4-Toluenesulfonyl chloride

This chemical does not meet GHS hazard criteria for 5.7% (53 of 926) of reports.

H290 (20%): May be corrosive to metals [Warning Corrosive to Metals]

H314 (62%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

H315 (32.3%): Causes skin irritation [Warning Skin corrosion/irritation]

H317 (21%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H318 (85.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H335 (53.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P234, P260, P261, P264, P264+P265, P271, P272, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P332+P317, P333+P317, P362+P364, P363, P390, P403+P233, P405, P406, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 926 reports by companies from 25 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 53 of 926 reports by companies.

There are 24 notifications provided by 873 of 926 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Fresh air, rest.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

Refer to the "General First Aid" section. Specific First Aid: For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required. (ERG, 2024)

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

SMALL FIRE: Dry chemical, CO2 or water spray.

LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.

FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)

Use dry powder, carbon dioxide. NO water. NO foam.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into containers. Carefully collect remainder. Then store and dispose of according to local regulations.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024)

Dry. Well closed. Store in an area without drain or sewer access.

0.45 [mg/m3]

5.0 [mg/m3]

30 [mg/m3]

Workplace Environmental Exposure Level (WEEL): Short-term Exposure Limit (STEL) 5 mg/cu m, ceiling.

A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered.

The substance is severely irritating to the eyes. The substance is irritating to the skin and respiratory tract.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)

WHEN HANDLING THESE MATERIALS, THERE SHOULD BE EDUCATION OF PERSONNEL IN NATURE OF HAZARD, PROVISION OF PERSONAL PROTECTIVE EQUIPMENT (SAFETY GOGGLES, GLOVES), ADEQUATE VENTILATION, & PROVISION FOR FLUSHING EYES OR SKIN WITH WATER. /ACID HALIDES/

NO open flames.

PREVENT DISPERSION OF DUST!

Use local exhaust or breathing protection.

Protective gloves.

Wear safety goggles or eye protection in combination with breathing protection if powder.

Do not eat, drink, or smoke during work.

P-toluene sulfonylchloride appears as a white to gray powdered solid with a distinctive odor. Insoluble in water and denser than water. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion, inhalation and skin absorption. Used to make other chemicals.

A white to gray solid; [CAMEO] Hygroscopic; [eChemPortal: SIDSUNEP] White or light yellow crystalline solid; [MSDSonline]

COLOURLESS-TO-YELLOW HYGROSCOPIC CRYSTALS WITH PUNGENT ODOUR.

CRYSTALS

TRICLINIC CRYSTALS FROM ETHER OR PETROLEUM ETHER

146 °C @ 15 MM HG

69-71 °C

128 °C c.c.

INSOL IN WATER; FREELY SOL IN ALCOHOL, BENZENE, ETHER

Solubility in water: reaction

1.3 g/cm³

1.33 @25 °C

Relative vapor density (air = 1): 6.6

Vapor pressure, Pa at 25 °C: 0.16

1 [mm Hg] @88 °C

Schoenflies notation

Chemical bond

Chemical shift

Dielectric constant

Internuclear distance

Lineshape

Molecular structure

Nuclear quadrupole resonance spectroscopy

Point group

Quadrupole coupling

Reaction coordinate

Spin-spin coupling constant

Surface tension

Toxic Gases & Vapors -> Acid Halides

Insoluble in water.

Acyl Halides, Sulfonyl Halides, and Chloroformates

Halogenating Agents

Redness. Pain.

Sore throat.

Dermatotoxin - Skin burns.

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

...PRODUCE SEVERE PRIMARY IRRITATION OF EYES, SKIN, OR RESP TRACT. DELAYED VESICATION IS NOT UNCOMMON. SENSITIZATION MAY ALSO OCCUR... /ACID HALIDES/

STRONG IRRITANT & VESICANT. /FROM TABLE/

WHILE CUMULATIVE TOXIC EFFECTS ARE THEORETICALLY POSSIBLE IF ORIGINAL ORG ACID IS ALSO KNOWN TO BE CUMULATIVE IN ACTION...IRRITANT PROPERTIES OF THE HALIDE PREVENT VOLUNTARY EXPOSURE TO SIGNIFICANT AMOUNTS... /ACID HALIDES/

REMSEN FAHLBERG SACCHARIN & ITS CONTAMINANTS (O-TOLUENE SULFONAMIDE (OTS), P-TOLUENE SULFONAMIDE (PTS), O-SULFAMOYL BENZOIC ACID, P-SULFAMOYL BENZOIC ACID) WERE TESTED FOR MUTAGENICITY. CONTAMINANTS OTS & ITS ISOMER PTS WERE MUTAGENIC IN AMES TEST & BASC TEST IN DROSOPHILA.

The substance is harmful to aquatic organisms.

The substance is harmful to aquatic organisms.

Corrosive

Unbreakable packaging. Put breakable packaging into closed unbreakable container.

UN Hazard Class: 8; UN Pack Group: II