rat) = 78,000 mg/m3/4H

LD50 Rat oral 9400 mg/kg.

LD50 Rat oral 7800 mg/kg

LC50 Rat inhalation 11,250 - 12,500 ppm/2 hr

LC50 Rat inhalation 13,220 ppm/3 hr

For more Non-Human Toxicity Values (Complete) data for Methyl methacrylate (18 total), please visit the HSDB record page.

Some compounds, such as the methyl, ethyl, n-propyl, or butyl methacrylates can produce inhibition of barium chloride-induced contraction of the isolated guinea pig ileum.

Toxicity threshold (cell multiplication inhibition test): Pseudomonas putida (bacteria): 100 mg/L

Toxicity threshold (cell multiplication inhibition test): Microcystis aeruginosa (alga) 120 mg/l

Toxicity threshold (cell multiplication inhibition test): Scenedesmus quadricauda (green alga) 37 mg/l.

Toxicity threshold (cell multiplication inhibition test): Entosiphon sulcatum (protozoa) 450 mg/l.

For more Ecotoxicity Values (Complete) data for Methyl methacrylate (54 total), please visit the HSDB record page.

/FIELD STUDIES/ In artificial streams (pilot rivers) supplied with the river water of Gave de Pau (France), we studied the effects of methyl methacrylate (MMA) on the autochthonous bivalve Unio tumidus transferred into the streams and on natural freshwater communities colonizing the channels. Unio tumidus and freshwater communities were exposed to MMA for 15 and 30 days, respectively, at measured concentrations ranging from 0.6 to 122 mg/L. Biomarkers studied in the digestive gland and gills of U. tumidus comprised detoxication systems (namely, antioxidant enzyme activities and glutathione status) and lipid peroxidation as a marker of cytotoxicity. Biocoenotic indicators were used to evaluate effects on benthic invertebrates and diatoms. In bivalves, a decrease in antioxidant levels was found at the lowest concentrations tested (0.6 and 6 mg/L), whereas an increase in lipid peroxidation and mortality was registered at 30 mg/L after 15 days of exposure. Disturbances in freshwater communities occurred after 30 days at MMA concentrations of greater than 30 mg/L. Antioxidant responses in bivalves were recorded at the lowest MMA concentration tested, which was close to the predicted no-effect concentration (0.74 mg/L), and cytotoxicity was registered at a concentration corresponding to the 21-day no-observed-effect concentration for Daphnia magna. On the basis of the criteria studied, antioxidant biomarkers of bivalves appeared to be more sensitive than biocoenotic indicators to MMA.

4.40e+03

1.90e+04

7.30e+02

3.10e+03

1.40e+03

4.00e+01

3.00e-01

1.40e+00

7.00e-01

Volatile

2.36e+03

1.30e+04

5.80e+04

2.20e+03

9.20e+03

4.20e+03

The substance is harmful to aquatic organisms.

Methyl methacrylate's production and use in polymethacrylate resins, in medicinal adhesives, dental technology, bone cements, as a water-repellent on concrete surfaces, a poly(methyl methacrylate) block binding agent, a nitrile rubber comonomer, an engineering adhesive for industrial flooring compositions, a precast concrete composite, and a resin mortar may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 38.5 mm Hg at 25 °C indicates methyl methacrylate will exist solely as a vapor in the atmosphere. Vapor-phase methyl methacrylate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and ozone; the half-lives for these reactions in air are estimated to be 15 hours and 1 day, respectively. Methyl methacrylate does not contain chromophores that absorb at wavelengths >290 nm (wavelength max = 239 nm) and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, methyl methacrylate is expected to have very high to high mobility based upon Koc values of 9-95. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 3.2X10-4 atm-cu m/mole. Methyl methacrylate may volatilize from dry soil surfaces based upon its vapor pressure. Utilizing the Japanese MITI test, 94% of the theoretical BOD was reached in 2 weeks indicating that biodegradation is an important environmental fate process. If released into water, methyl methacrylate is expected to adsorb to suspended solids and sediment based upon the Koc values. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 5.7 hours and 4.8 days, respectively. An estimated BCF of 4 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis half-lives for methyl methacrylate of 4 years, 140 days, 14 days, and 3.4 hours have been calculated at pH values of 7, 8, 9 and 11, respectively. The rate constant for the aqueous-phase reaction of methyl methacrylate with photochemically-produced hydroxyl radicals has been determined to be 1.2X10+10 L/mol-sec at pH 7; this corresponds to an aqueous half-life of approximately 67 days at an aqueous hydroxyl radical concentration of 1X10-17 mol/L. Occupational exposure to methyl methacrylate may occur through inhalation and dermal contact with this compound at workplaces where methyl methacrylate is produced or used. Monitoring and use data indicate that the general population may be exposed to methyl methacrylate via inhalation of ambient air, ingestion of food and drinking water, and dermal contact with this compound or other products containing methyl methacrylate. (SRC)

Methyl methacrylate is not known to occur naturally(1).

Methyl methacrylate's production and use in polymethacrylate resins(1), in medicinal adhesives, dental technology, bone cements, and as a water-repellent on concrete surfaces(2), as a poly(methyl methacrylate) block binding agent, nitrile rubber comonomer, engineering adhesive for industrial flooring compositions, precast concrete composite, and resin mortar(3) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 9-72(2) and as high as 95(3), indicate that methyl methacrylate is expected to have very high to high mobility in soil(SRC). Volatilization of methyl methacrylate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.2X10-4 atm-cu m/mole(SRC), based upon its vapor pressure, 38.5 mm Hg(4), and water solubility, 1.57X10+4 mg/L(5). Methyl methacrylate is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Screening tests indicate that methyl methacrylate is readily biodegradable(6-8); it reached 94% of its theoretical BOD in 2 weeks using an activated sludge inoculum(6).

AQUATIC FATE: Based on a classification scheme(1), Koc values of 9-72(2) and as high as 95(3), indicate that methyl methacrylate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon an estimated Henry's Law constant of 3.2X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 38.5 mm Hg(5), and water solubility, 1.57X10+4 mg/L(6). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 5.7 hours and 4.8 days, respectively(SRC). According to a classification scheme(7), an estimated BCF of 4(SRC), from its log Kow of 1.38(8) and a regression-derived equation(9), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A base-catalyzed second-order hydrolysis rate constant of 5.6X10-2 L/mol-sec was determined for methyl methacrylate(10); this corresponds to half-lives of 4 years, 140 days, 14 days, and 3.4 hours at pH values of 7, 8, 9 and 11, respectively(SRC). The rate constant for the aqueous-phase reaction with photochemically-produced hydroxyl radicals has been determined to be 1.2X10+10 L/mol-sec at pH 7(11); this corresponds to an aqueous half-life of approximately 67 days at an aqueous hydroxyl radical concentration of 1X10-17 mol/L(12). Screening tests indicate that methyl methacrylate is readily biodegradable(13-15); it reached 94% of its theoretical BOD in 2 weeks using an activated sludge inoculum(13).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methyl methacrylate, which has a vapor pressure of 38.5 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase methyl methacrylate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 15 hours(SRC), calculated from its rate constant of 2.6X10-11 cu cm/molecule-sec at 25 °C(3). The rate constant for the reaction of methyl methacrylate with ozone is 1.1X10-17 cu cm/molc-sec(4), corresponding to a half-life of 1 day at an atmospheric concentration of 7X10+11 molecules/cu cm(5). Methyl methacrylate does not contain chromophores that absorb at wavelengths >290 nm (wavelength max = 239 nm)(6) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

AEROBIC: Methyl methacrylate, present at 100 mg/L, reached 94% of its theoretical BOD in 2 weeks using an activated sludge inoculum in the Japanese MITI test(1). In the modified Japanese MITI test, methyl methacrylate reached 32% of its theoretical BOD after 28 days; in a closed bottle test, methyl methacrylate released 88% of carbon dioxide evolution after 28 days; and >95% methyl methacrylate was degraded in the Zahn-Wellens test, time not specified(2). Methyl methacrylate was reported to be completely degraded by activated sludge in approximately 20 hours(3). In a standard biodegradability test using sewage seed, 42% of the theoretical BOD was consumed in 19 days, including a 3-4 day lag period; with acclimated seed, 66% of the theoretical BOD was consumed in 22 days(4). The biodegradation rate for methyl methacrylate at 75 ppm starting concentration, treated using a mixed microbial population immobilized in calcium alginate gel, was 9.3 ppm/hr; this corresponded to 89% removal due to biodegradation(5).

The rate constant for the vapor-phase reaction of methyl methacrylate with photochemically-produced hydroxyl radicals has been estimated as 2.6X10-11 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 15 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(2). The atmospheric lifetime of methyl methacrylate was reported to be <1 day to 1.5 days(3). Reaction products include pyruvic acid, methyl pyruvate, and epoxides(4). The rate constant for the aqueous-phase reaction with photochemically-produced hydroxyl radicals has been determined to be 1.2X10+10 L/mol-sec at pH 7(5); this corresponds to an aqueous half-life of approximately 67 days at an aqueous hydroxyl radical concentration of 1X10-17 mol/L(6). The rate constant for the vapor-phase reaction of methyl methacrylate with ozone has been estimated as 1.1X10-17 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). This corresponds to an atmospheric half-life of about 1 day at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(7). A base-catalyzed second-order hydrolysis rate constant of 5.6X10-2 L/mol-sec was determined for methyl methacrylate(8); this corresponds to half-lives of 4 years, 140 days, 14 days, and 3.4 hours at pH values of 7, 8, 9 and 11, respectively(SRC). Methyl methacrylate does not contain chromophores that absorb at wavelengths >290 nm (wavelength max = 239 nm)(9) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 4 was calculated in fish for methyl methacrylate(SRC), using a log Kow of 1.38(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of methyl methacrylate has been measured as 9-72(1) and as high as 95(2). According to a classification scheme(3), this Koc range suggests that methyl methacrylate is expected to have very high to high mobility in soil.

The Henry's Law constant for methyl methacrylate is estimated as 3.2X10-4 atm-cu m/mole(SRC) derived from its vapor pressure, 38.5 mm Hg(1), and water solubility, 1.57X10+4 mg/L(2). This Henry's Law constant indicates that methyl methacrylate is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 5.7 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 4.8 days(SRC). Methyl methacrylate's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of methyl methacrylate from dry soil surfaces may exist based upon its vapor pressure(1).

GROUNDWATER: Methyl methacrylate was not detected (detection limit: 0.35 ug/L) in 78 shallow groundwater wells from Glassboro, NJ, sampled Sept 1 to Dec 31, 1996(1).

DRINKING WATER: Methyl methacrylate was identified in commercial deionized charcoal-filtered water in New Orleans, LA, concentration not specified(1). Grab samples of raw and treated water were taken at waterworks treating lowland river water in the UK between March and December 1976; methyl methacrylate was identified in the survey of treated water, concentration unknown(2). Methyl methacrylate was listed as one of the many organic chemicals identified in drinking water in the US and Europe as of 1974(3). Methyl methacrylate was identified, but not quantified, in USA drinking water(4) and in finished drinking water at levels <1 ppb(5).

SURFACE WATER: In a survey conducted at 14 heavily industrialized river basins in the U.S., methyl methacrylate was detected in the Chicago area (204 sites sampled), 10 ppb(1) and in Lake Michigan (91 sites sampled), 10 ppb(2). Dutch surface water samples taken from 1992 to 1997 from the Rhine, Meuse, and Westerscheld were reported as <0.1 mg/L for methyl methacrylate, the northern delta area had concentrations of 0.1 mg/L(3).

Methyl methacrylate was detected in exhaust stacks from a plant where acrylic resin based paints were dried, concentration ranging from 5-20 ppm(1). Methyl methacrylate is a gaseous product of the combustion of polymethyl methacrylate(1). Methyl methacrylate was not detected in the extrusion emissions from generic polycarbonate resin types of food contact, compact discs, UV stabilized, radiation stabilized, branched, PC/ABS blend, or carbon resistant products(2). Methyl methacrylate was detected in the emissions of impact modified extrusion at 74.19-75.27 ug/g of material tested(2).

URBAN/SUBURBAN: According to a survey taken Nov 2002 to March 2003 outside of 74 residential homes in Ottawa, Ontario, Canada, methyl methacrylate was detected at 0.33 ug/cu m in 1% of the samples(1).

INDOOR: Methyl methacrylate was identified in Norwegian dental workroom air following finishing and polishing of a denture base resin, at a concentration of approximately 100 ppm(1). In a survey taken Nov 2002 to March 2003 of 75 residential homes in Ottawa, Ontario, Canada, methyl methacrylate was detected at 0.005-1.12 ug/cu m in 11% of the samples(2).

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U162, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

1.By absorbing it in vermiculite, dry sand, earth or similar material ... 2. By atomizing in suitable combustion chamber.

Do not empty into drains.

/GUIDE 129P: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /Methyl methacrylate monomer, stabilized/

/GUIDE 129P: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. /Methyl methacrylate monomer, stabilized/

/GUIDE 129P: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering. /Methyl methacrylate monomer, stabilized/

/GUIDE 129P: FLAMMABLE LIQUIDS (POLAR/WATER-MISCIBLE/NOXIOUS)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. /Methyl methacrylate monomer, stabilized/

For more DOT Emergency Guidelines (Complete) data for Methyl methacrylate (8 total), please visit the HSDB record page.

1247 129P

1247 129P(inhibited)

UN 1247; Methyl methacrylate monomer, stabilized[United Nations; Recommendations on the Transport of Dangerous Goods. Model Regulations. Vol. I, 16th Revised Edition (2009). Available from, as of March 22, 2010: http://www.unece.org/trans/danger/publi/unrec/rev16/16files_e.html]

Hazard Class or Division: 3; Methyl methacrylate monomer, stabilized[United Nations; Recommendations on the Transport of Dangerous Goods. Model Regulations. Vol. I, 16th Revised Edition (2009). Available from, as of March 22, 2010: http://www.unece.org/trans/danger/publi/unrec/rev16/16files_e.html]

49 072 50; Methyl methacrylate monomer, inhibited

49 072 55; Methyl methacrylate monomer, uninhibited

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Flammable Liquid

Symbol: F, Xi; R: 11-37/38-43; S: (2)-24-37-46; Note: D

UN Hazard Class: 3; UN Pack Group: II