Dibutyltin oxide

H301: Toxic if swallowed [Danger Acute toxicity, oral]

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H360FD: May damage fertility; May damage the unborn child [Danger Reproductive toxicity]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P203, P260, P264, P264+P265, P270, P280, P301+P316, P302+P352, P305+P354+P338, P317, P318, P319, P321, P330, P332+P317, P362+P364, P405, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for 0.8% (5 of 642) of reports.

H301 (86.4%): Toxic if swallowed [Danger Acute toxicity, oral]

H302 (12%): Harmful if swallowed [Warning Acute toxicity, oral]

H315 (66.2%): Causes skin irritation [Warning Skin corrosion/irritation]

H317 (60.3%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H318 (94.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H341 (90.2%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H360 (66.8%): May damage fertility or the unborn child [Danger Reproductive toxicity]

H360FD (24%): May damage fertility; May damage the unborn child [Danger Reproductive toxicity]

H370 (62.5%): Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372 (67.3%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H373 (27.7%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

H400 (25.9%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (43.6%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

H411 (52.2%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P203, P260, P261, P264, P264+P265, P270, P272, P273, P280, P301+P316, P301+P317, P302+P352, P305+P354+P338, P308+P316, P317, P318, P319, P321, P330, P332+P317, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 642 reports by companies from 33 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 5 of 642 reports by companies.

There are 32 notifications provided by 637 of 642 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]

H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P273, P391, and P501 (click each P-code to see the statement)

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H360: May damage fertility or the unborn child [Danger Reproductive toxicity]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

P203, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P305+P354+P338, P308+P316, P317, P318, P319, P321, P330, P332+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

H300: Fatal if swallowed [Danger Acute toxicity, oral]

H316: Causes mild skin irritation [Warning Skin corrosion/irritation]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

P203, P260, P264, P264+P265, P270, P280, P301+P316, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P405, and P501 (click each P-code to see the statement)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

Use water spray, powder, carbon dioxide.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Cool. Separated from food and feedstuffs, oxidants and bases. Provision to contain effluent from fire extinguishing.

0.02 [mg/m3], inhalable fraction, as Sn[German Research Foundation (DFG)]

0.1 [mg/m3], as Sn

25.0 [mg/m3], as Sn

0.2 [mg/m3], as Sn

(as Sn): 0.1 mg/m

(as Sn): 2 mg/m

(as Sn): 0.004 mg/m

A harmful concentration of airborne particles can be reached quickly when dispersed.

The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the nervous system. This may result in impaired functions. Exposure could cause death.

NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Prevent build-up of electrostatic charges (e.g., by grounding).

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Use local exhaust or breathing protection.

Protective gloves.

Wear face shield or eye protection in combination with breathing protection.

Do not eat, drink, or smoke during work. Wash hands before eating.

Dry Powder; Liquid; Wet Solid; Dry Powder; CBI

White solid; [Merck Index] White powder; [Sigma-Aldrich MSDS]

WHITE POWDER.

161.9 °C

Solubility in water, mg/l at 20 °C: 3.9-4.2 (very poor)

Relative density (water = 1): 1.5

Vapor pressure, Pa at 25 °C: 0.000004

5.33 (calculated)

Metals -> Tin Compounds, Organic

FCS -> FDA Cumulative Estimated Daily Intake (CEDI)

FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local release of pro-inflammatory cytokines, tumor necrosis factor-_, and/or interleukins. They may also induce apoptosis by direct action on neuronal cells. Organotin compounds stimulate the neuronal release of and/or decrease of neuronal cell uptake of neurotransmitters in brain tissue, including aspartate, GABA, glutamate, norepinephrine, and serotonin. This may be either a contributing factor to or result of the neuronal cell loss. The immunotoxic effects of organotins are characterized by thymic atrophy caused by the suppression of proliferation of immature thymocytes and apoptosis of mature thymocytes. Organotin compounds are believed to exert these effects by suppressing DNA and protein synthesis, inducing the expression of genes involved in apoptosis (such as nur77), and disrupting the regulation of intracellular calcium levels, giving rise to the uncontrolled production of reactive oxygen species, release of cytochrome c to the cytosol, and the proteolytic and nucleolytic cascade of apoptosis. The suppression of proliferation of immature thymocytes further results in the suppression of T-cell-mediated immune responses. Organotins are also endocrine disruptors and are believed to contribute to obesity by inappropriate receptor activation, leading to adipocyte differentiation. Inorganic tin triggers eryptosis, contributing to tin-induced anemia. (L308, A182, A184)

No indication of carcinogenicity to humans (not listed by IARC).

Breathing or swallowing, or skin contact with organotins, can interfere with the way the brain and nervous system work, causing death in severe cases. Organic tin compounds may also damage the immune and reproductive system. (L307, L308)

The substance can be absorbed into the body by inhalation and by ingestion.

Oral (L308) ; inhalation (L308) ; dermal (L308)

Headache. Confusion.

Redness. Pain. Further see Inhalation.

Redness. Pain.

See Inhalation.

Inorganic or organic tin compounds placed on the skin or in the eyes can produce skin and eye irritation. (L308)

Neurotoxin - Other CNS neurotoxin

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

The substance is very toxic to aquatic organisms. The substance may cause long-term effects in the aquatic environment. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

The substance is very toxic to aquatic organisms. The substance may cause long-term effects in the aquatic environment. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

Unbreakable packaging. Put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs.

Symbol: T, N; R: 21-25-36/38-48/23/25-50/53; S: (1/2)-35-36/37/39-45-60-61; Note: A, 1

UN Hazard Class: 6.1