phenyltrichlorosilane

This chemical does not meet GHS hazard criteria for 0.8% (1 of 119) of reports.

H312 (76.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H314 (99.2%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318 (20.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H330 (37.8%): Fatal if inhaled [Danger Acute toxicity, inhalation]

H335 (22.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P260, P261, P264, P264+P265, P271, P280, P284, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P320, P321, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 119 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 1 of 119 reports by companies.

There are 9 notifications provided by 118 of 119 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

H227: Combustible liquid [Warning Flammable liquids]

H312: Harmful in contact with skin [Warning Acute toxicity, dermal]

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]

H330: Fatal if inhaled [Danger Acute toxicity, inhalation]

H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]

P210, P260, P264, P264+P265, P270, P271, P280, P284, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P308+P316, P316, P317, P320, P321, P362+P364, P363, P370+P378, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

Warning: Trichlorophenylsilane releases hydrochloric acid on contact with moisture and is extremely corrosive to the skin and mucous membranes. Caustion is advised.

Signs and Symptoms of Trichlorophenylsilane Exposure: Signs and symptoms of acute ingestion exposure to trichloro- phenylsilane may be severe and include increased salivation, intense thirst, difficulty swallowing, chills, pain, and shock. Oral, esophageal, and stomach burns are common. Vomitus generally has a coffee-ground appearance. The potential for circulatory collapse is high following ingestion of dichloromethylphenylsilane. Acute inhalation exposure may result in sneezing, choking, laryngitis, dyspnea (shortness of breath), respiratory tract irritation, and chest pain. Bleeding of nose and gums, ulceration of the nasal and oral mucosa, pulmonary edema, chronic bronchitis, and pneumonia may also occur. If the eyes have come in contact with trichlorophenylsilane, irritation, pain, swelling, corneal erosion, and blindness may result. Dermatitis (red, inflamed skin), severe burns, pain, and shock generally follow dermal exposure.

Emergency Life-Support Procedures: Acute exposure to trichlorophenylsilane may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:

1. Move victims to fresh air. Emergency personnel should avoid self-exposure to trichlorophenylsilane.

2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.

3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

4. Rush to a health care facility.

Dermal/Eye Exposure:

1. Remove victims from exposure. Emergency personnel should avoid self-exposure to trichlorophenylsilane.

3. Remove contaminated clothing as soon as possible.

4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.

5. Wash exposed skin areas thoroughly with soap and water.

6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

7. Rush to a health care facility.

Ingestion Exposure:

1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.

2. DO NOT induce vomiting or attempt to neutralize!

4. Activated charcoal is of no value.

5. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert.

6. Rush to a health care facility. (EPA, 1998)

General First Aid:

· Call 911 or emergency medical service.

· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.

· Move victim to fresh air if it can be done safely.

· Administer oxygen if breathing is difficult.

· If victim is not breathing:

-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.

-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).

-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.

· Remove and isolate contaminated clothing and shoes.

· For minor skin contact, avoid spreading material on unaffected skin.

· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.

· For severe burns, immediate medical attention is required.

· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.

· Keep victim calm and warm.

· Keep victim under observation.

· For further assistance, contact your local Poison Control Center.

· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.

Specific First Aid:

Full protective clothing, including self-contained breathing apparatus, coat, pants, gloves, boots, and bands around legs, arms, and waist should be provided. No skin surface should be exposed. Move container from fire area if you can do so without risk. Cool containers that are exposed to flames with water from the side until well after fire is out. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire.

Dry chemical, carbon dioxide, fog, or foam. May react violently with water. (EPA, 1998)

If material on fire or involved in fire: use dry chemical, dry sand, or carbon dioxide; do not use water on material itself; if large quantities of combustibles are involved, use water in flooding quantities as spray and fog; use water spray to knock down vapors; cool all affected containers with flooding quantities of water; apply water from as far a distance as possible.

Wear positive pressure self-contained breathing apparatus ... Wear appropriate chemical protective gloves, boots, and goggles.

Do not use water or hydrous agents. Full protective clothing, including self-contained breathing apparatus, coat, pants, gloves, boots, and bands around legs, arms, and waist should be provided. No skin surface should be exposed. Move container from fire area if you can do so without risk. Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. Do not get water inside containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any signs of deforming), withdraw immediately to a secure position.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep unauthorized personnel away.

· Stay upwind, uphill and/or upstream.

· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

· All equipment used when handling the product must be grounded.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

· Stop leak if you can do it without risk.

· A vapor-suppressing foam may be used to reduce vapors.

· FOR CHLOROSILANES, use alcohol-resistant foam to reduce vapors.

· DO NOT GET WATER on spilled substance or inside containers.

· Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material.

· Prevent entry into waterways, sewers, basements or confined areas.

Small Spill

· Cover with DRY earth, DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain.

· Use clean, non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal.

HCl - when spill Phenyltrichlorosilane into water.

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 1804 datasheet.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Immediate precautionary measure

· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.

· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.

· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.

When spilled in water

Small spill:

- ISOLATE in all directions: 30 m (100 ft)

Large spill:

- PROTECT people from downwind during DAY time: 0.1 km (0.1 mi)

- PROTECT people from downwind during NIGHT time: 0.1 km (0.1 mi)

- PROTECT people from downwind during DAY time: 0.3 km (0.2 mi)

- PROTECT people from downwind during NIGHT time: 1.0 km (0.6 mi)

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Ventilate area of spill or leak. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. Keep this chemical out of a confined space, such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the build-up of explosive concentrations. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

SRP: Contaminated protective clothing should be segregated in a manner that results in no direct personal contact by personnel who handle, dispose of, or clean the clothing. Quality assurance procedures to confirm the efficacy of the cleaning procedures should be implemented prior to the decontaminated protective clothing being returned for reuse by the workers. Contaminated clothing (including shoes/socks) should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. A vapor-suppressing foam may be used to reduce vapors. FOR CHLOROSILANES, use alcohol-resistant foam to reduce vapors. DO NOT GET WATER on spilled substance or inside containers. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Prevent entry into waterways, sewers, basements or confined areas.

SMALL SPILL: Cover with DRY earth, DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain. Use clean, non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal. (ERG, 2024)

SRP: Operations involving entry into tanks or closed vessels, and emergency situations, require consideration of potentially oxygen deficient, or "immediately dangerous to life and health" IDLH environments. This may necessitate use of a self-contained breathing apparatus (SCBA), or a positive pressure supplied air respirator.

Store in tightly closed containers in a cool, well-ventilated area away from water at temperatures below 50 °C. Phenyl trichlorosilane can give off corrosive hydrogen chloride gas on contact with water, stream, or moisture. Sources of ignition, such as smoking and open flames, are prohibited where phenyl trichlorosilane is used, handled, or stored in a manner that could create a potential fire or explosion hazard.

All containers, pipes, apparatus, installations, and structures used for manufacture, storage, transport, or use of these substances must be of material resistant to corrosive substances or be protected by suitable coatings ... All containers or receptacles should be clearly labelled to indicate their contents and should bear the danger symbol for corrosives. /Corrosive substances/

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.

· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: ppm)

AEGL 2: Irreversible or other serious, long-lasting adverse health effects or an impaired ability to escape (Unit: ppm)

AEGL 3: Life-threatening health effects or death (Unit: ppm)

AEGLs Status: Final

0.60 [ppm]

7.3 [ppm]

33 [ppm]

· Note: Most foams will react with the material and release corrosive/toxic gases.

CAUTION: For Acetyl bromide (UN1716), use CO2 or dry chemical only.

Small Fire

· CO2, dry chemical, dry sand, alcohol-resistant foam.

Large Fire

· Water spray, fog or alcohol-resistant foam.

· FOR CHLOROSILANES, DO NOT USE WATER; use alcohol-resistant foam.

· If it can be done safely, move undamaged containers away from the area around the fire.

· Avoid aiming straight or solid streams directly onto the product.

Fire Involving Tanks, Rail Tank Cars or Highway Tanks

· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.

· Do not get water inside containers.

· Cool containers with flooding quantities of water until well after fire is out.

· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.

· ALWAYS stay away from tanks in direct contact with flames.

Table: AEGLs for Phenyltrichlorosilane (ppm) (interim) [Table#2768]

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

Those who have to handle ... /chlorosilanes/ should wear goggles and if necessary a /NIOSH approved respirator/. Handling should be done as far as possible under suitably ventilated hoods. /Chlorosilanes/

Acid-vapor type respiratory protection; rubber gloves; chemical worker's goggles; other protective equipment as necessary to protect eyes and skin.

Wear protective gloves and clothing to prevent any reasonable probability of skin contact ... Contact lenses should not be worn when working with this chemical. Wear splash-proof chemical goggles and face shield unless full facepiece respiratory protection is worn ... Provide emergency showers and eyewash.

Where ... /closed-circuit apparatus/ is not possible ... rely on suitable personal protective equipment. Such equipment should ... comprise: corrosion-resistant and impervious suits or overalls, foot protection, hand and arm protection, head, ... eye, and face protection; where corrosive gases /are/ expected, appropriate respiratory protective equipment is required, ranging from simple respirators to air or oxygen lines or self-contained breathing apparatus, coupled with gas-tight goggles ... No universally suitable material for ... personal equipment can be indicated, but ... natural rubbers, synthetic rubbers, polyvinyl chloride, polypropylene, or polyethylene either in sheet form or with fabric backing are suitable. Where aprons are used ... these should have bibs; sleeves should be worn outside gauntlets or gloves and ... trouser legs should cover tops of shoes in order to prevent splashes .... /Corrosive substances/

Phenyltrichlorosilane appears as a colorless liquid with a pungent odor. Decomposed by moisture or water to hydrochloric acid with evolution of heat. Corrosive to metals and tissue.

Colorless liquid; [Hawley]

Colorless liquid

395 °F at 760 mmHg (EPA, 1998)

201 °C @760 [mm Hg]

196 °F (EPA, 1998)

196 °F (91 °C) (open cup)

Soluble in carbon tetrachloride, chloroform, carbon disulfide

Soluble in benzene, ether, perchloroethylene

1.326 at 64.4 °F (EPA, 1998) - Denser than water; will sink

1.321 g/cu cm at 20 °C

1.321 @ 20°C

7.36 (EPA, 1998) - Heavier than air; will sink (Relative to Air)

7.36 (AIR= 1)

15.0 [mmHg]

0.426 mm Hg at 25 °C

> 400 °C at 1013 hPa

The silanes decomp at elevated temp to liberate hydrogen and deposit a high purity silicon, which leads to some of the principal uses of silanes. /Silanes/

Hydrogen chloride and phosgene gases may form; both are toxic and irritating.

When heated to decomposition, it emits toxic fumes of /hydrogen chloride/.

Corrosive

Index of refraction = 1.5230 at 20 °C/D

Readily hydrolyzed by moisture with liberation of hydrogen chloride

Dangerous fire risk /Silane compounds/

Organo-functional silanes are noted for their ability to bond organic polymer systems to inorganic substrates. /Silane compounds/

The reaction of organosilanes with halogens and halogen cmpd usually proceeds in good yield through cleavage of the Si--H bond and formation of the silicon-halogen bond. Reaction with fluorine, however, does not proceed satisfactorily because of cleavage of not only the Si--H but also C--Si and C--H bonds. Direct halogenation with chlorination, bromine, and iodine proceeds smoothly, however. /Organosilanes/

13C nuclear magnetic resonance spectrum

29Si nuclear magnetic resonance spectrum

Schoenflies notation

Boiling point

Chemical bond

Chemical shift

Crystal structure

Fusion temperature

Heat of sublimation

Internuclear distance

Melting temperature

Molar mass

Molecular structure

Nuclear quadrupole resonance spectroscopy

Reacts violently with water, steam, moist air, alcohols, acetone, light metals with generation of heat and combustible (H2) and corrosive (HCl) gases. On contact with air it gives off HCl gas. [Handling Chemicals Safely 1980. p. 924].

Phenyltrichlorosilane reacts vigorously with water to generate gaseous HCl. Based on a scenario where the chemical is spilled into an excess of water (at least 5 fold excess of water), half of the maximum theoretical yield of Hydrogen Chloride gas will be created in 2.6 minutes. Experimental details are in the following: "Development of the Table of Initial Isolation and Protective Distances for the 2008 Emergency Response Guidebook", ANL/DIS-09-2, D.F. Brown, H.M. Hartmann, W.A. Freeman, and W.D. Haney, Argonne National Laboratory, Argonne, Illinois, June 2009.

Chlorosilanes

Water-Reactive

Air-Reactive

Chlorosilanes, such as PHENYLTRICHLOROSILANE are compounds in which silicon is bonded to from one to four chlorine atoms with other bonds to hydrogen and/or alkyl groups. Chlorosilanes react with water, moist air, or steam to produce heat and toxic, corrosive fumes of hydrogen chloride. They may also produce flammable gaseous H2. They can serve as chlorination agents. Chlorosilanes react vigorously with both organic and inorganic acids and with bases to generate toxic or flammable gases.

Reacts with surface moisture to form hydrogen chloride, which is corrosive to common metals.

React with water or steam to produce heat and toxic and corrosive fumes of /hydrogen chloride/.

Readily hydrolyzed by moisture, with liberation of hydrogen chloride.

Trichlorosilanes may react violently with strong oxidants, strong acids, bases, amines, alcohols, acetone, ammonia. Attacks many metals in presence of water releasing explosive hydrogen gas.

Dermatotoxin - Skin burns.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

LC50 (mice) = 330 mg/m3/2h

LC50 Mouse inhalation 0.33 mg/L 2 hr

LD50 Rat oral 2390 mg/kg

LD50 Mouse iv 100 mg/kg

LD50 Rabbit skin 1166 mg/kg 24 hr

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Silane, Chlorosilane, and Related Compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal (refer to ingestion protocol in Section Three ... . Cover skin burns with sterile dressings after decontamination ... . /Silane, Chlorosilane, and Related Compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Early intubation at the first sign of upper airway obstruction may be necessary. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Silane, Chlorosilane, and related compounds/

/SIGNS AND SYMPTOMS/ Acute inhalation exposure may result in sneezing, choking, laryngitis, dyspnea (shortness of breath), respiratory tract irritation, and chest pain. Higher exposure can cause pulmonary edema, a medical emergency that can be delayed for several hours. This can cause death. Bleeding of nose and gums, ulceration of the nasal and oral mucosa, pulmonary edema, chronic bronchitis, and pneumonia may also occur. If the eyes have come in contact with dimethyldichlorosilane, irritation, pain, swelling, corneal erosion, and blindness may result. Dermatitis (red, inflamed skin), severe burns, pain, and shock generally follow dermal exposure. Inhalation irritates mucous membranes. Severe gastrointestinal damage may occur. Vapors cause severe eye and lung injury. Upon short contact, second and third degree burns may occur. Signs and symptoms of acute ingestion of dimethyldichlorosilane may be severe and include increased salivation, intense thirst, difficulty swallowing, chills, pain, and shock. Oral, esophageal, and stomach burns are common. /Dimethyldichlorosilane/

/SIGNS AND SYMPTOMS/ Inhalation irritates mucous membranes. Contact with liq causes severe burns of eyes and skin ... Vapors cause severe irritation of eyes and throat and can cause eye and lung injury. They cannot be tolerated even at low concn. Causes second- and third-degree burns on short contact ...

/SIGNS AND SYMPTOMS/ Causes severe eye and skin burns. Serious health hazard. May be harmful if inhaled. Irritating to eye, skin, and respiratory system. /Dimethylchlorosilane/

/SIGNS AND SYMPTOMS/ Short Term Exposure: corrosive to the eyes, skin, and respiratory tract. Eye contact may damage the corneas and cause blindness. Inhalation may cause throat to swell causing suffocation, and may cause pulmonary edema, a medical emergency that can be delayed for several hours. This can cause death. Highly toxic; may cause death or permanent injury after short inhalation exposure to small quantity. Chemical burns to all exposed membranes and tissues with severe tissue destruction. Delayed - after oral exposure stomach and intestines may perforate to be obstructed by scar tissue. Ingestion may cause mild to moderately severe oral and esophageal burns, with severe burns occurring in stomach. Perforations and peritonitis may occur. Severe irritation may produce spontaneous vomiting. Viscid white or blood-stained foamy mucus and threads of tissue may appear in mouth. Long Term Exposure: Many highly irritating substances can cause lung damage; bronchitis may develop.

For more Human Toxicity Excerpts (Complete) data for Phenyltrichlorosilane (6 total), please visit the HSDB record page.

/LABORATORY ANIMALS: Acute Exposure/ The acute toxicity of trichlorophenylsilane is low in rats treated by stomach tube (oral LD50 2390 mg/kg bw), moderate in rabbits treated dermally (24-hour LD50 0.89 mL (1166 mg)/kg body weight), and high in mice exposed by inhalation (2-hour LC50 0.33 mg/L) or by intravenous injection (LD50 100 mg/kg bw). The mice exposed to low vapor concentrations (0.12 - 0.3 mg/L) showed signs of mucosal irritation (breathlessness, asphyxia, cyanosis) as well as agitated motor activity, convulsions, spreading of hind limbs), and those that died displayed various changes in the lungs, liver and brain.

/LABORATORY ANIMALS: Acute Exposure/ In an inhalation hazard test, 6 male albino rats survived exposure to the concentrated vapor for 8 hours.

/LABORATORY ANIMALS: Acute Exposure/ Application of the liquid to the skin or eyes of rabbits produces corrosion, and the vapor is also irritating to the eyes of mice and rabbits.

/LABORATORY ANIMALS: Acute Exposure/ Various chlorosilanes, such as Me3SiCl, Me2SiCl2, MeSiCl3, and HSiCl3, were tested in a single dose repeated inhalation study against a positive control exposed to hydrochloric acid. No clinical signs of toxicity were noted which were treatment related. The conclusion of the study showed no difference between gaseous HCl and the chlorosilanes in question at the levels used (30 and 34 ppm).

For more Non-Human Toxicity Excerpts (Complete) data for Phenyltrichlorosilane (11 total), please visit the HSDB record page.

EC50; Species: Tetrahymena thermophila (Ciliate protozoa, stationary growth phase); Conditions: static, 32 °C; Concentration: 285000 ug/L for 48 hr; Effect: population changes, general, proliferation rate /formulation/

Chlorosilane compounds' production and use as intermediates for silicone products may result in their release to the environment through various waste streams. However, these compounds decompose to release hydrogen chloride upon contact with water or steam. Therefore, volatilization, biodegradation, and bioconcentration are not expected to be important environmental fate processes. /Chlorosilanes/ (SRC)

AQUATIC FATE: In water, chlorosilanes are hydrolyzed rapidly, releasing hydrochloric acid. /Chlorosilane/

ATMOSPHERIC FATE: In the trophosphere, the ultimate fate of chlorosilane is probably determined by hydrolysis of the silicon-chlorine bonds in water droplets. /Chlorosilanes/

ATMOSPHERIC FATE: In arid regions, some transport of chlorosilanes to the stratosphere might occur. In the stratosphere, photolysis by short wavelength light is expected. /Chlorosilanes/

Silane compounds decompose upon contact with water or steam to produce heat and toxic and corrosive fumes of hydrogen chloride. Silane ignites spontaneously in air(1,2). With a little ammonia, it forms a self-igniting product(1). /Chlorosilanes/

Chlorosilanes are not expected to persist long enough to bioconcentrate. /Chlorosilanes/

The high volatility of /chlorosilanes/ suggests that they will move freely into the atmosphere. /Chlorosilanes/

According to the 2006 TSCA Inventory Update Report, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use for phenyltrichlorosilane is 100 to 999; the data may be greatly underestimated(1).

EC50; Species: Tetrahymena thermophila (Ciliate protozoa, stationary growth phase); Conditions: static, 32 °C; Concentration: 285000 ug/L for 48 hr; Effect: population changes, general, proliferation rate /formulation/

Chlorosilane compounds' production and use as intermediates for silicone products may result in their release to the environment through various waste streams. However, these compounds decompose to release hydrogen chloride upon contact with water or steam. Therefore, volatilization, biodegradation, and bioconcentration are not expected to be important environmental fate processes. /Chlorosilanes/ (SRC)

AQUATIC FATE: In water, chlorosilanes are hydrolyzed rapidly, releasing hydrochloric acid. /Chlorosilane/

ATMOSPHERIC FATE: In the trophosphere, the ultimate fate of chlorosilane is probably determined by hydrolysis of the silicon-chlorine bonds in water droplets. /Chlorosilanes/

ATMOSPHERIC FATE: In arid regions, some transport of chlorosilanes to the stratosphere might occur. In the stratosphere, photolysis by short wavelength light is expected. /Chlorosilanes/

Silane compounds decompose upon contact with water or steam to produce heat and toxic and corrosive fumes of hydrogen chloride. Silane ignites spontaneously in air(1,2). With a little ammonia, it forms a self-igniting product(1). /Chlorosilanes/

Chlorosilanes are not expected to persist long enough to bioconcentrate. /Chlorosilanes/

The high volatility of /chlorosilanes/ suggests that they will move freely into the atmosphere. /Chlorosilanes/

According to the 2006 TSCA Inventory Update Report, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use for phenyltrichlorosilane is 100 to 999; the data may be greatly underestimated(1).

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

If ... THERE IS NO FIRE, go directly to the Table of Initial Isolation and Protective Action Distances /(see table below)/ ... to obtain initial isolation and protective action distances. IF THERE IS A FIRE, or IF A FIRE IS INVOLVED, go directly to the appropriate guide /(see guide(s) below)/ and use the evacuation information shown under PUBLIC SAFETY. /Phenyltrichlorosilane (when spilled in water)/

Table: Table of Isolation and Protective Action Distances for Phenyltrichlorosilane (when spilled in water) [Table#2765]

Table of Water-Reactive Materials Which Produce Toxic Gases

Table: Materials Which Produce Large Amounts of Toxic-by-Inhalation (TIH) Gas(es) When Spilled in Water [Table#2766]

/GUIDE 156: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE/WATER-SENSITIVE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

/GUIDE 156: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE/WATER-SENSITIVE)/ Health: TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat which will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

For more DOT Emergency Guidelines (Complete) data for Phenyltrichlorosilane (10 total), please visit the HSDB record page.

UN 1804; Phenyltrichlorosilane[United Nations; Recommendations on the Transport of Dangerous Goods. Model Regulations. Vol. I, 16th Revised Edition (2009). Available from, as of March 22, 2010: http://www.unece.org/trans/danger/publi/unrec/rev16/16files_e.html]

Hazard Class or Division: 8; Phenyltrichlorosilane[United Nations; Recommendations on the Transport of Dangerous Goods. Model Regulations. Vol. I, 16th Revised Edition (2009). Available from, as of March 22, 2010: http://www.unece.org/trans/danger/publi/unrec/rev16/16files_e.html]

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Corrosive