2,4,6-trichlorophenol

H302: Harmful if swallowed [Warning Acute toxicity, oral]

H315: Causes skin irritation [Warning Skin corrosion/irritation]

H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H351: Suspected of causing cancer [Warning Carcinogenicity]

H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P203, P264, P264+P265, P270, P273, P280, P301+P317, P302+P352, P305+P351+P338, P318, P321, P330, P332+P317, P337+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement)

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Aggregated GHS information provided per 46 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]

H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

P203, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P308+P316, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

P203, P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P318, P321, P330, P332+P317, P337+P317, P362+P364, P405, and P501 (click each P-code to see the statement)

H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Fresh air, rest.

Remove contaminated clothes. To remove substance use polyethylene glycol 300 or vegetable oil. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Phenols are very toxic poisons AND corrosive and irritating, so that inducing vomiting may make medical problems worse. IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)

Use foam, dry powder, carbon dioxide.

If material /is/ involved in /a/ fire, extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn or burns with difficulty. /Trichlorophenol/

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Special hazards arising from the substance or mixture: Carbon oxides, hydrogen chloride gas.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Activated carbon is a good method for removing chlorophenols from water. Competitive adsorption occurs between chlorophenols & humic substances present in nearly all municipal water supplies. This competition decr the capacity of carbon for chlorophenols. /Chlorophenols/

Land Spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with plastic sheet to prevent dissolving in rain or fire fighting water. /Trichlorophenol/

Water Spill: Use natural deep water pockets, excavated lagoons, or sand bag barriers to trap material at bottom. If dissolved, apply activated carbon at ten times the spilled amount in region of 10 ppm or greater concentration. Remove trapped material with suction hoses. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates. /Trichlorophenol/

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

Accidental Release Measures. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste numbers D042 and F027, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

2,4,6-Trichlorophenol is a potential candidate for rotary kiln incineration, with a temperature range of 820 to 1,600 °C and a residence time of seconds.

Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced. Recommendable method: Incineration. Not recommendable method: Discharge to sewer.

PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/

For more Disposal Methods (Complete) data for 2,4,6-TRICHLOROPHENOL (13 total), please visit the HSDB record page.

Keep material out of water sources and sewers; Build dikes to contain flow as necessary. Keep upwind; Avoid breathing vapors or dusts; Wash away any material which may have contacted the body with copious amounts of water or soap and water. /Trichlorophenol/

Smoking, eating, and drinking before washing should be absolutely prohibited when any pesticide ... is being handled or used. /Pesticides/

PRECAUTIONS FOR "CARCINOGENS": Smoking, drinking, eating, storage of food or of food & beverage containers or utensils, & the application of cosmetics should be prohibited in any laboratory. All personnel should remove gloves, if worn, after completion of procedures in which carcinogens have been used. They should ... wash ... hands, preferably using dispensers of liq detergent, & rinse ... thoroughly. Consideration should be given to appropriate methods for cleaning the skin, depending on nature of the contaminant. No standard procedure can be recommended, but the use of organic solvents should be avoided. Safety pipettes should be used for all pipetting. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": In animal laboratory, personnel should remove their outdoor clothes & wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... clothing should be changed daily but ... discarded immediately if obvious contamination occurs ... /also,/ workers should shower immediately. In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. If gowns are of distinctive color, this is a reminder that they should not be worn outside of lab. /Chemical Carcinogens/

For more Preventive Measures (Complete) data for 2,4,6-TRICHLOROPHENOL (16 total), please visit the HSDB record page.

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should store this material at ambient temperatures and keep it away from oxidizing materials. (NTP, 1992)

Provision to contain effluent from fire extinguishing. Separated from strong oxidants and food and feedstuffs. Well closed. Store in an area without drain or sewer access.

PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place.

1.0 [mg/m3]

27 [mg/m3]

160 [mg/m3]

Acute Oral: 0.01 mg/kg/day (Rat) (L159)

Intermediate oral: 0.003 mg/kg/day (Rat) (L159)

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached when dispersed.

The substance is severely irritating to the eyes, skin and respiratory tract.

Repeated or prolonged contact with skin may cause dermatitis including chloracne. The substance may have effects on the liver. This may result in impaired functions. This substance is possibly carcinogenic to humans. Tumours have been detected in experimental animals but may not be relevant to humans.

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

/Wear/ approved dust respirator for toxic dusts; goggles; protective clothing to prevent contact with skin. /Trichlorophenol/

Wear appropriate chemical protective gloves, boots and goggles. /Trichlorophenol/

PRECAUTIONS FOR "CARCINOGENS": ... Dispensers of liq detergent /should be available./ ... Safety pipettes should be used for all pipetting. ... In animal laboratory, personnel should ... wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. ... gowns ... /should be/ of distinctive color, this is a reminder that they are not to be worn outside the laboratory. /Chemical Carcinogens/

Eye/face protection: Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

For more Personal Protective Equipment (PPE) (Complete) data for 2,4,6-TRICHLOROPHENOL (7 total), please visit the HSDB record page.

PREVENT DISPERSION OF DUST!

Use ventilation (not if powder), local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety goggles or face shield.

Do not eat, drink, or smoke during work.

2,4,6-trichlorophenol appears as yellow to pinkish-orange needles or orange fluffy solid. Strong phenolic odor. (NTP, 1992)

Colorless to yellow solid with a strong odor of phenol; [HSDB] Yellow-brown crystalline chunks; [MSDSonline]

COLOURLESS-TO-YELLOW CRYSTALS WITH CHARACTERISTIC ODOUR.

Crystals from ligroin

Yellow flakes

Orthorhombic needles from acetic acid

Strong phenolic odor

Taste threshold in water: 2.0 ug/l

475 °F at 760 mmHg (NTP, 1992)

246 °C @760 [mm Hg]

157.1 °F (NTP, 1992)

99 °C c.c.

less than 0.1 mg/mL at 64 °F (NTP, 1992)

In water, 500 mg/L at 25 °C

525 g/100 g acetone; 113 g/100 g benzene; 37 g/100 g carbon tetrachloride; 335 g/100 g diacetone alcohol; 400 g/100 g denatured alcohol formula; 525 g/100 g methanol; 163 g/100 g pine oil; 16 g/100 g Stoddard solvent; 100 g/100 g toluene; 37 g/100 g turpentine

Soluble in ethanol, ethyl ether, acetic acid

Solubility in water, g/l at 20 °C: 0.8 (very poor)

1.675 at 77 °F (NTP, 1992) - Denser than water; will sink

Density: 1.4901g/cu cm at 75 °C

Density (at 25 °C): 1.7 g/cm³

1.4901 @ 75°C

1 mmHg at 169.7 °F ; 5 mmHg at 222.6 °F (NTP, 1992)

0.008 [mmHg]

0.008 mm Hg at 25 °C

Vapor pressure, Pa at 76.5 °C: 133

0.75 [mm Hg] @71.8 °C

log Kow = 3.69

Stable up to its melting point

Stable under recommended storage conditions.

When heated to decomposition it emits toxic fumes of /hydrogen chloride/.

14,092.8 g cal/g mole

Moderately acidic substance

Odor Threshold Low: 200.0 [ppm]

Odor threshold (recognition) from CHEMINFO

100 ug/L at 30 °C; 1,222 ug/L at 25 °C /Purity not specified/

pKa = 6.23 at 25 °C

128.7 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID5021386]

Specific gravity: 1.675 at 25 °C/4 °C

Volatilie with steam, but not from alkaline solution

As a group, the chlorophenols are characterized by an odor which has been described as unpleasant, medicinal, pungent, phenolic, strong, or persistent. /Chlorinated phenols/

Insoluble in water.

Phenols and Cresols

Acids, Weak

Aryl Halides

2,4,6-TRICHLOROPHENOL is incompatible with acid chlorides, acid anhydrides and oxidizing agents. It can be converted to the sodium salt by reaction with sodium carbonate. Forms ethers, esters and salts by reaction with metals and amines. Undergoes substitution reactions such as nitration, alkylation, acetylation and halogenation. Can be hydrolyzed by reaction with bases at elevated temperatures and pressures. Reacts with alkalis at high temperatures (NTP, 1992).

Incompatible materials: Strong oxidizing agents.

IDENTIFICATION AND USE: 2,4,6-Trichlorophenol (2,4,6 -TCP) is a colorless needle or yellow solid that has a strong phenolic odor. This germicidal agent was used as a fungicide, bactericide, wood preservative, biocide, and intermediate in production of higher chlorinated phenols. It is not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. HUMAN EXPOSURE AND TOXICITY: Trichlorophenols produce redness and edema on skin contact and on prolonged exposure mild to moderate chemical burns of skin of man. In eye they induce conjunctival irritation and sometimes corneal injury and iritis. Dusts are irritating to nose and pharynx and systemic effects presumably resemble phenol. Trichlorophenols can have an irritating effect on the lung, and it cannot be excluded that long-term exposure may produce pulmonary fibrosis. Children with low levels (<3.58 ug/g) and high levels (=3.58 ug/g) of urinary 2,4,6-TCP had a higher risk of parent-reported ADHD compared to children with levels below the limit of detection after adjusting for covariates. It was concluded that exposure to TCP may increase the risk of behavioral impairment in children. The potential neurotoxicity of these chemicals should be considered in public health efforts to reduce environmental exposures/contamination, especially in countries where organochlorine pesticides are still commonly used. 2,4,6-Trichlorophenol is reasonably anticipated to be a human carcinogen according to NTP. ANIMAL STUDIES: In rats lethal doses of chlorophenols produce restlessness, increased rate of respiration, rapidly developing motor weakness, tremors, clonic convulsions, dyspnea, and coma. 2,4,6-TCP produces these signs but decreased activity and motor weakness do not appear quite so promptly. 2,4,6-TCP was not hepatotoxic in rats as assessed by measurement of hepatic glucose-6-phosphatase and serum sorbitol dehydrogenase. Carcinogenesis bioassays were conducted by giving 2,4,6-TCP in feed to groups of male and female rats and male mice for two years. Adverse effects at two years were leukocytosis and monocytosis of peripheral blood and hyperplasia of bone marrow in both sexes of rats. In mice, liver toxicity, including individual liver cell abnormalities, focal areas of cellular alteration, and focal and nodular areas of hyperplasia were commonly present. TCP caused leukemias/lymphomas in male rats, and possibly in female rats and female mice as well, and induced liver tumors in male and female mice. 2,4,6-TCP, a non-mutagen to Salmonella, was negative in tests for chromosome breakage in vitro, but did produce numerical chromosome changes and micronuclei in V79 cells. 2,4,6-TCP induces structural chromosome aberrations in CHO cells and in V79 cells using a 3-hr treatment and 20-hr sampling time (17-hr recovery). Positive results were obtained when a recovery time of 4-12 hr was allowed after the 24-hr treatment with 2,4,6-TCP, and when 2,4,6-TCP was tested with S9. ECOTOXICITY STUDIES: 2,4,6-TCP was applied at single doses of into compartments of a natural experimental pond to study the effect on biota. Changes seen included a rapid decline of daphnia concentration to zero after phytoplankton, a continuous increase of contamination indicators like flagellates and microorganisms, and a significant decrease in O2 concentration as a secondary effect of the changed balance between autotrophic and heterotrophic populations.

2,4,6-Trichlorophenol is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesterase. Because of its essential function, chemicals that interfere with the action of acetylcholinesterase are potent neurotoxins, causing excessive salivation and eye-watering in low doses, followed by muscle spasms and ultimately death. Nerve gases and many substances used in insecticides have been shown to act by binding a serine in the active site of acetylcholine esterase, inhibiting the enzyme completely. Acetylcholine esterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions, in order to allow the muscle or organ to relax. The result of acetylcholine esterase inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop. Among the most common acetylcholinesterase inhibitors are phosphorus-based compounds, which are designed to bind to the active site of the enzyme. The structural requirements are a phosphorus atom bearing two lipophilic groups, a leaving group (such as a halide or thiocyanate), and a terminal oxygen.

2,4,6-Trichlorophenol

Hematologic

Semi-Volatile Organic Compound (SVOC)

Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP

CLASSIFICATION: B2; probable human carcinogen. BASIS FOR CLASSIFICATION: Based on no human data and sufficient evidence in animals; namely, increased incidence of lymphomas or leukemia in male rats and hepatocellular adenomas or carcinomas in male and female mice. HUMAN CARCINOGENICITY DATA: None. ANIMAL CARCINOGENICITY DATA: Sufficient.

Evaluation: There is limited evidence in humans for the carcinogenicity of combined exposures to polychlorophenols or to their sodium salts. There is limited evidence in experimental animals for the carcinogenicity of 2,4,6-trichlorophenol. Overall evaluation: Combined exposures to polychlorophenols or to their sodium salts are possibly carcinogenic to humans (Group 2B). /Polychlorophenols/

2,4,6-Trichlorophenol: reasonably anticipated to be a human carcinogen.

Group 2B: Possibly carcinogenic to humans

Volume 117: (2019) Pentachlorophenol and Some Related Compounds

TR-155: Bioassay of 2,4,6-Trichlorophenol for Possible Carcinogenicity (CASRN 88-06-2) (1979 )

12/13/78

Clear Evidence

No Evidence

It is concluded that under the conditions of this bioassay, 2,4,6-trichlorophenol was carcinogenic in male F344 rats, inducing lymphomas or leukemias. The test chemical was also carcinogenic in both sexes of B6C3F1 mice, inducing hepatocellular carcinomas or adenomas.

2B, possibly carcinogenic to humans. (L135)

Acute exposure to cholinesterase inhibitors can cause a cholinergic crisis characterized by severe nausea/vomiting, salivation, sweating, bradycardia, hypotension, collapse, and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved. Accumulation of ACh at motor nerves causes overstimulation of nicotinic expression at the neuromuscular junction. When this occurs symptoms such as muscle weakness, fatigue, muscle cramps, fasciculation, and paralysis can be seen. When there is an accumulation of ACh at autonomic ganglia this causes overstimulation of nicotinic expression in the sympathetic system. Symptoms associated with this are hypertension, and hypoglycemia. Overstimulation of nicotinic acetylcholine receptors in the central nervous system, due to accumulation of ACh, results in anxiety, headache, convulsions, ataxia, depression of respiration and circulation, tremor, general weakness, and potentially coma. When there is expression of muscarinic overstimulation due to excess acetylcholine at muscarinic acetylcholine receptors symptoms of visual disturbances, tightness in chest, wheezing due to bronchoconstriction, increased bronchial secretions, increased salivation, lacrimation, sweating, peristalsis, and urination can occur. Certain reproductive effects in fertility, growth, and development for males and females have been linked specifically to organophosphate pesticide exposure. Most of the research on reproductive effects has been conducted on farmers working with pesticides and insecticdes in rural areas. In females menstrual cycle disturbances, longer pregnancies, spontaneous abortions, stillbirths, and some developmental effects in offspring have been linked to organophosphate pesticide exposure. Prenatal exposure has been linked to impaired fetal growth and development. Neurotoxic effects have also been linked to poisoning with OP pesticides causing four neurotoxic effects in humans: cholinergic syndrome, intermediate syndrome, organophosphate-induced delayed polyneuropathy (OPIDP), and chronic organophosphate-induced neuropsychiatric disorder (COPIND). These syndromes result after acute and chronic exposure to OP pesticides.

The substance can be absorbed into the body through the skin and by ingestion.

Oral (L159); inhalation (L159) ; dermal (L159)

Cough. Sore throat.

Redness. Pain.

Vomiting. Burning sensation. Diarrhoea.

Inhalation of 2,4,6-trichlorophenol may cause coughing and sore throat. Eye or skin contact causes redness and pain at the site of contact. Convulsions, diarrhoea, dizziness, deadache, shortness of breath, vomiting, weakness, and ataxia may occur after ingestion. (L160)

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.

Other Poison - Uncoupler

NTP Carcinogen - Reasonably anticipated to be a human carcinogen.

1 x 10^-3 mg/kg-day

PDF Document

See the IRIS entry for 2,4,6-Trichlorophenol

IRIS Current

PPRTV Current

ATSDR Final

LD50 Rat oral 2.8 g/kg

LD50 Rat oral 820 mg/kg

LD50 RAT ip 276 mg/kg

If the compound has been ingested, rapid gastric lavage should be performed using 5% sodium bicarbonate. For skin contact, the skin should be washed with soap and water. If the compound has entered the eyes, they should be washed with large quantities of isotonic saline or water. In serious cases, atropine and/or pralidoxime should be administered. Anti-cholinergic drugs work to counteract the effects of excess acetylcholine and reactivate AChE. Atropine can be used as an antidote in conjunction with pralidoxime or other pyridinium oximes (such as trimedoxime or obidoxime), though the use of '-oximes' has been found to be of no benefit, or possibly harmful, in at least two meta-analyses. Atropine is a muscarinic antagonist, and thus blocks the action of acetylcholine peripherally.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Phenols and related compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist respirations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Administer activated charcoal ... . Do not use emetics ... . Cover skin burns with dry, sterile dressings after decontamination ... . Maintain body temperature. /Phenols and related compounds/

EC50; Species: Scenedesmus subspicatus (Green Algae); Conditions: freshwater, static; Concentration: 279000 ug/L for 49-79 min; Effect: population, decreased photosynthesis

EC50; Species: Chlorella vulgaris (Green Algae) Exponential Growth Phase, 50000 cells/mL; Conditions: freshwater, static, 21 °C; Concentration: 10000 ug/L for 4 hr; Effect: general growth /formulation/

EC50; Species: Pseudokirchneriella subcapitata (Green Algae) Exponential Growth Phase, 50000 cells/mL; Conditions: freshwater, static, 21 °C; Concentration: 3500 ug/L for 4 hr; Effect: general growth /formulation/

EC50; Species: Daphnia magna (Water Flea) age 0-24 hr; Conditions: freshwater, flow through, 17.2 (16.5-18.4) °C, pH 7.39 (6.84-7.80), hardness 44.7 mg/L CaCO3 (40.8-47.6 mg/L CaCO3), alkalinity 43.0 mg/L CaCO3 (40.4-49.5 mg/L CaCO3), dissolved oxygen 8.7 (4.8-10.7) mg/L ; Concentration: 3340 ug/L for 48 hr (95% confidence interval: 2810-3970 ug/L); Effect: intoxication, immobilization

For more Ecotoxicity Values (Complete) data for 2,4,6-TRICHLOROPHENOL (12 total), please visit the HSDB record page.

/AQUATIC SPECIES/ 2,4,6-trichlorophenol was applied at single doses of 5 mg/L in duplicates into compartments of a natural experimental pond to study the effect on biota. Changes seen included a rapid decline of Daphnia concentration to zero after phytoplankton, a continuous increase of contamination indicators like flagellates and microorganisms, and a significant decrease in O2 concentration as a secondary effect of the changed balance between autotrophic and heterotrophic populations.

/AQUATIC SPECIES/ Rainbow trout were exposed for 4 or 8 days to various types of toxicants, each applied to the test water at a high sublethal concentration. The activity of liver uridine diphosphate-glucuronosyltransferase was assayed from the submitochondrial fraction using p-nitrophenol as an aglycone. Activity of uridine diphosphate-glucuronosyltransferase was inhibited by 2,4,6-trichlorophenol.

/AQUATIC SPECIES/ Correlation was found between acute (24 hr) toxicity (median inhibitory concn IC50) to Daphnia magna of 17 chlorophenols /including 2,4,6-trichlorophenol/ and their octanol water partition coefficients, dissociation constants, melting points, the perimeter of the efficient section of the molecule or molecular connectivity index of the first order. Phenols with chlorine in para-position were more toxic than those with chlorine in ortho-position.

4.90e+01

2.10e+02

9.10e-01

4.00e+00

4.10e+00

5.00e+00

4.00e-03

1.10e-02

1.00e-03

Volatile

1.90e+02

2.50e+03

9.10e+01

4.00e+02

3.60e+01

The substance is very toxic to aquatic organisms. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

2,4,6-Trichlorophenol's production and use in the manufacture of the fungicide Prochloraz may result in its release to the environment through various waste streams. Its former use as a defoliant, herbicide, and fungicide may have resulted in its direct release to the environment. 2,4,6-Trichlorophenol may also be released to the environment as a result of the chlorination of phenol-containing wastewater or drinking water and from the bleaching process in pulp and paper mills. If released to air, a vapor pressure of 0.008 mm Hg at 25 °C indicates 2,4,6-trichlorophenol will exist solely as a vapor in the atmosphere. Vapor-phase 2,4,6-trichlorophenol will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 24 days. 2,4,6-Trichlorophenol contains chromophores that absorb at wavelengths >290 nm and, therefore, may be susceptible to direct photolysis by sunlight. If released to soil, 2,4,6-trichlorophenol is expected to have moderate to slight mobility based upon Koc values of 150-2200. The pKa of 2,4,6-trichlorophenol is 6.23, indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts. Volatilization from moist soil surfaces of the neutral form is expected to be an important fate process based upon an estimated Henry's Law constant of 4.2X10-6 atm-cu m/mole. Volatilization from moist soil of the anion form is not expected because anions do not volatilize. 2,4,6-Trichlorophenol is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Utilizing the Japanese MITI test, 82.5-89.3% of the theoretical BOD was reached in 2 weeks indicating that biodegradation is an important environmental fate process. If released into water, 2,4,6-trichlorophenol is expected to adsorb to suspended solids and sediment based upon the Koc values. 2,4,6-Trichlorophenol will biodegrade in water based on results of 100% degradation in 8-14 days. Volatilization from water surfaces of the anion form is not expected to be an important fate process based upon this compound's pKa. However, the neutral form of 2,4,6-trichlorophenol is expected to volatilize based on the Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 20 and 150 days, respectively. BCF values of 87-676 in fish suggest bioconcentration in aquatic organisms is moderate to high. 2,4,6-Trichlorophenol is expected to undergo photolysis in surface waters based on an aqueous photodegradation half-life of 2.1 hours. 2,4,6-Trichlorophenol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions. Occupational exposure to 2,4,6-trichlorophenol may occur through inhalation and dermal contact with this compound at workplaces where 2,4,6-trichlorophenol is produced or used. Monitoring data indicate that the general population may be exposed to 2,4,6-trichlorophenol via ingestion of contaminated fish or drinking water. (SRC)

2,4,6-Trichlorophenol is not known to occur as a natural product. However, it may be formed during forest fires(1).

2,4,6-Trichlorophenol's production and use in the manufacture of the fungicide Prochloraz(1) may result in its release to the environment through various waste streams. Its former use as a defoliant, herbicide, and fungicide(2) may have resulted in its direct release to the environment. 2,4,6-Trichlorophenol may also be released to the environment as a result of the chlorination of phenol-containing wastewater or drinking water(3) and from the bleaching process in pulp and paper mills(4).

2,4,6-Trichlorophenol can be formed when industrial wastewater containing phenol or certain aromatic acids is treated with hypochlorite.

Chlorophenols may be produced inadvertently by chlorination reactions which take place during the disinfection of wastewater effluents or drinking water sources. Chlorinated phenols represent important compounds with regard to potential point source and non-point source water contamination. /Chlorinated phenols/

TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 150-2200(2-4), indicate that 2,4,6-trichlorophenol is expected to have moderate to slight mobility in soil(SRC). The pKa of 2,4,6-trichlorophenol is 6.23(5), indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(6). Volatilization of the anion form of 2,4,6-trichlorophenol from moist soil surfaces is not expected because anions do not volatilize(SRC). Volatilization of neutral 2,4,6-trichlorophenol from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.2X10-6 atm-cu m/mole(SRC), based upon its vapor pressure, 0.008 mm Hg(7), and water solubility, 500 mg/L(8). 2,4,6-Trichlorophenol is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(7). This compound is expected to biodegrade in soils with aerobic and anaerobic biodegradation half-lives in soils of about 5 and 20 days, respectively(9).

AQUATIC FATE: Based on a classification scheme(1), a Koc values of 150-2200(2-4), indicate that 2,4,6-trichlorophenol is expected to adsorb to suspended solids and sediment(SRC). A pKa of 6.23(5) indicates 2,4,6-trichlorophenol will exist partially in the anion form at pH values of 5 to 9 and, therefore, volatilization of the anion form from water surfaces is not expected to be an important fate process(SRC). Volatilization of the neutral form from water surfaces is expected(6) based upon an estimated Henry's Law constant of 4.2X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 0.008 mm Hg(7), and water solubility, 500 mg/L(8). Using this Henry's Law constant and an estimation method(6), volatilization half-lives for the neutral form from a model river and model lake are 20 and 150 days, respectively(SRC). 2,4,6-Trichlorophenol is expected to undergo photolysis in surface waters based on an aqueous photodegradation half-life of 2.1 hours when irradiated with light at environmentally relevant wavelengths(9). 2,4,6-Trichlorophenol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(6). According to a classification scheme(10), BCFs of 87-676(11-13) in fish, suggest bioconcentration in aquatic organisms is moderate to high(SRC). 2,4,6-Trichlorophenol biodegraded 100% in 8-14 days in filtered and unfiltered water(14).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2,4,6-trichlorophenol, which has a vapor pressure of 0.008 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2,4,6-trichlorophenol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 24 days(SRC), calculated from its rate constant of 6.1X10-13 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 2,4,6-Trichlorophenol contains chromophores that absorb at wavelengths >290 nm(4) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). Coated on silica gels and irradiated with light wavelengths >290 nm for 17 hours, 2,4,6-trichlorophenol was degraded 65.8%(5).

AEROBIC: 2,4,6-Trichlorophenol biodegraded 100% in 10-14 days with an 8 day lag time in filtered water and in 8-10 days with a 2 day lag time in water with sediment(1). 2,4,6-Trichlorophenol is expected to biodegrade in aerobic soils with a biodegradation half-life of about 5 days(2). Total degradation of 2,4,6-trichlorophenol in Dunkirk silt loam took 5 days and in Mardin silt loam took 13 days(3). In Labisch soil, 2,4,6-trichlorophenol biodegraded 67% in 60 days(4). 2,4,6-Trichlorophenol was aerobically degraded 95% in 3 days and 27% in 80 days in non-sterile and sterile clay loam, respectively(5). Microbial degradation, volatilization, and photodecomposition were ruled out in the sterile soil indicating that other mechanisms contribute to degradation(5). Activated sludge made from soil resulted in 100% removal of 2,4,6-trichlorophenol in 3 days(6); sewage seed resulted in complete removal in 7 days(7); 39% removal by activated sludge in 14 days was reported(8). 2,4,6-Trichlorophenol was readily degraded in an aerobic microcosm using soils from the saturated zone(9). A 2,4-dichlorophenol-acclimated soil inoculum completely degraded an unspecified initial concentration of 2,4,6-trichlorophenol in 28 days(10). 2,4,6-Trichlorophenol, present at 1.5 mg/L, was completely degraded in 8 days using an inoculum derived from river sediment obtained near a petrochemical plant(11). The compound was 92% degraded in 30 days using an activated sludge inoculum(12). 2,4,6-Trichlorophenol, present at 100 mg/L, reached 82.5-89.3% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(13).

ANAEROBIC: 2,4,6-Trichlorophenol is expected to biodegrade in anaerobic soils with a biodegradation half-life of about 20 days(1). A pentachlorophenol acclimated anaerobic digester degraded 2,4,6-trichlorophenol to 2,4-dichlorophenol in 36 hours(2). An anaerobic sludge digester completely converted 2,4,6-trichlorophenol to 4-chlorophenol in 13 days(3). Anaerobic degradation of 28% and 25% in 80 days was reported in non-sterile and sterile clay loam(4). Microbial degradation, volatilization, and photodecomposition were ruled out in both sterile and non-sterile soils under anaerobic conditions indicating that other mechanisms contribute to degradation(4). 2,4,6-Trichlorophenol was degraded 82% in 12 hrs using an anaerobic fluidized bed reactor(5). 2,4,6-Trichlorophenol was readily degraded in an anaerobic microcosm using subsurface soils from both unsaturated and saturated zones(6).

The rate constant for the vapor-phase reaction of 2,4,6-trichlorophenol with photochemically-produced hydroxyl radicals has been estimated as 6.1X10-13 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 24 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 2,4,6-Trichlorophenol contains chromophores that absorb at wavelengths >290 nm(2) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). Coated on silica gels and irradiated with light wavelengths >290 nm for 17 hours, 2,4,6-trichlorophenol was degraded 65.8%(3). The rate constant for the reaction of hydroxyl radicals in aqueous solutions is 1.7X10+7 L/mol-sec(4); this corresponds to an aquatic half-life of 130 years at an aquatic concentration of 1X10-17 hydroxyl radicals per liter(5). 2,4,6-Trichlorophenol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(6). 2,4,6-Trichlorophenol is expected to photodegrade in surface waters based on an aqueous photodegradation half-life of 2.1 hours when irradiated with light at environmentally relevant wavelengths(7).

BCFs of 250-310 were reported for Golden Orfe fish (1,2). BCFs of 87 and 676 were reported for flagfish (Jordanella floridae)(3). A BCF of 270 was also reported(4). According to a classification scheme(5), these BCF values suggest that bioconcentration in aquatic organisms is moderate to high(SRC).

The Koc values of 2,4,6-trichlorophenol in soil at pH 6, 7 and 7.7 were measured as 2200, 600 and 150 respectively(1). Koc values of 1300 and 800 were determined in river and lake sediment at an unspecified pH(2). Koc values of 2000(3), 1050(4) and 1070(5) were also reported for 2,4,6-trichlorophenol. According to a classification scheme(6), these Koc values suggest that 2,4,6-trichlorophenol is expected to have moderate to slight mobility in soil. The pKa of 2,4,6-trichlorophenol is 6.23(7), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(8).

A pKa of 6.23(1) indicates 2,4,6-trichlorophenol will exist partially in the anion form at pH values of 5 to 9 and, therefore, volatilization of the ionic form from water and moist surfaces is not expected to be an important fate process(SRC). The Henry's Law constant for 2,4,6-trichlorophenol is estimated as 4.2X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 0.008 mm Hg(2), and water solubility, 500 mg/L(3). This Henry's Law constant indicates that neutral 2,4,6-trichlorophenol is expected to volatilize from water surfaces(4). Based on this Henry's Law constant, the volatilization half-life of the neutral form from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 20 days(SRC). The volatilization half-life of the neutral form from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 150 days(SRC). 2,4,6-Trichlorophenol's estimated Henry's Law constant indicates that volatilization from moist soil surfaces of the neutral form may occur(SRC). 2,4,6-Trichlorophenol is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2).

GROUNDWATER: 2,4,6-Trichlorophenol was detected in 7 of 12 groundwater samples collected near a Finnish sawmill at an average and maximum of 0.03 and 12 ppb, respectively(1). At a creosote waste site in Conroe, TX, 2,4,6-trichlorophenol was detected in 3 of 5 groundwater samples at 91.3 ppb 50 ft from the nearest pit and was not detected in 5 samples 300 ft from the nearest pit(2). 2,4,6-Trichlorophenol was identified, not quantified, in groundwater in western suburbs of Melbourne, Australia(3). 2,4,6-Trichlorophenol was detected in 1 of 20 groundwater wells dug for testing near Mt St Helens (1981-1982) at 1.1 ppb(4). 2,4,6-Trichlorophenol was identified, not quantified, in the groundwater near a US army site in Rhode Island(5).

DRINKING WATER: 2,4,6-Trichlorophenol was identified, not quantified, in finished US drinking water(2-4). The mean concentration of 2,4,6-trichlorophenol in Utah drinking water was 0.7 ug/L(8). 2,4,6-Trichlorophenol was detected at 16-60 parts per trillion in the finished drinking water of 3 of 6 Canadian cities in Feb 1985 and at 12 parts per trillion in the raw water of 1 of 6 cities(5). 2,4,6-Trichlorophenol frequency of detection/maximum level parts per trillion in samples from 40 potable water treatment plants in Canada: treated water, 11/719 (Oct-Dec, 1984), 11/61 (Feb-Mar, 1985), 8/148 (May-Jul, 1985), raw water, 3/23 (Oct/Dec, 1984)(6). 2,4,6-Trichlorophenol was detected in the drinking water of Ville Mercier, Quebec at 0.1 ug/L(7). 2,4,6-Trichlorophenol was detected in the tap water of Janakka and Jyvaskyla, Finland at 30 and 14 parts per trillion, respectively(1). 2,4,6-Trichlorophenol was not detected (detection limit 0.008 mg/L) in drinking water samples from two treatment plants along the Tigris River, Baghdad(9).

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste numbers D042 and F027, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

2,4,6-Trichlorophenol is a potential candidate for rotary kiln incineration, with a temperature range of 820 to 1,600 °C and a residence time of seconds.

Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced. Recommendable method: Incineration. Not recommendable method: Discharge to sewer.

PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/

For more Disposal Methods (Complete) data for 2,4,6-TRICHLOROPHENOL (13 total), please visit the HSDB record page.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Chlorophenols, liquid; Chlorophenols, solid/

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. /Chlorophenols, liquid; Chlorophenols, solid/

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Chlorophenols, liquid; Chlorophenols, solid/

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Chlorophenols, liquid; Chlorophenols, solid/

For more DOT Emergency Guidelines (Complete) data for 2,4,6-TRICHLOROPHENOL (8 total), please visit the HSDB record page.

UN 2020; Chlorophenols, solid

UN 2021; Chlorophenols, liquid

IMO 6.1; Chlorophenols, solid; Chlorophenols, liquid

49 403 25; Trichlorophenol

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. /Chlorophenols, solid; Chlorophenols, liquid/

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. /Chlorophenols, solid; Chlorophenols, liquid/

PRECAUTIONS FOR "CARCINOGENS": Procurement ... of unduly large amt ... should be avoided. To avoid spilling, carcinogens should be transported in securely sealed glass bottles or ampoules, which should themselves be placed inside strong screw-cap or snap-top container that will not open when dropped & will resist attack from the carcinogen. Both bottle & the outside container should be appropriately labelled. ... National post offices, railway companies, road haulage companies & airlines have regulations governing transport of hazardous materials. These authorities should be consulted before ... material is shipped. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": When no regulations exist, the following procedure must be adopted. The carcinogen should be enclosed in a securely sealed, watertight container (primary container), which should be enclosed in a second, unbreakable, leakproof container that will withstand chem attack from the carcinogen (secondary container). The space between primary & secondary container should be filled with absorbent material, which would withstand chem attack from the carcinogen & is sufficient to absorb the entire contents of the primary container in the event of breakage or leakage. Each secondary container should then be enclosed in a strong outer box. The space between the secondary container & the outer box should be filled with an appropriate quantity of shock-absorbent material. Sender should use fastest & most secure form of transport & notify recipient of its departure. If parcel is not received when expected, carrier should be informed so that immediate effort can be made to find it. Traffic schedules should be consulted to avoid ... arrival on weekend or holiday ... /Chemical Carcinogens/

Do not transport with food and feedstuffs. Marine pollutant.

H302; H315; H319; H351; H400; H410

UN Hazard Class: 6.1; UN Pack Group: III